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Article: An Unusual Painless Lesion on the Shin.

Goel, Aakanksha / Shrivastava, Prabhat / Gupta, Varsha / Tomar, Reena

2023 Volume 38, Issue 3, Page(s) e518

Language	English
Publishing date	2023-05-31
Publishing country	Oman
Document type	Journal Article
ZDB-ID	2571431-4
ISSN	2070-5204 ; 1999-768X
ISSN (online)	2070-5204
ISSN	1999-768X
DOI	10.5001/omj.2023.24
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Article ; Online: Congenital muscular torticollis in 'late-comers': A proposal for grading of severity and outcome scales.

Goel, Aakanksha / Shrivastava, Prabhat / Goel, Arun / Bhandari, Padam S

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2022 Volume 75, Issue 8, Page(s) 2831–2870

MeSH term(s)	Humans ; Neck Muscles ; Torticollis/congenital
Language	English
Publishing date	2022-06-20
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2022.06.053
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Article: Nasal Measurements in Indian Population of North-East Region: Angular Parameters with Literature Review.

Goel, Aakanksha / Bhandari, P S / Shrivastava, Prabhat / Goel, Arun

Journal of maxillofacial and oral surgery

2023 Volume 22, Issue 4, Page(s) 841–847

Abstract: Background: Just like linear nasal parameters, angular nasal parameters form the basis of any rhinoplasty, especially in various ethnic groups to maintain the specific racial characteristics while creating an aesthetic nose. The objective of this study ... ...

Abstract	Background: Just like linear nasal parameters, angular nasal parameters form the basis of any rhinoplasty, especially in various ethnic groups to maintain the specific racial characteristics while creating an aesthetic nose. The objective of this study was to measure and study the outcomes of angular nasal parameters in north-east Indians and to contrast them with available literature on Oriental, Caucasian and Indian population in general. Methods: This cross-sectional study was carried out in 150 young adults from north-east region of India. Surface landmarks were marked, and standard photographs were taken. Nine angular parameters were measured from the left lateral and basal view photographs of the face using computer software. Data were analysed by Student's ' Results: All the angular measurements were found to be greater in females except nasofacial angle, columella tip angle and interaxial angle. Differences in nasofrontal angle, columella labial angle, nasofacial angle and columella tip angle between males and females were statistically significant. Nasofrontal and columella labial angles were more acute in the study population compared to Caucasians, Orientals and other Indians while nasofacial, interaxial and interalar angles were larger. Conclusion: The north-east Indian nose is dissimilar to that of rest of the country as well as that of Caucasians and Orientals with respect to angular parameters.
Language	English
Publishing date	2023-10-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-023-02020-4
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Article ; Online: Perceptions of primary and secondary care clinicians treating diabetic foot: A pan India study and quantitative analysis.

Tayade, Apakrita / Kumar, Prabhat / Kumar, Saurav / Ghyar, Rupesh / Shrivastava, Amber / Ravi, Bhallamudi

Diabetes research and clinical practice

2023 Volume 206, Page(s) 111008

Abstract: Aim: The study quantifies clinicians' perceptions and challenges during different stages of diabetic foot treatment. Diabetic neuropathy (DN), which is a major consequence of diabetes, significantly increases the risk of lower limb amputation. This can ... ...

Abstract	Aim: The study quantifies clinicians' perceptions and challenges during different stages of diabetic foot treatment. Diabetic neuropathy (DN), which is a major consequence of diabetes, significantly increases the risk of lower limb amputation. This can be prevented to a large extent by foot care, early detection, and lesion treatment. Methods: Ninety-two Indian clinicians of various demographics, medical specializations, and experiences were interviewed. Diabetic foot treatment by primary and secondary care clinicians was assessed. This study evaluates aspects related to patient awareness, compliance, and shortcomings of current diagnostic techniques. Results: A two-sample Mann-Whitney statistical method was used to infer the perceptions of clinicians on hypothesis questions. Primary and secondary care clinicians' perceptions differed for the hypotheses related to objective assessment (p-value = 0.001), operator variability (p-value = 0.03), and patient compliance (p-value = 0.047). Conversely, both groups held comparative perspectives for the awareness (p-value = 0.369) and examination time (p-value = 0.276) hypotheses. Conclusions: All clinicians strongly supported the need for an objective assessment to reduce the misdiagnosis of DN. Further, DNis often underdiagnosed due to a lack of awareness and knowledgeamong people with diabetes. Secondary care clinicians acknowledged a need for trained operators to reduce reliability errors. These insights provide directions for future research in this field.
MeSH term(s)	Humans ; Diabetic Foot/diagnosis ; Diabetic Foot/therapy ; Reproducibility of Results ; Secondary Care ; Diabetic Neuropathies ; Amputation, Surgical ; Diabetes Mellitus
Language	English
Publishing date	2023-11-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2023.111008
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Article ; Online: Urinary metabolite signatures reflect the altered host metabolism in severe obstructive sleep apnea.

Mohit / Tomar, Manendra Singh / Araniti, Fabrizio / Sahai, Prabhat Kumar / Singh, Bhanu Pratap / Shrivastava, Ashutosh / Chand, Pooran

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2023 Volume 1231, Page(s) 123938

Abstract: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder. The onset and progression of OSA are often linked with severe cardiovascular and metabolic comorbidities. At the same time, given the increasing prevalence of OSA, novel methods ... ...

Abstract	Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder. The onset and progression of OSA are often linked with severe cardiovascular and metabolic comorbidities. At the same time, given the increasing prevalence of OSA, novel methods to screen OSA and its follow-up are needed. Untargeted metabolic profiling of OSA patients and healthy controls was planned to capture a snapshot of urinary metabolites and potential biomarkers using the gas chromatography-mass spectrometry (GC-MS) method.Polysomnography (PSG) confirmed severe OSA patients with AHI index ≥ 30 were considered for urine sample collection. The sample size was constituted of OSA (n = 36) and healthy controls (n = 36). Metabolite extraction and derivatization were performed and metabolomic analysis was performed by using GC-MS.The obtained data set was statistically analyzed using univariate and multivariate analysis. The Orthogonal partial least-squares discriminant analysis (OPLS-DA) was performed to screen differential metabolites between OSA patients and healthy controls.The metabolomic analysis revealed a total of 142 significantly altered metabolites of interest.Biomarker analysis allows for the creation of a list of putative urinary biomarkers including GABA, malic acid, glutamic acid, epichoric acid etc., with an accuracy of 99.8 % to 100 % for OSA screening. Subsequently, pathway analysis revealed that related biochemical pathways like the tricarboxylic acid cycle (TCA), glutamate/glutamine, amino acid and fatty acid metabolism, that are significantly interlinked with these metabolic biomarkers can play a crucial role in the pathogenesis of OSA. This study paves the way to undertake mass screening in a larger population to identify specific and reliable biomarkers.
MeSH term(s)	Humans ; Biomarkers/urine ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Metabolomics/methods ; Gas Chromatography-Mass Spectrometry/methods ; Comorbidity
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2023.123938
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Article ; Online: A huge pleomorphic adenoma of the submandibular salivary gland.

Rai, Ashutosh / Sharma, Sushil / Shrivastava, Prabhat / Singh, Mangal

BMJ case reports

2018 Volume 2018

Abstract: The most common tumour of salivary gland is pleomorphic adenoma (PA). They are benign, painless, can grow into big tumours but usually do not affect nerves or lymph nodes. PA most commonly occurs in the parotid gland but it may involve submandibular, ... ...

Abstract	The most common tumour of salivary gland is pleomorphic adenoma (PA). They are benign, painless, can grow into big tumours but usually do not affect nerves or lymph nodes. PA most commonly occurs in the parotid gland but it may involve submandibular, lingual and minor salivary glands also. They can attain giant proportions and weigh several kilograms. We report a giant PA arising in the submandibular gland and treated by complete surgical excision without any complication. A female patient presented with a tumour in the submandibular region and front of neck with a history of more than 18 years. The weight of the resected mass was 4.35 kg. Patient's fear of surgery and lack of awareness were the main reasons for her long-standing swelling. Such giant PAs of the submandibular gland are very rare in medical literature.
MeSH term(s)	Adenoma, Pleomorphic/diagnostic imaging ; Adenoma, Pleomorphic/pathology ; Adenoma, Pleomorphic/surgery ; Biopsy ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Submandibular Gland Neoplasms/diagnostic imaging ; Submandibular Gland Neoplasms/pathology ; Submandibular Gland Neoplasms/surgery ; Treatment Outcome ; Tumor Burden
Language	English
Publishing date	2018-03-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2017-222249
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Article ; Online: Circular economy fertilization: Phycoremediated algal biomass as biofertilizers for sustainable crop production.

Sharma, Gulshan Kumar / Khan, Shakeel Ahmad / Shrivastava, Manoj / Bhattacharyya, Ranjan / Sharma, Anil / Gupta, Dipak Kumar / Kishore, Prabhat / Gupta, Navindu

Journal of environmental management

2021 Volume 287, Page(s) 112295

Abstract: There is an urgent need to meet the demand of water and nutrients by their reuse and recycling to gratify sustainable food production system and resource conservation. Chlorella minutissima was found to be very effective in the removal of electrical ... ...

Abstract	There is an urgent need to meet the demand of water and nutrients by their reuse and recycling to gratify sustainable food production system and resource conservation. Chlorella minutissima was found to be very effective in the removal of electrical conductivity (EC), total dissolved solids, phosphorous (P), potassium (K), ammonium, nitrate, biological oxygen demand (BOD
MeSH term(s)	Biomass ; Chlorella ; Crop Production ; Fertilization ; Fertilizers/analysis ; Nitrogen ; Soil
Chemical Substances	Fertilizers ; Soil ; Nitrogen (N762921K75)
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.112295
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Article ; Online: Burns demand our attention.

Shrivastava, Prabhat / Keswani, Sunil

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

2011 Volume 43, Issue Suppl, Page(s) S3

Language	English
Publishing date	2011-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2118680-7
ISSN	1998-376X ; 0970-0358
ISSN (online)	1998-376X
ISSN	0970-0358
DOI	10.4103/0970-0358.70713
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Article ; Online: Dextran carrier macromolecule for colon specific delivery of celecoxib.

Shrivastava, Prabhat K / Shrivastava, Sushant K

Current drug delivery

2010 Volume 7, Issue 2, Page(s) 144–151

Abstract: The colon specific polymeric conjugates of celecoxib were prepared with dextran of different molecular weight Mr approximately 40 000, 70 000, and 100 000 (CSD-40, CSD-70 and CSD-100). Succinic acid was used as linker between the drug and dextran. The ... ...

Abstract	The colon specific polymeric conjugates of celecoxib were prepared with dextran of different molecular weight Mr approximately 40 000, 70 000, and 100 000 (CSD-40, CSD-70 and CSD-100). Succinic acid was used as linker between the drug and dextran. The prepared conjugates were characterized by UV, IR, 1H NMR and HPLC. The maximum degree of substitution 3.9+/-0.20 % was found with the dextran CSD-100 conjugates. The percent release of drug obtained by in-vitro hydrolysis studies, was found to be 24.37+/- 0.6, 23.0 +/- 0.5 and 20.13+/- 0.8 in simulated colonic fluid (SCF) pH 6.8 while 17.90 +/- 0.4, 16.8+/- 0.75 and 15.47 +/- 0.5 in simulated intestinal fluid (SIF) pH 7.4 for CSD-40, CSD-70 and CSD-100, respectively, in both medium. The drug release from the conjugates was observed for 24 h in 3% w/v rat caecal content and found to be 41.77 +/- 1.2, 39.03 +/- 1.0 and 35.26 +/- 1.09 for CSD-40, CSD-70 and CSD-100 conjugates, respectively. The half life of conjugates was determined and was found to be short in 3% w/v rat caecal content. No amount of drug was released in simulated gastric fluid pH 1.2 and stomach homogenate in 2 h. The amount of drug released from small intestine homogenate was 3.4+/- 0.1 percent in 12 h for the CSD-40. The above result suggests that dextran could be used as a macromolecular carrier for colon specific drug delivery of celecoxib.
MeSH term(s)	Animals ; Celecoxib ; Colon/drug effects ; Dextrans/administration & dosage ; Dextrans/chemistry ; Dextrans/pharmacokinetics ; Drug Carriers/administration & dosage ; Drug Carriers/chemical synthesis ; Drug Carriers/pharmacokinetics ; Drug Compounding ; Drug Delivery Systems/methods ; Extracellular Fluid/metabolism ; Hydrolysis ; In Vitro Techniques ; Macromolecular Substances/administration & dosage ; Macromolecular Substances/chemical synthesis ; Macromolecular Substances/pharmacokinetics ; Molecular Weight ; Pyrazoles/administration & dosage ; Pyrazoles/chemistry ; Pyrazoles/pharmacokinetics ; Rats ; Rats, Wistar ; Succinic Acid/chemistry ; Sulfonamides/administration & dosage ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics
Chemical Substances	Dextrans ; Drug Carriers ; Macromolecular Substances ; Pyrazoles ; Sulfonamides ; Succinic Acid (AB6MNQ6J6L) ; Celecoxib (JCX84Q7J1L)
Language	English
Publishing date	2010-02-12
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/156720110791011828
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Article ; Online: Post-burn scars and scar contractures.

Goel, Arun / Shrivastava, Prabhat

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

2011 Volume 43, Issue Suppl, Page(s) S63–71

Abstract: The mortality and morbidity from burns have diminished tremendously over the last six to seven decades. However, these do not truly reflect whether the victim could go back to society as a useful person or not and lead a normal life because of the ... ...

Abstract	The mortality and morbidity from burns have diminished tremendously over the last six to seven decades. However, these do not truly reflect whether the victim could go back to society as a useful person or not and lead a normal life because of the inevitable post-burn scars, contractures and other deformities which collectively have aesthetic and functional considerations. This article gives an overview of the post-burn scars and scar contractures, especially their prevention, minimisation and principles of management.
Language	English
Publishing date	2011-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2118680-7
ISSN	1998-376X ; 0970-0358
ISSN (online)	1998-376X
ISSN	0970-0358
DOI	10.4103/0970-0358.70724
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