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  1. Article ; Online: The Reply.

    Mardikar, Harshawardhan / Mardikar, Manjusha / Deshpande, Niteen / Deshpande, Mohan / Admane, Parag

    The American journal of medicine

    2021  Volume 135, Issue 3, Page(s) e81

    MeSH term(s) COVID-19 ; Humans ; India
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 Second Wave in India - Wait or Act?

    Mardikar, Harshawardhan / Mardikar, Manjusha / Deshpande, Niteen / Deshpande, Mohan / Admane, Parag

    The American journal of medicine

    2021  Volume 134, Issue 11, Page(s) 1309

    MeSH term(s) Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Administration, Intravenous ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Ambulatory Care/methods ; Ambulatory Care/organization & administration ; Antiviral Agents/administration & dosage ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/epidemiology ; Critical Pathways/organization & administration ; Critical Pathways/trends ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Risk Adjustment/methods ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Triage/methods ; Triage/trends
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stress echo for evaluation of valvular heart disease.

    Yavagal, S T / Deshpande, Niteen / Admane, Parag

    Indian heart journal

    2014  Volume 66, Issue 1, Page(s) 131–138

    Abstract: Resting echocardiography is the most important tool for diagnosing valvular heart disease. However, treatment planning in valvular heart diseases may require additional information in some patients, particularly asymptomatic patients with severe valve ... ...

    Abstract Resting echocardiography is the most important tool for diagnosing valvular heart disease. However, treatment planning in valvular heart diseases may require additional information in some patients, particularly asymptomatic patients with severe valve disease or symptomatic patients with moderate disease. Stress echocardiography provides invaluable information in these situations and aids decision making. Stress echocardiography is performed using either physical stress or dobutamine stress and various valve parameters are monitored during the stress. Further, the ventricular performance, which is an important determinant of outcome in valve disease is also closely monitored during stress which helps immensely in planning the intervention. Lastly, possibility of associated coronary artery disease can also be evaluated, especially in the elderly. This article discusses the role of stress evaluation in assessment of valve disease in the commonly encountered clinical situations.
    MeSH term(s) Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/physiopathology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/physiopathology ; Echocardiography, Stress/methods ; Evaluation Studies as Topic ; Female ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/physiopathology ; Humans ; Male ; Mitral Valve Stenosis/diagnostic imaging ; Mitral Valve Stenosis/physiopathology ; Sensitivity and Specificity ; Severity of Illness Index ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Language English
    Publishing date 2014-01-20
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2013.12.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 616: Show issues Location:
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  4. Article ; Online: Changing management of acute MI--perspectives from India.

    Mardikar, Harshawardhan M / Deshpande, Niteen V / Admane, Parag

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2012  Volume 8 Suppl P, Page(s) P55–61

    Abstract: Management of acute myocardial infarction (AMI) in India essentially rests on the established reperfusion strategies with unique adaptations compelled by the socioeconomic structure of the country. Due to limited availability of trained interventionists ... ...

    Abstract Management of acute myocardial infarction (AMI) in India essentially rests on the established reperfusion strategies with unique adaptations compelled by the socioeconomic structure of the country. Due to limited availability of trained interventionists coupled with financial limitations, thrombolysis remains the most utilised reperfusion therapy for AMI. Patient education through the active participation of physicians concerning the early detection of symptoms suggestive of AMI can enhance the impact of thrombolysis on the outcomes by narrowing the door-to-needle time. This article discusses some of these unique issues and possible solutions in the emerging economies to optimise outcomes in AMI.
    MeSH term(s) Cost-Benefit Analysis ; Developing Countries/economics ; Early Diagnosis ; Emergency Medical Services/trends ; Health Care Costs ; Health Knowledge, Attitudes, Practice ; Health Services Accessibility/economics ; Health Services Accessibility/trends ; Humans ; India ; Myocardial Infarction/diagnosis ; Myocardial Infarction/economics ; Myocardial Infarction/therapy ; Patient Education as Topic ; Percutaneous Coronary Intervention/economics ; Percutaneous Coronary Intervention/trends ; Quality Improvement/trends ; Socioeconomic Factors ; Thrombolytic Therapy/economics ; Thrombolytic Therapy/trends ; Time Factors ; Time-to-Treatment/trends ; Transportation of Patients/trends ; Treatment Outcome
    Language English
    Publishing date 2012-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJV8SPA10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A prospective study evaluating efficacy of polymer free Pronova XR stent in treatment of denovo coronary artery stenosis.

    Deshpande, N V / Admane, Parag / Deshpande, Mohan / Mardikar, H M

    Indian heart journal

    2014  Volume 66, Issue 1, Page(s) 11–15

    Abstract: Background: Drug eluting stents have remarkably improved results of percutaneous coronary angioplasty. Most of the currently available drug eluting stents uses a durable polymer as drug carrier which has been implicated in local inflammatory response ... ...

    Abstract Background: Drug eluting stents have remarkably improved results of percutaneous coronary angioplasty. Most of the currently available drug eluting stents uses a durable polymer as drug carrier which has been implicated in local inflammatory response and continued incidence of late and very late stent thrombosis. The Pronova XR stent is one from those new generation polymer free sirolimus eluting stents in which pharmaceutical excipient is used for the timed release of sirolimus from the XR stent platform instead of a polymeric coating.
    Methodology: We consecutively recruited 121 patients undergoing elective or urgent PCI at our center. All the patients were followed up clinically and mandatory follow up angiogram at 6 months was done for one third of the total patients. An independent core lab analyzed paired angiograms.
    Results: The primary efficacy endpoint was death, MI, TVR at 6 months which occurred in 6.66% patients. The QCA analysis showed reference vessel diameter of 2.5 + 0.44 mm at baseline and the minimal luminal diameter was 0.88 + 0.43 mm giving baseline diameter stenosis of 65.26 + 15.89%. The immediate post procedure in-segment diameter stenosis assessed was 23.68 + 8.96% which increased to 36.02 + 24.48% at follow up with a late lumen loss of 0.25 + 0.76 mm at mean of 191 days.
    Conclusion: Coronary angioplasty with polymer free Pronova XR stents results in acceptable late lumen loss and very low target lesion revascularisation at short and intermediate term in unselected patients.
    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/instrumentation ; Angioplasty, Balloon, Coronary/methods ; Angioplasty, Balloon, Coronary/mortality ; Cohort Studies ; Coronary Angiography/methods ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/mortality ; Coronary Stenosis/therapy ; Drug-Eluting Stents ; Excipients/pharmacology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Polymers ; Prospective Studies ; Prosthesis Design ; Prosthesis Failure ; Risk Assessment ; Severity of Illness Index ; Sirolimus/administration & dosage ; Statistics, Nonparametric ; Survival Rate ; Treatment Outcome
    Chemical Substances Excipients ; Polymers ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2014-03-24
    Publishing country India
    Document type Clinical Trial ; Comparative Study ; Journal Article
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2013.12.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 616: Show issues Location:
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  6. Article: Recent advances in the management of acute myocardial infarction.

    Mardikar, H M / Deshpande, N V / Admane, Parag

    The Journal of the Association of Physicians of India

    2011  Volume 59 Suppl, Page(s) 31–36

    Abstract: Recently the reperfusion therapy in the form of Primary Percutaneous Coronary intervention (PPCI) has become the gold standard for the treatment of Acute Myocardial Infarction. In spite of rapid revascularization either with PPCI or thrombolytic therapy, ...

    Abstract Recently the reperfusion therapy in the form of Primary Percutaneous Coronary intervention (PPCI) has become the gold standard for the treatment of Acute Myocardial Infarction. In spite of rapid revascularization either with PPCI or thrombolytic therapy, the significant number of patients develops decreased left ventricular function leading to heart failure which can increase long-term mortality and morbidity. The number of strategies are being evolved and evaluated to reduce this post infarct heart failure. They are being developed at the level of optimizing the outcomes of PPCI, protection against the reperfusion injury, and novel therapies like cardiac repair and regeneration and sonothrombolysis. Thrombus aspiration using simple aspiration catheters during PPCI are getting established as a useful adjunct tool to reduce distal embolisation and consequently improving myocardial salvage. The newer antiplatelet drugs like Prasugrel and Ticagrelor may replace the Clopidogrel to reduce ischemic complications. The reduction in reperfusion injury using drugs has shown mixed results. The newer modalities like cardiac repair and regeneration using stem cell therapy looks promising but are yet to be established.
    MeSH term(s) Antifibrinolytic Agents/therapeutic use ; Disease Management ; Humans ; Ischemic Preconditioning ; Myocardial Infarction/drug therapy ; Myocardial Infarction/therapy ; Myocardial Reperfusion ; Stem Cell Transplantation ; Thrombolytic Therapy ; Treatment Outcome
    Chemical Substances Antifibrinolytic Agents
    Language English
    Publishing date 2011-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Safety and efficacy of bivalirudin with glycoprotein IIb/IIIa for high-risk percutaneous coronary intervention.

    Deshpande, Niteen V / Pratiti, Rebecca / Admane, Parag / Mukherjee, Debabrata / Mardikar, Harshawardhan M

    Indian heart journal

    2012  Volume 64, Issue 5, Page(s) 444–448

    Abstract: Aims: The aim of the study was to assess the safety and efficacy of bivalirudin + glycoprotein (Gp) IIb/IIIa inhibitor as compared to unfractionated heparin (UFH) + Gp IIb/IIIa inhibitor in high risk patients undergoing elective percutaneous coronary ... ...

    Abstract Aims: The aim of the study was to assess the safety and efficacy of bivalirudin + glycoprotein (Gp) IIb/IIIa inhibitor as compared to unfractionated heparin (UFH) + Gp IIb/IIIa inhibitor in high risk patients undergoing elective percutaneous coronary intervention (PCI). The primary end point was time to sheath removal and ambulation where as peri-procedure myocardial damage, access site bleeding and major adverse cardiac events (MACE) rates were secondary end points.
    Methods: One hundred and one high risk patients undergoing elective PCI were randomly assigned to either bivalirudin + GpIIb/IIIa inhibitor or UFH + Gp IIb/IIIa inhibitor. PCI was performed by standard technique and activated clotting time was monitored immediately on arrival to recovery area and every 60 min thereafter. Sheath were pulled out once ACT was below 150 seconds and patients were mobilized 6hrs after sheath were removed. Peri-procedure myocardial damage was assessed by serial Trop I levels.
    Results: Patient assigned to bivalirudin + tirofiban has significantly reduced time to sheath removal and ambulation as compared to those who received UFH + tirofiban (p < 0.0001) although peak Act did not differ in the groups. Peak Trop I levels were significantly lower in bivalirudin + tirofiban group (p = 0.023) and peri-procedure Trop I elevation occurred in significantly lower number of patients treated with bivalirudin + tirofiban (p = 0.029).
    Conclusions: The combination of bivalirudin + tirofiban was safe and effective as compared to UFH + tirofiban in high risk patients undergoing elective PCI.
    MeSH term(s) Aged ; Antithrombins/adverse effects ; Antithrombins/therapeutic use ; Biomarkers/blood ; Coronary Thrombosis/blood ; Coronary Thrombosis/etiology ; Coronary Thrombosis/prevention & control ; Drug Therapy, Combination ; Female ; Fibrinolytic Agents/adverse effects ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/chemically induced ; Heparin/adverse effects ; Heparin/therapeutic use ; Hirudins/adverse effects ; Humans ; India ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Peptide Fragments/adverse effects ; Peptide Fragments/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors ; Recombinant Proteins/adverse effects ; Recombinant Proteins/therapeutic use ; Time Factors ; Tirofiban ; Treatment Outcome ; Troponin I/blood ; Tyrosine/adverse effects ; Tyrosine/analogs & derivatives ; Tyrosine/therapeutic use ; Whole Blood Coagulation Time
    Chemical Substances Antithrombins ; Biomarkers ; Fibrinolytic Agents ; Hirudins ; Peptide Fragments ; Platelet Aggregation Inhibitors ; Platelet Glycoprotein GPIIb-IIIa Complex ; Recombinant Proteins ; Troponin I ; Tyrosine (42HK56048U) ; Heparin (9005-49-6) ; Tirofiban (GGX234SI5H) ; bivalirudin (TN9BEX005G)
    Language English
    Publishing date 2012-07-27
    Publishing country India
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 604366-5
    ISSN 0019-4832
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2012.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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