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Article ; Online: Alleviating the consequences of nuclear disasters on views on radiation risks among physicians and patients: Fukushima experience.

Tamaki, Tomoaki / Ozaki, Akihiko / Sato, Hisashi / Tsubokura, Masaharu / Suzuki, Yoshiyuki

2021 Volume 11, Page(s) 3069

MeSH term(s)	Disasters ; Fukushima Nuclear Accident ; Humans ; Physicians
Language	English
Publishing date	2021-04-30
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.11.03069
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Article ; Online: Theoretical Validation of

Fujimoto, Keiichi / Higaki, Tamaki / Abe, Jun / Fujita, Masaharu / Kawakami, Tsuyoshi

Chemical research in toxicology

2022 Volume 35, Issue 11, Page(s) 2107–2121

Abstract: Amino acid derivative reactivity assay (ADRA) is ... ...

Abstract	Amino acid derivative reactivity assay (ADRA) is an
MeSH term(s)	Animals ; Animal Testing Alternatives/methods ; Indicators and Reagents ; Skin/metabolism ; Biological Assay/methods ; Cysteine/chemistry
Chemical Substances	Indicators and Reagents ; Cysteine (K848JZ4886)
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/acs.chemrestox.2c00228
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Zs.A 2320: Show issues

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Article ; Online: The "GU-GU-RU" project to eliminate discrimination related to the health effects of the Fukushima nuclear accident.

Amir, Isamu / Eguchi, Yuichiro / Saotome, Kousaku / Ogawa, Soichiro / Kojima, Yoshiyuki / Tamaki, Tomoaki / Tsubokura, Masaharu

BMC public health

2023 Volume 23, Issue 1, Page(s) 2050

Abstract: Background: Although 12 years have passed since Great East Japan Earthquake and following Fukushima nuclear accident, approximately 40% of Japanese citizen still believe that the current radiation exposure in Fukushima residents will likely/ very likely ...

Abstract	Background: Although 12 years have passed since Great East Japan Earthquake and following Fukushima nuclear accident, approximately 40% of Japanese citizen still believe that the current radiation exposure in Fukushima residents will likely/ very likely to cause genetic effects of radiation. This incorrect understanding could continue unexpected discrimination and prejudice towards those from Fukushima now and in the future. In order to provide updated knowledge and eliminate rumors related to radiation, Japanese Ministry of the Environment has launched "GU-GU-RU" project in 2021 with consisting of five sections. Objective: (1) To discuss the objectives and effects of the "GU-GU-RU" project (results after the first year), (2) to present administrative measures that may be effective in the long-term to prevent unjustified discrimination and prejudice, and (3) to eliminate rumors in the event of future large-scale disasters, including radiation disasters. Methods: We showed the contents of each sections carried out under the project and observed the result of first-year activities in each section. Results: Among the programs, the "Radiation College" has steadily produced positive results, with nearly 1,300 students participating and 50 students sharing their thoughts and ideas. In addition, the project has adopted strategies such as creating and broadcasting a TV program and collaborations with manga, which are expected to have a significant impact on society. Conclusions: Compared to previous efforts on disseminating information related to health effect of radiation exposure, the "GU-GU-RU" project has taken a different approach in providing primary data of radiation and its health effects, which could become a better understanding of health effects of radiation for the general public, in order to eliminate rumors that may lead unjustified discrimination and prejudice.
MeSH term(s)	Humans ; Fukushima Nuclear Accident ; Disasters ; Earthquakes ; Radiation Exposure ; Japan ; Nuclear Power Plants
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16883-2
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Article ; Online: Impact of Cytokine Release Syndrome on Cardiac Function After Chimeric Antigen Receptor-T Cell Therapy.

Sunayama, Isamu / Min, Kyung-Duk / Orihara, Yoshiyuki / Oboshi, Makiko / Yoshihara, Satoshi / Yoshihara, Kyoko / Tamaki, Hiroya / Teramoto, Masahiro / Nishimura, Koichi / Eguchi, Akiyo / Naito, Yoshiro / Higasa, Satoshi / Asakura, Masanori / Ishihara, Masaharu

JACC. Asia

2023 Volume 3, Issue 6, Page(s) 944–946

Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Journal Article
ISSN	2772-3747
ISSN (online)	2772-3747
DOI	10.1016/j.jacasi.2023.08.010
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Article ; Online: Outcomes of Cessation of Nucleos(t)ide Analog Administration on Hepatitis B Virus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation: A Nationwide Retrospective Study.

Onozawa, Masahiro / Kusumoto, Shigeru / Najima, Yuho / Hashimoto, Hiroya / Okada, Kohei / Tamaki, Masaharu / Tanaka, Masatsugu / Sato, Takayuki / Takahashi, Tsutomu / Hatano, Kaoru / Onodera, Koichi / Moriuchi, Yukiyoshi / Yakushijin, Kimikazu / Kanda, Junya / Nagafuji, Koji / Ogata, Masao / Nakano, Nobuaki / Tamori, Akihiro / Mizokami, Masashi

Transplantation and cellular therapy

2024 Volume 30, Issue 3, Page(s) 330.e1–330.e8

Abstract: Monitoring of hepatitis B virus (HBV)-DNA and HBV-DNA-guided preemptive therapy using nucleos(t)ide analogs (NAs) are recommended to prevent the development of hepatitis due to HBV reactivation after allogeneic hematopoietic stem cell transplantation ( ... ...

Abstract	Monitoring of hepatitis B virus (HBV)-DNA and HBV-DNA-guided preemptive therapy using nucleos(t)ide analogs (NAs) are recommended to prevent the development of hepatitis due to HBV reactivation after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in recipients with resolved HBV infection. However, little is known about the appropriate duration of NA treatment and the effect of NA cessation on the recurrence of HBV reactivation. This study aimed to clarify the consequences of NA cessation in allo-HSCT recipients with resolved HBV infection who experienced HBV reactivation following transplantation. We retrospectively reviewed the clinical records of recipients with resolved HBV infection (hepatitis B surface antigen [HBsAg]-negative, anti-HBc-positive) before allo-HSCT who had been diagnosed with HBV reactivation (HBsAg-positive and/or HBV-DNA detectable) after allo-HSCT between January 2010 and December 2020. A total of 72 patients from 16 institutions were registered (median age, 60 years; age range, 27 to 73 years; 42 males and 30 females). The day of initial HBV reactivation ranged from day 10 to day 3034 after allo-HSCT (median, 513 days). Anti-HBs were lost in >80% of the patients at the time of HBV reactivation. All 72 patients received preemptive NAs, and no fatal HBV reactivation-related hepatitis was observed. HBV-DNA without hepatitis was continuously detected in 5 patients during the follow-up period. Administration of NAs was discontinued in 24 of 72 patients (33%) by physician decision. Second HBV reactivation occurred in 11 of the 24 patients (46%) in whom administration of NAs was discontinued. The duration of NA treatment did not differ significantly between patients with or without second HBV reactivation. The frequency of further HBV reactivation tended to be lower in patients with an anti-HBs titer of >10 mIU/mL at the time of NA cessation. Multiple reactivations of HBV after NA cessation was common in patients with HBV reactivation who underwent allo-HSCT despite the long duration of NAs. Careful monitoring of HBV-DNA is important even after the discontinuation of NAs in the case with HBV reactivation after allo-HSCT, because multiple reactivations could occur. Active immunization by HB vaccine might be effective for suppressing further HBV reactivation after cessation of NAs.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Adult ; Aged ; Hepatitis B virus/genetics ; Retrospective Studies ; Hepatitis B Surface Antigens/therapeutic use ; DNA, Viral/therapeutic use ; Hepatitis B/prevention & control ; Hepatitis B/diagnosis ; Hepatitis B/drug therapy ; Hepatitis B Antibodies/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hepatitis A
Chemical Substances	Hepatitis B Surface Antigens ; DNA, Viral ; Hepatitis B Antibodies
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2024.01.059
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Zs.A 5082: Show issues

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Article ; Online: Gene expression and TCR amino acid sequences selected by HLA-A02:01-restricted CTLs specific to HTLV-1 in ATL patients.

Kusuda, Machiko / Nakasone, Hideki / Yoshimura, Kazuki / Okada, Yosuke / Tamaki, Masaharu / Matsuoka, Akari / Ishikawa, Takuto / Meno, Tomohiro / Nakamura, Yuhei / Kawamura, Masakatsu / Takeshita, Junko / Kawamura, Shunto / Yoshino, Nozomu / Misaki, Yukiko / Gomyo, Ayumi / Tanihara, Aki / Kimura, Shun-Ichi / Kako, Shinichi / Kanda, Yoshinobu

British journal of haematology

2023 Volume 202, Issue 3, Page(s) 578–588

Abstract: Adult T-cell leukaemia/lymphoma (ATL) is an aggressive malignancy of peripheral T cells caused by human T-cell lymphotropic virus type-1 (HTLV-1). Tax is the most important regulatory protein for HTLV-1. We aimed to reveal a unique amino acid sequence ( ... ...

Abstract	Adult T-cell leukaemia/lymphoma (ATL) is an aggressive malignancy of peripheral T cells caused by human T-cell lymphotropic virus type-1 (HTLV-1). Tax is the most important regulatory protein for HTLV-1. We aimed to reveal a unique amino acid sequence (AA) of complementarity-determining region 3 (CDR3) of the T-cell receptor (TCR)β and TCRα chains of HLA-A*02:01-restricted Tax
MeSH term(s)	Adult ; Humans ; Human T-lymphotropic virus 1/genetics ; T-Lymphocytes, Cytotoxic ; Amino Acid Sequence ; Leukemia-Lymphoma, Adult T-Cell/genetics ; Leukemia-Lymphoma, Adult T-Cell/therapy ; Receptors, Antigen, T-Cell/genetics ; Gene Expression ; Gene Products, tax/genetics ; HTLV-I Infections/genetics ; HTLV-I Infections/pathology
Chemical Substances	Receptors, Antigen, T-Cell ; Gene Products, tax
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18918
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Uh III Zs.182: Show issues

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Article ; Online: Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation.

Tamaki, Masaharu / Akahoshi, Yu / Ashizawa, Masahiro / Misaki, Yukiko / Koi, Satoshi / Kim, Sung-Won / Ozawa, Yukiyasu / Fujiwara, Shin-Ichiro / Kako, Shinichi / Matsuoka, Ken-Ichi / Sawa, Masashi / Katayama, Yuta / Onizuka, Makoto / Kanda, Yoshinobu / Fukuda, Takahiro / Atsuta, Yoshiko / Yakushijin, Kimikazu / Nakasone, Hideki

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7166

Abstract: Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GVHD). However, a ... ...

Abstract	Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GVHD). However, a clinical significance of anti-thymocyte globulin (ATG) in the female-to-male allo-HCT has not been elucidated. In this study, we retrospectively evaluated male patients who underwent allo-HCT between 2012 and 2019 in Japan. In the female-to-male allo-HCT cohort (n = 828), the use of ATG was not associated with a decreased risk of GVHD (HR of acute GVHD 0.691 [95% CI: 0.461-1.04], P = 0.074; HR of chronic GVHD 1.06 [95% CI: 0.738-1.52], P = 0.76), but was associated with favorable overall survival (OS) and a decreased risk of non-relapse mortality (NRM) (HR of OS 0.603 [95% CI: 0.400-0.909], P = 0.016; HR of NRM 0.506 [95% CI: 0.300-0.856], P = 0.011). The use of ATG in female-to-male allo-HCT resulted in survival outcomes that were almost equivalent to those in the male-to-male allo-HCT group. Therefore, GVHD prophylaxis with ATG might overcome the inferiority of survival outcomes in female-to-male allo-HCT.
MeSH term(s)	Humans ; Male ; Female ; Antilymphocyte Serum/therapeutic use ; Retrospective Studies ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease/etiology ; Tissue Donors ; Transplantation Conditioning/methods
Chemical Substances	Antilymphocyte Serum
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34442-y
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Article ; Online: Plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1) level as a blood biomarker of neurological damage after allogeneic hematopoietic cell transplantation.

Okada, Yosuke / Nakasone, Hideki / Yoshimura, Kazuki / Tamaki, Masaharu / Kusuda, Machiko / Nakamura, Yuhei / Kawamura, Masakatsu / Kawamura, Shunto / Takeshita, Junko / Yoshino, Nozomu / Misaki, Yukiko / Gomyo, Ayumi / Tanihara, Aki / Kimura, Shun-Ichi / Kako, Shinichi / Kanda, Yoshinobu

International journal of hematology

2023 Volume 118, Issue 3, Page(s) 340–346

Abstract: Several biofluid-based biomarkers for traumatic brain injury show promise for use in diagnosis and outcome prediction. In contrast, few studies have investigated biomarkers for non-traumatic brain injury. We focused on ubiquitin C-terminal hydrolase-L1 ( ... ...

Abstract	Several biofluid-based biomarkers for traumatic brain injury show promise for use in diagnosis and outcome prediction. In contrast, few studies have investigated biomarkers for non-traumatic brain injury. We focused on ubiquitin C-terminal hydrolase-L1 (UCH-L1), which has been proposed as a screening tool for traumatic brain injury, and investigated whether the plasma UCH-L1 level could also be a useful biomarker in patients with non-traumatic brain injury. We measured UCH-L1 in 25 patients who had experienced neurological complications after allogeneic hematopoietic cell transplantation (HCT) and 22 control patients without any complications or graft-versus-host disease. Although UCH-L1 levels before HCT did not differ significantly (P = 0.053), levels after HCT were higher in patients with neurological complications compared with the control group (P < 0.001). At a UCH-L1 cutoff value of 0.072 ng/ml, sensitivity was 68.0% and specificity was 100%. The statistical power of UCH-L1 for neurological complications seemed to be higher than that of CT and comparable to that of MRI. Thus, increased levels of UCH-L1 might reflect the presence of neurological damage even in patients with non-traumatic brain injury. Further large cohort investigations are warranted.
MeSH term(s)	Humans ; Brain Injuries/diagnosis ; Ubiquitin Thiolesterase ; Biomarkers ; Prognosis ; Hematopoietic Stem Cell Transplantation/adverse effects
Chemical Substances	Ubiquitin Thiolesterase (EC 3.4.19.12) ; Biomarkers
Language	English
Publishing date	2023-07-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03642-7
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Zs.A 269: Show issues

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Article ; Online: Evaluation of the mechanical properties and biocompatibility of gypsum-containing calcium silicate cements.

Hayashi, Yumiyo / Kawaki, Harumi / Hori, Masaharu / Shintani, Kohei / Hasegawa, Tomoya / Tanaka, Masashi / Kondoh, Nobuo / Yoshida, Takakazu / Kawano, Satoshi / Tamaki, Yukimichi

Dental materials journal

2021 Volume 40, Issue 4, Page(s) 863–869

Abstract: Mineral trioxide aggregate (MTA) cement is widely used in the field of endodontic treatment. We herein synthesized calcium silicates from calcium carbonate and silicon dioxide, with the aim of reducing the cost associated with the MTA. Additionally, we ... ...

Abstract	Mineral trioxide aggregate (MTA) cement is widely used in the field of endodontic treatment. We herein synthesized calcium silicates from calcium carbonate and silicon dioxide, with the aim of reducing the cost associated with the MTA. Additionally, we prepared gypsum-containing calcium silicate cement to reduce the setting time while enhancing the mechanical strength. We evaluated the physical properties of this cement and investigated the response of human dental pulp stem cells (hDPSCs) grown in culture media containing cement eluate. Our results revealed that calcium silicates could be easily synthesized in lab-scale. Furthermore, we demonstrate that gypsum addition helps shorten the setting time while increasing the compressive strength of dental cements. The synthesized gypsum-containing calcium silicate cement showed minimal cytotoxicity and did not inhibit the proliferation of hDPSCs. These results suggested that the newly developed calcium silicate material could be a promising pulp capping material.
MeSH term(s)	Aluminum Compounds ; Calcium ; Calcium Compounds ; Calcium Sulfate ; Dental Cements ; Drug Combinations ; Humans ; Materials Testing ; Oxides ; Silicate Cement ; Silicates
Chemical Substances	Aluminum Compounds ; Calcium Compounds ; Dental Cements ; Drug Combinations ; Oxides ; Silicates ; Silicate Cement (1327-39-5) ; calcium silicate (S4255P4G5M) ; Calcium (SY7Q814VUP) ; Calcium Sulfate (WAT0DDB505)
Language	English
Publishing date	2021-02-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605650-7
ISSN	1881-1361 ; 0287-4547
ISSN (online)	1881-1361
ISSN	0287-4547
DOI	10.4012/dmj.2020-086
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Zs.B 2687: Show issues

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Article ; Online: Unrelated female-to-male bone marrow transplantation would be preferred over cord blood transplantation in male patients.

Cytotherapy

2023 Volume 25, Issue 11, Page(s) 1220–1228

Abstract: Background aims: Allogeneic hematopoietic stem cell transplantation from female donors to male recipients (female-to-male allo-HCT) is a well-established risk factor for a greater incidence of non-relapse mortality (NRM) and chronic graft-versus-host ... ...

Abstract	Background aims: Allogeneic hematopoietic stem cell transplantation from female donors to male recipients (female-to-male allo-HCT) is a well-established risk factor for a greater incidence of non-relapse mortality (NRM) and chronic graft-versus-host disease (GVHD). In contrast, unrelated cord blood transplantation (UCBT) is associated with a lower incidence of chronic GVHD. In this study, survival outcomes were compared between the UCBT and unrelated female-to-male bone marrow transplantation (UFMBMT) groups. Methods: We evaluated male allo-HCT recipients who underwent UCBT or UFMBMT between 2012 and 2020 in Japan. There were 2517 cases in the UCBT group, 456 cases in the HLA-matched UFMBMT group and 457 cases in the HLA-mismatched UFMBMT group. Results: HLA-mismatched UFMBMT was significantly associated with a decreased risk of relapse (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.57-0.98], P = 0.033) and HLA-matched UFMBMT had the tendency of a decreased risk of relapse (HR 0.78; 95% CI 0.61-1.01, P = 0.059). HLA-matched UFMBMT was also associated with favorable OS (HR 0.82; 95% CI 0.69-0.97, P = 0.021). The relationship between the donor sources and relapse was similarly observed in the lymphoid malignancy cohort. Conclusions: The difference of graft-versus leukemia effect by H-Y immunity according to donor sources might contribute to the difference in clinical impact. It might be desirable for patients who could sufficiently wait for donor coordination to select BMT rather than UCBT, even if only unrelated female donors are available for male recipients.
MeSH term(s)	Humans ; Male ; Female ; Bone Marrow Transplantation/adverse effects ; Cord Blood Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Unrelated Donors ; Recurrence ; Chronic Disease ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Retrospective Studies
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2023.06.002
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