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  1. Article ; Online: Caution with the use of dexamethasone in patients with COVID-19 in its initial phases.

    Callejas Rubio, J L / Aomar Millan, I / Moreno-Higueras, M / Martín Ripoll, L / Yuste Osorio, E / Ríos-Fernández, R

    Revista clinica espanola

    2021  Volume 221, Issue 10, Page(s) 592–595

    Abstract: Introduction: The effect of dexamethasone in the initial phase of infection by SARS-CoV-2 and its influence on COVID-19 is not well defined. We describe clinical-radiological characteristics, the cytokine storm parameters, and the clinical evolution of ... ...

    Abstract Introduction: The effect of dexamethasone in the initial phase of infection by SARS-CoV-2 and its influence on COVID-19 is not well defined. We describe clinical-radiological characteristics, the cytokine storm parameters, and the clinical evolution of a series of patients treated with dexamethasone in the disease's initial phase.
    Method: A study of 8 patients who received dexamethasone before the development of COVID-19. We evaluate clinical variables, imaging tests, cytokine release parameters, treatment used and patient evolution.
    Results: All patients received a 6 mg/day dose with a mean duration of 4.5 days before admission. High resolution computed tomography (HRCT) revealed that most of them presented a severe extension; most patients had a slightly elevated level of cytokine release parameters. Three patients required high-flow oxygen therapy due to respiratory failure; none required orotracheal intubation or died.
    Conclusion: Dexamethasone in the early stages of SARS-CoV-2 infection appears to be associated with severe COVID-19.
    MeSH term(s) COVID-19/drug therapy ; Cytokine Release Syndrome ; Dexamethasone ; Humans ; SARS-CoV-2
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-09-17
    Publishing country Spain
    Document type Case Reports
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Precaución con el uso de dexametasona en pacientes con COVID-19 en sus fases iniciales.

    Callejas Rubio, J L / Aomar Millan, I / Moreno-Higueras, M / Martín Ripoll, L / Yuste Osorio, E / Ríos-Fernández, R

    Revista clinica espanola

    2021  Volume 221, Issue 10, Page(s) 592–595

    Abstract: Introduction: The effect of dexamethasone in the initial phase of infection by SARS-CoV-2 and its influence on COVID-19 is not well defined. We describe clinical-radiological characteristics, the cytokine storm parameters, and the clinical evolution of ... ...

    Title translation Caution with the use of dexamethasone in patients with COVID-19 in its initial phases.
    Abstract Introduction: The effect of dexamethasone in the initial phase of infection by SARS-CoV-2 and its influence on COVID-19 is not well defined. We describe clinical-radiological characteristics, the cytokine storm parameters, and the clinical evolution of a series of patients treated with dexamethasone in the disease's initial phase.
    Method: A study of 8 patients who received dexamethasone before the development of COVID-19. We evaluate clinical variables, imaging tests, cytokine release parameters, treatment used and patient evolution.
    Results: All patients received a 6 mg/day dose with a mean duration of 4.5 days before admission. High resolution computed tomography (HRCT) revealed that most of them presented a severe extension; most patients had a slightly elevated level of cytokine release parameters. Three patients required high-flow oxygen therapy due to respiratory failure; none required orotracheal intubation or died.
    Conclusion: Dexamethasone in the early stages of SARS-CoV-2 infection appears to be associated with severe COVID-19.
    Language Spanish
    Publishing date 2021-03-06
    Publishing country Spain
    Document type Case Reports ; English Abstract
    ZDB-ID 123597-7
    ISSN 1578-1860 ; 0014-2565 ; 0014-2565
    ISSN (online) 1578-1860 ; 0014-2565
    ISSN 0014-2565
    DOI 10.1016/j.rce.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis.

    Álvarez-Cienfuegos, A / Cantero-Nieto, L / García-Gomez, J A / Callejas-Rubio, J L / González-Gay, M A / Ortego-Centeno, N

    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

    2019  Volume 23, Issue 4, Page(s) 561–567

    MeSH term(s) Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/pathology ; Bone Density ; Case-Control Studies ; Female ; Homocysteine/blood ; Humans ; Middle Aged ; Osteoporosis/etiology ; Osteoporotic Fractures/etiology ; Risk Assessment ; Risk Factors
    Chemical Substances Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2040951-5
    ISSN 1094-6950
    ISSN 1094-6950
    DOI 10.1016/j.jocd.2019.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mortality and cardiovascular risk in vasculitis ANCA. Importance of hypertension and renal function. Experience from southern Spain.

    Martin-Gómez, M A / Rodríguez Torres, A / Espinosa Hernández, M / Lopez Mendoza, M / Sabio Sánchez, J M / Martin Armada, M / Martin Suarez, I / Callejas Rubio, J L / Castilla Castellano, M M / Anglada Pintado, J C / Barnosi Marín, A C / Martinez Esteban, M D / Castilla Guerra, L / De Ramón Garrido, E

    Hipertension y riesgo vascular

    2023  Volume 41, Issue 1, Page(s) 5–16

    Abstract: Background: Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV).: Objectives: To evaluate the mortality and it's causes and CVD and its vascular risk factors ( ... ...

    Abstract Background: Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV).
    Objectives: To evaluate the mortality and it's causes and CVD and its vascular risk factors (VRFs) in AAV patients in Andalusia.
    Methods: A multicenter cohort of 220 AAV patients followed-up from 1979 until June 2020 was studied in Andalussia, south of Spain. The information, including socio-demographic and clinical data was recorded retrospectively through chart review. Data was analysed using Chi
    Results: During a mean ± standard deviation follow-up of 96.79 ± 75.83 months, 51 patients died and 30 presented at least one CVE. Independent prognostic factors of mortality were age (HR 1.083, p=0.001) and baseline creatinine (HR 4.41, p=0.01). Independent prognostic factors of CVE were age [hazard ratio (HR) 1.042, p=0.005] and the presence of hypertension (HTN) six months after diagnosis (HR 4.641, p=0.01). HTN, diabetes and renal failure, all of these important VRFs, are more prevalent in AAV patients than it is described in matched general population.
    Conclusions: Age and baseline renal function, but not CVEs, are predictors of mortality and age and early HTN are independent predictors for having a CVE. CVD screening in AAV patients is demanded.
    MeSH term(s) Humans ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology ; Antibodies, Antineutrophil Cytoplasmic ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Heart Disease Risk Factors ; Hypertension/complications ; Hypertension/epidemiology ; Kidney ; Retrospective Studies ; Risk Factors ; Spain/epidemiology
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-07-28
    Publishing country Spain
    Document type Multicenter Study ; Journal Article
    ISSN 1989-4805
    ISSN (online) 1989-4805
    DOI 10.1016/j.hipert.2023.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Optical coherence tomography angiography in the early diagnosis of Susac syndrome.

    García-Serrano, J L / Muñoz de Escalona-Rojas, J E / Callejas-Rubio, J L / Barrero-Hernández, F J

    Neurologia (Barcelona, Spain)

    2017  Volume 35, Issue 1, Page(s) 62–63

    Title translation Angiografía por tomografía de coherencia óptica en el diagnóstico precoz del síndrome de Susac.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Adult ; Angiography ; Diagnosis, Differential ; Early Diagnosis ; Female ; Hearing Loss/etiology ; Humans ; Susac Syndrome/diagnostic imaging ; Susac Syndrome/drug therapy ; Susac Syndrome/pathology ; Tinnitus/etiology ; Tomography, Optical Coherence
    Chemical Substances Adrenal Cortex Hormones
    Language Spanish
    Publishing date 2017-09-25
    Document type Case Reports ; Letter
    ISSN 2173-5808
    ISSN (online) 2173-5808
    DOI 10.1016/j.nrl.2017.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mujer de 42 años con pancitopenia.

    García-Pereña, L / Moreno-Higueras, M / Parra-Rosado, P / Gallo-Padilla, L / Callejas-Rubio, J L

    Semergen

    2016  Volume 42, Issue 8, Page(s) 596–597

    Title translation A 42 year-old woman with pancytopenia.
    MeSH term(s) Adult ; Female ; Humans ; Pancytopenia/etiology ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/diagnosis
    Language Spanish
    Publishing date 2016-11
    Publishing country Spain
    Document type Case Reports ; Letter
    ISSN 1578-8865
    ISSN (online) 1578-8865
    DOI 10.1016/j.semerg.2016.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antiphospholipid syndrome, antiphospholipid antibodies and solid organ transplantation.

    González-Moreno, J / Callejas-Rubio, J L / Ríos-Fernández, R / Ortego-Centeno, N

    Lupus

    2015  Volume 24, Issue 13, Page(s) 1356–1363

    Abstract: Antiphospholipid syndrome is considered a high risk factor for any kind of surgery. Considering that all solid organ transplants are critically dependent on the patency of vascular anastomosis, there is much concern about the consequences this pro- ... ...

    Abstract Antiphospholipid syndrome is considered a high risk factor for any kind of surgery. Considering that all solid organ transplants are critically dependent on the patency of vascular anastomosis, there is much concern about the consequences this pro-thrombotic condition may have on transplantation. Relatively little information is available in the literature assessing the real risk that antiphospholipid syndrome or the presence of antiphospholipid antibodies represent in solid organ transplantation. The aim of this article is to review the literature related to transplantation of solid organs in patients diagnosed with antiphospholipid syndrome or patients with positive antiphospholipid antibodies.
    MeSH term(s) Antibodies, Anticardiolipin/immunology ; Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/surgery ; Female ; Humans ; Lupus Coagulation Inhibitor/immunology ; Middle Aged ; Organ Transplantation ; Risk Factors ; Thrombophilia/diagnosis ; Thrombophilia/etiology ; Thrombophilia/therapy ; Thrombosis/immunology ; Thrombosis/physiopathology ; Transplantation Immunology ; Treatment Outcome
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Antiphospholipid ; Lupus Coagulation Inhibitor
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203315595129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis.

    Villanueva-Martin, Gonzalo / Acosta-Herrera, Marialbert / Carmona, Elio G / Kerick, Martin / Ortego-Centeno, Norberto / Callejas-Rubio, Jose Luis / Mages, Norbert / Klages, Sven / Börno, Stefan / Timmermann, Bernd / Bossini-Castillo, Lara / Martin, Javier

    Journal of autoimmunity

    2023  Volume 140, Page(s) 103097

    Abstract: Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing fibrosis. SSc patients show altered immune cell composition and activation in the peripheral blood (PB). PB monocytes (Mos) are recruited into tissues where they ... ...

    Abstract Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing fibrosis. SSc patients show altered immune cell composition and activation in the peripheral blood (PB). PB monocytes (Mos) are recruited into tissues where they differentiate into macrophages, which are directly involved in fibrosis. To understand the role of CD14
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2023.103097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Low bone mass and carotid atherosclerosis in lupus erythematosus patients from Granada, a city in the south of Spain.

    López-Robles, C / Ríos-Fernández, R / Callejas-Rubio, J L / Moreno-Escobar, E / Ortego-Centeno, N

    Lupus

    2016  Volume 25, Issue 2, Page(s) 223–224

    MeSH term(s) Bone Density ; Carotid Artery Diseases/epidemiology ; Female ; Humans ; Lumbar Vertebrae/injuries ; Lupus Erythematosus, Systemic/epidemiology ; Osteoporosis/epidemiology ; Spinal Fractures/epidemiology ; Thoracic Vertebrae/injuries
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203315608255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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