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  1. Audio / Video ; Online: Mapping Nepal’s agrarian transition

    Sugden, Fraser / Dhakal, Suresh / Rai, Janak

    2023  

    Abstract: ... Suresh Dhakal (Cultural Anthropologist, Central Department of Anthropology, Tribhuvan University), and Dr ...

    Abstract The TAFSSA CGIAR Initiative is hosting a series of webinars to highlight research from South Asia on food security, sustainable healthy diets, farmer livelihoods and resilience, and land, air, and groundwater conservation. For the eigth webinar on November 8, Dr. Fraser Sugden (School of Geography, Earth and Environmental Sciences Senior Lecturer in Human Geography International Lead-Research, University of Birmingham), Dr. Suresh Dhakal (Cultural Anthropologist, Central Department of Anthropology, Tribhuvan University), and Dr. Janak Rai (Associate Professor/Reader, Tribhuvan University) will present.
    Keywords production ; food systems ; cropping patterns ; cultivated land ; economic aspects
    Language English
    Publishing date 2023-12-04T20:22:39Z
    Publisher International Maize and Wheat Improvement Center
    Publishing country fr
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Sulfone-Mediated S

    Patel, Nitinchandra D / Wei, Xudong / Byrne, Denis / Narayanan, Bikshandarkoil A / Pennino, Scott / Sarvestani, Max / Saha, Anjan / Haddad, Nizar / Kapadia, Suresh / Lorenz, Jon C / DeCroos, Philomen / Ye, Andrew / Lee, Heewon / Grinberg, Nelu / Hossain, Azad / Busacca, Carl A / Yee, Nathan K / Senanayake, Chris H

    The Journal of organic chemistry

    2020  Volume 85, Issue 13, Page(s) 8339–8351

    Abstract: ... a highly reactive S ...

    Abstract An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive S
    MeSH term(s) Antiviral Agents ; Ethers ; Hepacivirus ; Hepatitis C ; Humans ; Protease Inhibitors/pharmacology ; Sulfones ; Viral Nonstructural Proteins
    Chemical Substances Antiviral Agents ; Ethers ; Protease Inhibitors ; Sulfones ; Viral Nonstructural Proteins
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.0c00554
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  3. Article: Correction: Neethirajan, S. Affective State Recognition in Livestock-Artificial Intelligence Approaches.

    Neethirajan, Suresh

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 14

    Abstract: The authors wish to make the following correction to the original paper [ ... ]. ...

    Abstract The authors wish to make the following correction to the original paper [...].
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12141856
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  4. Article ; Online: Visible-Light Enabled C(s

    Yedase, Girish Suresh / Jha, Avishek Kumar / Yatham, Veera Reddy

    The Journal of organic chemistry

    2022  Volume 87, Issue 8, Page(s) 5442–5450

    Abstract: ... operates under mild reaction conditions and tolerates a variety of functional groups affording C(s ...

    Abstract We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C(s
    MeSH term(s) Bromides ; Catalysis ; Halogens ; Nickel ; Oxidation-Reduction
    Chemical Substances Bromides ; Halogens ; Nickel (7OV03QG267)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c00251
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  5. Article ; Online: S.T.O.N.E Score versus Guy’s Stone Score in the Prediction of Stone Clearance in Percutaneous Nephrolithotomy

    JOHN PETER / SURESH BHAT / FREDRICK PAUL

    Journal of Clinical and Diagnostic Research, Vol 18, Iss 01, Pp 05-

    A Cross-sectional Study

    2024  Volume 08

    Abstract: ... postoperative complications. Various scoring systems have been described to predict both of these outcomes. S.T.O.N.E. Score ... and Guy's Stone Score (GSS) are two of the most widely used scoring systems. S.T.O.N.E. Score ... of the two scoring systems, namely S.T.O.N.E. Score and GSS. Materials and Methods ...

    Abstract Introduction: Percutaneous Nephrolithotomy (PCNL) has become the standard of care for large renal calculi. The aim of the surgery is to achieve maximum stone clearance with minimal postoperative complications. Various scoring systems have been described to predict both of these outcomes. S.T.O.N.E. Score and Guy's Stone Score (GSS) are two of the most widely used scoring systems. S.T.O.N.E. Score comprises of Size of the stone, Tract length, degree of Obstruction of the urinary system, Number of stones, and Essence. Aim: To compare the predictive power for stone clearance and postoperative complications of the two scoring systems, namely S.T.O.N.E. Score and GSS. Materials and Methods: This cross-sectional study was conducted at the Department of Genitourinary Surgery at Government Medical College, Kottayam, Kerala, India from March 2019 to August 2020. All patients above 18 years undergoing PCNL were included. A total of 122 patients were studied by calculating the preoperative S.T.O.N.E. Score and GSS and comparing them with post-PCNL stone clearance and complications. The association of both S.T.O.N.E. Score and GSS with stone clearance was estimated by plotting the Receiver Operating Curve (ROC) curve using Statistical Package for Social Sciences (SPSS) version 20, International Business Machines (IBM) SPSS Statistics windows, version 20.0 (Armonk, NY: IBM Corp.). A p-value <0.05 was considered statistically significant. Results: The mean age of the subjects was 49.8±12.47 years. A total of 76 males and 46 females were included in the present study. The mean S.T.O.N.E. Score among the study subjects was 7.12±1.57, and the mean GSS was 2.09±0.48. Complete stone clearance was achieved in 96 (78.7%) patients. A total of 22 (18%) patients had postoperative complications. Both scores had a significant association with stone clearance (p<0.001 for both) and postoperative complications (p-value for S.T.O.N.E. Score was 0.019 and GSS was 0.007). Conclusion: Both the S.T.O.N.E. Score and GSS can predict ...
    Keywords fluoroscopy ; kidney calculi ; renal calculi ; reciever operating curve ; staghorn calculi ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
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  6. Article ; Online: Patient’s Perspectives of Telepsychiatry

    Naik, Shalini S / Manjunatha, Narayana / Kumar, Channaveerachari Naveen / Math, Suresh Bada / Moirangthem, Sydney

    Indian Journal of Psychological Medicine

    The Past, Present and Future

    2020  Volume 42, Issue 5_suppl, Page(s) 102S–107S

    Abstract: Access to mental health care has significant disparities due to treatment gap, more so particularly for the remotely residing, physically vulnerable, aging populations. Adoption of technology will enable more people to receive specialty care addressing ... ...

    Abstract Access to mental health care has significant disparities due to treatment gap, more so particularly for the remotely residing, physically vulnerable, aging populations. Adoption of technology will enable more people to receive specialty care addressing distance, transportation and cost-related barriers to treatment engagement from the comfort of home. Telemedicine has been regarded as “electronic personal protective equipment” by reducing the number of physical contacts and risk contamination for patients during COVID-19 crisis. This review aimed to give a broad view of patients’ perception of the use of telepsychiatry in terms of clinical outcome, cost-effectiveness, and solutions to address patients’ challenges with the adoption of technology. Over the years, telepsychiatry, both in synchronous and asynchronous modalities, had shown to improve patients’ adherence to treatment, follow-up rates, and clinical symptoms, overcome stigma and discrimination, and save cost expenses accessing health care with better satisfaction and usability outcomes. Its utility is widespread such as in delivering care emergency evaluation, crisis intervention, conducting neuropsychological assessments, psychotherapy, promoting lifestyle modification, enhancing self-efficacy, and overcoming patients’ linguistic and cultural barriers to care. However, patients’ privacy and confidentiality and psychiatrists’ legal liability remain as matter of major concern in digital platform. To keep up with the pace of technology and patients’ expectations, a more agile approach is essential to develop, improve, and evaluate telepsychiatric interventions.
    Keywords Clinical Psychology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2622378-8
    ISSN 0975-1564 ; 0253-7176
    ISSN (online) 0975-1564
    ISSN 0253-7176
    DOI 10.1177/0253717620963341
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  7. Article ; Online: Isolation and estimation of flavonoid compound(s) of

    Kumar, Deepak / Kaur, Amanpreet / Madaan, Reecha / Kumar, Suresh

    Natural product research

    2020  Volume 36, Issue 8, Page(s) 2186–2190

    Abstract: Based on ethnobotanical surveys, an Indian traditional plant, i.e., ...

    Abstract Based on ethnobotanical surveys, an Indian traditional plant, i.e.,
    MeSH term(s) Asteraceae/chemistry ; Flavonoids/chemistry ; Phytochemicals/analysis ; Plant Extracts/chemistry ; Reproducibility of Results ; Seeds/chemistry
    Chemical Substances Flavonoids ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2020.1849204
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  8. Article ; Online: A phase II study of Bruton’s tyrosine kinase inhibition for the prevention of anaphylaxis

    Ragha V. Suresh / Collin Dunnam / Dhananjay Vaidya / Robert A. Wood / Bruce S. Bochner / Donald W. MacGlashan Jr. / Melanie C. Dispenza

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 16

    Abstract: ... for which there are no currently FDA-approved preventative therapies. Bruton’s tyrosine kinase (BTK) is ...

    Abstract BACKGROUND IgE-mediated anaphylaxis is a potentially fatal systemic allergic reaction for which there are no currently FDA-approved preventative therapies. Bruton’s tyrosine kinase (BTK) is an essential enzyme for IgE-mediated signaling pathways and is an ideal pharmacologic target to prevent allergic reactions. In this open-label trial, we evaluated the safety and efficacy of acalabrutinib, a BTK inhibitor that is FDA approved to treat some B cell malignancies, in preventing clinical reactivity to peanut in adults with peanut allergy.METHODS After undergoing graded oral peanut challenge to establish their baseline level of clinical reactivity, 10 patients had a 6-week rest period, then received 4 standard doses of 100 mg acalabrutinib twice daily and underwent repeat food challenge. The primary endpoint was the change in patients’ threshold dose of peanut protein to elicit an objective clinical reaction.RESULTS At baseline, patients tolerated a median of 29 mg of peanut protein before objective clinical reaction. During subsequent food challenge on acalabrutinib, patients’ median tolerated dose significantly increased to 4,044 mg (range 444–4,044 mg). 7 patients tolerated the maximum protocol amount (4,044 mg) of peanut protein with no clinical reaction, and the other 3 patients’ peanut tolerance increased between 32- and 217-fold. 3 patients experienced a total of 4 adverse events that were considered to be possibly related to acalabrutinib; all events were transient and nonserious.CONCLUSION Acalabrutinib pretreatment achieved clinically relevant increases in patients’ tolerance to their food allergen, thereby supporting the need for larger, placebo-controlled trials.TRIAL REGISTRATION ClinicalTrials.gov NCT05038904FUNDING AstraZeneca Pharmaceuticals, the Johns Hopkins Institute for Clinical and Translational Research, the Ludwig Family Foundation, and NIH grants AI143965 and AI106043.
    Keywords Immunology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
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  9. Article: Comparative evaluation of volumetric changes between two pediatric rotary files (Kedo-S plus, Kedo-SG blue) and manual files (hand K-files) during canal preparation of primary mandibular molars: an

    Suresh, Balaji / Jeevanandan, Ganesh / Ravindran, Vignesh / Vishwanathaiah, Satish / Syed, Ather Ahmed / Mokhtari, Nasrin / Jaafari, Atlal Hassan Hussain / Dawood, Tazeen / Maganur, Prabhadevi C

    The Journal of clinical pediatric dentistry

    2024  Volume 48, Issue 2, Page(s) 57–63

    Abstract: ... free environment. The patented rotary file system, Kedo-S, designed for primary teeth, introduced ...

    Abstract Pediatric endodontics has become popular due to advancements in cleaning, shaping and irrigation systems, resulting in faster and effective removal of infected pulp, saving time, and creating a pathogen-free environment. The patented rotary file system, Kedo-S, designed for primary teeth, introduced a single file generation for efficient pulp therapy. However, there are currently no studies assessing canal preparation in primary mandibular molars using nano-CT (computed Tomography). To evaluate the volumetric changes of two recently introduced pediatric rotary file systems in comparison with conventional hand file systems in primary mandibular molar using an ultra-high resolution nano-CT. This
    MeSH term(s) Child ; Humans ; Tooth, Deciduous ; Root Canal Preparation ; Dental Pulp Cavity/diagnostic imaging ; Molar/diagnostic imaging ; Molar/surgery ; Dental Pulp
    Language English
    Publishing date 2024-03-03
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 1062408-9
    ISSN 1053-4628 ; 0145-5508
    ISSN 1053-4628 ; 0145-5508
    DOI 10.22514/jocpd.2024.033
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  10. Article ; Online: pLMSNOSite: an ensemble-based approach for predicting protein S-nitrosylation sites by integrating supervised word embedding and embedding from pre-trained protein language model.

    Pratyush, Pawel / Pokharel, Suresh / Saigo, Hiroto / Kc, Dukka B

    BMC bioinformatics

    2023  Volume 24, Issue 1, Page(s) 41

    Abstract: Background: Protein S-nitrosylation (SNO) plays a key role in transferring nitric oxide-mediated ... These results show that pLMSNOSite performs better than the compared approaches for the prediction of S ... significant improvement in the prediction performance of S-nitrosylation sites and represents a robust ...

    Abstract Background: Protein S-nitrosylation (SNO) plays a key role in transferring nitric oxide-mediated signals in both animals and plants and has emerged as an important mechanism for regulating protein functions and cell signaling of all main classes of protein. It is involved in several biological processes including immune response, protein stability, transcription regulation, post translational regulation, DNA damage repair, redox regulation, and is an emerging paradigm of redox signaling for protection against oxidative stress. The development of robust computational tools to predict protein SNO sites would contribute to further interpretation of the pathological and physiological mechanisms of SNO.
    Results: Using an intermediate fusion-based stacked generalization approach, we integrated embeddings from supervised embedding layer and contextualized protein language model (ProtT5) and developed a tool called pLMSNOSite (protein language model-based SNO site predictor). On an independent test set of experimentally identified SNO sites, pLMSNOSite achieved values of 0.340, 0.735 and 0.773 for MCC, sensitivity and specificity respectively. These results show that pLMSNOSite performs better than the compared approaches for the prediction of S-nitrosylation sites.
    Conclusion: Together, the experimental results suggest that pLMSNOSite achieves significant improvement in the prediction performance of S-nitrosylation sites and represents a robust computational approach for predicting protein S-nitrosylation sites. pLMSNOSite could be a useful resource for further elucidation of SNO and is publicly available at https://github.com/KCLabMTU/pLMSNOSite .
    MeSH term(s) Animals ; Proteins/metabolism ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Protein Processing, Post-Translational ; Signal Transduction
    Chemical Substances Proteins ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-023-05164-9
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