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  1. Article ; Online: Reply to: Further advancing emergency department triage prediction.

    Covino, Marcello / Sandroni, Claudio / Gasbarrini, Antonio / Franceschi, Francesco

    Resuscitation

    2023  Volume 191, Page(s) 109952

    MeSH term(s) Humans ; Triage ; Emergency Service, Hospital ; ROC Curve
    Language English
    Publishing date 2023-08-28
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Increased Thrombotic Risk in COVID-19: Evidence and Controversy.

    De Vita, Antonio / Franceschi, Francesco / Covino, Marcello

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: The pandemic of respiratory disease caused by the novel coronavirus named SARS-CoV-2, which emerged at the end of 2019, is still ongoing [ ... ]. ...

    Abstract The pandemic of respiratory disease caused by the novel coronavirus named SARS-CoV-2, which emerged at the end of 2019, is still ongoing [...].
    Language English
    Publishing date 2023-07-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased Thrombotic Risk in COVID-19

    Antonio De Vita / Francesco Franceschi / Marcello Covino

    Journal of Clinical Medicine, Vol 12, Iss 4441, p

    Evidence and Controversy

    2023  Volume 4441

    Abstract: The pandemic of respiratory disease caused by the novel coronavirus named SARS-CoV-2, which emerged at the end of 2019, is still ongoing [.] ...

    Abstract The pandemic of respiratory disease caused by the novel coronavirus named SARS-CoV-2, which emerged at the end of 2019, is still ongoing [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: The Impact of Smoking on Microbiota: A Narrative Review.

    Cicchinelli, Sara / Rosa, Federico / Manca, Federica / Zanza, Christian / Ojetti, Veronica / Covino, Marcello / Candelli, Marcello / Gasbarrini, Antonio / Franceschi, Francesco / Piccioni, Andrea

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as a new, major player in human health. Its deregulation-dysbiosis-is considered a new risk factor for several illnesses. Some studies highlight a ... ...

    Abstract Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as a new, major player in human health. Its deregulation-dysbiosis-is considered a new risk factor for several illnesses. Some studies highlight a cross-interaction between these two risk factors-smoke and dysbiosis-that may explain the pathogenesis of some diseases. We searched the keywords "smoking OR smoke AND microbiota" in the title of articles on PubMed
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041144
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  5. Article: Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship.

    Piccioni, Andrea / Rosa, Federico / Mannucci, Sergio / Manca, Federica / Merra, Giuseppe / Chiloiro, Sabrina / Candelli, Marcello / Covino, Marcello / Gasbarrini, Antonio / Franceschi, Francesco

    Biomedicines

    2023  Volume 11, Issue 3

    Abstract: There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of ... ...

    Abstract There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11030707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Familial Hypercholesterolemia and Acute Coronary Syndromes: The Microbiota-Immunity Axis in the New Diagnostic and Prognostic Frontiers.

    Piccioni, Andrea / Niccolai, Elena / Rozzi, Gloria / Spaziani, Giacomo / Zanza, Christian / Candelli, Marcello / Covino, Marcello / Gasbarrini, Antonio / Franceschi, Francesco / Amedei, Amedeo

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Familial hypercholesterolemia is a common genetic disorder with a propensity towards early onset of atherosclerotic cardiovascular disease (CVD). The main goal of therapy is to reduce the LDL cholesterol and the current treatment generally consists of ... ...

    Abstract Familial hypercholesterolemia is a common genetic disorder with a propensity towards early onset of atherosclerotic cardiovascular disease (CVD). The main goal of therapy is to reduce the LDL cholesterol and the current treatment generally consists of statin, ezetimibe and PCSK9 inhibitors. Unfortunately, lowering LDL cholesterol may be difficult for many reasons such as the variation of response to statin therapy among the population or the high cost of some therapies (i.e., PCSK9 inhibitors). In addition to conventional therapy, additional strategies may be used. The gut microbiota has been recently considered to play a part in chronic systemic inflammation and hence in CVD. Several studies, though they are still preliminary, consider dysbiosis a risk factor for various CVDs through several mechanisms. In this review, we provide an update of the current literature about the intricate relation between the gut microbiota and the familial hypercholesterolemia.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Impact of Climate Change and Extreme Weather Conditions on Cardiovascular Health and Acute Cardiovascular Diseases.

    De Vita, Antonio / Belmusto, Antonietta / Di Perna, Federico / Tremamunno, Saverio / De Matteis, Giuseppe / Franceschi, Francesco / Covino, Marcello

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Climate change is widely recognized as one of the most significant challenges facing our planet and human civilization. Human activities such as the burning of fossil fuels, deforestation, and industrial processes release greenhouse gases into the ... ...

    Abstract Climate change is widely recognized as one of the most significant challenges facing our planet and human civilization. Human activities such as the burning of fossil fuels, deforestation, and industrial processes release greenhouse gases into the atmosphere, leading to a warming of the Earth's climate. The relationship between climate change and cardiovascular (CV) health, mediated by air pollution and increased ambient temperatures, is complex and very heterogeneous. The main mechanisms underlying the pathogenesis of CV disease at extreme temperatures involve several regulatory pathways, including temperature-sympathetic reactivity, the cold-activated renin-angiotensin system, dehydration, extreme temperature-induced electrolyte imbalances, and heat stroke-induced systemic inflammatory responses. The interplay of these mechanisms may vary based on individual factors, environmental conditions, and an overall health background. The net outcome is a significant increase in CV mortality and a higher incidence of hypertension, type II diabetes mellitus, acute myocardial infarction (AMI), heart failure, and cardiac arrhythmias. Patients with pre-existing CV disorders may be more vulnerable to the effects of global warming and extreme temperatures. There is an urgent need for a comprehensive intervention that spans from the individual level to a systemic or global approach to effectively address this existential problem. Future programs aimed at reducing CV and environmental burdens should require cross-disciplinary collaboration involving physicians, researchers, public health workers, political scientists, legislators, and national leaders to mitigate the effects of climate change.
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030759
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  8. Article ; Online: Gut Microbiota, LADA, and Type 1 Diabetes Mellitus

    Andrea Piccioni / Federico Rosa / Sergio Mannucci / Federica Manca / Giuseppe Merra / Sabrina Chiloiro / Marcello Candelli / Marcello Covino / Antonio Gasbarrini / Francesco Franceschi

    Biomedicines, Vol 11, Iss 707, p

    An Evolving Relationship

    2023  Volume 707

    Abstract: There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of ... ...

    Abstract There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.
    Keywords gut microbiota ; type 1 diabetes mellitus ; LADA ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Electric scooter-related accidents: a possible protective effect of helmet use on the head injury severity.

    Cittadini, Francesca / Aulino, Giovanni / Petrucci, Martina / Valentini, Silvia / Covino, Marcello

    Forensic science, medicine, and pathology

    2022  Volume 19, Issue 3, Page(s) 319–324

    Abstract: Despite electric scooter use has proliferated in Italy since 2019, actionable data regarding injury incidence and patterns associated with electric scooter accidents are limited. This study aims at analyzing the rate, clinical, and demographic features ... ...

    Abstract Despite electric scooter use has proliferated in Italy since 2019, actionable data regarding injury incidence and patterns associated with electric scooter accidents are limited. This study aims at analyzing the rate, clinical, and demographic features of electric scooter accidents accessed to the Emergency Department (ED) of Fondazione Policlinico Universitario A. Gemelli IRCSS (Rome, Italy). This retrospective study included all patients older than 18 years riding an electric scooter in the ED from June 2019 to April 2022. Personal data, injury circumstances, helmet use, and health data were collected. Abbreviated Injury Scale (AIS) codes of all diagnoses were recorded, and the Injury Severity Score (ISS) was calculated for each patient. The analysis includes 92 patients admitted to the ED due to an e-scooter accident during the study period, with an increase in years. Thirty-two patients presented bone fractures especially concerning the extremities and the face districts. The median Injury Severity Score in the study cohort was 3, with the highest AIS represented by AIS Pelvic-Extremity and AIS External. Moreover, statistical significance was found between AIS Head-Neck and severity of trauma. E-scooters have become a familiar sight in cities worldwide recently, with many new companies renting them for use. But their arrival has also brought new safety concerns. Although most injuries reported are minor, the meager rate of helmet use is critical. Implementing compulsory helmet use for electric scooters for all ages could be a protective factor for being patient with head trauma on urban streets.
    MeSH term(s) Humans ; Retrospective Studies ; Head Protective Devices ; Craniocerebral Trauma/epidemiology ; Craniocerebral Trauma/prevention & control ; Fractures, Bone/epidemiology ; Accidents, Traffic
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-022-00546-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Fragility Fractures in End-Stage Chronic Kidney Disease (CKD) Population: Patient-Related and CKD-Related Factor Analysis-A Single-Center Experience.

    De Mauro, Domenico / De Luca, Gianmarco / Marino, Silvia / Smakaj, Amarildo / Rovere, Giuseppe / Liuzza, Francesco / Covino, Marcello / Fulignati, Pierluigi / Grandaliano, Giuseppe / El Ezzo, Omar

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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