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  1. Article ; Online: Re: Phillip J. Gray, Chun Chieh Lin, Matthew R. Cooperberg, Ahmedin Jemal, Jason A. Efstathiou. Temporal Trends and the Impact of Race, Insurance, and Socioeconomic Status in the Management of Localized Prostate Cancer. Eur Urol 2017;71:729-37.

    Gild, Philipp / von Landenberg, Nicolas / Cole, Alexander P

    European urology

    2017  Volume 71, Issue 6, Page(s) e181–e182

    Language English
    Publishing date 2017-06
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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  2. Book ; Online: Does the $h_\alpha$ index reinforce the Matthew effect in science? Agent-based simulations using Stata and R

    Bornmann, Lutz / Ganser, Christian / Tekles, Alexander / Leydesdorff, Loet

    2019  

    Abstract: ... One of their most important points is that the index reinforces the Matthew effect in science ... The user can investigate under which conditions $h_\alpha$ reinforces the Matthew effect. The results ... of our study confirm what Leydesdorff et al. (2019) expected: the $h_\alpha$ index reinforces the Matthew ...

    Abstract Recently, Hirsch (2019a) proposed a new variant of the h index called the $h_\alpha$ index. He formulated as follows: "we define the $h_\alpha$ index of a scientist as the number of papers in the h-core of the scientist (i.e. the set of papers that contribute to the h-index of the scientist) where this scientist is the $\alpha$-author" (p. 673). The $h_\alpha$ index was criticized by Leydesdorff, Bornmann, and Opthof (2019). One of their most important points is that the index reinforces the Matthew effect in science. We address this point in the current study using a recently developed Stata command (h_index) and R package (hindex), which can be used to simulate h index and $h_\alpha$index applications in research evaluation. The user can investigate under which conditions $h_\alpha$ reinforces the Matthew effect. The results of our study confirm what Leydesdorff et al. (2019) expected: the $h_\alpha$ index reinforces the Matthew effect. This effect can be intensified if strategic behavior of the publishing scientists and cumulative advantage effects are additionally considered in the simulation.
    Keywords Computer Science - Digital Libraries ; Physics - Physics and Society
    Subject code 001
    Publishing date 2019-05-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Legumain Regulates Regulatory T Cells in Hypertension.

    Alexander, Matthew R / Harrison, David G

    Circulation research

    2024  Volume 134, Issue 1, Page(s) 30–32

    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; TNF Receptor-Associated Factor 6 ; CD4-Positive T-Lymphocytes ; Hypertension/therapy
    Chemical Substances asparaginylendopeptidase (EC 3.4.22.34) ; TNF Receptor-Associated Factor 6
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.324010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  4. Article ; Online: Immune mechanisms in the pathophysiology of hypertension.

    Nguyen, Bianca A / Alexander, Matthew R / Harrison, David G

    Nature reviews. Nephrology

    2024  

    Abstract: Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, most individuals with hypertension fail to achieve adequate blood pressure control. Moreover, even with adequate control, a residual ...

    Abstract Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, most individuals with hypertension fail to achieve adequate blood pressure control. Moreover, even with adequate control, a residual risk of cardiovascular events and associated organ damage remains. These findings suggest that current treatment modalities are not addressing a key element of the underlying pathology. Emerging evidence implicates immune cells as key mediators in the development and progression of hypertension. In this Review, we discuss our current understanding of the diverse roles of innate and adaptive immune cells in hypertension, highlighting key findings from human and rodent studies. We explore mechanisms by which these immune cells promote hypertensive pathophysiology, shedding light on their multifaceted involvement. In addition, we highlight advances in our understanding of autoimmunity, HIV and immune checkpoints that provide valuable insight into mechanisms of chronic and dysregulated inflammation in hypertension.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-024-00838-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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  5. Article ; Online: Flow Disturbances: Competing Interests in a Case of Hypertensive Emergency.

    Alexander, Matthew R / Aday, Aaron W / Lewis, Julia / Deyholos, Christine J / Luther, James M

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 4, Page(s) 676–681

    MeSH term(s) Humans ; Hypertensive Crisis ; Hypertension/diagnosis ; Hypertension/drug therapy
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.124.22107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  6. Article ; Online: Modulating T Cell Phenotype and Function to Treat Hypertension.

    Fehrenbach, Daniel J / Nguyen, Bianca / Alexander, Matthew R / Madhur, Meena S

    Kidney360

    2023  Volume 4, Issue 4, Page(s) e534–e543

    Abstract: Hypertension is the leading modifiable risk factor of worldwide morbidity and mortality because of its effects on cardiovascular and renal end-organ damage. Unfortunately, BP control is not sufficient to fully reduce the risks of hypertension, ... ...

    Abstract Hypertension is the leading modifiable risk factor of worldwide morbidity and mortality because of its effects on cardiovascular and renal end-organ damage. Unfortunately, BP control is not sufficient to fully reduce the risks of hypertension, underscoring the need for novel therapies that address end-organ damage in hypertension. Over the past several decades, the link between immune activation and hypertension has been well established, but there are still no therapies for hypertension that specifically target the immune system. In this review, we describe the critical role played by T cells in hypertension and hypertensive end-organ damage and outline potential therapeutic targets to modulate T-cell phenotype and function in hypertension without causing global immunosuppression.
    MeSH term(s) Humans ; T-Lymphocytes ; Hypertension/drug therapy ; Kidney ; Cardiovascular System ; Risk Factors
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.

    Brenes, Lucas R / Johnson, Alexander D / Lohse, Matthew B

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280233

    Abstract: Candida albicans is a normal member of the human microbiome and an opportunistic fungal pathogen. This species undergoes several morphological transitions, and here we consider white-opaque switching. In this switching program, C. albicans reversibly ... ...

    Abstract Candida albicans is a normal member of the human microbiome and an opportunistic fungal pathogen. This species undergoes several morphological transitions, and here we consider white-opaque switching. In this switching program, C. albicans reversibly alternates between two cell types, named "white" and "opaque," each of which is normally stable across thousands of cell divisions. Although switching under most conditions is stochastic and rare, certain environmental signals or genetic manipulations can dramatically increase the rate of switching. Here, we report the identification of two new inputs which affect white-to-opaque switching rates. The first, exposure to sub-micromolar concentrations of (E,E)-farnesol, reduces white-to-opaque switching by ten-fold or more. The second input, an inferred PKA phosphorylation of residue T208 on the transcriptional regulator Efg1, increases white-to-opaque switching ten-fold. Combining these and other environmental inputs results in a variety of different switching rates, indicating that a given rate represents the integration of multiple inputs.
    MeSH term(s) Humans ; Candida albicans/drug effects ; Candida albicans/genetics ; Candida albicans/metabolism ; Farnesol/pharmacology ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Genetic Techniques ; Phenotype ; Phosphorylation
    Chemical Substances EFG1 protein, Candida albicans ; Farnesol (4602-84-0) ; Fungal Proteins
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.

    Lucas R Brenes / Alexander D Johnson / Matthew B Lohse

    PLoS ONE, Vol 18, Iss 1, p e

    2023  Volume 0280233

    Abstract: Candida albicans is a normal member of the human microbiome and an opportunistic fungal pathogen. This species undergoes several morphological transitions, and here we consider white-opaque switching. In this switching program, C. albicans reversibly ... ...

    Abstract Candida albicans is a normal member of the human microbiome and an opportunistic fungal pathogen. This species undergoes several morphological transitions, and here we consider white-opaque switching. In this switching program, C. albicans reversibly alternates between two cell types, named "white" and "opaque," each of which is normally stable across thousands of cell divisions. Although switching under most conditions is stochastic and rare, certain environmental signals or genetic manipulations can dramatically increase the rate of switching. Here, we report the identification of two new inputs which affect white-to-opaque switching rates. The first, exposure to sub-micromolar concentrations of (E,E)-farnesol, reduces white-to-opaque switching by ten-fold or more. The second input, an inferred PKA phosphorylation of residue T208 on the transcriptional regulator Efg1, increases white-to-opaque switching ten-fold. Combining these and other environmental inputs results in a variety of different switching rates, indicating that a given rate represents the integration of multiple inputs.
    Keywords Medicine ; R ; Science ; Q
    Subject code 420
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  9. Article: Bilateral Virchow nodes: an unusual finding of pulmonary small-cell neuroendocrine carcinoma metastasis.

    Zdilla, Matthew J / Gross, Alexander R / Hajarat, Tara / Vos, Jeffrey A

    Autopsy & case reports

    2023  Volume 13, Page(s) e2023455

    Abstract: An enlarged left-sided supraclavicular node is a signal node for cancer metastasis. In such a case, the enlarged lymph node is often referred to as a Virchow node. The left-sided nature of the node is due to the drainage of the thoracic duct. So, the ... ...

    Abstract An enlarged left-sided supraclavicular node is a signal node for cancer metastasis. In such a case, the enlarged lymph node is often referred to as a Virchow node. The left-sided nature of the node is due to the drainage of the thoracic duct. So, the enlargement of a Virchow node is typically associated with malignancies, including gastrointestinal, pulmonary, and genitourinary carcinomas, in addition to lymphomas. This report documents a particularly unusual finding: bilateral Virchow nodes, representing metastasis of small-cell neuroendocrine carcinoma.
    Language English
    Publishing date 2023-11-13
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2023.455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vitamin B

    Mars Brisbin, Margaret / Schofield, Alese / McIlvin, Matthew R / Krinos, Arianna I / Alexander, Harriet / Saito, Mak A

    ISME communications

    2023  Volume 3, Issue 1, Page(s) 88

    Abstract: Many marine microbes require vitamin ... ...

    Abstract Many marine microbes require vitamin B
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article
    ISSN 2730-6151
    ISSN (online) 2730-6151
    DOI 10.1038/s43705-023-00298-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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