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  1. Article ; Online: #IchbinHannah and the fight for permanent jobs for postdocs: How a fictitious postdoc (almost) triggered a fundamental reform of German academia: How a fictitious postdoc (almost) triggered a fundamental reform of German academia.

    Dirnagl, Ulrich

    EMBO reports

    2022  Volume 23, Issue 3, Page(s) e54623

    Abstract: Regarding postdocs as disposable labour with limited contracts is damaging for science. Universities need to offer them better career perspectives. ...

    Abstract Regarding postdocs as disposable labour with limited contracts is damaging for science. Universities need to offer them better career perspectives.
    MeSH term(s) Career Choice ; Germany ; Humans ; Research/organization & administration ; Research Personnel/legislation & jurisprudence ; Universities/legislation & jurisprudence
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202254623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  2. Book: Rodent models of stroke

    Dirnagl, Ulrich

    (Neuromethods ; 47 ; Springer protocols)

    2010  

    Author's details ed. by Ulrich Dirnagl
    Series title Neuromethods ; 47
    Springer protocols
    Collection
    Language English
    Size XII, 286 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT016486829
    ISBN 978-1-6076-1749-5 ; 1-6076-1749-8 ; 9781607617501 ; 1607617501
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4387 order for loan Magazin

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  3. Article ; Online: Promoting research quality.

    Dirnagl, Ulrich / Pariente, Nonia

    PLoS biology

    2024  Volume 22, Issue 2, Page(s) e3002554

    Abstract: Plenty of awards recognize scientific contributions, but a unique and important one honors those whose efforts significantly enhance the quality and robustness of research. We discuss why this is important to promote trust in science. ...

    Abstract Plenty of awards recognize scientific contributions, but a unique and important one honors those whose efforts significantly enhance the quality and robustness of research. We discuss why this is important to promote trust in science.
    MeSH term(s) Awards and Prizes ; Trust
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6193: Show issues Location:
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  4. Article ; Online: Institutions can retool to make research more rigorous.

    Dirnagl, Ulrich

    Nature

    2020  Volume 588, Issue 7837, Page(s) 197

    MeSH term(s) Academic Medical Centers ; Research
    Language English
    Publishing date 2020-10-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-02905-1
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    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Preregistration of exploratory research: Learning from the golden age of discovery.

    Dirnagl, Ulrich

    PLoS biology

    2020  Volume 18, Issue 3, Page(s) e3000690

    Abstract: Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the ...

    Abstract Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful.
    MeSH term(s) Humans ; Peer Review, Research/standards ; Publishing/trends ; Qualitative Research ; Research Design/standards
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3000690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: The p value wars (again).

    Dirnagl, Ulrich

    European journal of nuclear medicine and molecular imaging

    2019  Volume 46, Issue 12, Page(s) 2421–2423

    MeSH term(s) Probability ; Statistics as Topic
    Language English
    Publishing date 2019-08-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-019-04467-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Conference proceedings: The QUEST Center in Berlin – a laboratory for behavior change in academic biomedicine

    Dirnagl, Ulrich

    2021  , Page(s) Abstr. 491

    Event/congress 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS); Berlin; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2020
    Keywords Medizin, Gesundheit
    Publishing date 2021-02-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/20gmds212
    Database German Medical Science

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  8. Article: Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research.

    Dirnagl, Ulrich

    Handbook of experimental pharmacology

    2019  Volume 257, Page(s) 71–79

    Abstract: Confirmation through competent replication is a founding principle of modern science. However, biomedical researchers are rewarded for innovation, and not for confirmation, and confirmatory research is often stigmatized as unoriginal and as a consequence ...

    Abstract Confirmation through competent replication is a founding principle of modern science. However, biomedical researchers are rewarded for innovation, and not for confirmation, and confirmatory research is often stigmatized as unoriginal and as a consequence faces barriers to publication. As a result, the current biomedical literature is dominated by exploration, which to complicate matters further is often disguised as confirmation. Only recently scientists and the public have begun to realize that high-profile research results in biomedicine can often not be replicated. Consequently, confirmation has become central stage in the quest to safeguard the robustness of research findings. Research which is pushing the boundaries of or challenges what is currently known must necessarily result in a plethora of false positive results. Thus, since discovery, the driving force of scientific progress, is unavoidably linked to high false positive rates and cannot support confirmatory inference, dedicated confirmatory investigation is needed for pivotal results. In this chapter I will argue that the tension between the two modes of research, exploration and confirmation, can be resolved if we conceptually and practically separate them. I will discuss the idiosyncrasies of exploratory and confirmatory studies, with a focus on the specific features of their design, analysis, and interpretation.
    MeSH term(s) Biomedical Research ; Data Collection/statistics & numerical data ; Reward
    Language English
    Publishing date 2019-11-06
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2019_278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  9. Book: Neuroinflammation in stroke

    Dirnagl, Ulrich

    with 9 tables

    (Ernst Schering Research Foundation workshop ; 47)

    2004  

    Author's details U. Dirnagl ; B. Elger ed
    Series title Ernst Schering Research Foundation workshop ; 47
    Collection
    Keywords Schlaganfall ; Nervenentzündung
    Subject Neuritis ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Language English
    Size XII, 219 S. : graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014235443
    ISBN 3-540-40348-5 ; 978-3-540-40348-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 254 order for loan Magazin

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  10. Article ; Online: Preregistration of exploratory research

    Ulrich Dirnagl

    PLoS Biology, Vol 18, Iss 3, p e

    Learning from the golden age of discovery.

    2020  Volume 3000690

    Abstract: Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the ...

    Abstract Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as publication bias. Preregistration works well when a clear hypothesis, primary outcome, and mode of analysis can be formulated. But is it also applicable and useful in discovery research, which develops theories and hypotheses, measurement techniques, and generates evidence that justifies further research? I will argue that only slight modifications are needed to harness the potential of preregistration and make exploratory research more trustworthy and useful.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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