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  1. Article ; Online: Contrasting Trends in Vascular Amputations: Progress or Peril?

    Hackam, Daniel G

    The Canadian journal of cardiology

    2022  Volume 39, Issue 3, Page(s) 331–332

    MeSH term(s) Humans ; Lower Extremity/blood supply ; Retrospective Studies ; Amputation, Surgical
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2150: Show issues Location:
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  2. Article ; Online: The Peripheral Arterial Disease Pandemic: No Let-up in Sight.

    Hackam, Daniel G

    The Canadian journal of cardiology

    2021  Volume 37, Issue 10, Page(s) 1496–1497

    MeSH term(s) Humans ; MicroRNAs ; Pandemics ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimal Medical Management of Asymptomatic Carotid Stenosis.

    Hackam, Daniel G

    Stroke

    2021  Volume 52, Issue 6, Page(s) 2191–2198

    Abstract: Asymptomatic carotid stenosis (ACS) due to atherosclerosis is a risk factor for ipsilateral ischemic cerebrovascular events and cognitive impairment. The prognosis of ACS has improved over the past 4 decades due largely to improvements in medical ... ...

    Abstract Asymptomatic carotid stenosis (ACS) due to atherosclerosis is a risk factor for ipsilateral ischemic cerebrovascular events and cognitive impairment. The prognosis of ACS has improved over the past 4 decades due largely to improvements in medical management. Most patients with ACS can be managed without revascularization, but some patients with vulnerable plaque should be considered for revascularization. Regardless of the decision to refer for revascularization, all patients with ACS should receive intensive medical management. This includes lifestyle modification (Mediterranean diet, exercise, and smoking cessation) and pharmacological therapy (antiplatelets, lipid-lowering agents, blood pressure reduction, and glycemic control). Patients with ACS often have atherosclerosis in other critical locations, and thus optimal medical therapy is likely to reduce events outside the carotid arteries. The nature of optimal medical therapy is described.
    MeSH term(s) Antihypertensive Agents/administration & dosage ; Asymptomatic Diseases/therapy ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/therapy ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/prevention & control ; Diet, Mediterranean ; Disease Management ; Humans ; Hypolipidemic Agents/administration & dosage ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/therapy ; Platelet Aggregation Inhibitors/administration & dosage ; Risk Factors ; Risk Reduction Behavior ; Stroke/etiology ; Stroke/physiopathology ; Stroke/prevention & control
    Chemical Substances Antihypertensive Agents ; Hypolipidemic Agents ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.033994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Changing Epidemiology of Cardiovascular Disease: Two Steps Forward, One Step Back.

    Hackam, Daniel G

    The Canadian journal of cardiology

    2020  Volume 36, Issue 7, Page(s) 995–996

    MeSH term(s) Canada/epidemiology ; Cardiovascular Diseases/epidemiology ; Cognitive Dysfunction ; Hospitalization ; Humans ; Stroke
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2020.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lipid-Modifying Therapies and Stroke Prevention.

    Hackam, Daniel G / Hegele, Robert A

    Current neurology and neuroscience reports

    2022  Volume 22, Issue 7, Page(s) 375–382

    Abstract: Purpose of review: We reviewed lipid-modifying therapies and the risk of stroke and other cerebrovascular outcomes, with a focus on newer therapies.: Recent findings: Statins and ezetimibe reduce ischemic stroke risk without increasing hemorrhagic ... ...

    Abstract Purpose of review: We reviewed lipid-modifying therapies and the risk of stroke and other cerebrovascular outcomes, with a focus on newer therapies.
    Recent findings: Statins and ezetimibe reduce ischemic stroke risk without increasing hemorrhagic stroke risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors similarly reduce ischemic stroke risk in statin-treated patients with atherosclerosis without increasing hemorrhagic stroke, even with very low achieved low-density lipoprotein cholesterol levels. Icosapent ethyl reduces the risk of total and first ischemic stroke in patients with established cardiovascular disease or diabetes mellitus. Clinical outcome trials are underway for newer lipid-modifying agents, including inclisiran, bempedoic acid, and pemafibrate. New biologic agents including evinacumab, pelacarsen, olpasiran, and SLN360 are also discussed. In addition to statins and ezetimibe, PCSK9 inhibitors and icosapent ethyl reduce the risk of ischemic stroke without increasing the risk of hemorrhagic stroke. These therapies dramatically expand options for reducing stroke in high-risk settings.
    MeSH term(s) Anticholesteremic Agents/pharmacology ; Anticholesteremic Agents/therapeutic use ; Cardiovascular Diseases ; Ezetimibe/therapeutic use ; Hemorrhagic Stroke ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ischemic Stroke ; Lipids/therapeutic use ; Proprotein Convertase 9/therapeutic use ; Stroke/drug therapy ; Stroke/prevention & control
    Chemical Substances Anticholesteremic Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipids ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Ezetimibe (EOR26LQQ24)
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-022-01197-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5549: Show issues Location:
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  6. Article ; Online: Prognosis of Asymptomatic Carotid Artery Occlusion: Systematic Review and Meta-Analysis.

    Hackam, Daniel G

    Stroke

    2016  Volume 47, Issue 5, Page(s) 1253–1257

    Abstract: Background and purpose: The aim of this systematic review was to quantify the risk of ipsilateral stroke in patients with asymptomatic carotid artery occlusion (ACAO).: Methods: Studies reporting ipsilateral stroke risk in ACAO were identified by a ... ...

    Abstract Background and purpose: The aim of this systematic review was to quantify the risk of ipsilateral stroke in patients with asymptomatic carotid artery occlusion (ACAO).
    Methods: Studies reporting ipsilateral stroke risk in ACAO were identified by a search of MEDLINE, EMBASE, and study bibliographies. Study estimates were pooled using a random effects model, and heterogeneity was quantified using the I(2) statistic. The primary outcome was the annual rate of ipsilateral stroke.
    Results: Thirteen studies were identified, encompassing 718 patients with ACAO who were followed up for a median of 2.8 years. The annual rate of ipsilateral stroke was 1.3% (95% confidence interval, 0.4-2.1; I(2)=53%). The annual rate of ipsilateral transient ischemic attack was 1.0% (95% confidence interval, 0.3-1.8; I(2)=40%). The annual rate of death was substantially higher at 7.7% (95% confidence interval, 4.3-11.2; I(2)=83%). Correction for possible publication bias for the primary outcome suggested a lower risk of ipsilateral stroke (0.3% per year; 95% confidence interval, -0.4 to 1.1).
    Conclusions: Stroke in ACAO is relatively infrequent, but patients face high mortality rates. This suggests the need for intensified medical therapy in ACAO.
    MeSH term(s) Carotid Stenosis/complications ; Carotid Stenosis/epidemiology ; Humans ; Prognosis ; Stroke/epidemiology ; Stroke/etiology ; Stroke/mortality
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.116.012760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  7. Article ; Online: Antiplatelet Therapy in Ischemic Stroke and Transient Ischemic Attack.

    Hackam, Daniel G / Spence, J David

    Stroke

    2019  Volume 50, Issue 3, Page(s) 773–778

    MeSH term(s) Brain Ischemia/drug therapy ; Drug Therapy, Combination ; Humans ; Ischemic Attack, Transient/drug therapy ; Platelet Aggregation Inhibitors/therapeutic use ; Stroke/drug therapy
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.023954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  8. Article ; Online: Cannabis and stroke: systematic appraisal of case reports.

    Hackam, Daniel G

    Stroke

    2015  Volume 46, Issue 3, Page(s) 852–856

    Abstract: Background and purpose: An increasing number of case reports link cannabis consumption to cerebrovascular events. Yet these case reports have not been scrutinized using criteria for causal inference.: Methods: All case reports on cannabis and ... ...

    Abstract Background and purpose: An increasing number of case reports link cannabis consumption to cerebrovascular events. Yet these case reports have not been scrutinized using criteria for causal inference.
    Methods: All case reports on cannabis and cerebrovascular events were retrieved. Four causality criteria were addressed: temporality, adequacy of stroke work-up, effects of rechallenge, and concomitant risk factors that could account for the cerebrovascular event.
    Results: There were 34 case reports on 64 patients. Most cases (81%) exhibited a temporal relationship between cannabis exposure and the index event. In 70%, the evaluation was sufficiently comprehensive to exclude other sources for stroke. About a quarter (22%) of patients had another stroke after subsequent re-exposure to cannabis. Finally, half of patients (50%) had concomitant stroke risk factors, most commonly tobacco (34%) and alcohol (11%) consumption.
    Conclusions: Many case reports support a causal link between cannabis and cerebrovascular events. This accords well with epidemiological and mechanistic research on the cerebrovascular effects of cannabis.
    MeSH term(s) Adolescent ; Adult ; Alcohol Drinking ; Cannabis/adverse effects ; Female ; Humans ; Male ; Marijuana Smoking/adverse effects ; Middle Aged ; Risk Factors ; Smoking ; Stroke/chemically induced ; Stroke/etiology ; Time Factors ; Young Adult
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.008680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cholesterol Lowering and Prevention of Stroke.

    Hackam, Daniel G / Hegele, Robert A

    Stroke

    2018  Volume 50, Issue 2, Page(s) 537–541

    MeSH term(s) Anticholesteremic Agents/therapeutic use ; Cholesterol/blood ; Humans ; Stroke/blood ; Stroke/prevention & control ; Stroke, Lacunar/blood ; Stroke, Lacunar/prevention & control
    Chemical Substances Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2018-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.023167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Translation of Cardiovascular Animal Models to Human Randomized Trials.

    Vyas, Manav V / Gros, Robert / Hackam, Daniel G

    The American journal of cardiology

    2020  Volume 137, Page(s) 141

    MeSH term(s) Animals ; Cardiovascular Diseases/therapy ; Humans ; Models, Animal ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2020-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2020.10.027
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