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  1. Article ; Online: Correction for: Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.

    Meng, Zibo / Ren, Dianyun / Zhang, Kun / Zhao, Jingyuan / Jin, Xin / Wu, Heshui

    Aging

    2023  Volume 15, Issue 24, Page(s) 15701–15702

    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation.

    Sun, Rui / Meng, Zibo / Lee, Hyeyoon / Offringa, Rienk / Niehrs, Christof

    Cell chemical biology

    2023  Volume 30, Issue 7, Page(s) 739–752.e8

    Abstract: Proteolysis-targeting chimeras (PROTACs) are an emerging technology for therapeutic intervention, but options to target cell surface proteins and receptors remain limited. Here we introduce ROTACs, bispecific WNT- and BMP-signaling-disabled R-spondin ( ... ...

    Abstract Proteolysis-targeting chimeras (PROTACs) are an emerging technology for therapeutic intervention, but options to target cell surface proteins and receptors remain limited. Here we introduce ROTACs, bispecific WNT- and BMP-signaling-disabled R-spondin (RSPO) chimeras, which leverage the specificity of these stem cell growth factors for ZNRF3/RNF43 E3 transmembrane ligases, to target degradation of transmembrane proteins. As a proof-of-concept, we targeted the immune checkpoint protein, programmed death ligand 1 (PD-L1), a prominent cancer therapeutic target, with a bispecific RSPO2 chimera, R2PD1. The R2PD1 chimeric protein binds to PD-L1 and at picomolar concentration induces its lysosomal degradation. In three melanoma cell lines, R2PD1 induced between 50 and 90% PD-L1 protein degradation. PD-L1 degradation was strictly dependent on ZNRF3/RNF43. Moreover, R2PD1 reactivates cytotoxic T cells and inhibits tumor cell proliferation more potently than Atezolizumab. We suggest that signaling-disabled ROTACs represent a paradigm to target cell surface proteins for degradation in a range of applications.
    MeSH term(s) Receptors, G-Protein-Coupled/metabolism ; Proteolysis ; B7-H1 Antigen/metabolism ; Wnt Signaling Pathway ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Receptors, G-Protein-Coupled ; B7-H1 Antigen ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Influence of Different Protection States on the Mental Fatigue of Nurses During the COVID-19 Pandemic.

    Jin, Haizhe / Xiao, Meng / Gong, Zibo / Zhao, Yinan

    Risk management and healthcare policy

    2022  Volume 15, Page(s) 1917–1929

    Abstract: Background: COVID-19 has brought greater workload pressures to the medical field, such as medical staff being required to wear personal protective equipment (PPE). While PPE can protect the safety of staff during the pandemic, it can also accelerate the ...

    Abstract Background: COVID-19 has brought greater workload pressures to the medical field, such as medical staff being required to wear personal protective equipment (PPE). While PPE can protect the safety of staff during the pandemic, it can also accelerate the accumulation of fatigue among operators.
    Objective: This study explores the influence of different protection states on the mental fatigue of nurses.
    Methods: In this study, 10 participants (5 males and 5 females) were randomly selected among applicants to monitor mental fatigue during the nurses' daily work in four different PPE states (low temperature and low protection; low temperature and high protection; high temperature and low protection; high temperature and high protection). The NASA subjective mental fatigue scale was used for subjective evaluation. Reaction time, attention concentration, attention distribution, memory, and main task completion time were used for objective evaluation.
    Results: The results demonstrated a significant difference in the effects of different protection states on mental fatigue. The state of high temperature and high protection had the greatest influence on mental fatigue, the state of low temperature and low protection had the least, and states of high (low) temperature and low (high) protection had intermediate effects on mental fatigue. Furthermore, the correlation between the subjective and objective fatigue indices was analyzed using a multiple regression model.
    Conclusion: This study clarified the influence of different protection states on the mental fatigue of nurses, and verified that nurses require more time and energy to complete the same work as before under high protection states. It provides a basis for evaluating the mental fatigue of nurses in the unique period of the COVID-19 pandemic and specific ideas for optimizing the nursing process.
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S377936
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  4. Article ; Online: Multifunctional Integrated Underwater Sound Absorption Materials

    Xianmei Chen / Lei Meng / Zibo Liu / Feiran Yang / Xin Jiang / Jun Yang

    Applied Sciences, Vol 13, Iss 5368, p

    A Review

    2023  Volume 5368

    Abstract: Rapid improvements in underwater vehicle technology have led to a significant increase in the demand for underwater sound absorption materials. These materials, unlike their counterparts utilized in air, must have high hydrostatic pressure resistance, ... ...

    Abstract Rapid improvements in underwater vehicle technology have led to a significant increase in the demand for underwater sound absorption materials. These materials, unlike their counterparts utilized in air, must have high hydrostatic pressure resistance, corrosion resistance, and other advantageous attributes. This necessitates the development of innovative, composite sound-absorbing materials with multifunctional properties, which presents substantial challenges for researchers. In this comprehensive review, we systematically analyze and categorize the mechanisms governing underwater sound absorption, hydrostatic pressure resistance, and corrosion prevention while considering related research advances. Furthermore, we provide an extensive overview of research advancements, existing challenges, and potential solutions pertaining to multifunctional and integrated underwater sound-absorbing materials. This review aims to serve as a valuable resource for future investigations into the development and optimization of multifunctional integrated underwater sound-absorbing materials, thereby contributing to the advancement of underwater vehicle technology.
    Keywords multifunctional materials ; underwater sound absorption ; anti-corrosion ; high hydrostatic pressure resistance ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 621
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice

    Bao, Bo-wen / Kang, Zibo / Zhang, Yu / Li, Kan / Xu, Ran / Guo, Meng-yao

    Biol Trace Elem Res. 2023 Apr., v. 201, no. 4 p.1878-1887

    2023  

    Abstract: Selenium (Se) is one of the essential trace elements in animal organisms with good antioxidant and immune-enhancing abilities. In this study, we investigated the effect and mechanism of Se deficiency on skeletal muscle cell differentiation. A selenium- ... ...

    Abstract Selenium (Se) is one of the essential trace elements in animal organisms with good antioxidant and immune-enhancing abilities. In this study, we investigated the effect and mechanism of Se deficiency on skeletal muscle cell differentiation. A selenium-deficient skeletal muscle model was established. The skeletal muscle tissue and blood Se content were significantly reduced in the Se deficiency group. HE staining showed that the skeletal muscle tissue had a reduced myofiber area and nuclei and an increased myofascicular membrane with Se deficiency. The TUNEL test showed massive apoptosis of skeletal muscle cells in Se deficiency. With Se deficiency, reactive oxygen species (ROS) and malondialdehyde (MDA) increased, and the activities of glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and catalase (CAT) were inhibited. In in vitro experiments, microscopic observations showed that the low-Se group had reduced C2C12 cell fusion and a reduced number of differentiated myotubes. In addition, qPCR results showed that differentiation genes (Myog, Myod, Myh2, Myh3, and Myf5) were significantly reduced in the low Se group. Meanwhile, Western blot analysis showed that the levels of differentiation proteins (Myog, Myod, and Myhc) were significantly reduced in the low-Se group. This finding indicates that Se deficiency reduces the expression of skeletal muscle cell differentiation factors. All the above data suggest that Se deficiency can lead to oxidative stress in skeletal muscle, resulting in a reduction in the differentiation capacity of muscle cells.
    Keywords Western blotting ; animals ; antioxidant activity ; apoptosis ; blood ; catalase ; cell differentiation ; cell fusion ; glutathione peroxidase ; malondialdehyde ; models ; muscles ; myotubes ; oxidative stress ; reactive oxygen species ; selenium ; skeletal muscle ; superoxide dismutase
    Language English
    Dates of publication 2023-04
    Size p. 1878-1887.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-022-03288-2
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Corrigendum to "The optimal dose of arsenic trioxide induced opposite efficacy in autophagy between K562 cells and their initiating cells to eradicate human myelogenous leukemia" [J. Ethnopharmacol. 196 (2017) 29-38].

    Guo, Zhenzhen / Meng, Mingjing / Geng, Shengnan / Du, Zhenhua / Zheng, Yaqiu / Yao, Jingjing / Li, Zibo / Han, Guang / Lin, Haihong / Du, Gangjun

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117391

    Language English
    Publishing date 2023-11-08
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117391
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: High-repetition-rate, quarter acoustic wave oscillation period pulse compression using transient stimulated Brillouin scattering.

    Cao, Chen / Wang, Yulei / Yue, Jianfeng / Meng, Zibo / Li, Kai / Yu, Yu / Bai, Zhenxu / Lu, Zhiwei

    Optics express

    2022  Volume 30, Issue 19, Page(s) 33721–33732

    Abstract: In this work we demonstrate the compression of laser pulses at a high repetition rate, using transient stimulated Brillouin scattering (SBS). Output pulses with pulse durations close to the quarter-acoustic wave oscillation period ( ... ...

    Abstract In this work we demonstrate the compression of laser pulses at a high repetition rate, using transient stimulated Brillouin scattering (SBS). Output pulses with pulse durations close to the quarter-acoustic wave oscillation period (τ
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.468375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: T-Cell-Based Platform for Functional Screening of T-Cell Receptors Identified in Single-Cell RNA Sequencing Data Sets of Tumor-Infiltrating T-Cells.

    Ehrenfried, Aaron Rodriguez / Zens, Stefan / Steffens, Laura K / Kehm, Hannes / Paul, Alina / Lauenstein, Claudia / Volkmar, Michael / Poschke, Isabel / Meng, Zibo / Offringa, Rienk

    Bio-protocol

    2024  Volume 14, Issue 8, Page(s) e4972

    Abstract: The advent of single-cell RNA sequencing (scRNAseq) has enabled in-depth gene expression analysis of several thousand cells isolated from tissues. We recently reported the application of scRNAseq toward the dissection of the tumor-infiltrating T-cell ... ...

    Abstract The advent of single-cell RNA sequencing (scRNAseq) has enabled in-depth gene expression analysis of several thousand cells isolated from tissues. We recently reported the application of scRNAseq toward the dissection of the tumor-infiltrating T-cell repertoire in human pancreatic cancer samples. In this study, we demonstrated that combined whole transcriptome and T-cell receptor (TCR) sequencing provides an effective way to identify tumor-reactive TCR clonotypes on the basis of gene expression signatures. An important aspect in this respect was the experimental validation of TCR-mediated anti-tumor reactivity by means of an in vitro functional assay, which is the subject of the present protocol. This assay involves the transient transfection of mRNA gene constructs encoding TCRα/β pairs into a well-defined human T-cell line, followed by co-cultivation with the tumor cells of interest and detection of T-cell activation by flow cytometry. Due to the high transfectability and the low background reactivity of the mock-transfected T-cell line to a wide variety of tumor cells, this assay offers a highly robust and versatile platform for the functional screening of large numbers of TCR clonotypes as identified in scRNAseq data sets. Whereas the assay was initially developed to test TCRs of human origin, it was more recently also applied successfully for the screening of TCRs of murine origin. Key features • Efficient functional screening of-and discrimination between-TCRs isolated from tumor-reactive vs. bystander T-cell clones. • Applicable to TCRs from CD8
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Research on Identification of COVID-19 News Elements based on Transfer Learning in Multi-task Environment

    Zhao Zibo / Wang Hao / Liu Youhua / Zhang Wei / Meng Zhen

    Zhishi guanli luntan, Vol 6, Iss 1, Pp 0-

    2021  

    Abstract: Purpose/significance] Under the background of novel coronavirus pneumonia, this paper proposes a method of identifying COVID-19 news elements in multi-task environment based on transfer learning to provide knowledge services of emergency for the public. ...

    Abstract [Purpose/significance] Under the background of novel coronavirus pneumonia, this paper proposes a method of identifying COVID-19 news elements in multi-task environment based on transfer learning to provide knowledge services of emergency for the public. [Method/process] Firstly, multiple tasks were used to identify news elements: Time elements were identified based on rules; besides, a cross domain element recognition model was constructed by integrating model transfer and deep learning methods. On this basis, the associated data of COVID-19 news elements was constructed, and the relationship between the elements was displayed by knowledge mapping. [Result/conclusion] The experimental results show that the F1 values of news elements except Drug are above 80%, which indicates that the transfer learning model can achieve fine recognition effect. Moreover, the knowledge map of associated data can intuitively display the key elements and main contents of news. In conclusion, the method proposed in this paper can effectively identify elements in COVID-19 news, thus it can help readers obtain important information from the news accurately and efficiently.
    Keywords multi-task ; Bibliography. Library science. Information resources ; Z
    Subject code 006
    Language Chinese
    Publishing date 2021-01-01T00:00:00Z
    Publisher LIS Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Predicted value of coagulation function for prognosis and admission time to negative RT-PCR detection in non-critical COVID-19 patients.

    Meng, Zibo / Ren, Dianyun / Liu, Yun / Lu, Xiaoming / Xiong, Wei / Jin, Xin

    Clinical and translational medicine

    2020  Volume 10, Issue 2, Page(s) e42

    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2697013-2
    ISSN 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.42
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