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  1. Article ; Online: Associations of current and childhood socioeconomic status and health outcomes amongst patients with knee or hip osteoarthritis in a Mexico City family-practice setting.

    Pisanty-Alatorre, Julio / Bello-Chavolla, Omar Yaxmehen / Vilchis-Chaparro, Eduardo / Goycochea-Robles, María Victoria

    BMC musculoskeletal disorders

    2024  Volume 25, Issue 1, Page(s) 91

    Abstract: Objectives: To examine the association of current and childhood socioeconomic status (SES) with patient-reported functional status, quality of life and disability in patients with knee or hip osteoarthritis (OA).: Methods: Cross-sectional study ... ...

    Abstract Objectives: To examine the association of current and childhood socioeconomic status (SES) with patient-reported functional status, quality of life and disability in patients with knee or hip osteoarthritis (OA).
    Methods: Cross-sectional study amongst individuals seeking care for any medical reason in a primary care family-practice clinic in Mexico City. We included individuals with self-reported doctor-diagnosed arthritis, recruited through waiting-room posters and invitations by treating family physicians. We administered a survey using validated Spanish language versions of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Osteoarthritis of Lower Limbs and Quality of Life (AMICAL), and the Stanford Health Assessment Questionnaire-Disability Index (HAQ-DI). To estimate current and childhood SES, we collected data on education level and occupation type for both the patient and their parents, as well as using a validated tool to estimate income quintile.
    Results: We recruited 154 patients and excluded 8 patients. There was a high correlation between outcome scores. Estimated income and education levels were correlated with WOMAC, AMICAL and HAQ-DI scores, and significant differences were found in all scores by occupation type. The associations for current SES variables and outcome scores remained significant independently of age, sex, BMI, and presence of diabetes or hypertension, and were largely explained by current income in mutually adjusted models. Childhood SES - in particular as measured through maternal education - was best correlated with AMICAL scores, though its effect seemed largely mediated by its association with current SES.
    Conclusions: Current Socioeconomic Status impacts functional status, quality of life and disability amongst OA patients in Mexico City. The WOMAC, AMICAL and HAQ-DI scores correlate with each other and are all potentially useful markers of disease severity. More research is needed to elucidate the relationships between childhood SES and OA outcomes. Awareness of life-course SES may be useful in identifying patients at risk for worse outcomes.
    MeSH term(s) Child ; Humans ; Osteoarthritis, Hip/diagnosis ; Osteoarthritis, Hip/epidemiology ; Cross-Sectional Studies ; Mexico/epidemiology ; Quality of Life ; Lower Extremity ; Outcome Assessment, Health Care
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-023-07107-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review.

    Escamilla-Cruz, Mariana / Magaña, Mario / Escandón-Perez, Sabrina / Bello-Chavolla, Omar Yaxmehen

    Dermatology and therapy

    2023  Volume 13, Issue 8, Page(s) 1721–1731

    Abstract: Finasteride and dutasteride are 5-alpha reductase selective inhibitors (5ARIs). They were introduced as therapeutic agents for the treatment of benign prostatic hyperplasia in 1992 and 2002, respectively; finasteride has also been approved for the ... ...

    Abstract Finasteride and dutasteride are 5-alpha reductase selective inhibitors (5ARIs). They were introduced as therapeutic agents for the treatment of benign prostatic hyperplasia in 1992 and 2002, respectively; finasteride has also been approved for the treatment of androgenetic alopecia since early 2000. These agents inhibit the conversion of testosterone (T) to 5α-dihydrotestosterone (5α-DHT), limiting steroidogenesis and playing a crucial role in the physiological function of the neuroendocrine system. Therefore, it has been proposed that blocking androgen synthesis with the use of 5ARIs would be beneficial in the treatment of various diseases related to states of hyperandrogenism. This review describes the dermatological pathologies in which 5ARIs have been used as part of the treatment, evaluation of the efficacy, and knowledge of the safety profile. Specifically, we discuss the application of 5ARIs in androgenetic alopecia, acne, frontal fibrosing alopecia, hirsutism, and the implications of adverse events associated with its use to inform about the applications of 5ARIs in general dermatology practice.
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-023-00974-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Institutional care in four Latin American countries: the importance of fostering public information and evaluation strategies.

    Wachholz, Patrick Alexander / Morsch, Patricia / Villalobos Dintrans, Pablo / Barrientos-Calvo, Isabel / Browne, Jorge / Bello-Chavolla, Omar Yaxmehen / Vega, Enrique

    Revista panamericana de salud publica = Pan American journal of public health

    2024  Volume 48, Page(s) e14

    Abstract: More than 8 million older people in Latin America depend on long-term care (LTC), accounting for 12% of people aged ≥ 60 years and almost 27% of those aged ≥ 80. It is crucial to develop sustainable strategies for providing LTC in the area, including ... ...

    Abstract More than 8 million older people in Latin America depend on long-term care (LTC), accounting for 12% of people aged ≥ 60 years and almost 27% of those aged ≥ 80. It is crucial to develop sustainable strategies for providing LTC in the area, including institutional care. This special report aims to characterize institutional LTC in four countries (Brazil, Chile, Costa Rica and Mexico), using available information systems, and to identify the strategies adopted to support institutional care in these countries. This narrative review used nationwide, open-access, public data sources to gather demographic estimates and information about institutional LTC coverage and the availability of open-access data for the proportion of people with LTC needs, the number of LTC facilities and the number of residents living in them. These countries have a larger share of older people than the average in Latin America but fewer LTC facilities than required by the demand. National surveys lack standardization in defining disability, LTC and dependency on care. Information about institutional care is mainly fragmented and does not regularly include LTC facilities, their residents and workers. Data are crucial to inform evidence-based decisions to favor prioritization and to support advances in promoting policies around institutional LTC in Latin America. Although information about institutional care in the region is fragmented and insufficient, this paper profiles the four selected countries. It highlights the need for a better structure for data-driven LTC information systems. The lack of information emphasizes the urgency of the need to focus on and encourage research into this topic.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1376934-0
    ISSN 1680-5348 ; 1020-4989
    ISSN (online) 1680-5348
    ISSN 1020-4989
    DOI 10.26633/RPSP.2024.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The evolving landscape of SARS-CoV-2 vaccination in Mexico: real-world evidence in Mexican pensioners.

    Antonio-Villa, Neftali Eduardo / Bello-Chavolla, Omar Yaxmehen / Fermín-Martínez, Carlos A / Fernández-Chirino, Luisa / Ramírez-García, Daniel

    Lancet regional health. Americas

    2023  Volume 27, Page(s) 100624

    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2023.100624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pushing the boundaries of precision nutrition to tackle Alzheimer's disease: is there a role for DHA?

    Fernandez-Chirino, Luisa / Antonio-Villa, Neftali Eduardo / Bello-Chavolla, Omar Yaxmehen

    The American journal of clinical nutrition

    2021  Volume 113, Issue 6, Page(s) 1396–1397

    MeSH term(s) Adult ; Alzheimer Disease ; Docosahexaenoic Acids ; Humans ; Middle Aged ; Neuroimaging ; Nutritional Status ; Phenotype
    Chemical Substances Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2021-04-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqab085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A spatio-temporal study of state-wide case-fatality risks during the first wave of the COVID-19 pandemic in Mexico.

    Ramìrez-Aldana, Ricardo / Gomez-Verjan, Juan Carlos / Bello-Chavolla, Omar Yaxmehen / Naranjo, Lizbeth

    Geospatial health

    2022  Volume 17, Issue s1

    Abstract: spatio-temporal analysis of the first wave of the coronavirus (COVID-19) pandemic in Mexico (April to September 2020) was performed by state. Descriptive analyses through diagrams, mapping, animations and time series representations were carried out. ... ...

    Abstract spatio-temporal analysis of the first wave of the coronavirus (COVID-19) pandemic in Mexico (April to September 2020) was performed by state. Descriptive analyses through diagrams, mapping, animations and time series representations were carried out. Greater risks were observed at certain times in specific regions. Various trends and clusters were observed and analysed by fitting linear mixed models and time series clustering. The association of co-morbidities and other variables were studied by fitting a spatial panel data linear model (SPLM). On average, the greatest risks were observed in Baja California Norte, Chiapas and Sonora, while some other densely populated states, e.g., Mexico City, had lower values. The trends varied by state and a four-order polynomial, including fixed and random effects, was necessary to model them. The most common risk development was observed in states belonging to two clusters and consisted of an initial increase followed by a decrease. Some states presented cluster configurations with a retarded risk increase before the decrease, while the risk increased throughout the time of study in others. A cyclic behaviour with a second increasing trend was also observed in some states. The SPLM approach revealed a positive significant association with respect to case fatality risk between certain groups, such as males and individuals aged 50 years and more, and the prevalence of chronic kidney disease, cardiovascular disease, asthma and hypertension. The analysis may provide valuable insight into COVID-19 dynamics applicable in future outbreaks, as well as identify determinants signifying certain trends at the state level. The combination of spatial and temporal information may provide a better understanding of the fatalities due to COVID-19.
    MeSH term(s) Aged ; COVID-19 ; Cluster Analysis ; Humans ; Male ; Mexico/epidemiology ; Middle Aged ; Pandemics ; Spatio-Temporal Analysis
    Language English
    Publishing date 2022-03-24
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2276179-2
    ISSN 1970-7096 ; 1827-1987
    ISSN (online) 1970-7096
    ISSN 1827-1987
    DOI 10.4081/gh.2022.1054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The evolving landscape of SARS-CoV-2 vaccination in Mexico

    Neftali Eduardo Antonio-Villa / Omar Yaxmehen Bello-Chavolla / Carlos A. Fermín-Martínez / Luisa Fernández-Chirino / Daniel Ramírez-García

    The Lancet Regional Health. Americas, Vol 27, Iss , Pp 100624- (2023)

    real-world evidence in Mexican pensioners

    2023  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative data.

    Bello-Chavolla, Omar Yaxmehen / Fermín-Martínez, Carlos A / Ramírez-García, Daniel / Vargas-Vázquez, Arsenio / Fernández-Chirino, Luisa / Basile-Alvarez, Martín Roberto / Sánchez-Castro, Paulina / Núñez-Luna, Alejandra / Antonio-Villa, Neftali Eduardo

    Lancet regional health. Americas

    2024  Volume 30, Page(s) 100688

    Abstract: Background: Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology of PASC in Mexico during 2022 and identify potential associations of covariates ... ...

    Abstract Background: Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology of PASC in Mexico during 2022 and identify potential associations of covariates with PASC prevalence using nationally representative data.
    Methods: We analyzed data from the 2022 Mexican National Health and Nutrition Survey (ENSANUT) from 24,434 participants, representing 85,521,661 adults ≥20 years. PASC was defined using both the National Institute for Health and Care Excellence (NICE) definition and a PASC score ≥12. Estimates of PASC prevalence were stratified by age, sex, rural vs. urban setting, social lag quartiles, number of reinfections, vaccination status and periods of predominance of SARS-CoV-2 circulating variants. Determinants of PASC were assessed using log-binomial regression models adjusted by survey weights.
    Findings: Persistent symptoms after SARS-CoV-2 infection were reported by 12.44% (95% CI 11.89-12.99) of adults ≥20 years in Mexico in 2022. The most common persistent symptoms were fatigue, musculoskeletal pain, headache, cough, loss of smell or taste, fever, post-exertional malaise, brain fog, anxiety, and chest pain. PASC was present in 21.21% (95% CI 19.74-22.68) of subjects with previously diagnosed COVID-19. Over 28.6% of patients with PASC reported symptoms persistence ≥6 months and 14.05% reported incapacitating symptoms. Higher PASC prevalence was associated with SARS-CoV-2 reinfections, depressive symptoms and living in states with high social lag. PASC prevalence, particularly its more severe forms, decreased with COVID-19 vaccination and for infections during periods of Omicron variant predominance.
    Interpretation: PASC remains a significant public health burden in Mexico as the COVID-19 pandemic transitions into endemic. Promoting SARS-CoV-2 reinfection prevention and booster vaccination may be useful in reducing PASC burden.
    Funding: This research was supported by Instituto Nacional de Geriatría in Mexico.
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2024.100688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insulin resistance potentiates the effect of remnant cholesterol on cardiovascular mortality in individuals without diabetes.

    Vargas-Vázquez, Arsenio / Fermín-Martínez, Carlos A / Antonio-Villa, Neftali Eduardo / Fernández-Chirino, Luisa / Ramírez-García, Daniel / Dávila-López, Gael / Díaz-Sánchez, Juan Pablo / Aguilar-Salinas, Carlos A / Seiglie, Jacqueline A / Bello-Chavolla, Omar Yaxmehen

    Atherosclerosis

    2024  , Page(s) 117508

    Abstract: Background and aims: Remnant cholesterol (RC) and insulin resistance (IR) have been independently associated with cardiovascular risk. Here, we evaluated the role of IR and RC on cardiovascular disease (CVD) mortality.: Methods: We conducted an ... ...

    Abstract Background and aims: Remnant cholesterol (RC) and insulin resistance (IR) have been independently associated with cardiovascular risk. Here, we evaluated the role of IR and RC on cardiovascular disease (CVD) mortality.
    Methods: We conducted an analysis of 16,113 individuals ≥20 years without diabetes from the National Health and Nutrition Examination Survey (NHANES-III/IV). RC levels were calculated using total cholesterol, non-HDL-c, and LDL-c; IR was defined as HOMA2-IR≥2.5 and CVD mortality as a composite of cardiovascular and cerebrovascular mortality. Multiple linear regression was used to assess the relationship between HOMA2-IR and RC and Cox regression models to assess their joint role in CVD mortality. Causally ordered mediation models were used to explore the mediating role of IR in RC-associated CVD mortality.
    Results: We identified an association between higher HOMA2-IR and higher RC levels. The effect of IR on CVD mortality was predominant (HR 1.32, 95%CI 1.18-1.48) and decreased at older ages (HR 0.934, 95%CI 0.918-0.959) compared to RC (HR 0.983, 95%CI 0.952-1.014). Higher risk of CVD mortality was observed in individuals with IR but normal RC (HR 1.37, 95%CI 1.25-1.50) and subjects with IR and high RC (HR 1.24, 95%CI 1.13-1.37), but not in subjects without IR but high RC. In mediation models, HOMA2-IR accounted for 78.2% (95%CI 28.11-98.89) of the effect of RC levels on CVD mortality.
    Conclusions: Our findings suggest that RC potentiates the risk of CVD mortality through its effect on whole-body insulin sensitivity, particularly among younger individuals.
    Language English
    Publishing date 2024-03-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2024.117508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In response to the comment on the article “Variability in case fatality rate risk due to Covid-19 according to health services provider in Mexico City hospitals”

    García-Peña, Carmen / Bello-Chavolla, Omar Yaxmehen / Castrejón-Perez, Roberto Carlos / Jácome-Maldonado, Luis David / Lozano-Juárez, Luis Raymundo

    Salud publica de Mexico

    2022  Volume 64, Issue 4, jul-ago, Page(s) 347–348

    Abstract: Not available. ...

    Title translation In response to the comment on the article “Variability in case fatality rate risk due to Covid-19 according to health services provider in Mexico City hospitals”.
    Abstract Not available.
    MeSH term(s) COVID-19 ; Health Services ; Hospitals, Urban ; Humans ; Mexico
    Language English
    Publishing date 2022-07-08
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
    DOI 10.21149/13845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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