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Article ; Online: Comorbid depression among adults with heart failure in Ethiopia: a hospital-based cross-sectional study.

Mulugeta, Henok / Sinclair, Peter M / Wilson, Amanda

2024 Volume 24, Issue 1, Page(s) 321

Abstract: ... Millennium Medical College and St. Peter Specialized Hospital. An interviewer-administered questionnaire was ...

Abstract	Background: Depression is a common comorbidity in adults with heart failure. It is associated with poor clinical outcomes, including decreased health-related quality of life and increased morbidity and mortality. There is a lack of data concerning the extent of this issue in Ethiopia. Consequently, this study aimed to assess the prevalence of comorbid depression and associated factors among adults living with heart failure in Ethiopia. Methods: A hospital-based cross-sectional study was conducted at the cardiac outpatient clinics of two selected specialist public hospitals in Addis Ababa, Ethiopia: St. Paul's Hospital Millennium Medical College and St. Peter Specialized Hospital. An interviewer-administered questionnaire was used to collect data from 383 adults with heart failure who attended the clinics and met the inclusion criteria. Depression was measured using the Patient Health Questionnaire (PHQ-9). A binary logistic regression model was fitted to identify factors associated with depression. All statistical analyses were conducted using STATA version 17 software. Results: The mean age of the participants was 55 years. On average, participants had moderate depression, as indicated by the mean PHQ-9 score of 11.02 ± 6.14, and 217 (56.6%, 95%CI 51.53-61.68) had comorbid depression. Significant associations with depression were observed among participants who were female (AOR: 2.31, 95%CI:1.30-4.08), had comorbid diabetes mellitus (AOR: 3.16, 95%CI: 1.47-6.82), were classified as New York Heart Association (NYHA) class IV (AOR: 3.59, 95%CI: 1.05-12.30), reported poor levels of social support (AOR: 6.04, 95%CI: 2.97-12.32), and took more than five medications per day (AOR: 5.26, 95%CI: 2.72-10.18). Conclusions: This study indicates that over half of all adults with heart failure in Ethiopia have comorbid depression, influenced by several factors. The findings have significant implications in terms of treatment outcomes and quality of life. More research in the area, including interventional and qualitative studies, and consideration of multifaceted approaches, such as psychosocial interventions, are needed to reduce the burden of comorbid depression in this population.
MeSH term(s)	Humans ; Ethiopia/epidemiology ; Female ; Heart Failure/epidemiology ; Heart Failure/psychology ; Male ; Cross-Sectional Studies ; Middle Aged ; Comorbidity ; Adult ; Prevalence ; Aged ; Depression/epidemiology ; Quality of Life/psychology ; Depressive Disorder/epidemiology
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05748-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: (Table S1) Chronostratigraphic constrains for sediment core AND1-1B, supplementary data to: Naish, Tim R; Powell, Ross; Levy, R; Wilson, Gary S; Scherer, Reed P; Talarico, Franco; Krissek, Lawrence A; Niessen, Frank; Pompilio, Massimo; Wilson, Terry; Carter, Lionel; DeConto, Robert M; Huybers, P; McKay, R; Pollard, David; Ross, J; Winter, Diane M; Barrett, Peter J; Browne, G; Cody, R; Cowan, Ellen A; Crampton, J; Dunbar, Gavin B; Dunbar, N; Florindo, Fabio; Gebhardt, Andrea Catalina; Graham, IJ; Hannah, Mike J; Hansaraj, D; Harwood, David M; Helling, D; Henrys, Stuart; Hinnov, L; Kuhn, Gerhard; Kyle, Philip R; Läufer, Andreas L; Maffioli, P; Magens, Diana; Mandernack, Kevin W; McIntosh, WC; Millan, C; Morin, Roger H; Ohneiser, Christian; Paulsen, Timothy S; Persico, Davide; Raine, J Ian; Reed, J; Riesselman, C; Sagnotti, Leo; Schmitt, D R; Sjunneskog, C; Strong, P; Taviani, Marco; Vogel, Stefan; Wilch, T; Williams, Trevor (2009): Obliquity-paced Pliocene West Antarctic ice sheet oscillations. Nature, 458(7236), 322-329

Naish, Tim R / Krissek, Lawrence A / Levy, R / Niessen, Frank / Pompilio, Massimo / Powell, Ross / Scherer, Reed P / Talarico, Franco / Wilson, Gary S / al., et

2009

Abstract: ... from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf ... and atmospheric CO2 concentration was as high as ~400 p.p.m.v. (van der Burgh et al., 1993, doi:10 ... that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated ...

Abstract	Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages (Hays et al., 1976, doi:10.1126/science.194.4270.1121), fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles (Raymo and Huybers, 2008, doi:10.1038/nature06589). Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch (~5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming (Solomon et al., 2007). Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, ~40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to ~3° C warmer than today ( Kim and Crowley, 2000, doi:10.1029/1999PA000459) and atmospheric CO2 concentration was as high as ~400 p.p.m.v. (van der Burgh et al., 1993, doi:10.1126/science.260.5115.1788, Raymo et al., 1996, doi:10.1016/0377-8398(95)00048-8). The evidence is consistent with a new ice-sheet/ice-shelf model (Pollard and DeConto, 2009, doi:10.1038/nature07809) that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt (Huybers, 2006, doi:10.1126/science.1125249) under conditions of elevated CO2.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/nature07867
DOI	10.1594/PANGAEA.769658
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Chronostratigraphy of sediment core CRP-2/2A (Table 1), supplementary data to: Wilson, Gary S; Bohaty, Steven M; Fielding, Christopher R; Florindo, Fabio; Hannah, Mike J; Harwood, David M; McIntosh, WC; Naish, Tim R; Roberts, Andrew P; Sagnotti, Leo; Scherer, Reed P; Strong, C Percy; Versub, KL; Villa, Giuliana; Watkins, David K; Webb, Peter-Noel; Woolfe, Ken (2000): Chronostratigraphy of CRP-2/2A, Victoria Land Basin, Antarctica. Terra Antartica, 7(4), 647-654

Wilson, Gary S / Bohaty, Steven M / Fielding, Christopher R / Florindo, Fabio / Hannah, Mike J / Harwood, David M / McIntosh, WC / Naish, Tim R / Roberts, Andrew P / al., et

2000

Abstract: The 624.15 m glaciomarine sedimentary succession recovered in the CRP-2/2A drillcore comprises ... possible, all of which suggest that sediment accumulation rates averaged ~180 m/m.y. between unconformities ... straightforward and average sedimentation rates were much higher (>1000 m/m.y.). Between 306.65 mbsf and ...

Abstract	The 624.15 m glaciomarine sedimentary succession recovered in the CRP-2/2A drillcore comprises lower Oligocene (<c. 31 Ma) to lower Miocene (18.5 Ma) strata that are overlain by a thin succession of Pliocene and Pleistocene strata. The age model for the CRP-2/2A drillhole, as presented in this paper, is based on combined microfossil biostratigraphy. 40Ar/39Ar age on volcanic material, 87Sr/86Sr analyses on mollusc shells, and correlation of a magnetic polarity zonation to the magnetic polarity time scale (MPTS). Between 25.92 and 109.05 metres below sea floor (mbsf), several alternative correlations to the MPTS are possible, all of which suggest that sediment accumulation rates averaged ~180 <mark>m/m.y. between unconformities, although actual sedimentation rates may have been higher. Between 109.05 and 306.65 mbsf, the age model is straightforward and average sedimentation rates were much higher (>1000 m/m.y.). Between 306.65 mbsf and the bottom of the drillcore (624.15 mbsf), fewer datums are available to constrain the age model and unique correlation with the MPTS is not possible, although high average sediment accumulation rates are likely. A significant unconformity is identified at 306.65 mbsf, which may represent as much as 5 m.y. of missing time. Additional unconformities at 25.92 and 130.27 mbsf account for c. 16 and 2.5 m.y. of missing time, respectively. The Oligocene-lower Miocene interval documented in the CRP-2/2A drillcore spans about 13 million years, however, it is possible that more time is missing in sequence-bounding unconformities than is represented in the stratigraphic record recovered in the CRP-2/2A drillcore.
Language	English
Dates of publication	2000-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to hdl:10013/epic.28244.d001
DOI	10.1594/PANGAEA.189249
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Satisfaction with asynchronous e-learning: An exploratory factor analysis of the Learner Satisfaction with Asynchronous e-Learning (LSAeL) instrument.

Sinclair, Peter M / Kable, Ashly / Oldmeadow, Christopher J / Wilson, Amanda

Nurse education in practice

2024 Volume 75, Page(s) 103897

Abstract: Aim: To describe the development and psychometric testing of the Learner Satisfaction with Asynchronous e-Learning (LSAeL) instrument.: Background: Existing satisfaction with e-learning instruments may not accurately evaluate learner satisfaction ... ...

Abstract	Aim: To describe the development and psychometric testing of the Learner Satisfaction with Asynchronous e-Learning (LSAeL) instrument. Background: Existing satisfaction with e-learning instruments may not accurately evaluate learner satisfaction with constructs associated with asynchronous e-learning. Design: Methodological study. Methods: Content, face and construct validity of the instrument were evaluated using a two-stage process. A five-member expert panel evaluated the instrument's content and face validity. A content validity index and a modified kappa co-efficient was used to calculate the content validity of individual test items and the global instrument and to adjust for chance agreement between raters. These data were then reviewed and individual items were removed, retained or refined accordingly. Using an empirically informed wholly asynchronous e-learning program 237 nursing students from a regional university in New South Wales, Australia completed the 35 item LSAeL instrument. An exploratory factor analysis (EFA) was then conducted to explore the dimensionality of the instrument. Results: Exploratory factor analysis identified a seven-factor solution with 30 items, explaining an 86.1% of the total variance, was the best fit for the data. Conclusion: The study demonstrates that the construct validity of the LSAeL instrument is acceptable. Instrument development is an iterative process and further testing with other cohorts and in other settings is required.
MeSH term(s)	Humans ; Computer-Assisted Instruction ; Learning ; Personal Satisfaction ; Factor Analysis, Statistical ; Australia ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-24
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2058575-5
ISSN	1873-5223 ; 1471-5953
ISSN (online)	1873-5223
ISSN	1471-5953
DOI	10.1016/j.nepr.2024.103897
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Article ; Online: Health-related quality of life and its influencing factors among people with heart failure in Ethiopia: using the revised Wilson and Cleary model.

Mulugeta, Henok / Sinclair, Peter M / Wilson, Amanda

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20241

Abstract: Heart failure is a challenging public health problem associated with poor health-related quality of life (HRQoL). Data on the quality of life of people with heart failure are limited in Ethiopia. This study aimed to assess the HRQoL and its influencing ... ...

Abstract	Heart failure is a challenging public health problem associated with poor health-related quality of life (HRQoL). Data on the quality of life of people with heart failure are limited in Ethiopia. This study aimed to assess the HRQoL and its influencing factors in people with heart failure in Ethiopia. A hospital-based, cross-sectional study design was conducted in the cardiac outpatient clinics of two tertiary-level hospitals in Addis Ababa, Ethiopia. Data were collected from people with heart failure who met the inclusion criteria using an interviewer-administered questionnaire. The HRQoL was measured using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). A multiple linear regression model was fitted to identify factors that influenced HRQoL. All statistical analyses were conducted using STATA version 17 software. A total of 383 people with heart failure participated in the study. The mean age of the participants was 55 years. The MLHFQ score was 48.03±19.73, and 54% of participants had poor HRQoL. Multiple linear regression analysis revealed that age (β= 0.12, 95% CI 0.11, 0.28), diabetes mellitus comorbidity (β= 4.47, 95% CI 1.41, 7.54), social support score (β= - 1.48, 95% CI - 1.93, - 1.03), and depression score (β = 1.74, 95% CI 1.52, 1.96) were significant factors influencing overall HRQoL (p < 0.05). This study found that people in Ethiopia with heart failure had poor HRQoL, influenced by several factors. The findings can help health professionals identify appropriate interventions to improve the HRQoL of people with heart failure.
MeSH term(s)	Humans ; Middle Aged ; Ethiopia/epidemiology ; Cross-Sectional Studies ; Quality of Life ; Heart Failure/epidemiology ; Heart
Language	English
Publishing date	2023-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47567-x
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Article ; Online: Prevalence of depression and its association with health-related quality of life in people with heart failure in low- and middle-income countries: A systematic review and meta-analysis.

Mulugeta, Henok / Sinclair, Peter M / Wilson, Amanda

PloS one

2023 Volume 18, Issue 3, Page(s) e0283146

Abstract: Introduction: Heart failure is a growing public health concern around the world. People with heart failure have a high symptom burden, such as depression, which affects health-related quality of life (HRQoL). The objective of this systematic review and ... ...

Abstract	Introduction: Heart failure is a growing public health concern around the world. People with heart failure have a high symptom burden, such as depression, which affects health-related quality of life (HRQoL). The objective of this systematic review and meta-analysis was to estimate the pooled prevalence of depression and evaluate its association with HRQoL among people with heart failure in low- and middle-income countries (LMICs). Methods: This systematic review was conducted in accordance with the JBI methodology. Electronic databases such as MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, Scopus and JBI EBP were searched to identify relevant studies published from January 2012 to August 2022. The methodological quality of each article was assessed using relevant JBI critical appraisal instruments. A random-effects model was employed to estimate the pooled prevalence of depression. Heterogeneity across the studies was investigated using Cochrane's Q test and I2 statistic. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines 2020 were followed for reporting the results. All statistical analyses were performed using STATA version 17 software. Results: After screening, a total of 21 eligible articles with 5074 participants with heart failure were included in this review. The pooled prevalence of depression among people with heart failure in LMICs was 51.5% (95% CI = 39.7, 63.3%, I2 = 99.00%). Subgroup analysis revealed, the highest prevalence in studies whose participants were in-patients, and from the Middle East and North Africa, and studies utilizing Becks Depression Inventory (BDI). Depression was positively associated with HRQoL. Conclusion: This review revealed that almost half of all people with heart failure in low- and middle-income countries have comorbid depression. People with heart failure and depressive symptoms had poor HRQoL. Therefore, early screening of depression is critical for improving HRQoL in this population. Systematic review registration: PROSPERO CRD42022361759.
MeSH term(s)	Humans ; Prevalence ; Depression/epidemiology ; Developing Countries ; Quality of Life ; Heart Failure/complications ; Heart Failure/epidemiology
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283146
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health-related quality of life of people with heart failure in low- and middle-income countries: a systematic review and meta-analysis.

Mulugeta, Henok / Sinclair, Peter M / Wilson, Amanda

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2023 Volume 33, Issue 5, Page(s) 1175–1189

Abstract: Purpose: Heart failure is a global health concern and associated with poor health-related quality of life and increased mortality. There is a disproportionate burden on patients and health systems in low- and middle-income countries. This systematic ... ...

Abstract	Purpose: Heart failure is a global health concern and associated with poor health-related quality of life and increased mortality. There is a disproportionate burden on patients and health systems in low- and middle-income countries. This systematic review and meta-analysis estimates the health-related quality of life of people with heart failure in low- and middle-income countries. Methods: A systematic literature search was conducted to identify relevant studies from January 2012 to November 2022 using the following databases: MEDLINE, EMBASE, PsycINFO, CINAHL, Web of Science, Scopus and JBI EBP database. Study screening, quality appraisal and data extraction were conducted using JBI methodology. A random-effects model was used to perform the meta-analysis. Heterogeneity was assessed using the I Results: A total of 33 studies with 5612 participants were included in this review. The Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Short-Form-36 questionnaire (SF-36) were the most used instruments across 19 and 8 studies, respectively. The pooled mean MLHFQ and SF-36 scores using the random-effects model were 46.08 (95% CI 35.06, 57.10) and 41.23 (95% CI 36.63, 45.83), respectively. In a subgroup analysis using both instruments, the highest health-related quality-of-life scores occurred in studies with inpatient participants. Conclusion: The overall health-related quality of life of people with heart failure in low- and middle-income countries is poor. Strategies should be strategically developed to improve the health-related quality of life of people with heart failure in these countries. Systematic review registration: PROSPERO CRD42022377781.
MeSH term(s)	Humans ; Heart Failure/psychology ; Quality of Life/psychology ; Developing Countries ; Surveys and Questionnaires ; Male ; Female
Language	English
Publishing date	2023-12-09
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-023-03563-2
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Article: Endovascular removal of a large free-floating thrombus of the descending thoracic aorta using the AngioVac system.

Wilson, William R / McCusker, Kevin H / Peeran, Syed M / Dourdoufis, Peter J

Journal of vascular surgery cases and innovative techniques

2024 Volume 10, Issue 3, Page(s) 101460

Abstract: Free-floating aortic mural thrombus in the minimally diseased or nonaneurysmal aorta is a rare, clinically significant source of peripheral embolism. We describe a 41-year-old woman with a history of left brachial thromboembolectomy who presented ... ...

Abstract	Free-floating aortic mural thrombus in the minimally diseased or nonaneurysmal aorta is a rare, clinically significant source of peripheral embolism. We describe a 41-year-old woman with a history of left brachial thromboembolectomy who presented atypical chest pain. Computed tomography angiography and transesophageal echocardiography revealed a 14.0 cm × 1.4 cm mobile mass in the proximal descending thoracic aorta. The thrombus was removed through a minimally invasive catheter-based approach using the AngioVac system.
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Case Reports
ISSN	2468-4287
ISSN	2468-4287
DOI	10.1016/j.jvscit.2024.101460
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Article ; Online: Prevalence of depression and its association with health-related quality of life in people with heart failure in low- and middle-income countries

Henok Mulugeta / Peter M. Sinclair / Amanda Wilson

PLoS ONE, Vol 18, Iss

A systematic review and meta-analysis

2023 Volume 3

Abstract: Introduction Heart failure is a growing public health concern around the world. People with heart failure have a high symptom burden, such as depression, which affects health-related quality of life (HRQoL). The objective of this systematic review and ... ...

Abstract	Introduction Heart failure is a growing public health concern around the world. People with heart failure have a high symptom burden, such as depression, which affects health-related quality of life (HRQoL). The objective of this systematic review and meta-analysis was to estimate the pooled prevalence of depression and evaluate its association with HRQoL among people with heart failure in low- and middle-income countries (LMICs). Methods This systematic review was conducted in accordance with the JBI methodology. Electronic databases such as MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, Scopus and JBI EBP were searched to identify relevant studies published from January 2012 to August 2022. The methodological quality of each article was assessed using relevant JBI critical appraisal instruments. A random-effects model was employed to estimate the pooled prevalence of depression. Heterogeneity across the studies was investigated using Cochrane’s Q test and I2 statistic. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines 2020 were followed for reporting the results. All statistical analyses were performed using STATA version 17 software. Results After screening, a total of 21 eligible articles with 5074 participants with heart failure were included in this review. The pooled prevalence of depression among people with heart failure in LMICs was 51.5% (95% CI = 39.7, 63.3%, I2 = 99.00%). Subgroup analysis revealed, the highest prevalence in studies whose participants were in-patients, and from the Middle East and North Africa, and studies utilizing Becks Depression Inventory (BDI). Depression was positively associated with HRQoL. Conclusion This review revealed that almost half of all people with heart failure in low- and middle-income countries have comorbid depression. People with heart failure and depressive symptoms had poor HRQoL. Therefore, early screening of depression is critical for improving HRQoL in this population. Systematic review registration: PROSPERO ...
Keywords	Medicine ; R ; Science ; Q
Subject code	306
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence of depression and its association with health-related quality of life in people with heart failure in low- and middle-income countries

Henok Mulugeta / Peter M Sinclair / Amanda Wilson

PLoS ONE, Vol 18, Iss 3, p e

A systematic review and meta-analysis.

2023 Volume 0283146

Abstract	Introduction Heart failure is a growing public health concern around the world. People with heart failure have a high symptom burden, such as depression, which affects health-related quality of life (HRQoL). The objective of this systematic review and meta-analysis was to estimate the pooled prevalence of depression and evaluate its association with HRQoL among people with heart failure in low- and middle-income countries (LMICs). Methods This systematic review was conducted in accordance with the JBI methodology. Electronic databases such as MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, Scopus and JBI EBP were searched to identify relevant studies published from January 2012 to August 2022. The methodological quality of each article was assessed using relevant JBI critical appraisal instruments. A random-effects model was employed to estimate the pooled prevalence of depression. Heterogeneity across the studies was investigated using Cochrane's Q test and I2 statistic. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines 2020 were followed for reporting the results. All statistical analyses were performed using STATA version 17 software. Results After screening, a total of 21 eligible articles with 5074 participants with heart failure were included in this review. The pooled prevalence of depression among people with heart failure in LMICs was 51.5% (95% CI = 39.7, 63.3%, I2 = 99.00%). Subgroup analysis revealed, the highest prevalence in studies whose participants were in-patients, and from the Middle East and North Africa, and studies utilizing Becks Depression Inventory (BDI). Depression was positively associated with HRQoL. Conclusion This review revealed that almost half of all people with heart failure in low- and middle-income countries have comorbid depression. People with heart failure and depressive symptoms had poor HRQoL. Therefore, early screening of depression is critical for improving HRQoL in this population. Systematic review registration: PROSPERO ...
Keywords	Medicine ; R ; Science ; Q
Subject code	306
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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