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  1. Article ; Online: Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer.

    Yang, Xiaojuan / Li, Feifei / Shi, Youyang / Wu, Yuanyuan / Yang, Rui / Liu, Xiaofei / Zhang, Yang / Zhang, Guangtao / Ma, Mei / Luo, Zhanyang / Han, Xianghui / Xie, Ying / Liu, Sheng

    Acta biochimica et biophysica Sinica

    2024  

    Abstract: Traditional Chinese medicine (TCM) has been used to treat triple-negative breast cancer (TNBC), a breast cancer subtype with poor prognosis. Clinical studies have verified that the Sanyingfang formula (SYF), a TCM prescription, has obvious effects on ... ...

    Abstract Traditional Chinese medicine (TCM) has been used to treat triple-negative breast cancer (TNBC), a breast cancer subtype with poor prognosis. Clinical studies have verified that the Sanyingfang formula (SYF), a TCM prescription, has obvious effects on inhibiting breast cancer recurrence and metastasis, prolonging patient survival, and reducing clinical symptoms. However, its active ingredients and molecular mechanisms are still unclear. In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1.
    Language English
    Publishing date 2024-03-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2024015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect size calculation needs to be specified with details: comment on Ying

    Luo, Yan / Furukawa, Toshi A

    Psychological medicine

    2022  Volume 53, Issue 9, Page(s) 4300–4301

    MeSH term(s) Humans ; Depression ; Cognitive Behavioral Therapy
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291722002057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1.

    Luo, Judong / Zhou, Xifa / Ge, Xin / Liu, Pengfei / Cao, Jianping / Lu, Xujing / Ling, Yang / Zhang, Shuyu

    Cancer science

    2013  Volume 104, Issue 11, Page(s) 1544–1551

    Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest malignancies worldwide. Ying Yang ...

    Abstract Esophageal squamous cell carcinoma (ESCC) is one of the deadliest malignancies worldwide. Ying Yang 1 (YY1), a ubiquitously expressed GLI-Krüppel zinc finger transcription factor, plays a regulatory role in a variety of fundamental biological processes, such as embryonic development, growth, apoptosis, differentiation and oncogenic transformation. The purpose of this study was to investigate the expression of YY1 in normal and cancerous esophageal tissues and its function in ESCC development. We found that the expression of YY1 mRNA was significantly increased in the tumor tissues, compared with the para-tissues or normal esophageal tissues. The increased expression of YY1 in tumor samples was further confirmed by immunohistochemistry. Furthermore, the overexpression of YY1 conferred radioresistance to the ESCC TE-1 cells and resulted in markedly reduced cell proliferation. Accordingly, the small interfering RNA-mediated silencing of YY1 expression in TE-1 cells resulted in increased proliferation by enhancing the binding of P21 to Cyclin D1 and CDK4, a protein complex known to mediate cell cycle progression. Moreover, besides P21, heme oxygenase-1 (HO-1) was identified as a YY1 downstream effector, as YY1 stimulated HO-1 expression in esophageal cancer cells. YY1 mediated biological function through transcription of HO-1. Forced expression of HO-1 could moderately suppress proliferation of TE-1 cells. The expression of YY1 significantly correlated with that of HO-1 in ESCC tissues. Taken together, we demonstrated overexpression of YY1 in esophageal carcinoma and identified HO-1 as its target.
    MeSH term(s) Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/ultrastructure ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/genetics ; Case-Control Studies ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival/radiation effects ; Esophageal Neoplasms/enzymology ; Esophageal Neoplasms/genetics ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Humans ; Radiation Tolerance ; Up-Regulation ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
    Chemical Substances YY1 Transcription Factor ; YY1 protein, human ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2013-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1347-9032
    ISSN (online) 1349-7006
    ISSN 1347-9032
    DOI 10.1111/cas.12248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Luo, Guo Ying: Asset price response to new information, the effects of conservatism bias and representativeness heuristic : New York, NY [u.a.], Springer, 2014 / [rezensiert von:] Jianfeng Yu

    Yu, Jianfeng / Luo, Guo Ying

    Journal of economic literature Bd. LII.2014, 4 (Dec.), S. 1170-1172

    2014  

    Language English
    Publisher Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 3076-4 ; 2010159-4
    ISSN 0022-0515
    ISSN 0022-0515
    Database ECONomics Information System

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  5. Book: Yi liao fu wu zi yuan diao du you hua li lun, fang fa ji ying yong

    Luo, Li

    Optimization in healthcare resource planning and scheduling modeling : theory methods and applications

    2014  

    Title variant Optimization in healthcare resource planning and scheduling modeling :
    Author's details Luo Li, Shi Yingkang zhu
    MeSH term(s) Health Care Rationing/methods ; Health Resources/supply & distribution
    Keywords China
    Language Chinese
    Size vii, 183 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787030396259 ; 7030396251
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article: The Trade-Off and Altitudinal Variations in Seed Weight-Number in Sinopodophyllum hexandrum (Royle) Ying (Berberidaceae) Populations from the Hengduan Mountains

    Meng, Li-Hua / Wang Yun / Luo Jian / Yang Yong-Ping / Duan Yuan-Wen

    Polish Journal of Ecology. 2014 Sept., v. 62, no. 3

    2014  

    Abstract: Given the finite resources of seed production, a trade-off between seed weight and number was expected. However, it still remains unclear how the seed weight-number trade-off changes if there are some mechanisms to enhance resource acquirements during ... ...

    Abstract Given the finite resources of seed production, a trade-off between seed weight and number was expected. However, it still remains unclear how the seed weight-number trade-off changes if there are some mechanisms to enhance resource acquirements during the fruit developments. Sinopodophyllum hexandrum presents furled leaves in flowering time but unfurled leaves in fruiting time, which is considered to enhance the photosynthates to fruit development. To determine the relationship between seed weight and number of S. hexandrum, we examined the altitudinal variations and the relationship between seed weight and number in the fruits from 27 populations of in 2009 and 2010. Our results showed that, along the altitudinal gradient, seed weight decreased significantly but seed number increased insignificantly, indicating that the selective pressure on seed production might come from seed dispersal in high altitude populations. There was no significant relationship between seed weight and number in most populations, but an inverse relationship was found between seed weight and number when the data from all populations were pooled, indicating the seed weight-number trade-off and resource limitation of seed production in S. hexandrum on species level. We suggested that the two unfurled leaves of S. hexandrum might contribute to the resources allocated to the fruit development via enhancing photosynthates, which might mask the seed weight-number trade-off on population level to some degree.
    Keywords Podophyllum hexandrum ; altitude ; flowering ; fruiting ; fruits ; leaves ; mountains ; photosynthates ; seed dispersal ; weight-number trade-off ; alpine environment
    Language English
    Dates of publication 2014-09
    Size p. 413-419.
    Publishing place Museum and Institute of Zoology, Polish Academy of Sciences
    Document type Article
    ZDB-ID 2322813-1
    ISSN 1505-2249
    ISSN 1505-2249
    DOI 10.3161%2F104.062.0303
    Database NAL-Catalogue (AGRICOLA)

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  7. Book: Da qi ying xiong zhuan

    Gu, Long / Luo, Liqun

    shang

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 9)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 9
    Language Chinese
    Dates of publication 1998-1995
    Size 8, 6, 465 p
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070581 ; 7806070583
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Da di fei ying

    Gu, Long / Luo, Liqun

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 17)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 17
    Language Chinese
    Dates of publication 1998-1995
    Size 8, 2, 531 p
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070611 ; 7806070613
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Xue ying wu

    Gu, Long / Luo, Liqun

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 44)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 44
    Language Chinese
    Dates of publication 1998-1995
    Size 8, 488 p
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070673 ; 7806070672
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  10. Book: Ying xiong wu lei

    Gu, Long / Luo, Liqun

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 22)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 22
    Language Chinese
    Dates of publication 1998-1995
    Size 8, 2, 508 p
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070635 ; 780607063X
    Database Former special subject collection: coastal and deep sea fishing

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