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  1. Article ; Online: Predictive association of

    Biswas, Mohitosh

    Pharmacogenomics

    2021  Volume 22, Issue 6, Page(s) 375–381

    Abstract: Lopinavir and ritonavir are substrates of permeability glycoprotein encoded ... ...

    Abstract Lopinavir and ritonavir are substrates of permeability glycoprotein encoded by
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/genetics ; COVID-19/drug therapy ; COVID-19/genetics ; COVID-19/virology ; Humans ; Lopinavir/therapeutic use ; Polymorphism, Single Nucleotide/genetics ; Ritonavir/therapeutic use ; SARS-CoV-2/drug effects
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2020-0096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications.

    Biswas, Mohitosh / Vanwong, Natchaya / Sukasem, Chonlaphat

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1285967

    Abstract: Autism spectrum disorder (ASD) may affect family and social life profoundly. Although there is no selective pharmacotherapy for ASD, the Food and Drug Administration (FDA) has recommended risperidone/aripiprazole to treat the associated symptoms of ASD, ... ...

    Abstract Autism spectrum disorder (ASD) may affect family and social life profoundly. Although there is no selective pharmacotherapy for ASD, the Food and Drug Administration (FDA) has recommended risperidone/aripiprazole to treat the associated symptoms of ASD, such as agitation/irritability. Strong associations of some pharmacokinetic/pharmacodynamic gene variants, e.g.,
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1285967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pharmacogenomics of chloroquine and hydroxychloroquine: current evidence and future implications.

    Biswas, Mohitosh / Sukasem, Chonlaphat

    Pharmacogenomics

    2023  Volume 24, Issue 15, Page(s) 831–840

    Abstract: As substrates of CYP2C8, CYP3A4/5 and CYP2D6, chloroquine's (CQ) and hydroxychloroquine's (HCQ) efficacy and safety may be affected by variants in the genes encoding these enzymes. This paper aims to assimilate the current evidence on the ... ...

    Abstract As substrates of CYP2C8, CYP3A4/5 and CYP2D6, chloroquine's (CQ) and hydroxychloroquine's (HCQ) efficacy and safety may be affected by variants in the genes encoding these enzymes. This paper aims to assimilate the current evidence on the pharmacogenomics of CQ/HCQ and to identify risk phenotypes affecting the safety or efficacy of these drugs. It has been found that some
    MeSH term(s) Humans ; Hydroxychloroquine/adverse effects ; Chloroquine/adverse effects ; Cytochrome P-450 CYP2C8 ; Cytochrome P-450 CYP2D6/genetics ; Pharmacogenetics
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; Cytochrome P-450 CYP2C8 (EC 1.14.14.1) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Clinical pharmacogenomics implementation in Thailand: a dream come true.

    Sukasem, Chonlaphat / Biswas, Mohitosh / Lungchukiet, Palita / Sangtian, Montinee

    Pharmacogenomics

    2023  Volume 24, Issue 6, Page(s) 297–301

    MeSH term(s) Humans ; Pharmacogenetics ; Thailand ; Precision Medicine
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Global distribution of CYP2C19 risk phenotypes affecting safety and effectiveness of medications.

    Biswas, Mohitosh

    The pharmacogenomics journal

    2020  Volume 21, Issue 2, Page(s) 190–199

    Abstract: Genetic variability of CYP2C19 may affect safety or efficacy of many clinically important medications as outlined in the clinical pharmacogenetics implementation consortium (CPIC) dosing guidelines. To determine the predictive prevalence of high-risk ... ...

    Abstract Genetic variability of CYP2C19 may affect safety or efficacy of many clinically important medications as outlined in the clinical pharmacogenetics implementation consortium (CPIC) dosing guidelines. To determine the predictive prevalence of high-risk phenotypes due to CYP2C19 genetic variants collectively in the world population and to establish a correlation how the identified high-risk phenotypes may affect safety or effectiveness of drugs, this study was conducted. Frequency of CYP2C19*2, *3 and *17 alleles were obtained from 1000 Genomes project Phase III in line with Fort Lauderdale principles. Phenotypes were assigned using international standardized consensus terms based on the carrier of characteristics alleles. Association of predicted high-risk phenotypes with the safety or effectiveness of medications was gained from CPIC dosing guidelines. Ultrarapid and poor metabolizers were considered as being as high-risk phenotypes for at least ten clinically important medications. Meta-analysis of the prevalence of high-risk phenotypes showed that it was statistically significant (p<0.0001) in different ethnic groups with pooled prevalence of 27.4% (95% CI 18-37%). The present study suggests that African (37.2; 95% CI 34-41%) and European (35.4; 95% CI 31-40%) population are being at particularly higher risk of either sub therapeutic drug responses or toxicities due to combined effects of CYP2C19*2, *3 and *17 variants. Large scale clinical studies are warranted to assess clinical outcomes of these medications considering CYP2C19 pharmacogenomics effects.
    MeSH term(s) Alleles ; Cytochrome P-450 CYP2C19/genetics ; Gene Frequency/genetics ; Genotype ; Humans ; Pharmaceutical Preparations/administration & dosage ; Pharmacogenetics/methods ; Phenotype
    Chemical Substances Pharmaceutical Preparations ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1)
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2106831-8
    ISSN 1473-1150 ; 1470-269X
    ISSN (online) 1473-1150
    ISSN 1470-269X
    DOI 10.1038/s41397-020-00196-3
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    Zs.A 5806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Effects of ACEIs and ARBs on Clinical Outcomes in COVID-19 Patients

    Biswas, Mohitosh

    SSRN Electronic Journal ; ISSN 1556-5068

    A Meta-Analysis

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3605176
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Pharmacogenomics in Asians: Differences and similarities with other human populations.

    Biswas, Mohitosh / Jinda, Pimonpan / Sukasem, Chonlaphat

    Expert opinion on drug metabolism & toxicology

    2023  Volume 19, Issue 1, Page(s) 27–41

    Abstract: Introduction: Various pharmacogenomic (PGx) variants differ widely in different ethnicities. and clinical outcomes associated with these variants may also be substantially varied. Literature was searched in different databases, i.e. PubMed, ... ...

    Abstract Introduction: Various pharmacogenomic (PGx) variants differ widely in different ethnicities. and clinical outcomes associated with these variants may also be substantially varied. Literature was searched in different databases, i.e. PubMed, ScienceDirect, Web of Science, and PharmGKB, from inception to 30 June 2022 for this review.
    Areas covered: Certain PGx variants were distinctly varied in Asian populations compared to the other human populations, e.g.
    Expert opinion: Asian countries should take measures toward expanding PGx research, as well as initiatives for the purposes of obtaining clinical benefits from this newly evolving and economically viable treatment model.
    MeSH term(s) Humans ; Clopidogrel ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2D6 ; HLA-B Antigens ; Liver-Specific Organic Anion Transporter 1 ; Pharmacogenetics ; Asian/genetics
    Chemical Substances Clopidogrel (A74586SNO7) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; HLA-B Antigens ; Liver-Specific Organic Anion Transporter 1 ; SLCO1B1 protein, human
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2023.2178895
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    Zs.A 6264: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Azole antifungals and inter-individual differences in drug metabolism: the role of pharmacogenomics and precision medicine.

    Biswas, Mohitosh / Shobana, John / Jinda, Pimonpan / Sukasem, Chonlaphat

    Expert opinion on drug metabolism & toxicology

    2023  Volume 19, Issue 3, Page(s) 165–174

    Abstract: Introduction: Azole antifungal drugs are commonly prescribed to treat invasive fungal infections in various disease conditions. However, these drugs are substrates and inhibitors of cytochrome P450 (CYP) enzymes, UGT1A4, and P-gp. The genetic variants ... ...

    Abstract Introduction: Azole antifungal drugs are commonly prescribed to treat invasive fungal infections in various disease conditions. However, these drugs are substrates and inhibitors of cytochrome P450 (CYP) enzymes, UGT1A4, and P-gp. The genetic variants of CYP3A4/5, CYP2C9, CYP2C19, ABCB1, or UGT1A4 can modify the safety or effectiveness of azole antifungals.
    Areas covered: This review has collated the recent advances in the pharmacogenomics of azole antifungals pertaining to their metabolism and the safety or effectiveness of their use. A literature search was performed in PubMed from inception to the 5
    Expert opinion: Optimizing the safety or effectiveness of most azole antifungals, excluding voriconazole, through pharmacogenomics remains largely theoretical, pending laboratory assessment in future studies. However, the ample evidence of the clinically significant pharmacogenetic impacts of voriconazole, due to the CYP2C19 genetic variability, favors clinical implementation. The inconsistencies of the pharmacogenomics-based dosing guidelines for voriconazole, from different international pharmacogenomics working groups, may hinder clinicians in assimilating and applying such pharmacogenetic information into clinical practice. Consideration of drug-drug interactions along with the pharmacogenetic effects may advance the precision medicine of azole antifungals and allow greater effectiveness in clinical practice.
    MeSH term(s) Humans ; Antifungal Agents/adverse effects ; Voriconazole/pharmacology ; Pharmacogenetics ; Cytochrome P-450 CYP2C19/genetics ; Precision Medicine ; Individuality ; Azoles/pharmacology ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Azoles ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2023.2203860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Potential clinically significant life-threatening drug–drug interactions of lopinavir and ritonavir used in the treatment of COVID-19

    Biswas, Mohitosh

    Experimental Results

    2020  Volume 1

    Abstract: Abstract Potential clinically significant life-threatening drug–drug interactions (DDIs) of lopinavir (LPV) and ritonavir (RTV) used in the treatment of COVID-19 is not systematically reviewed. It was aimed to identify severe DDI pairs of LPV/RTV from ... ...

    Abstract Abstract Potential clinically significant life-threatening drug–drug interactions (DDIs) of lopinavir (LPV) and ritonavir (RTV) used in the treatment of COVID-19 is not systematically reviewed. It was aimed to identify severe DDI pairs of LPV/RTV from international resources predicted to cause life-threatening adverse drug reactions (ADRs). Severe DDI pairs predicted to cause life-threatening ADRs were identified from the FDA and Liverpool COVID-19 prescribing information of LPV/RTV. In total, 62 severe DDI pairs were identified from the FDA and Liverpool COVID-19 resources predicted to cause life-threatening ADRs in patients with COVID-19. Of these, seven unique DDI pairs (11.3%; 95% CI 3%–19%) were identified from the FDA only whereas 45 unique DDI pairs (72.6%; 95% CI 61%–84%) were identified from the Liverpool COVID-19 drug interactions resource. Of interest, only 10 DDI pairs (16.1%; 95% CI 7%–25%) were recognized by both of these drug interaction resources. Clinicians should not entirely rely on any individual DDI resource for checking life threatening ADRs of LPV/RTV in patients with COVID-19.
    Keywords covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ISSN 2516-712X
    DOI 10.1017/exp.2020.53
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Association between

    Biswas, Mohitosh / Kali, Sumaiya Khatun / Sarker, Ashish Kumar / Sukasem, Chonlaphat

    Expert opinion on drug safety

    2023  Volume 22, Issue 9, Page(s) 807–817

    Abstract: Background: Clopidogrel's responsiveness may be affected by the paraoxonase-1 (PON1) enzyme encoded by the : Research design and methods: Different databases were searched systematically for eligible studies, and risk ratio (RR) was measured using ... ...

    Abstract Background: Clopidogrel's responsiveness may be affected by the paraoxonase-1 (PON1) enzyme encoded by the
    Research design and methods: Different databases were searched systematically for eligible studies, and risk ratio (RR) was measured using RevMan software where
    Results: Nineteen studies were included consisting of 17,815 patients. It was found that patients carrying either homozygous or a combination of heterozygous and homozygous variants were not significantly associated with increased risk of MACEs compared to the non-carriers (
    Conclusions: The results suggest that the
    MeSH term(s) Humans ; Clopidogrel/adverse effects ; Polymorphism, Genetic ; Aryldialkylphosphatase/genetics ; Cardiovascular Diseases ; Genotype
    Chemical Substances Clopidogrel (A74586SNO7) ; Aryldialkylphosphatase (EC 3.1.8.1) ; PON1 protein, human (EC 3.1.8.1)
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2023.2212152
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