LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Your last searches

  1. AU=Kivrak Mehmet
  2. AU="Seguine, Clementine"

Search results

Result 1 - 10 of total 79

Search options

  1. Article: How Efficient Is ChatGPT in Accessing Accurate and Quality Health-Related Information?

    Ulusoy, Ibrahim / Yılmaz, Mehmet / Kıvrak, Aybars

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46662

    Abstract: Background and objective The field of artificial intelligence (AI) is advancing at a rapid pace, impacting all aspects of human life. Chat Generative Pre-trained Transformer (ChatGPT), which represents one of AI's most recent and remarkable achievements, ...

    Abstract Background and objective The field of artificial intelligence (AI) is advancing at a rapid pace, impacting all aspects of human life. Chat Generative Pre-trained Transformer (ChatGPT), which represents one of AI's most recent and remarkable achievements, has garnered significant attention and popularity in the academic community. ChatGPT, a language model-based chatbot developed by OpenAI, responds quickly and provides answers to the questions put to it. This chatbot has the ability to gather content from a variety of sources on the internet. However, its success in providing correct information has not yet been comprehensively analyzed. In light of this, this study aimed to engage in a comparative content analysis of health-related information provided by ChatGPT and a few selected websites. Methods We performed a qualitative analysis of data obtained from various information sources by using the DISCERN score and the Journal of the American Medical Association (JAMA) benchmark criteria. In addition, readability levels of the content were measured by using the Flesch-Kincaid grade level, Gunning Fog Index, and Simple Measure of Gobbledygook (SMOG) index. Results Based on our findings, there was no statistically significant difference between the websites and ChatGPT in DISCERN scores. However, the JAMA score was statistically significantly higher for websites. With regard to the Flesch-Kincaid grade level, Gunning Fog Index, and SMOG index values, the data obtained from the websites had higher readability. Conclusion Although AI is starting to play a significant role in our everyday lives, it has yet to surpass traditional methods of accessing information in terms of readability and reliability.
    Language English
    Publishing date 2023-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46662
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Lung cancer detection based on computed tomography image using convolutional neural networks.

    Ozcelik, Neslihan / Kıvrak, Mehmet / Kotan, Abdurrahman / Selimoğlu, İnci

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2023  Volume 32, Issue 3, Page(s) 1795–1805

    Abstract: Background: Lung cancer is the most common type of cancer, accounting for 12.8% of cancer cases worldwide. As initially non-specific symptoms occur, it is difficult to diagnose in the early stages.: Objective: Image processing techniques developed ... ...

    Abstract Background: Lung cancer is the most common type of cancer, accounting for 12.8% of cancer cases worldwide. As initially non-specific symptoms occur, it is difficult to diagnose in the early stages.
    Objective: Image processing techniques developed using machine learning methods have played a crucial role in the development of decision support systems. This study aimed to classify benign and malignant lung lesions with a deep learning approach and convolutional neural networks (CNNs).
    Methods: The image dataset includes 4459 Computed tomography (CT) scans (benign, 2242; malignant, 2217). The research type was retrospective; the case-control analysis. A method based on GoogLeNet architecture, which is one of the deep learning approaches, was used to make maximum inference on images and minimize manual control.
    Results: The dataset used to develop the CNNs model is included in the training (3567) and testing (892) datasets. The model's highest accuracy rate in the training phase was estimated as 0.98. According to accuracy, sensitivity, specificity, positive predictive value, and negative predictive values of testing data, the highest classification performance ratio was positive predictive value with 0.984.
    Conclusion: The deep learning methods are beneficial in the diagnosis and classification of lung cancer through computed tomography images.
    MeSH term(s) Humans ; Lung Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Neural Networks, Computer ; Retrospective Studies ; Deep Learning ; Male ; Sensitivity and Specificity ; Female ; Middle Aged ; Case-Control Studies ; Aged
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-230810
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Efficacy of autologous stem cell therapy in femoral head avascular necrosis: a comparative study.

    Ulusoy, İbrahim / Yılmaz, Mehmet / Kıvrak, Aybars

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 799

    Abstract: Objective: Avascular necrosis of the femoral head is a disease usually seen in middle-aged individuals. Although many aetiological factors have been blamed, there are still aetiological factors that have not been fully elucidated. Although treatment ... ...

    Abstract Objective: Avascular necrosis of the femoral head is a disease usually seen in middle-aged individuals. Although many aetiological factors have been blamed, there are still aetiological factors that have not been fully elucidated. Although treatment options show a wide range, early and appropriate treatment is of great importance to preserve the hip joint. In our study, we compared the results of core decompression and core decompression combined with bone marrow mesenchymal stem cell implantation in patients with avascular necrosis of the femoral head.
    Material method: In this retrospective study, Steinberg stage 1-2 patients operated on for avascular necrosis of the femoral head between 2018 and 2023 were analysed. Separate groups were formed from patients who underwent isolated core decompression and core decompression + bone marrow mesenchymal stem cell implantation. Age, gender, Steinberg staging, aetiology of the disease, follow-up period, progression to hip arthroplasty, Vas scores, Harris hip scores (HHS), and complications were evaluated. Harris hip scores at preoperative and 2-year follow-up periods; VAS scores at preoperative, 3-month, 6-month, 1-year, and 2-year follow-up periods were analysed.
    Results: In the study, 44 patients were analysed. While 25 patients underwent core decompression only (group 1), 19 patients underwent core decompression and bone marrow mesenchymal stem cell implantation (group 2). The mean age of the patients in group 1 was 39.3 ± 6.5 years, and the mean age of the patients in group 2 was 38.4 ± 6.7 years. The mean follow-up was 31.85 ± 4.4 months in group 1 and 32.2 ± 4.1 months in group 2. Total hip arthroplasty was performed in 2 of the patients in group 1 (one of the patients underwent total hip arthroplasty at month 28 and the other at month 33).
    Conclusion: The treatment of avascular necrosis of the femoral head varies according to various staging methods. Early diagnosis of the disease and correct treatment are very important for the patient's quality of life in the future. In our research, we found that patients who received both core decompression and stem cell implantation for early-stage avascular necrosis of the femoral head exhibited decreased pain at the 6-month, 1-year, and 2-year follow-up examinations. Additionally, their hip function improved at the 24-month mark according to the HHS evaluation.
    MeSH term(s) Middle Aged ; Humans ; Adult ; Femur Head Necrosis/surgery ; Treatment Outcome ; Femur Head/surgery ; Retrospective Studies ; Quality of Life ; Decompression, Surgical/methods ; Arthroplasty, Replacement, Hip ; Bone Marrow Transplantation/methods
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-04297-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs

    Kivrak, Mehmet Bugra / Aydın, İbrahim

    Reproduction in Domestic Animals. 2023 Mar., v. 58, no. 3 p.379-386

    2023  

    Abstract: This study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre‐pubertal ewe lambs. Here, 12 1–3‐year‐old Merino rams and 60 7–9‐month‐old Merino sheep were included in the ...

    Abstract This study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre‐pubertal ewe lambs. Here, 12 1–3‐year‐old Merino rams and 60 7–9‐month‐old Merino sheep were included in the study. The sheep were randomly divided into sulpiride (n = 30) and control (n = 30) groups. The sulpiride group was subcutaneously injected with 0.6 mg/kg sulpiride twice daily (morning and evening) for 9 days. During these 9 days, blood samples were taken from the sheep before drug administration and at 4 h after every drug administration. The number of ovulating animals in the sulpiride group was significantly higher than that in the control group (90% vs. 32%). No oestrous signs were observed in either group during ram release. Further, there were no differences in the levels of mean follicle‐stimulating hormone in the two groups based on treatment (p = .2), time (p = .3) or treatment‐by‐time interaction (p = .3). After sulpiride administration, the luteinizing hormone (LH) levels of the sulpiride group rapidly increased and remained stable for a long time, whereas physiological LH fluctuations in the control group remained unchanged. Within‐group changes in terms of LH concentrations were significant for both groups (p < .001), whereas LH pulse frequency was significantly different between the sulpiride group (p = .03). Therefore, it is concluded that sulpiride can be used as a non‐steroidal alternative to stimulate pre‐pubertal ewe lambs and sheep during anoestrus.
    Keywords Merino ; anestrus ; antagonists ; blood ; dopamine ; drugs ; ewes ; follicle-stimulating hormone ; luteinizing hormone ; ovulation ; puberty ; rams
    Language English
    Dates of publication 2023-03
    Size p. 379-386.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1015187-4
    ISSN 1439-0531 ; 0936-6768
    ISSN (online) 1439-0531
    ISSN 0936-6768
    DOI 10.1111/rda.14295
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  5. Article ; Online: Determination of the Effect of Different Doses of ECG Applications on Reproductive Parameters in Primiparous Akkaraman Kangal Sheep

    Abdurrahman Takcı / Mehmet Buğra Kıvrak / Murat Yüksel

    Turkish Journal of Agriculture: Food Science and Technology, Vol 11, Iss

    2023  Volume 6

    Abstract: To increase meat production at a level parallel to meet the demand of the increasing world population in recent years, reproductive management in farm animals must be successful. In order to reach the desired level of fertility in sheep, particularly ... ...

    Abstract To increase meat production at a level parallel to meet the demand of the increasing world population in recent years, reproductive management in farm animals must be successful. In order to reach the desired level of fertility in sheep, particularly starting with the non-prolific breeds, anoestrus period applications should be carried out effectively. In this study, different doses of equine chorionic gonadotropin were applied to determine the effective eCG dose for underwent estrus synchronization with progesterone in anoestrus Kangal ewes whose milk and wool yield has been completely abandoned by the breeder for various reasons and whose only economic benefit is lamb production. A total of 225 Kangal Akkaraman Sheep breeds, 2 years old, with a body condition score of 2.5-3.5 and an average weight of 40-50 kg, were included in the study. In line with this purpose, ewes were divided into 3 groups, containing 75 primiparous sheep. A vaginal sponge containing progesterone was inserted into the animals in all groups on day 0. Seven days after this application (on the 7th day), vaginal sponges were removed and Prostaglandin F2α (PGF2α) was applied. When the vaginal sponge was removed and the PGF2α was administered, 400 IU of eCG was given to animals in Group 1 (n:75), 500 IU of eCG was administrated to animals in Group 2 (n:75), and 600 IU of eCG was injected to the ewes in Group 3. The effectiveness of different doses of eCG application on reproductive parameters such as estrous rate, pregnancy rate, multiple pregnancy rate, and the number of offspring was evaluated. While no statistical difference could be determined between the groups in terms of the stated reproductive parameters, numerically more offspring were obtained in the group in which eCG was applied at a low rate (Group 1). In the light of this information, it is concluded that 400 IU eCG can be as effective as 600 IU eCG in sexual stimulation of Kangal ewes in anestrus.
    Keywords Anestrus ; eCG ; Kangal ; Ewe ; Sexual-stimulation ; Reproduction ; Agriculture ; S ; Agriculture (General) ; S1-972
    Subject code 630
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Turkish Science and Technology Publishing (TURSTEP)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Induction of ovulation using repeated doses of sulpiride, a dopamine antagonist, in ewe lambs.

    Kivrak, Mehmet Bugra / Aydin, Ibrahim

    Reproduction in domestic animals = Zuchthygiene

    2022  Volume 58, Issue 3, Page(s) 379–386

    Abstract: This study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre-pubertal ewe lambs. Here, 12 1-3-year-old Merino rams and 60 7-9-month-old Merino sheep were included in the ...

    Abstract This study aimed to test the hypothesis that sulpiride can increase the concentration of circulating gonadotropin that can promote puberty in pre-pubertal ewe lambs. Here, 12 1-3-year-old Merino rams and 60 7-9-month-old Merino sheep were included in the study. The sheep were randomly divided into sulpiride (n = 30) and control (n = 30) groups. The sulpiride group was subcutaneously injected with 0.6 mg/kg sulpiride twice daily (morning and evening) for 9 days. During these 9 days, blood samples were taken from the sheep before drug administration and at 4 h after every drug administration. The number of ovulating animals in the sulpiride group was significantly higher than that in the control group (90% vs. 32%). No oestrous signs were observed in either group during ram release. Further, there were no differences in the levels of mean follicle-stimulating hormone in the two groups based on treatment (p = .2), time (p = .3) or treatment-by-time interaction (p = .3). After sulpiride administration, the luteinizing hormone (LH) levels of the sulpiride group rapidly increased and remained stable for a long time, whereas physiological LH fluctuations in the control group remained unchanged. Within-group changes in terms of LH concentrations were significant for both groups (p < .001), whereas LH pulse frequency was significantly different between the sulpiride group (p = .03). Therefore, it is concluded that sulpiride can be used as a non-steroidal alternative to stimulate pre-pubertal ewe lambs and sheep during anoestrus.
    MeSH term(s) Female ; Animals ; Sheep ; Sulpiride ; Dopamine Antagonists ; Sexual Maturation/physiology ; Follicle Stimulating Hormone ; Ovulation/physiology
    Chemical Substances Sulpiride (7MNE9M8287) ; Dopamine Antagonists ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2022-11-29
    Publishing country Germany
    Document type Randomized Controlled Trial, Veterinary ; Journal Article
    ZDB-ID 1015187-4
    ISSN 1439-0531 ; 0936-6768
    ISSN (online) 1439-0531
    ISSN 0936-6768
    DOI 10.1111/rda.14295
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: An investigation of ensemble learning methods in classification problems and an application on non-small-cell lung cancer data

    Mehmet Kivrak / Cemil Colak

    Medicine Science, Vol 11, Iss 2, Pp 924-

    2022  Volume 33

    Abstract: This study aims to classify NSCLC death status and consists of patient records of 24 variables created by the open-source dataset of the cancer data site. Besides, basic classifiers such as SMO (Sequential Minimal Optimization), K-NN (K-Nearest Neighbor), ...

    Abstract This study aims to classify NSCLC death status and consists of patient records of 24 variables created by the open-source dataset of the cancer data site. Besides, basic classifiers such as SMO (Sequential Minimal Optimization), K-NN (K-Nearest Neighbor), random forest, and XGBoost (Extreme Gradient Boosting), which are machine learning methods, and their performances, and voting, bagging, boosting, and stacking methods from ensemble learning methods were used. Performance evaluation of models was compared in terms of accuracy, specificity, sensitivity, precision, and Roc curve. The basic classifier performances of random forest, SMO, K-NN, and XGBoost classifiers, their performances in the bagging ensemble learning method, and their performances in the boosting ensemble learning method are evaluated. In addition, Model 1 (random forest + SMO), Model 2 (XGBoost + K-NN), Model 3 (random forest + K-NN), Model 4 (XGBoost+SMO), Model 5 (SMO+K-NN + random forest), Model 6 (SMO+K-NN+XGBoost) and Model 7 (SMO+K-NN + random forest + XGBoost) the performances of in different metrics were expressed. The boosting ensemble learning method, which provides the maximum classification performance with XGBoost, achieved a 0.982 accuracy value, 0.971 sensitivity value, 0.989 precision value, 0.989 specificity value, and 0.998 ROC curve. It is recommended to use ensemble learning methods for classification problems in patients with a high prevalence of cancer to achieve successful results. [Med-Science 2022; 11(2.000): 924-33]
    Keywords nscls ; machine learning ; ensemble learning ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 006
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Society of TURAZ AKADEMI
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  8. Article ; Online: Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication.

    Balin, Mehmet / Kıvrak, Tarık

    Cardiovascular therapeutics

    2019  Volume 2019, Page(s) 9592378

    Abstract: Background/objective: Intermittent claudication (IC) is the symptom of peripheral artery disease (PAD) and causes functional disability. Remote ischemic preconditioning (RIPC), is a phenomenon in which a short period of sub-critical ischemia, protects ... ...

    Abstract Background/objective: Intermittent claudication (IC) is the symptom of peripheral artery disease (PAD) and causes functional disability. Remote ischemic preconditioning (RIPC), is a phenomenon in which a short period of sub-critical ischemia, protects tissues against ischemia/reperfusion/injury. We considered to test the hypothesis that RIPC in PAD patients suffering from IC would increase muscle resistance to ischemia and thus improve walking-capacity.
    Materials/methods: A total of 63 patients with proven-IC underwent two treadmill tests (graded treadmill protocol) with a 28-day interval in between. Patients were consecutively assigned for the non/RIPC-group and RIPC-group procedure one by one. Patients received 5-cycles of alternating 5-minute inflation and 5-minute deflation of blood-pressure cuffs on nondominant upper-limb every day for four weeks. Initial claudication distance (ICD), total walking distance (TWD) and time to relief of claudication (TRC) were recorded during procedure.
    Results: Patients receiving-RIPC exhibited a marked increase in ICD and TWD between basal and last tests: 209.1 ± 15.4 m vs. 226 ± 15.0 m and 368.8 ± 21.0 m vs. 394 ± 19.9 m, respectively (
    Conclusion: A significant increase in ICD and TWD were observed in last/treadmill test in RIPC-group. In addition, a significant decrease in TRC was observed in last/treadmill test in RIPC-group. In non/RIPC-group, no improvement was observed in ICD, TWD and TRC.
    MeSH term(s) Aged ; Exercise Tolerance ; Female ; Humans ; Intermittent Claudication/diagnosis ; Intermittent Claudication/physiopathology ; Intermittent Claudication/therapy ; Ischemic Preconditioning/adverse effects ; Ischemic Preconditioning/methods ; Male ; Middle Aged ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/therapy ; Recovery of Function ; Regional Blood Flow ; Therapeutic Occlusion/adverse effects ; Time Factors ; Treatment Outcome ; Upper Extremity/blood supply ; Walk Test ; Walking
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2428378-2
    ISSN 1755-5922 ; 1755-5914
    ISSN (online) 1755-5922
    ISSN 1755-5914
    DOI 10.1155/2019/9592378
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Cyber-WISE: A Cyber-Physical Deep Wireless Indoor Positioning System and Digital Twin Approach.

    Karakusak, Muhammed Zahid / Kivrak, Hasan / Watson, Simon / Ozdemir, Mehmet Kemal

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 24

    Abstract: In recent decades, there have been significant research efforts focusing on wireless indoor localization systems, with fingerprinting techniques based on received signal strength leading the way. The majority of the suggested approaches require ... ...

    Abstract In recent decades, there have been significant research efforts focusing on wireless indoor localization systems, with fingerprinting techniques based on received signal strength leading the way. The majority of the suggested approaches require challenging and laborious Wi-Fi site surveys to construct a radio map, which is then utilized to match radio signatures with particular locations. In this paper, a novel next-generation cyber-physical wireless indoor positioning system is presented that addresses the challenges of fingerprinting techniques associated with data collection. The proposed approach not only facilitates an interactive digital representation that fosters informed decision-making through a digital twin interface but also ensures adaptability to new scenarios, scalability, and suitability for large environments and evolving conditions during the process of constructing the radio map. Additionally, it reduces the labor cost and laborious data collection process while helping to increase the efficiency of fingerprint-based positioning methods through accurate ground-truth data collection. This is also convenient for working in remote environments to improve human safety in locations where human access is limited or hazardous and to address issues related to radio map obsolescence. The feasibility of the cyber-physical system design is successfully verified and evaluated with real-world experiments in which a ground robot is utilized to obtain a radio map autonomously in real-time in a challenging environment through an informed decision process. With the proposed setup, the results demonstrate the success of RSSI-based indoor positioning using deep learning models, including MLP, LSTM Model 1, and LSTM Model 2, achieving an average localization error of ≤2.16 m in individual areas. Specifically, LSTM Model 2 achieves an average localization error as low as 1.55 m and 1.97 m with 83.33% and 81.05% of the errors within 2 m for individual and combined areas, respectively. These outcomes demonstrate that the proposed cyber-physical wireless indoor positioning approach, which is based on the application of dynamic Wi-Fi RSS surveying through human feedback using autonomous mobile robots, effectively leverages the precision of deep learning models, resulting in localization performance comparable to the literature. Furthermore, they highlight its potential for suitability for deployment in real-world scenarios and practical applicability.
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23249903
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Comparison of posterior segment ocular parameters of Familial mediterranean fever with homozygous M694V mutation and carriers with heterozygous M694V mutation in children.

    Kivrak, Ulviye / Köle, Mehmet Tolga / Küçük, Nuran / Akçay, Güzide

    Photodiagnosis and photodynamic therapy

    2023  Volume 43, Page(s) 103680

    Abstract: Purpose: The aim of this study is to comparatively evaluate the posterior segment ocular parameters of Familial Mediterranean fever (FMF) patients, asymptomatic FMF carriers, and the healthy controls in the pediatric age group.: Methods: The study ... ...

    Abstract Purpose: The aim of this study is to comparatively evaluate the posterior segment ocular parameters of Familial Mediterranean fever (FMF) patients, asymptomatic FMF carriers, and the healthy controls in the pediatric age group.
    Methods: The study included 30 FMF patients with homozygous M694V mutation in remission under colchicine therapy, 12 asymptomatic FMF carriers with heterozygous M694V mutation, and 41 age-sex-matched healthy controls. All patients underwent detailed eye examination, and peripapillary retinal nerve fiber layer (pRNFL) thickness, central macular thickness (CMT), subfoveal choroidal thickness (SCT), macular vascular densities, and foveal avascular zone (FAZ) areas were measured using swept-source optical coherence tomography angiography.
    Results: In this study, the mean pRNFL thickness was statistically significantly thinner (p = 0.010) in the FMF patients group compared to the FMF carriers group and the healthy control group, especially in the inferior quadrant of pRNFL (p = 0.042). The CMT in asymptomatic FMF carriers group was statistically significantly thicker than in FMF patients group (p = 0.037), especially the superior and inferior quadrants of macula were affected (p = 0.024; p = 0.020, respectively). In addition, this study showed that the changes of pRNFL thickness and CMT in pediatric patients with FMF were moderately correlated with the duration of diagnosis. There was no significant difference between the groups in terms of macular vascular densities and FAZ values.
    Conclusion: FMF is a hereditary autoinflammatory disease that causes multi-organ involvement, and this study showed that posterior segment ocular parameters could be affected not only in FMF patients but also in asymptomatic FMF carriers.
    MeSH term(s) Humans ; Child ; Familial Mediterranean Fever/genetics ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/drug therapy ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Mutation ; Optic Disk
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2023-06-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103680
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top