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Article ; Online: Markers of graft injury and the conundrum of racial disparities in outcomes after heart transplantation: Early insights for long term outcomes.

Coglianese, Erin / Potena, Luciano

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2022 Volume 41, Issue 7, Page(s) 859–860

MeSH term(s)	Healthcare Disparities ; Heart Transplantation ; Humans ; Racial Groups
Language	English
Publishing date	2022-02-19
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2022.02.010
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Article ; Online: Case 37-2022: A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules.

Roberts, Matthew B / Lee, Jarone / Murphy, Mark C / Kim, Arthur Y / Coglianese, Erin E / Hilburn, Caroline

The New England journal of medicine

2022 Volume 387, Issue 23, Page(s) 2172–2183

MeSH term(s)	Humans ; Middle Aged ; Fatigue/etiology ; Weight Loss ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/etiology
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMcpc2211357
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Article ; Online: A second chance for a new heart? The role of metabolic and bariatric surgery in patients with end-stage heart failure.

Palenzuela, Deanna L / Agarwal, Divyansh / Flanders, Karen / Coglianese, Erin / Tsao, Lana / D'Alessandro, David / Lewis, Gregory D / Fitzsimons, Michael / Gee, Denise

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2024 Volume 28, Issue 4, Page(s) 389–393

Abstract: Background: Obesity is an independent risk factor for heart failure (HF). Substantial weight loss has been shown to reverse obesity-related cardiomyopathy. This study aimed to report our institution's experience with laparoscopic sleeve gastrectomy (LSG) ...

Abstract	Background: Obesity is an independent risk factor for heart failure (HF). Substantial weight loss has been shown to reverse obesity-related cardiomyopathy. This study aimed to report our institution's experience with laparoscopic sleeve gastrectomy (LSG) in patients with morbid obesity and end-stage HF. Methods: Between 2018 and 2022, 26 patients with end-stage HF were referred for LSG. Of 26 patients, 16 underwent an operation, and 10 did not. After institutional review board approval, a retrospective electronic medical record review was performed to evaluate (i) age, (ii) preoperative weight, (iii) decrease in body mass index (BMI) score, (iv) whether the patient underwent heart transplantation, and (v) mortality. Data analysis was performed using Stata/SE (version 17.0; StataCorp). The Wilcoxon rank-sum test was used to compare continuous variables between the cohorts, and the Pearson chi-square test was used for binary variables with Bonferroni correction applied. Results: The LSG and non-LSG cohorts had comparable ages (P = .088) and starting BMI score (P = .918), and a proportion of patients had a ventricular assist device (P = .191). Patients who underwent LSG lost significantly more weight than the patients who did not, with an average decrease in BMI score of 8.9 kg/m Conclusion: LSG may be safe and effective for weight loss in patients with HF. This operation may provide patients affected by obesity with end-stage HF the lifesaving opportunity to achieve transplant candidacy.
MeSH term(s)	Humans ; Retrospective Studies ; Laparoscopy ; Bariatric Surgery ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Heart Failure/complications ; Heart Failure/surgery ; Gastrectomy ; Body Mass Index ; Weight Loss ; Treatment Outcome
Language	English
Publishing date	2024-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1016/j.gassur.2024.02.013
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Article ; Online: Left Ventricular Assist Device Explant and Mitral Valve Replacement for Myocardial Recovery.

Ton, Van-Khue / Thomas, Sunu / Coglianese, Erin / D'Alessandro, David / Lewis, Gregory D

Circulation. Heart failure

2021 Volume 14, Issue 8, Page(s) e008251

MeSH term(s)	Aged ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Valve Prosthesis/adverse effects ; Heart-Assist Devices/adverse effects ; Humans ; Male ; Mitral Valve/physiopathology ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/physiopathology
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.120.008251
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Article: Clinical monitoring of stage B heart failure: echocardiography.

Coglianese, Erin E / Wang, Thomas J

Heart failure clinics

2012 Volume 8, Issue 2, Page(s) 169–178

Abstract: Estimates of the prevalence of asymptomatic left ventricular systolic dysfunction (LVSD) vary widely depending on the study sample and definition of LVSD. Subtle reductions in LV systolic or diastolic function are now detectable with newer ... ...

Abstract	Estimates of the prevalence of asymptomatic left ventricular systolic dysfunction (LVSD) vary widely depending on the study sample and definition of LVSD. Subtle reductions in LV systolic or diastolic function are now detectable with newer echocardiographic measures, which can influence estimates of the burden of stage B heart failure (HF). If the definition is broadened to include diastolic filling abnormalities, the estimated prevalence of stage B HF increases dramatically. This article reviews the rationale for echocardiographic screening for stage B HF, describes currently available measures of cardiac structure and function, and assesses the potential role of echocardiography in selected subgroups.
MeSH term(s)	Body Mass Index ; Comorbidity ; Coronary Disease/epidemiology ; Coronary Disease/physiopathology ; Diastole/physiology ; Echocardiography, Doppler/methods ; Elasticity Imaging Techniques ; Heart Atria/pathology ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Humans ; Hypertension/physiopathology ; Risk Factors ; Systole/physiology ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212019-1
ISSN	1551-7136
ISSN	1551-7136
DOI	10.1016/j.hfc.2011.11.007
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Article ; Online: Proteomic Signatures During Treatment in Different Stages of Heart Failure.

Michelhaugh, Sam A / Camacho, Alexander / Ibrahim, Nasrien E / Gaggin, Hanna / D'Alessandro, David / Coglianese, Erin / Lewis, Gregory D / Januzzi, James L

Circulation. Heart failure

2020 Volume 13, Issue 8, Page(s) e006794

Abstract: Background: Proteomics have already provided novel insights into the pathophysiology of heart failure (HF) with reduced ejection fraction. Previous studies have evaluated cross-sectional protein signatures of HF, but few have characterized proteomic ... ...

Abstract	Background: Proteomics have already provided novel insights into the pathophysiology of heart failure (HF) with reduced ejection fraction. Previous studies have evaluated cross-sectional protein signatures of HF, but few have characterized proteomic changes following HF with reduced ejection fraction treatment with ARNI (angiotensin receptor/neprilysin inhibitor) therapy or left ventricular assist devices. Methods: In this retrospective omics study, we performed targeted proteomics (N=625) of whole blood sera from patients with American College of Cardiology/American Heart Association stage D (N=29) and stage C (N=12) HF using proximity extension assays. Samples were obtained before and after (median=82 days) left ventricular assist device implantation (stage D; primary analysis) and ARNI therapy initiation (stage C; matched reference). Oblique principal component analysis and point biserial correlations were used for feature extraction and selection; standardized mean differences were used to assess within and between-group differences; and enrichment analysis was used to generate and cluster Gene Ontology terms. Results: Core sets of proteins were identified for stage C (N=9 proteins) and stage D (N=18) HF; additionally, a core set of 5 shared HF proteins (NT-proBNP [N-terminal pro-B type natriuretic peptide], ESM [endothelial cell-specific molecule]-1, cathepsin L1, osteopontin, and MCSF-1) was also identified. For patients with stage D HF, moderate (δ, 0.40-0.60) and moderate-to-large (δ, 0.60-0.80) sized differences were observed in 8 of their 18 core proteins after left ventricular assist devices implantation. Additionally, specific protein groups reached concentration levels equivalent ( Conclusions: HF with reduced ejection fraction severity associates with distinct proteomic signatures that reflect underlying disease attributes; these core signatures may be useful for monitoring changes in cardiac function following initiation on ARNI or left ventricular assist device implantation.
MeSH term(s)	Angiotensin Receptor Antagonists/therapeutic use ; Biomarkers/blood ; Echocardiography ; Female ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Neprilysin/antagonists & inhibitors ; Principal Component Analysis ; Proteomics ; Retrospective Studies ; Stroke Volume/physiology
Chemical Substances	Angiotensin Receptor Antagonists ; Biomarkers ; Neprilysin (EC 3.4.24.11)
Language	English
Publishing date	2020-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.119.006794
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Article ; Online: Effect of Impella 5.5 on Preexisting Functional Mitral Regurgitation in Patients with Heart Failure-Related Cardiogenic Shock.

Kataria, Rachna / Khalil, Abdurrahman / Coglianese, Erin / Crowley, Jerome / Silverman, Michael G / Shelton, Kenneth / Michel, Eriberto / D'Alessandro, David / Ton, Van-Khue

Structural heart : the journal of the Heart Team

2022 Volume 6, Issue 4, Page(s) 100072

Abstract: Background: Heart failure-related cardiogenic shock (HF-CS) is increasingly common. Moderate/severe functional mitral regurgitation (FMR) is commonly seen in patients presenting with decompensated heart failure and is associated with worse outcomes. ... ...

Abstract	Background: Heart failure-related cardiogenic shock (HF-CS) is increasingly common. Moderate/severe functional mitral regurgitation (FMR) is commonly seen in patients presenting with decompensated heart failure and is associated with worse outcomes. Percutaneous mechanical circulatory support devices are increasingly used to provide hemodynamic support for ongoing CS. There is no description of the impact of Impella device on hemodynamic response when used in combination with preexisting FMR. Methods: Retrospective review of patients aged ≥18 years, who underwent Impella 5.5 implant for HF-CS, and who had a transthoracic echocardiogram performed pre- and post-Impella. Results: Of 24 patients, 33% had moderate-to-severe/severe FMR, 38% had mild-moderate/moderate FMR, and 29% had trace/mild FMR on pre-Impella transthoracic echocardiogram. Additional right ventricular assist device was simultaneously inserted in 3 patients, of whom 1 had severe, 1 had moderate, and another had mild FMR pre-Impella. Despite maximally tolerated Impella unloading, 6 patients (25%) had persistent moderate-severe/severe FMR, and 9 (37.5%) patients had persistent moderate FMR. Overall, however, there was a decrease in central venous pressure, pulmonary artery diastolic pressure, serum lactate, and vasoactive-inotrope score at 24 hours post-Impella, and survival was high at 83%. Conclusions: In a retrospective cohort of patients admitted with HF-CS who underwent Impella 5.5 implant for hemodynamic support, Impella did not seem to acutely ameliorate FMR severity. Despite this, there was a significant improvement in hemodynamic response at 24 hours post-Impella. In carefully selected patients, especially those with isolated left ventricular failure, Impella 5.5 may provide adequate hemodynamic support even in the presence of higher severity FMR.
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ISSN	2474-8714
ISSN (online)	2474-8714
DOI	10.1016/j.shj.2022.100072
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Article ; Online: Predicting outcome in patients with asymptomatic aortic stenosis.

Coglianese, Erin E / Davidoff, Ravin

Circulation

2009 Volume 120, Issue 1, Page(s) 9–11

MeSH term(s)	Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/surgery ; Humans ; Predictive Value of Tests ; Risk Factors ; Severity of Illness Index
Language	English
Publishing date	2009-07-07
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.109.875591
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Article ; Online: NT-proBNP and predictors of event free survival and left ventricular systolic function recovery in peripartum cardiomyopathy.

Imran, Tasnim F / Mohebali, Donya / Lopez, Diana / Goli, Rahul R / DeFilippis, Ersilia M / Truong, Sandy / Bello, Natalie A / Gaziano, J Michael / Djousse, Luc / Coglianese, Erin E / Feinberg, Loryn / Wu, Wen-Chih / Choudhary, Gaurav / Arany, Zoltan / Kociol, Robb / Sabe, Marwa A

International journal of cardiology

2022 Volume 357, Page(s) 48–54

Abstract: Objective: To determine predictors of adverse outcomes in peripartum cardiomyopathy (PPCM).: Methods and results: We conducted a multi-center cohort study across four centers to identify subjects with PPCM with the following criteria: LVEF <40%, ... ...

Abstract	Objective: To determine predictors of adverse outcomes in peripartum cardiomyopathy (PPCM). Methods and results: We conducted a multi-center cohort study across four centers to identify subjects with PPCM with the following criteria: LVEF <40%, development of heart failure within the last month of pregnancy or within 5 months of delivery and no other identifiable cause of heart failure with reduced ejection fraction. Outcomes included 1) survival free from major adverse events (need for extra-corporeal membrane oxygenation, ventricular assist device, orthotopic heart transplantation or death) and 2) LVEF recovery ≥ 50%. Using a univariate logistic regression analysis, we identified significant clinical predictors of these outcomes, which were then used to create multivariable models. NT-proBNP at the time of diagnosis was examined both as a continuous variable (log transformed) in logistic regression and as a dichotomous variable (values above and below the median) using the log-rank test. In all, 237 women (1993 to 2017) with 736.4 person-years of follow-up, met criteria for PPCM. Participants had a mean age of 32.4 ± 6.7 years, mean BMI 30.6 ± 7.8 kg/m2; 63% were White. After median follow-up of 3.6 years (IQR 1.1-7.8), 113 (67%) had LVEF recovery, and 222 (94%) had survival free from adverse events. Significant predictors included gestational age, gravidity, systolic blood pressure, smoking, heart rate, initial LVEF, and diuretic use. In a subset of 110 patients with measured NTproBNP levels, we found a higher event free survival for women with NTproBNP <2585 pg/ml (median) as compared to women with NTproBNP ≥2585 pg/ml (log-rank test p-value 0.018). Conclusion: Gestational age, gravidity, current or past tobacco use, systolic blood pressure, heart rate, initial LVEF and diuretic requirement at the time of diagnosis were associated with survival free from adverse events and LVEF recovery. Initial NT-proBNP was significantly associated with event free survival.
MeSH term(s)	Adult ; Cardiomyopathies ; Cohort Studies ; Diuretics ; Female ; Heart Failure/diagnosis ; Humans ; Male ; Natriuretic Peptide, Brain ; Peptide Fragments ; Peripartum Period ; Pregnancy ; Progression-Free Survival ; Puerperal Disorders ; Recovery of Function ; Stroke Volume ; Ventricular Function, Left/physiology
Chemical Substances	Diuretics ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.03.052
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Article ; Online: The value of psychosocial factors in patient selection and outcomes after heart transplantation.

Coglianese, Erin E / Samsi, Mekhala / Liebo, Max J / Heroux, Alain L

Current heart failure reports

2014 Volume 12, Issue 1, Page(s) 42–47

Abstract: Heart transplantation remains the gold standard treatment for advanced heart failure, although its use is limited by donor organ availability. To ensure that the rare resource of a donor heart is allocated appropriately, the evaluation of the heart ... ...

Abstract	Heart transplantation remains the gold standard treatment for advanced heart failure, although its use is limited by donor organ availability. To ensure that the rare resource of a donor heart is allocated appropriately, the evaluation of the heart transplant candidates includes extensive medical and psychosocial assessments. These psychosocial factors are critically important to understand pre-heart transplant because it is known that psychosocial evaluation and psychosocial comorbidities have a strong association with post-heart transplant outcomes. The critical factors to assess are psychological functioning, adherence to medical recommendations, and social support. These factors are likely inter-related and have been shown to have an effect on the health-related quality of life and overall survival. Recently, new tools have been developed to standardize the evaluation process. In this review, we will discuss the tools available to assess psychosocial factors in the transplant candidate and discuss the role these factors have on post-heart transplant outcomes.
MeSH term(s)	Heart Failure/psychology ; Heart Failure/surgery ; Heart Transplantation/psychology ; Humans ; Medication Adherence ; Patient Selection ; Social Support ; Treatment Outcome
Language	English
Publishing date	2014-12-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151202-4
ISSN	1546-9549 ; 1546-9530
ISSN (online)	1546-9549
ISSN	1546-9530
DOI	10.1007/s11897-014-0233-5
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