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  1. Article: Widespread Multidrug Resistance of

    Gabucci, Claudia / Baldelli, Giulia / Amagliani, Giulia / Schiavano, Giuditta Fiorella / Savelli, David / Russo, Ilaria / Di Lullo, Stefania / Blasi, Giuliana / Napoleoni, Maira / Leoni, Francesca / Primavilla, Sara / Massacci, Francesca Romana / Garofolo, Giuliano / Petruzzelli, Annalisa

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081292
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  2. Article: Social responsibility in practice

    Leoni, Giulia

    Journal of management history : JMH Vol. 23, No. 2 , p. 133-151

    an Italian case from the early 20th century

    2017  Volume 23, Issue 2, Page(s) 133–151

    Author's details Giulia Leoni
    Keywords Case studies ; Corporate social responsibility ; Italy ; Family business ; Management history ; Accounting history
    Language English
    Publisher Emerald
    Publishing place Bingley
    Document type Article
    ZDB-ID 1238516-5 ; 2020279-9
    ISSN 1751-1348 ; 1355-252X
    ISSN 1751-1348 ; 1355-252X
    Database ECONomics Information System

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  3. Article ; Online: Phage-mediated colistin resistance in Acinetobacter baumannii.

    Lucidi, Massimiliano / Imperi, Francesco / Artuso, Irene / Capecchi, Giulia / Spagnoli, Cinzia / Visaggio, Daniela / Rampioni, Giordano / Leoni, Livia / Visca, Paolo

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

    2024  Volume 73, Page(s) 101061

    Abstract: Aims: Antimicrobial resistance is a global threat to human health, and Acinetobacter baumannii is a paradigmatic example of how rapidly bacteria become resistant to clinically relevant antimicrobials. The emergence of multidrug-resistant A. baumannii ... ...

    Abstract Aims: Antimicrobial resistance is a global threat to human health, and Acinetobacter baumannii is a paradigmatic example of how rapidly bacteria become resistant to clinically relevant antimicrobials. The emergence of multidrug-resistant A. baumannii strains has forced the revival of colistin as a last-resort drug, suddenly leading to the emergence of colistin resistance. We investigated the genetic and molecular basis of colistin resistance in A. baumannii, and the mechanisms implicated in its regulation and dissemination.
    Methods: Comparative genomic analysis was combined with genetic, biochemical, and phenotypic assays to characterize Φ19606, an A. baumannii temperate bacteriophage that carries a colistin resistance gene.
    Results: Ф19606 was detected in 41% of 523 A. baumannii complete genomes and demonstrated to act as a mobile vehicle of the colistin resistance gene eptA1, encoding a functional lipid A phosphoethanolamine transferase. The eptA1 gene is coregulated with its chromosomal homolog pmrC via the PmrAB two-component system and confers colistin resistance when induced by low calcium and magnesium levels. Resistance selection assays showed that the eptA1-harbouring phage Ф19606 promotes the emergence of spontaneous colistin-resistant mutants.
    Conclusions: Φ19606 is an unprecedented example of a self-transmissible phage vector implicated in the dissemination of colistin resistance.
    MeSH term(s) Humans ; Colistin/pharmacology ; Colistin/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Acinetobacter baumannii/genetics ; Bacterial Proteins/genetics ; Drug Resistance, Bacterial/genetics ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Microbial Sensitivity Tests ; Drug Resistance, Multiple, Bacterial/genetics
    Chemical Substances Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2024-01-28
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1474513-6
    ISSN 1532-2084 ; 1368-7646
    ISSN (online) 1532-2084
    ISSN 1368-7646
    DOI 10.1016/j.drup.2024.101061
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    Zs.A 5099: Show issues Location:
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  4. Article: In vitro

    Collalto, Diletta / Giallonardi, Giulia / Fortuna, Alessandra / Meneghini, Carlo / Fiscarelli, Ersilia / Visca, Paolo / Imperi, Francesco / Rampioni, Giordano / Leoni, Livia

    Frontiers in microbiology

    2022  Volume 13, Page(s) 845231

    Abstract: The chronic lung infection caused ... ...

    Abstract The chronic lung infection caused by
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.845231
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  5. Article: Metformin and the Liver: Unlocking the Full Therapeutic Potential.

    Perazza, Federica / Leoni, Laura / Colosimo, Santo / Musio, Alessandra / Bocedi, Giulia / D'Avino, Michela / Agnelli, Giulio / Nicastri, Alba / Rossetti, Chiara / Sacilotto, Federica / Marchesini, Giulio / Petroni, Maria Letizia / Ravaioli, Federico

    Metabolites

    2024  Volume 14, Issue 4

    Abstract: Metformin is a highly effective medication for managing type 2 diabetes mellitus. Recent studies have shown that it has significant therapeutic benefits in various organ systems, particularly the liver. Although the effects of metformin on metabolic ... ...

    Abstract Metformin is a highly effective medication for managing type 2 diabetes mellitus. Recent studies have shown that it has significant therapeutic benefits in various organ systems, particularly the liver. Although the effects of metformin on metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis are still being debated, it has positive effects on cirrhosis and anti-tumoral properties, which can help prevent the development of hepatocellular carcinoma. Furthermore, it has been proven to improve insulin resistance and dyslipidaemia, commonly associated with liver diseases. While more studies are needed to fully determine the safety and effectiveness of metformin use in liver diseases, the results are highly promising. Indeed, metformin has a terrific potential for extending its full therapeutic properties beyond its traditional use in managing diabetes.
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14040186
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  6. Article ; Online: Ratio Indexes Based on Spectral Electroencephalographic Brainwaves for Assessment of Mental Involvement: A Systematic Review.

    Marcantoni, Ilaria / Assogna, Raffaella / Del Borrello, Giulia / Di Stefano, Marina / Morano, Martina / Romagnoli, Sofia / Leoni, Chiara / Bruschi, Giulia / Sbrollini, Agnese / Morettini, Micaela / Burattini, Laura

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 13

    Abstract: Background: This review systematically examined the scientific literature about electroencephalogram-derived ratio indexes used to assess human mental involvement, in order to deduce what they are, how they are defined and used, and what their best ... ...

    Abstract Background: This review systematically examined the scientific literature about electroencephalogram-derived ratio indexes used to assess human mental involvement, in order to deduce what they are, how they are defined and used, and what their best fields of application are. (2) Methods: The review was carried out according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. (3) Results: From the search query, 82 documents resulted. The majority (82%) were classified as related to mental strain, while 12% were classified as related to sensory and emotion aspects, and 6% to movement. The electroencephalographic electrode montage used was low-density in 13%, high-density in 6% and very-low-density in 81% of documents. The most used electrode positions for computation of involvement indexes were in the frontal and prefrontal cortex. Overall, 37 different formulations of involvement indexes were found. None of them could be directly related to a specific field of application. (4) Conclusions: Standardization in the definition of these indexes is missing, both in the considered frequency bands and in the exploited electrodes. Future research may focus on the development of indexes with a unique definition to monitor and characterize mental involvement.
    MeSH term(s) Humans ; Electroencephalography/methods ; Brain Waves ; Prefrontal Cortex ; Electrodes
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23135968
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  7. Article ; Online: The neurovascular retinal involvement in a large population of patients recovered from COVID-19: an OCT and OCT angiography study.

    Cosmo, Eleonora / Frizziero, Luisa / Schiavon, Stefano / Cattelan, Anna Maria / Leoni, Davide / Capizzi, Alfio / Torresin, Tommaso / Midena, Giulia / Armato Smaniotto Dai Roveri, Edoardo / Parrozzani, Raffaele / Midena, Edoardo

    Eye (London, England)

    2024  

    Abstract: Background: This study aimed to assess the neuronal and microvascular retinal and choroidal involvement in COVID-19 recovered patients using optical coherence tomography (OCT) and OCT angiography (OCTA).: Methods: This observational cross-sectional ... ...

    Abstract Background: This study aimed to assess the neuronal and microvascular retinal and choroidal involvement in COVID-19 recovered patients using optical coherence tomography (OCT) and OCT angiography (OCTA).
    Methods: This observational cross-sectional study recruited patients recovered from COVID-19 and a group of healthy controls for comparisons. OCT (peripapillary scan and macular map) and OCTA (macular map) were performed to obtain: the central subfield thickness (CST), the macular volume (MV), the peripapillary retinal nerve fibre layer (pRNFL) thickness, the vessel area density (VAD), vessel length fraction (VLF), vessel diameter index (VDI) and fractal dimension (FD) of the superficial vascular plexus (SVP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), and the vessel density (VD), stromal density (SD) and vascular/stromal (V/S) ratio of the choriocapillaris (CC) and choroid (Ch). Data regarding disease severity, administered therapy and prior comorbidities were collected.
    Results: We recruited 676 eyes from 338 patients and 98 eyes from 49 healthy controls. VAD of all the three retinal plexuses, VLF and VDI of ICP and DCP and VD of CC were significantly reduced in patients versus controls. No differences were found in CST, MV and pRNFL. A multivariate analysis showed that oxygen therapy, previous cardio/cerebrovascular events and hypertension negatively influenced vascular parameters.
    Conclusion: A microvascular retinal and choriocapillaris damage may be identified secondary to SARS-CoV-2 infection, even after recovery. OCTA may represent a reproducible and non-invasive tool to assess microangiopathy in these patients, with particular regard to those with previous cardio/cerebrovascular events, hypertension and those who received oxygen therapy.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-024-02991-9
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    Zs.B 3010: Show issues Location:
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    Zs.MO 603: Show issues

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  8. Article ; Online: Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in

    Giallonardi, Giulia / Letizia, Morgana / Mellini, Marta / Frangipani, Emanuela / Halliday, Nigel / Heeb, Stephan / Cámara, Miguel / Visca, Paolo / Imperi, Francesco / Leoni, Livia / Williams, Paul / Rampioni, Giordano

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1183681

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Quinolones/pharmacology ; Quorum Sensing ; Pseudomonas aeruginosa/genetics ; Prophages ; Biofilms ; Autolysis
    Chemical Substances Quinolones
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1183681
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  9. Article: Metabolic Profile of Patients with Smith-Magenis Syndrome: An Observational Study with Literature Review.

    Cipolla, Clelia / Sessa, Linda / Rotunno, Giulia / Sodero, Giorgio / Proli, Francesco / Veredice, Chiara / Giorgio, Valentina / Leoni, Chiara / Rosati, Jessica / Limongelli, Domenico / Kuczynska, Eliza / Sforza, Elisabetta / Trevisan, Valentina / Rigante, Donato / Zampino, Giuseppe / Onesimo, Roberta

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10091451
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  10. Article ; Online: Dipeptidyl Peptidase-4 Inhibitors, Glucagon-like Peptide-1 Receptor Agonists, and Sodium-Glucose Cotransporter-2 Inhibitors and COVID-19 Outcomes.

    Foresta, Andreana / Ojeda-Fernandez, Luisa / Macaluso, Giulia / Roncaglioni, Maria Carla / Tettamanti, Mauro / Fortino, Ida / Leoni, Olivia / Genovese, Stefano / Baviera, Marta

    Clinical therapeutics

    2023  Volume 45, Issue 4, Page(s) e115–e126

    Abstract: Purpose: It has been reported that dipeptidyl peptidase-4 inhibitors (DPP-4i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have a role in modulation of inflammation associated with ... ...

    Abstract Purpose: It has been reported that dipeptidyl peptidase-4 inhibitors (DPP-4i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have a role in modulation of inflammation associated with coronavirus disease 2019 (COVID-19). This study assessed the effect of these drug classes on COVID-19-related outcomes.
    Methods: Using a COVID-19 linkable administrative database, we selected patients aged ≥40 years with at least 2 prescriptions of DPP-4i, GLP-1 RA, or SGLT-2i or any other antihyperglycemic drug and a diagnosis of COVID-19 from February 15, 2020, to March 15, 2021. Adjusted odds ratios (ORs) with 95% CIs were used to calculate the association between treatments and all-cause and in-hospital mortality and COVID-19-related hospitalization. A sensitivity analysis was performed by using inverse probability treatment weighting.
    Findings: Overall, 32,853 subjects were included in the analysis. Multivariable models showed a reduction of the risk for COVID-19 outcomes for users of DPP-4i, GLP-1 RA, and SGLT-2i compared with nonusers, although statistical significance was reached only in DPP-4i users for total mortality (OR, 0.89; 95% CI, 0.82-0.97). The sensitivity analysis confirmed the main results reaching a significant reduction for hospital admission in GLP-1 RA users and in-hospital mortality in SGLT-2i users compared with nonusers.
    Implications: This study found a beneficial effect in the risk reduction of COVID-19 total mortality in DPP-4i users compared with nonusers. A positive trend was also observed in users of GLP-1 RA and SGLT-2i compared with nonusers. Randomized clinical trials are needed to confirm the effect of these drug classes as potential therapy for the treatment of COVID-19.
    MeSH term(s) Humans ; COVID-19/complications ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/therapeutic use ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2023.02.007
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