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  1. Article: Puumala hantavirus in Slovenia: analyses of S and M segment sequences recovered from patients and rodents.

    Avsic-Zupanc, Tatjana / Petrovec, Miroslav / Duh, Darja / Plyusnina, Angelina / Lundkvist, Ake / Plyusnin, Alexander

    Virus research

    2007  Volume 123, Issue 2, Page(s) 204–210

    Abstract: ... from all nine patients and partial M segment sequences could be recovered from seven. Partial S and M segments ... study sites were selected with regard to the HFRS cases. Partial S segment sequences were recovered ... in natural foci of this zoonotic infection. Analysis of the complete S segment sequences recovered for two ...

    Abstract In Slovenia, the co-existence of Dobrava and Puumala (PUUV) hantaviruses in a single endemic region has been demonstrated. This study presents selected Slovenian HFRS cases caused by PUUV combined with genetic analysis of viral genome sequences recovered from clinical specimens and tissue samples of Clethrionomys glareolus (bank voles). Serum samples from nine HFRS patients were included in the study. Rodents study sites were selected with regard to the HFRS cases. Partial S segment sequences were recovered from all nine patients and partial M segment sequences could be recovered from seven. Partial S and M segments sequences were also recovered from five C. glareouls captured at three different study sites. The sequences from Slovenian clinical specimens and rodent tissue samples belonged to the PUUV genotype and formed a distinct genetic lineage of PUUV. Human and rodent PUUV sequences located in the closest proximity to each other on the phylogenetic trees suggest genetic links between the human cases and the hantaviral strains circulating in natural foci of this zoonotic infection. Analysis of the complete S segment sequences recovered for two wild-type PUUV strains confirmed the existence of a distinct genetic lineage and also indicated a possible quasispecies type of Slovenian PUUV.
    MeSH term(s) Animals ; Arvicolinae/virology ; Disease Reservoirs/virology ; Genome, Viral ; Hemorrhagic Fever with Renal Syndrome/immunology ; Hemorrhagic Fever with Renal Syndrome/virology ; Humans ; Molecular Sequence Data ; Phylogeny ; Puumala virus/classification ; Puumala virus/genetics ; Slovenia ; Species Specificity
    Language English
    Publishing date 2007-02
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2006.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Real-world users of triple therapy for asthma in the US.

    Hansel, Nadia N / Abbott, Carl B / Averell, Carlyne M / Germain, Guillaume / Laliberté, François / Mahendran, Malena / Duh, Mei S / Settipane, Russell A

    The American journal of managed care

    2024  Volume 30, Issue 2, Page(s) 74–81

    Abstract: Objectives: For patients with asthma who remain symptomatic on a medium-dose inhaled corticosteroid/long-acting β2 agonist, addition of a long-acting muscarinic antagonist as a supplementary controller is a recommended option. However, real-world data ... ...

    Abstract Objectives: For patients with asthma who remain symptomatic on a medium-dose inhaled corticosteroid/long-acting β2 agonist, addition of a long-acting muscarinic antagonist as a supplementary controller is a recommended option. However, real-world data on the characteristics and treatment patterns of these patients are limited. This study described the demographics and clinical characteristics of new users of single- or multiple-inhaler triple therapy and treatment patterns preceding triple-therapy initiation.
    Study design: This retrospective cohort study used medical and pharmacy claims data from the IQVIA PharMetrics Plus database.
    Methods: The study population comprised adults with asthma with or without chronic obstructive pulmonary disease (COPD) initiating triple therapy with single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI; 100/62.5/25 μg) or multiple-inhaler triple therapy (MITT) between September 18, 2017, and September 30, 2019. Demographics, clinical characteristics, and treatment patterns in the 12 months preceding triple-therapy initiation were described (baseline period).
    Results: A total of 12,395 patients were included. Among FF/UMEC/VI initiators with asthma (n = 1301), the mean age was 49.0 years and 59.3% were women. During the baseline period, 81.5% of patients used controller therapy, 94.7% used rescue medications, and 42.0% reported at least 1 asthma-related exacerbation; the annual mean exacerbation rate was 0.96. Similar trends were observed among patients with asthma initiating MITT and patients with comorbid asthma-COPD initiating FF/UMEC/VI or MITT.
    Conclusion: In real-world practice, triple therapy is often utilized following other asthma controller medication use. High disease burden, as evidenced by substantial use of rescue medications and continued asthma-related exacerbations, suggests that patients may not have achieved adequate asthma control prior to triple-therapy initiation.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Male ; Bronchodilator Agents/therapeutic use ; Retrospective Studies ; Administration, Inhalation ; Asthma/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Fluticasone/therapeutic use ; Muscarinic Antagonists/therapeutic use ; Drug Combinations
    Chemical Substances Bronchodilator Agents ; Fluticasone (CUT2W21N7U) ; Muscarinic Antagonists ; Drug Combinations
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2024.89494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparative effectiveness of lenalidomide/dexamethasone-based triplet regimens for treatment of relapsed and/or refractory multiple myeloma in the United States: An analysis of real-world electronic health records data.

    Ailawadhi, Sikander / Cheng, Mu / Cherepanov, Dasha / DerSarkissian, Maral / Stull, Dawn Marie / Hilts, Annalise / Chun, Justin / Duh, Mei Sheng / Sanchez, Larysa

    Current problems in cancer

    2024  Volume 50, Page(s) 101078

    Abstract: Background: This retrospective longitudinal study compared the effectiveness of dexamethasone+lenalidomide (Rd)-based triplet regimens containing proteasome inhibitors (PIs) ixazomib (IRd), carfilzomib (KRd), and bortezomib (VRd) or monoclonal ... ...

    Abstract Background: This retrospective longitudinal study compared the effectiveness of dexamethasone+lenalidomide (Rd)-based triplet regimens containing proteasome inhibitors (PIs) ixazomib (IRd), carfilzomib (KRd), and bortezomib (VRd) or monoclonal antibodies (MABs) elotuzumab (ERd) and daratumumab (DRd) in patients with relapsed/refractory multiple myeloma (RRMM)-including those with high cytogenetic risk-primarily treated at community oncology clinics in the United States.
    Methods: Electronic health records of adult RRMM patients in a deidentified real-world database (01/01/2014-09/30/2020) who initiated IRd, KRd, VRd, ERd, or DRd in the second or later line of therapy (LOT) were analyzed. The index date was the date of initiation of each LOT and baseline was the 6-month pre-index period. Duration of therapy (DOT), time to next therapy (TTNT), progression-free survival (PFS), and overall survival (OS) were compared across regimens with multivariable Cox proportional hazards models.
    Results: Of the 1,185 patients contributing 1,332 LOTs, 985 had standard cytogenetic risk (median age, 71 years) and 180 had high risk (median age, 69 years). Compared with other regimens, DRd was associated with longer DOT overall (adjusted hazard ratio [95 % confidence interval]: 1.84 [1.42, 2.38] vs. KRd, 1.65 [1.20, 2.28] vs. ERd, 1.58 [1.23, 2.04] vs. IRd, and 1.54 [1.18, 2.00] vs. VRd), and longer TTNT and PFS. KRd was associated with shorter OS compared with DRd (1.45 [1.01, 2.08]) and VRd (1.32 [1.01, 1.73]). High-risk patients had similar outcomes with all triplet regimens.
    Conclusion: Although DRd improved clinical outcomes overall, Rd-based triplet regimens containing a PI or MAB are similarly effective in high-risk RRMM.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2024.101078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Somatic and Germline Mutations in Atypical Parathyroid Tumors.

    Ullmann, Timothy M / Mulder, Michelle / Davis, Stephanie / Rajwani, Taufiq / Khanafshar, Elham / Duh, Quan-Yang

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 10, Page(s) 942–943

    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.2342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Material Hardship, Protective Factors, Children's Special Health Care Needs, and the Health of Mothers and Fathers.

    Fuller, Anne E / Duh-Leong, Carol / Brown, Nicole M / Garg, Arvin / Oyeku, Suzette O / Gross, Rachel S

    Academic pediatrics

    2023  Volume 24, Issue 2, Page(s) 267–276

    Abstract: Background: Parents of children with special health care needs (CSHCN) are at risk of poorer health outcomes. Material hardships also pose significant health risks to parents. Little is known about how protective factors may mitigate these risks and if ... ...

    Abstract Background: Parents of children with special health care needs (CSHCN) are at risk of poorer health outcomes. Material hardships also pose significant health risks to parents. Little is known about how protective factors may mitigate these risks and if effects are similar between mothers and fathers.
    Methods: This was a cross-sectional survey study conducted using the US 2018/2019 National Survey of Children's Health, including parents of children 0 to 17 with income <200% of the federal poverty level. Separately, for parents of children with and without special health care needs (N-CSHCN), weighted logistic regression measured associations between material hardship, protective factors (family resilience, neighborhood cohesion, and receipt of family-centered care), and 2 outcomes: mental and physical health of mothers and fathers. Interactions were assessed between special health care needs status, material hardship, and protective factors.
    Results: Sample consisted of parents of 16,777 children; 4440 were parents of CSHCN. Most outcomes showed similar associations for both mothers and fathers of CSHCN and N-CSHCN: material hardship was associated with poorer health outcomes, and family resilience and neighborhood cohesion associated with better parental health outcomes. Family-centered care was associated with better health of mothers but not fathers. Interaction testing showed that the protective effects of family resilience were lower among fathers of CSHCN experiencing material hardship.
    Conclusions: Family resilience and neighborhood cohesion are associated with better health outcomes for all parents, though these effects may vary by experience of special health care needs, parent gender, and material hardship.
    MeSH term(s) Child ; Female ; Humans ; Child Health ; Cross-Sectional Studies ; Family Health ; Protective Factors ; Resilience, Psychological ; Health Services Accessibility ; Health Services Needs and Demand ; Disabled Children
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2023.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Venous thromboembolic disease in admitted blunt trauma patients: what matters?

    Lineberry, Camille / Alexis, Dimitri / Mukhi, Ambika / Duh, Kevin / Tharakan, Mathew / Vosswinkel, James A / Jawa, Randeep S

    Thrombosis journal

    2023  Volume 21, Issue 1, Page(s) 111

    Abstract: Background: Venous thromboembolic events (VTE) are a significant cause of morbidity and mortality following traumatic injury. We examined demographic characteristics, chemoprophylaxis, and outcomes of VTE patients with blunt trauma requiring ... ...

    Abstract Background: Venous thromboembolic events (VTE) are a significant cause of morbidity and mortality following traumatic injury. We examined demographic characteristics, chemoprophylaxis, and outcomes of VTE patients with blunt trauma requiring hospitalization.
    Methods: A retrospective review of adult blunt trauma hospitalizations with and without VTE between 2012 and 2019 was conducted. Deaths in the emergency department were excluded. Univariate and multivariable analyses, including machine learning classification algorithms for VTE, were performed.
    Results: Of 10,926 admitted adult blunt trauma patients, 177 had VTE events. VTE events occurred at a median of 6 [IQR 3-11] days, with 7.3% occurring within 1 day of admission. VTE patients were more often male, and more often underwent surgery. They had higher injury severity as well as longer intensive care unit and hospital lengths of stay. While VTE occurred throughout the spectrum of injury severity, 27.7% had low injury severity (ISS < = 9). In multivariable analyses, both heparin and enoxaparin had reduced adjusted odds ratios for VTE.
    Conclusion: Approximately 7.3% of VTE events occurred within one day of admission. A substantial proportion of VTE events occurred in patients with low injury severity (ISS < = 9). Subcutaneous unfractionated heparin and enoxaparin chemoprophylaxis were both inversely associated with VTE. These findings underscore the need for vigilance for VTE identification in blunt trauma patients throughout their hospitalization and VTE prevention efforts.
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-023-00555-7
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  7. Article ; Online: Nerve monitoring in endocrine surgery: Practice patterns differ among surgeons for parathyroidectomy and thyroidectomy.

    Conroy, Patricia C / Wilhelm, Alexander / Rajwani, Taufiq / Mulder, Michelle / Gosnell, Jessica / Shen, Wen T / Duh, Quan-Yang / Roman, Sanziana / Sosa, Julie Ann

    Surgery

    2023  Volume 175, Issue 4, Page(s) 1040–1048

    Abstract: Background: It is unknown whether intraoperative nerve monitoring is associated with reduced vocal cord dysfunction after parathyroidectomy. We aimed to investigate intraoperative nerve monitoring use among Collaborative Endocrine Surgery Quality ... ...

    Abstract Background: It is unknown whether intraoperative nerve monitoring is associated with reduced vocal cord dysfunction after parathyroidectomy. We aimed to investigate intraoperative nerve monitoring use among Collaborative Endocrine Surgery Quality Improvement Program surgeons and factors associated with vocal cord dysfunction after parathyroidectomy.
    Methods: Patients who underwent parathyroidectomy included in the Collaborative Endocrine Surgery Quality Improvement Program (2014-2022) were identified. The annual percent change in parathyroidectomies performed with intraoperative nerve monitoring was calculated using joinpoint regression. Multivariable logistic regression was used to compare outcomes between patients undergoing parathyroidectomy with/without intraoperative nerve monitoring. To compare surgeon-specific trends, Collaborative Endocrine Surgery Quality Improvement Program thyroidectomy and parathyroidectomy datasets (2014-2021) were combined. Parathyroidectomies performed by surgeons who used intraoperative nerve monitoring consistently in thyroidectomy were identified. Factors associated with intraoperative nerve monitoring were examined using multivariable logistic regression.
    Results: A total of 9,813 patients underwent parathyroidectomy. Intraoperative nerve monitoring was used in 49% of cases (n = 4,818). There was an increase in parathyroidectomies with intraoperative nerve monitoring from 2014 to 2018 (annual percent change 22.2, P = .01), followed by a plateau (2018-2022 annual percent change -0.66, P = .85). Few patients (0.44%, n = 43) developed vocal cord dysfunction. Vocal cord dysfunction was not associated with intraoperative nerve monitoring (adjusted odds ratio 0.92, P = .75). Whereas 41% (n = 56/138) of surgeons used intraoperative nerve monitoring routinely in parathyroidectomy, 65% (n = 90/138) used it routinely in thyroidectomy. Among surgeons who used intraoperative nerve monitoring routinely in thyroidectomy, only 57% used it routinely in parathyroidectomy; factors associated with intraoperative nerve monitoring during parathyroidectomy included reoperation (adjusted odds ratio 2.51, P < .01), secondary/tertiary hyperparathyroidism (adjusted odds ratio 1.42, P = .02), multiglandular disease (adjusted odds ratio 1.76, P < .001), and non-localized disease (adjusted odds ratio 1.65, P < .001).
    Conclusion: Endocrine surgeons use intraoperative nerve monitoring selectively. Surgeons who routinely use intraoperative nerve monitoring during thyroidectomy are more likely to use it during parathyroidectomy. Future studies should determine who may benefit most from intraoperative nerve monitoring in parathyroidectomy.
    MeSH term(s) Humans ; Thyroidectomy/adverse effects ; Parathyroidectomy/adverse effects ; Vocal Cord Dysfunction/etiology ; Surgeons
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.11.024
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  8. Article ; Online: Disease burden and treatment adherence among children and adolescent patients with asthma.

    Averell, Carlyne M / Laliberté, François / Germain, Guillaume / Slade, David J / Duh, Mei S / Spahn, Joseph

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2021  Volume 59, Issue 8, Page(s) 1687–1696

    Abstract: Objective: To assess asthma burden and medication adherence in a US de-identified patient level claims database.: Methods: This retrospective observational study used the IQVIA PHARMETRICS PLUS database to identify patients aged 5-17 years, diagnosed ...

    Abstract Objective: To assess asthma burden and medication adherence in a US de-identified patient level claims database.
    Methods: This retrospective observational study used the IQVIA PHARMETRICS PLUS database to identify patients aged 5-17 years, diagnosed with asthma between 01/01/2012-09/30/2017 (asthma cohort), and those initiating treatment with twice-daily inhaled corticosteroids (ICS) or twice-daily ICS/long-acting beta
    Results: The asthma cohort included 186,868 patients (112,689 children, mean age 7.9 years; 74,179 adolescents, mean age 14.3 years). During baseline, 34.5% used ICS or ICS/LABA, 24% used oral corticosteroids, 11.1% had ≥1 asthma-related emergency department visit, 2.2% had ≥1 asthma-related hospitalization. Among treatment cohorts, 47,276 and 10,247 patients initiated twice-daily ICS and ICS/LABA, respectively (mean ages: 9.9; 12.5 years). Mean PDC adherence to twice-daily ICS and ICS/LABA was 30% and 34% at 6 months (PDC ≥0.8: 4.3%; 6.1%); 21% and 24% at 12 months (PDC ≥0.8: 1.8%; 2.8%). Persistence with twice-daily ICS and ICS/LABA was 10.1% and 14.2% at 6 months; 5.6% and 8.0% at 12 months.
    Conclusions: A large disease burden and unmet need exist among US children/adolescent asthma patients, evidenced by low use of, and poor adherence to, ICS-containing medication, the notable proportion of oral corticosteroid users, and higher-than-expected asthma-related emergency department and hospitalization rates.
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones ; Adrenergic beta-Agonists/therapeutic use ; Anti-Asthmatic Agents/therapeutic use ; Asthma/chemically induced ; Asthma/drug therapy ; Asthma/epidemiology ; Child ; Cost of Illness ; Drug Therapy, Combination ; Humans ; Treatment Adherence and Compliance
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-Agonists ; Anti-Asthmatic Agents
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2021.1955377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Infant Feeding Practices and Social Support Networks Among Immigrant Chinese American Mothers With Economic Disadvantage in New York City.

    Duh-Leong, Carol / Yin, H Shonna / Salcedo, Vanessa / Mui, Angel / Perrin, Eliana M / Yi, Stella S / Zhao, Qiuqu / Gross, Rachel S

    Journal of human lactation : official journal of International Lactation Consultant Association

    2022  Volume 39, Issue 1, Page(s) 168–177

    Abstract: Background: Maternal social support promotes healthy infant feeding practices, which influence healthy growth and development. Less is known about how the interplay of social support networks and multicultural health beliefs may influence infant feeding ...

    Abstract Background: Maternal social support promotes healthy infant feeding practices, which influence healthy growth and development. Less is known about how the interplay of social support networks and multicultural health beliefs may influence infant feeding practices, particularly among immigrant Chinese American mothers with economic disadvantage and low breastfeeding rates.
    Research aim: To explore the role of social support networks in the development of infant feeding practices in immigrant Chinese American mothers with infants.
    Methods: This was a prospective, cross-sectional qualitative study where we conducted semi-structured interviews in Mandarin, Cantonese, or English with Chinese American mothers of infants (
    Results: Three themes emerged describing how broad transnational communities and close family and friends influence maternal-infant feeding practices: (1) Gathering and processing infant feeding information from broad transnational resources (i.e., from both the mother's country of residence and the mother's country of origin); (2) aligning maternal feeding attitudes with cultural health beliefs of local social networks; and (3) gaining confidence with transactional maternal-infant feeding interactions.
    Conclusions: Strategies to promote healthy infant feeding should consider how family supports and culturally-relevant coaching can help align multilevel transnational social networks with healthy infant feeding practices.
    MeSH term(s) Female ; Infant ; Humans ; Mothers ; Breast Feeding ; New York City ; Cross-Sectional Studies ; East Asian People ; Prospective Studies ; Emigrants and Immigrants ; Social Support ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1138470-0
    ISSN 1552-5732 ; 0890-3344
    ISSN (online) 1552-5732
    ISSN 0890-3344
    DOI 10.1177/08903344221121571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Frequency and economic burden of exacerbations in inhaled corticosteroid/long-acting beta-agonist-treated patients with asthma: A retrospective US claims study.

    Sheng Duh, Mei / Roberts, Melissa H / Rothnie, Kieran J / Cheng, Wendy Y / Thompson-Leduc, Philippe / Zhang, Shiyuan / Czira, Alexandrosz / Slade, David / Greatsinger, Alexandra / Zhang, Adina / Mapel, Douglas

    Respiratory medicine

    2024  Volume 226, Page(s) 107629

    Abstract: Introduction: Despite adherence to inhaled corticosteroid/long-acting β: Methods: Retrospective, longitudinal study analyzed data from Optum's de-identified Clinformatics® Data Mart Database recorded between October 1, 2015, and December 31, 2019. ... ...

    Abstract Introduction: Despite adherence to inhaled corticosteroid/long-acting β
    Methods: Retrospective, longitudinal study analyzed data from Optum's de-identified Clinformatics® Data Mart Database recorded between October 1, 2015, and December 31, 2019. Eligibility criteria included patients ≥18 years of age with ≥1 ICS/LABA claim and ≥1 medical claim for asthma in the 12 months pre-index (first ICS/LABA claim). Primary objectives included describing moderate exacerbation frequency, and associated healthcare resource utilization (HRU) and costs. A secondary objective was assessing the relationship between moderate exacerbations and subsequent risk of severe exacerbations. Patients were stratified by moderate exacerbation frequency in the 12 months post index. Moderate exacerbations were identified using a newly developed algorithm.
    Results: In the first 12 months post index 61.6% of patients experienced ≥1 moderate exacerbation. Mean number of asthma-related visits was 4.1 per person/year and median total asthma-related costs was $3544. HRU and costs increased with increasing exacerbation frequency. Outpatient and inpatient visits accounted for a similar proportion of these costs. Moderate exacerbations were associated with an increased rate and risk of future severe exacerbations (incidence rate ratio, 1.56; hazard ratio, 1.51 [both p < 0.001]).
    Conclusions: This study highlighted that a high proportion of patients continue to experience moderate exacerbations despite ICS/LABA therapy and subsequently experience increased economic burden and risk of future severe exacerbations.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2024.107629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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