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  1. Article ; Online: Should pancreaticoduodenectomy be the standard procedure for true middle bile duct cancer? An updated meta-analysis.

    Zizzo, Maurizio / Morini, Andrea / Zanelli, Magda / Fabozzi, Massimiliano

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 12, Page(s) 1595–1599

    MeSH term(s) Humans ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/methods ; Bile Duct Neoplasms/surgery ; Bile Ducts/surgery ; Pancreatectomy
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Meta-Analysis ; Letter
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.08.002
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    Zs.A 6326: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Surgical management of splenic flexure cancer: an open question in need of recommendations based on strong evidences.

    Zizzo, Maurizio / Morini, Andrea / Zanelli, Magda / Fabozzi, Massimiliano

    Minerva surgery

    2023  Volume 79, Issue 2, Page(s) 228–230

    MeSH term(s) Humans ; Colon, Transverse/surgery ; Colonic Neoplasms/surgery ; Splenic Neoplasms
    Language English
    Publishing date 2023-11-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.10019-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 25: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Operable colon cancer: New therapeutic perspectives, same old problems.

    Morini, Andrea / Zizzo, Maurizio / Fabozzi, Massimiliano

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

    2023  Volume 112, Issue 2, Page(s) 135–136

    MeSH term(s) Humans ; Colonic Neoplasms/surgery
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Letter
    ZDB-ID 2077691-3
    ISSN 1799-7267 ; 1457-4969
    ISSN (online) 1799-7267
    ISSN 1457-4969
    DOI 10.1177/14574969231181491
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    Uk I Zs.224: Show issues Location:
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  4. Article ; Online: Yes, it is time for wider uptake for intracorporeal anastomosis for minimally invasive right colectomy.

    Morini, Andrea / Zizzo, Maurizio / Tumiati, David / Fabozzi, Massimiliano

    ANZ journal of surgery

    2023  Volume 93, Issue 7-8, Page(s) 2039

    MeSH term(s) Humans ; Colectomy ; Colonic Neoplasms/surgery ; Anastomosis, Surgical ; Laparoscopy ; Treatment Outcome ; Retrospective Studies ; Operative Time
    Language English
    Publishing date 2023-05-30
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18553
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    Zs.A 180: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: D3 Lymphadenectomy in Right Hemicolectomy: Current Vision and New Perspectives.

    Morini, Andrea / Zizzo, Maurizio / Giunta, Alessandro

    Surgical innovation

    2023  Volume 30, Issue 5, Page(s) 676–677

    MeSH term(s) Humans ; Lymph Node Excision ; Colectomy ; Colonic Neoplasms/surgery ; Laparoscopy
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Letter
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506221150550
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    Zs.A 4269: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Inhibitory effect and underlying mechanism of essential oil of Prangos ferulacea Lindl (L.) on spontaneous and induced uterine contractions in non-pregnant rats.

    Zizzo, Maria Grazia / Cicio, Adele / Bruno, Maurizio / Serio, Rosa

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 167, Page(s) 115570

    Abstract: Evidence suggests the use of natural compounds as support in the management of uterine contractility disorders. We recently demonstrated that the essential oil of Apiacea Prangos ferulacea (L.) (Prangoil) modulates intestinal smooth muscle contractility. ...

    Abstract Evidence suggests the use of natural compounds as support in the management of uterine contractility disorders. We recently demonstrated that the essential oil of Apiacea Prangos ferulacea (L.) (Prangoil) modulates intestinal smooth muscle contractility. Thus, we aimed to evaluate if Prangoil could also affect the contractility of uterine muscle in non-pregnant rat and to investigate the related action mechanism/s. The effects of the aromatic monoterpenes, β-ocimene and carvacrol, constituents of Prangoil, were also evaluated. Spontaneous contractions and contraction-induced by K
    Language English
    Publishing date 2023-09-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115570
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    Ud II Zs.198: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Essential oil of Sicilian Prangos ferulacea (L.) Lindl. and its major component, β-ocimen, affect contractility in rat small and large intestine.

    Zizzo, Maria Grazia / Cicio, Adele / Bruno, Maurizio / Serio, Rosa

    Journal of ethnopharmacology

    2023  Volume 313, Page(s) 116531

    Abstract: Ethnopharmacological relevance: Prangos ferulacea (L.) Lindl is an Apiaceae plant, widely used in traditional medicine. Recently, chemical composition and biological activities of its essential oil (Prangroil) have been reported, but there are no ... ...

    Abstract Ethnopharmacological relevance: Prangos ferulacea (L.) Lindl is an Apiaceae plant, widely used in traditional medicine. Recently, chemical composition and biological activities of its essential oil (Prangroil) have been reported, but there are no studies on possible effects on intestinal contractility.
    Aims of the study: We investigated the effects of essential oil Sicilian Prangoil on the contractility of rat small (duodenum) and large (colon) intestine and the related action mechanism.
    Materials and methods: Responses to Prangoil and to its major component β-ocimen in intestinal segments were assessed in vitro as changes in isometric tension.
    Results: Prangoil, induced in duodenum, depending upon doses, contraction and/or muscular relaxation. Instead, in colon Prangoil only reduced the phasic contractions and induced muscular relaxation. β-ocimen, in both segments, produced only reduction of the spontaneous contractions without affecting basal tone. Prangoil contractile effects were abolished by ω-conotoxin, neural N-type Ca
    Conclusion: Prangoil affects the contractility of small and large intestine in rat, with regional differences, via potentiation of neural cholinergic activity, blockade of L-type voltage-gated calcium channel and reduction of Ca
    MeSH term(s) Rats ; Animals ; Acetylcholinesterase ; Muscle, Smooth ; Muscle Contraction ; Colon ; Cholinergic Agents/pharmacology ; Calcium Channels, L-Type/physiology ; omega-Conotoxins/pharmacology
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Cholinergic Agents ; Calcium Channels, L-Type ; omega-Conotoxins
    Language English
    Publishing date 2023-05-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116531
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    Zs.A 1494: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 Gy total body irradiation.

    Cui, Wanchang / Hull, Lisa / Zizzo, Alex / Wang, Li / Lin, Bin / Zhai, Min / Xiao, Mang

    Animal microbiome

    2023  Volume 5, Issue 1, Page(s) 42

    Abstract: Background: Recent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice, mini-pigs and nonhuman primates after radiation exposure. Blocking IL-18 ... ...

    Abstract Background: Recent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice, mini-pigs and nonhuman primates after radiation exposure. Blocking IL-18 using its endogenous binding protein (IL-18BP) increases mice survival after radiation exposure by decreasing bone marrow interferon-gamma levels.
    Methods: To further characterize the roles of IL-18 in response to radiation, both wild type and IL-18 knockout (IL-18 KO) mice were exposed to 9.0 Gy total body irradiation (TBI). The 30-day survival result demonstrated that IL-18 KO mice were significantly more resistant to radiation compared to the wild type mice (p < 0.0001). Mouse faecal samples were collected at pre-radiation (d0), d1, d3, d7, d14, d21 and d29 after radiation exposure. Microbiome profiling was performed on the faecal samples using 16S and ITS sequencing technology.
    Results: Data analysis showed that there was significant difference in the bacterial microbiome between wild type and IL-18 KO mice. Cohousing of wild type and IL-18 KO mice decreased the bacterial microbiome difference between the two genotypes. Much fewer bacterial genera were significantly changed in wild type mice than the IL-18 KO mice after radiation exposure. The different composition of the IL-18 KO mice and wild type mice persisted even after radiation exposure. Bacterial genera that significantly correlated with other genera were identified in the IL-18 KO and wild type mice. The metabolic pathways that differentially expressed in both genotypes were identified. The animal bacterial microbiome data could be used to predict the animal's radiation status. The fungal microbiome had no significant difference regarding genotype or time after radiation exposure.
    Conclusion: The current study helps understand the gut microbiome in different genetic backgrounds and its temporal changes after radiation exposure. Our data provide insight into the mechanisms underlying radiation-induced toxicity and help identify bacteria important in response to radiation.
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ISSN 2524-4671
    ISSN (online) 2524-4671
    DOI 10.1186/s42523-023-00262-8
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  9. Article: Integrating the PD-L1 Prognostic Biomarker in Non-Muscle Invasive Bladder Cancer in Clinical Practice-A Comprehensive Review on State-of-the-Art Advances and Critical Issues.

    Sanguedolce, Francesca / Falagario, Ugo Giovanni / Zanelli, Magda / Palicelli, Andrea / Zizzo, Maurizio / Busetto, Gian Maria / Cormio, Angelo / Carrieri, Giuseppe / Cormio, Luigi

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Bladder cancer (BC) is one of the most prevalent cancers worldwide. Non-muscle invasive bladder cancer (NMIBC), comprising the majority of initial BC presentations, requires accurate risk stratification for optimal management. This review explores the ... ...

    Abstract Bladder cancer (BC) is one of the most prevalent cancers worldwide. Non-muscle invasive bladder cancer (NMIBC), comprising the majority of initial BC presentations, requires accurate risk stratification for optimal management. This review explores the evolving role of programmed cell death ligand 1 (PD-L1) as a prognostic biomarker in NMIBC, with a particular focus on its implications in the context of Bacillus Calmette-Guérin (BCG) immunotherapy. The literature suggests a potential association between elevated PD-L1 status and adverse outcomes, resistance to BCG treatment, and disease progression. However, conflicting findings and methodological issues highlight the heterogeneity of PD-L1 assessment in NMIBC, probably due to the complex biological mechanisms that regulate the interaction between PD-L1 and the tumor microenvironment. The identification of PD-L1 as a prognostic biomarker provides ground for tailored therapeutic interventions, including immune checkpoint inhibitors (ICIs). Nevertheless, challenges such as intratumoral heterogeneity and technical issues underscore the need for standardized protocols and larger, homogeneous trials. This review contributes to the ongoing debate on the personalized management of NMIBC patients, focusing on the advances and perspectives of incorporating PD-L1 as a biomarker in this setting.
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082182
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  10. Article: Laparoscopic management of colovesical fistula in different clinical scenarios.

    Campobasso, Davide / Zizzo, Maurizio / Biolchini, Federico / Castro-Ruiz, Carolina / Frattini, Antonio / Giunta, Alessandro

    Journal of minimal access surgery

    2023  Volume 20, Issue 2, Page(s) 175–179

    Abstract: Introduction: Colovesical fistula (CVF) is a condition with various aetiologies and presentations. Surgical treatment is necessary in most cases. Due to its complexity, open approach is preferred. However, laparoscopic approach is reported in the ... ...

    Abstract Introduction: Colovesical fistula (CVF) is a condition with various aetiologies and presentations. Surgical treatment is necessary in most cases. Due to its complexity, open approach is preferred. However, laparoscopic approach is reported in the management of CVF due to diverticular disease. The aim of this study was to analyse the management and outcome of patients with CVF of different aetiologies treated with laparoscopic approach.
    Patients and methods: This was a retrospective study. We retrospectively reviewed all patients undergoing elective laparoscopic management of CVF from March 2015 to December 2019.
    Statistical analysis used: None.
    Results: Nine patients underwent laparoscopic management of CVF. There were no intraoperative complications or conversions to open surgery. A sigmoidectomy was performed in eight cases. In one patient, a fistulectomy with sigmoid and bladder defect closure was performed. In two cases of locally advanced colorectal cancer with bladder invasion, a multi-stage procedure with temporary colostomy was chosen. In three cases, with no intraoperative leakage, we did not perform bladder suture. Four Clavien I-II complications were recorded. Two fragile patients died in the post-operative period. No patients required re-operation. At a median follow-up of 21 months (interquartile range: 6-47), none of the patients had recurrence of fistula.
    Conclusions: CVF can be managed with laparoscopic approach by skilled laparoscopic surgeons in different clinical scenarios. Bladder suture is not necessary if leakage is absent. Informed counselling to the patient must be guaranteed concerning the risk of major complications and mortality in case of CVF due to malignant disease.
    Language English
    Publishing date 2023-04-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2186884-0
    ISSN 1998-3921 ; 0972-9941
    ISSN (online) 1998-3921
    ISSN 0972-9941
    DOI 10.4103/jmas.jmas_245_22
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