LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Determination of the Cancer Genome Atlas (TCGA) Endometrial Cancer Molecular Subtypes Using the Variant Interpretation and Clinical Decision Support Software MH Guide.

    Mustea, Alexander / Ralser, Damian J / Egger, Eva / Ziehm, Ulrike / Vivas, Sonia / Brock, Stephan / Jackson, David / Condic, Mateja / Meisel, Christian / Otten, Lucia / Laib, Anna / Cordova, Miguel Cubas / Hartmann, Rahel / Stein, Martin A / Koensgen, Dominique / Stope, Matthias B

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Background: The Cancer Genome Atlas (TCGA) network (United States National Cancer Institute) identified four molecular endometrial cancer (EC) subtypes using an extensive multi-method approach. The aim of this study was to determine the four TCGA EC ... ...

    Abstract Background: The Cancer Genome Atlas (TCGA) network (United States National Cancer Institute) identified four molecular endometrial cancer (EC) subtypes using an extensive multi-method approach. The aim of this study was to determine the four TCGA EC molecular subtypes using a single-method whole-exome sequencing (WES)-based approach provided by MH Guide (Molecular Health, Heidelberg, Germany).
    Methods: WES and clinical data of n = 232 EC patients were obtained from TCGA. The four TCGA EC molecular subtypes designated as (i) Mutated Polymerase ε (POLE), (ii) Microsatellite Instability (MSI), (iii) Copy Number (CN) low and, (iv) CN-high were determined using the MH Guide software. The prognostic value of the subtypes determined by MH Guide were compared with the TCGA classification.
    Results: Analysis of WES data using the MH Guide software led to the precise identification of the four EC molecular subtypes analogous to the TCGA classification. Both approaches displayed high concordance in terms of prognostic significance.
    Conclusions: The multi-method-based TCGA EC molecular subtypes can reliably be reproduced by the single-method-based MH Guide approach. The easy-to-implement single-method MH Guide approach represents a promising diagnostic tool.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Pravastatin for prevention of HELLP syndrome: A case report.

    Otten, Lucia Anna / van der Ven, Katrin / Kühr, Marietta / Gembruch, Ulrich / Merz, Waltraut Maria

    Medicine

    2017  Volume 96, Issue 42, Page(s) e8229

    Abstract: Rationale: Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome.: Patient concerns: The first pregnancy necessitated ... ...

    Abstract Rationale: Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome.
    Patient concerns: The first pregnancy necessitated termination of pregnancy at gestational age (GA) 20+5 for HELLP. Intrauterine fetal death at GA 22+5 occurred in the second pregnancy, whilst on temporizing management of HELLP.
    Diagnoses: Severe, recurrent early-onset HELLP syndrome.
    Interventions: In her fourth pregnancy, pravastatin was commenced at GA 13.
    Outcomes: The course of pregnancy was uncomplicated, and a healthy, appropriate for gestational age fetus was delivered at term.
    Lessons: Pravastatin may be effective in prevention of HELLP. The hepatic uptake may be of particular advantage.
    MeSH term(s) Adult ; Female ; Gestational Age ; HELLP Syndrome/prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Live Birth ; Pravastatin/administration & dosage ; Pregnancy ; Recurrence ; Term Birth ; Treatment Outcome
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pravastatin (KXO2KT9N0G)
    Language English
    Publishing date 2017-10-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000008229
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Behandlung von HIV in der Schwangerschaft – Entwicklung über eine Dekade.

    Pitzen, Isabelle Catherine / Otten, Lucia Anna / Dresbach, Till / Boesecke, Christoph / Wasmuth, Jan-Christian / Mueller, Andreas / Gembruch, Ulrich / Merz, Waltraut M / Strassburg, Christian P / Haberl, Annette / Rockstroh, Juergen K / Poralla, Silvia / Schwarze-Zander, Carolynne

    Zeitschrift fur Geburtshilfe und Neonatologie

    2018  Volume 223, Issue 1, Page(s) 26–32

    Abstract: Introduction: Worldwide, 37 million people are infected with HIV; more than 50% are women. Currently, MTCT (mother-to-child transmission) can be reduced to<1%. The intention of the present study was to analyze the development of (1) the course of ... ...

    Title translation Treatment of HIV in Pregnancy - Progress Over One Decade.
    Abstract Introduction: Worldwide, 37 million people are infected with HIV; more than 50% are women. Currently, MTCT (mother-to-child transmission) can be reduced to<1%. The intention of the present study was to analyze the development of (1) the course of pregnancy of HIV-infected women, (2) the mode of delivery and (3) the post-exposure prophylaxis of the newborn over the last decade.
    Methodology: In this retrospective study, data from HIV-infected women who between 2005 and 2016 received care at the HIV outpatient department and gave birth at the Department of Obstetrics at University Hospital Bonn was analyzed. Furthermore, neonatal data was collected and HIV-MTCT was evaluated.
    Results: In the 2005-2016 study period, 87 pregnancies in 61 women were identified. Seventy babies were born alive at the Department of Obstetrics, University Hospital Bonn. 53% of these women were of African origin. The median of CD4
    Conclusions: Between 2005 and 2016 no vertical HIV transmission from mother to child occurred (0/70). Due to the change in treatment strategy, the elective cesarean section rate fell significantly as well the rate of premature births. An optimal interdisciplinary collaboration builds the basis for successful treatment of HIV in pregnancy.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; Cesarean Section ; Female ; Germany ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/transmission ; Humans ; Infant, Newborn ; Infant, Premature, Diseases/prevention & control ; Infectious Disease Transmission, Vertical/prevention & control ; Obstetric Labor, Premature/prevention & control ; Post-Exposure Prophylaxis ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Retrospective Studies
    Language German
    Publishing date 2018-12-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0300-967X ; 0948-2393 ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0300-967X ; 0948-2393 ; 1615-5300
    DOI 10.1055/a-0741-7700
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Conference proceedings: Prospektiver Vergleich von dorsalen Dekompressionen und dorsalen Dekompressionen mit dynamischer flexions-begrenzender Stabilisierung: Ein Vergleich der 12-Monats-Ergebnisse

    Jansen, Tom / Bornemann, Rahel / Otten, Lucia Anna / Kabir, Koroush / Wirtz, Dieter C. / Pflugmacher, Robert

    2013  , Page(s) PO21–82

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2013
    Keywords Medizin, Gesundheit ; Dynamische Stabilisierung ; Dekompression ; Spinalkanalstenose ; Limiflex
    Publishing date 2013-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13dkou740
    Database German Medical Science

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Conference proceedings: Vergleich klinischer und radiologischer Daten bei der Behandlung von Patienten mit osteoporotischen Wirbelkörper-Kompressionsfrakturen mit Radiofrequenz-Kyphoplastie oder mit Ballon-Kyphoplastie: 2 Jahres Ergebnisse

    Bornemann, Rahel / Jansen, Tom / Otten, Lucia Anna / Kabir, Koroush / Wirtz, Dieter C. / Pflugmacher, Robert

    2013  , Page(s) PO12–109

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2013
    Keywords Medizin, Gesundheit ; Osteoporose ; Wirbelkörperfraktur ; Kyphoplastie
    Publishing date 2013-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13dkou605
    Database German Medical Science

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Behandlung von HIV in der Schwangerschaft – Entwicklung über eine Dekade

    Pitzen, Isabelle Catherine / Otten, Lucia Anna / Dresbach, Till / Boesecke, Christoph / Wasmuth, Jan-Christian / Mueller, Andreas / Gembruch, Ulrich / Merz, Waltraut M. / Strassburg, Christian P. / Haberl, Annette / Rockstroh, Juergen K. / Poralla, Silvia / Schwarze-Zander, Carolynne

    Zeitschrift für Geburtshilfe und Neonatologie

    2018  Volume 223, Issue 01, Page(s) 26–32

    Abstract: Einleitung: Mehr als 50% der rund 37 Mio. Menschen, die weltweit mit HIV leben, sind Frauen. Heutzutage kann die MTCT (Mother-to-child Transmission) auf<1% reduziert werden. Intention der vorliegenden Untersuchung war es, die Entwicklung (1) des ... ...

    Abstract Einleitung: Mehr als 50% der rund 37 Mio. Menschen, die weltweit mit HIV leben, sind Frauen. Heutzutage kann die MTCT (Mother-to-child Transmission) auf<1% reduziert werden. Intention der vorliegenden Untersuchung war es, die Entwicklung (1) des Schwangerschaftsverlaufs HIV-positiver Frauen, (2) des Entbindungsmodus und (3) der Postexpositionsprophylaxe der Neugeborenen, über den Verlauf der letzten Dekade aufzuzeigen.
    Methodik: Im Zeitraum 2005–2016 wurden die HIV- und geburtshilflichen Daten aller HIV-positiver, schwangerer Frauen, der Bonner HIV-Kohorte und die neonatalen Daten der HIV-exponierten Kinder ausgewertet. Die HIV-MTCT wurde für diesen Zeitraum untersucht.
    Ergebnisse: Es wurden 87 Schwangerschaften bei 61 Frauen identifiziert. 70 Kinder wurden an der Universitätsfrauenklinik Bonn lebend geboren. Die Frauen waren zu 53% afrikanischer Herkunft. Der Median der CD4 -Zellzahl betrug präpartal 510 Zellen/μl (IQR 444) und lag bei 32 Frauen (52%) über 500 Zellen/μl. Die HI-Viruslast war präpartal bei 77% vollständig supprimiert (<50 HIV-1-RNA Kopien/ml) und lag bei 92% präpartal<400 HIV-1-RNA Kopien/ml. Im Vergleich zu dem Zeitraum 2005–2011 kam es zu einer deutlichen Reduktion der primären Sectiorate von 77 auf 58% im Zeitraum 2012–2016. Der Anteil der Kinder, die nach der 37 Schwangerschaftswoche geboren wurden, stieg nach 2012 von 60 auf 69% erkennbar an. Während im Zeitraum 2005–2011 78% der Neugeborenen mit ihrem Geburtsgewicht zwischen der 10. und 90. Perzentile lagen, nahm der Anteil nach 2012 auf 92% zu. 54 der 70 Neugeborenen (77%) wurden einem niedrig-normalen Transmissionsrisiko zugeordnet. In keinem Fall (0/70) kam es zu einer HIV-Transmission von Mutter zu Kind.
    Zusammenfassung: In den Jahren 2005–2016 der Analyse hat keine vertikale HIV-Transmission von Mutter zu Kind stattgefunden. Es kam zu einer deutlichen Reduktion der primären Sectiorate und und zu einem Rückgang der Frühgeborenenrate, was die Änderung der Behandlungsstrategie in diesem Zeitraum widerspiegelt. Eine optimale interdisziplinäre Zusammenarbeit bleibt Grundlage für eine erfolgreiche Versorgung HIV-positiver, schwangerer Frauen.
    Keywords HIV ; Schwangerschaft ; Hochaktive antiretrovirale Therapie (HAART) ; Sectio caesarea ; HIV ; pregnancy ; Highly Active Anti-Retroviral Therapy (HAART) ; caesarean section
    Language German
    Publishing date 2018-12-04
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/a-0741-7700
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: COvid MEdicaTion (COMET) study

    Sablerolles, Roos S G / Hogenhuis, Freija E F / Lafeber, Melvin / van de Loo, Bob P A / Borgsteede, Sander D / Boersma, Eric / Versmissen, Jorie / van der Kuy, Hugo M / COMET Research team, / Aleman, Jacomien / Nagele, Fiona / Stemer, Gunar / Tournoy, Jos / derLinden, Lorenz van / Krusteva, Irena / Safipour, Zohreh / Bengaard, Anne Kathrine / Houlind, Morten Baltzer / Kerjean, Nathalie Pons /
    Grand, Jennifer Le / Zenico, Carito / Berlinghini, Silvia / Caruso, Francesca / Peverini, Manola / Pieraccini, Fabio / Bini, Katia / Candela, Marco / DiCarlo, Marco / Grinta, Roberto / Salaffi, Fausto / Schimizzi, Anna Maria / Tardella, Marika / Verri, Federica / Tessari, Roberto / Marchesini, Francesca / Chessa, Paola / Gambera, Marco / Martignoni, Isabella / Rametta, Giovanna / Pappalardo, Francesco / Rossi, Lucia / Fantini, Laura / Maria, Elisa / Gambarelli, Giorgia / Berlinghini, Sivlia / Martini, Gabriella / Pagliarino, Simone / Loche, Elena / Agnoletto, Laura / Boni, Gloria / Falcao, Margarida / Farinha, Helena / Mendes, Dina / Rijo, Joao / Carmo, Ines / Falcao, Fatima / Soares, Joana / Solano, Mariana / Viegas, Erica / Miarons, Marta / QueraltGorgas, Maria / Yubero, Cristina García / Horcajada, Laura Portillo / Keijzers, Kim / Lim, Silke / Haelst, Ingrid van / Andrews, Louise / Sombogaard, Ferdi / Berg, Roland van den / Boutkourt, Firdaouss / Kemper, Marleen / Slob, Elise / Kan, Erikvan / Helmers, Annemiek Otten / Filius, Margreet / Hemminga, Wietske / Ghazarian, Caroline / Hilarius, Doranne / Kappers, Mariette / Etten, Ronald van / Onzenoort, Hein van / Wijngaarden, Peter van / Diepstraten, Jeroen / Roelofsen, Eveline / Meuwese, Edmé Roobol / Wierenga, Peter / Graaf, Ingrid Hoogendoorn de / Verdonk, Judith / Ebbens, Marieke / Hendriksen, Linda / Linden, Paul van der / Crommentuijn, Kristel / Wit, Hugo de / Guda, Kaylen / Dijk, Suzanne van / Bosch, Tessa / Krens, Lisanne / Slijfer, Monique / Hurkens, Kim / Wong, Dennis / Deben, Debbie / Ezinga, Marieke / Nieuwkoop, Kees van / Visser, Loes / Boemaars, Ebbie / Maat, Barbara / Derijks, Luc / Janssen, Paddy / Bulsink, Arjan / Horst, Peter ter / Fleming, Glenda / Goodfellow, Nicola / Scott, Michael / Bell, Helen / Hanley, Joanne / Stoppelaar, Francine de

    protocol for a cohort study

    2020  

    Abstract: Various theories about drugs such as ACE inhibitors or angiotensin II receptor blockers (ARBs) in relation to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and clinical outcomes of COVID-19 are circulating in both mainstream media and ... ...

    Abstract Various theories about drugs such as ACE inhibitors or angiotensin II receptor blockers (ARBs) in relation to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and clinical outcomes of COVID-19 are circulating in both mainstream media and medical literature. These are based on the fact that ACE2 facilitates SARS-CoV-2 cell invasion via binding of a viral spike protein to ACE2. However, the effect of ACE inhibitors, ARBs and other drugs on ACE2 is unclear and all theories are based on conflicting evidence mainly from animal studies. Therefore, clinical evidence is urgently needed. The aim of this study is to investigate the relationship between use of these drugs on clinical outcome of patients with COVID-19. Patients will be included from several hospitals in Europe. Data will be collected in a user-friendly database (Digitalis) on an external server. Analyses will be adjusted for sex, age and presence of cardiovascular disease, hypertension and diabetes. These results will enable more rational choices for randomised controlled trials for preventive and therapeutic strategies in COVID-19.
    Keywords Protocol ; covid19
    Language English
    Publishing date 2020-07-01 00:00:00.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top