LIVIVO - Search results -

Search results

Result 1 - 10 of total 346

Search options

Article ; Online: Development and evaluation of a Web-based tool to estimate type 2 diabetes risk: Diab_Alert.

Barreda-Pérez, Mario / de la Torre, Isabel / López-Coronado, Miguel / Rodrigues, Joel J P C / García de la Iglesia, Teresa

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2013 Volume 19, Issue 2, Page(s) 81–87

Abstract: Objective: Diabetes and its complications are major causes of morbidity and mortality around the world. This article presents a new multilingual, mobile-compatible Web-based tool to estimate the risk of suffering from type 2 diabetes (Diab_Alert) after ... ...

Abstract	Objective: Diabetes and its complications are major causes of morbidity and mortality around the world. This article presents a new multilingual, mobile-compatible Web-based tool to estimate the risk of suffering from type 2 diabetes (Diab_Alert) after the individual answers a brief questionnaire. The rationale for building the tool is to raise the public awareness of diabetes and its consequences. People should be concerned about the fact that this disease can be prevented even in cases of prediabetes, when medication is crucial to avoid the emergence of diabetes. The application shows a message with the global risk for each user and encloses with it a graph that shows the probability of suffering from diabetes in the next 10 years, which other tools do not illustrate. This way, people at high risk can ask for advice from their physician and get basal glucose tests done more often. Subjects and methods: The questions are based on research performed by experts, mainly the Diabetes Population Risk Tool and the Finnish Diabetes Risk Score. Results: Up to April 26, 2012, 141 users have completed this test. Of this group, 125 have used the Spanish language version, and of the other participants, 7 used English, 7 used Portuguese, and 2 used French. The number of individuals who have completed the questionnaire is too small to draw conclusions, although results are not as advanced as expected. Most of them are young and hence are at low risk, but those over 45 years of age are at a higher risk, especially men. Conclusions: This tool can help users become more aware of their risk of diabetes and initiate lifestyle changes, such as improved nutrition or increased physical activity, which may reduce their risk of developing the disease. The tool has been designed to be easily translated into multiple languages and to work on multiple platforms, with a standard version for computers and a simpler version for mobile devices.
MeSH term(s)	Adult ; Aged ; Diabetes Mellitus, Type 2/prevention & control ; Female ; Humans ; Internet ; Language ; Male ; Middle Aged ; Prediabetic State/diagnosis ; Predictive Value of Tests ; Risk Assessment/methods ; Surveys and Questionnaires ; User-Computer Interface
Language	English
Publishing date	2013-02
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2012.0110
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4576: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: High dose subcutaneous Anakinra to treat acute respiratory distress syndrome secondary to cytokine storm syndrome among severely ill COVID-19 patients

Iglesias-Julián, Enrique / López-Veloso, María / de-la-Torre-Ferrera, Noelia / Barraza-Vengoechea, Julio Cesar / Delgado-López, Pedro David / Colazo-Burlato, María / Ubeira-Iglesias, Marta / Montero-Baladía, Miguel / Lorenzo-Martín, Andrés / Minguito-de-la-Iglesia, Javier / García-Muñoz, Juan Pablo / Sanllorente-Sebastián, Rodrigo / Vicente-González, Blanca / Alemán-Alemán, Ana / Buzón-Martín, Luis

J Autoimmun

Abstract: OBJECTIVE: Severely ill COVID-19 patients may end in acute respiratory distress syndrome (ARDS) and multi-organ failure. Some of them develop a systemic hyperinflammatory state produced by the massive release of inflammatory agents, known as cytokine ... ...

Abstract	OBJECTIVE: Severely ill COVID-19 patients may end in acute respiratory distress syndrome (ARDS) and multi-organ failure. Some of them develop a systemic hyperinflammatory state produced by the massive release of inflammatory agents, known as cytokine storm syndrome (CSS). Inhibition of IL-1 by Anakinra (ANK) is a potential life-saving therapy for severe CSS cases. We propose a rationale for the use of subcutaneous ANK and review our initial experience in a small cohort of severe COVID-19 CSS patients. METHODS: Retrospective cohort study of COVID-19 patients developing ARDS (PaO2/FiO2 <300) and exhibiting signs of hyperinflammation (ferritin >1000 ng/mL and/or d-dimers > 1.5 µg/mL, plus IL-6 < 40 mg/mL) that received ANK. For comparison, a propensity score matched historical cohort of patients treated with IL-6 inhibitor Tocilizumab (TCZ) was used. Patients had previously received combinations of azithromycin, hydroxy-chloroquine, and methyl-prednisolone. Laboratory findings, respiratory function and adverse effects were monitored. Resolution of ARDS within the first 7 days of treatment was considered a favorable outcome. RESULTS: Subcutaneous ANK (100 mg every 6 h) was given to 9 COVID-19 ARDS CSS patients (77.8% males). Median age was 62 years (range, 42 to 87). A TCZ cohort of 18 patients was selected by propensity score matching and treated with intravenous single dose of 600 mg for patients weighing >75 Kg, or 400 mg if < 75 Kg. Prior to treatment, median PaO2/FiO2 ratio of the ANK and TCZ cohorts were 193 and 249, respectively (p = 0.131). After 7 days of treatment, PaO2/FiO2 ratio improved in both groups to 279 (104-335) and 331 (140-476, p = 0.099) respectively. On day 7, there was significant reduction of ferritin (p = 0.046), CRP (p = 0.043), and IL-6 (p = 0.043) levels in the ANK cohort but only of CRP (p = 0.001) in the TCZ group. Favorable outcome was achieved in 55.6% and 88.9% of the ANK and TCZ cohorts, respectively (p = 0.281). Two patients that failed to respond to TCZ improved after ANK treatment. Aminotransferase levels significantly increased between day 1 and day 7 (p = 0.004) in the TCZ group. Mortality was the same in both groups (11%). There were not any opportunistic infection in the groups nor other adverse effects attributable to treatment. CONCLUSION: Overall, 55.6% of COVID-19 ARDS CSS patients treated with ANK exhibited favorable outcome, not inferior to a TCZ treated matched cohort. ANK may be a potential alternative to TCZ for patients with elevated aminotransferases, and may be useful in non-responders to TCZ.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #722639
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Correction of mandibular deviation and maxillary occlusal canting with mandibular "early" surgery and microscrews: Two case reports.

de la Iglesia, Fernando / Lopez, Anna / Mareque, Javier / Gutierrez, Javier / Walter, André / Puigdollers, Andreu

International orthodontics

2019 Volume 17, Issue 2, Page(s) 384–394

Abstract: Facial asymmetry is a common complaint in patients with facial concerns. Some patients have mandibular asymmetries that have light maxillary cant compensation due to a reduced gingival exposure. A common treatment in facial asymmetries is bimaxillary ... ...

Abstract	Facial asymmetry is a common complaint in patients with facial concerns. Some patients have mandibular asymmetries that have light maxillary cant compensation due to a reduced gingival exposure. A common treatment in facial asymmetries is bimaxillary surgery treatment. However, there are no cases of non-severe occlusal plane canting (OPC) with mandibular asymmetry treated with mandibular surgery and miniscrews for the extrusion of the maxillary molars. The aim of this article is to show how to correct mandibular asymmetries combined with OPC by making a single mandibular "early surgery" combined with the extrusion of the maxilla with miniscrews to correct the occlusal plane in order to avoid a Le Fort I surgery. This type of treatment provides lower medical costs, shorter surgeries, and less postoperative discomfort and invasion for patients.
MeSH term(s)	Bone Screws ; Cephalometry ; Dental Occlusion ; Facial Asymmetry/surgery ; Female ; Humans ; Male ; Malocclusion/diagnosis ; Malocclusion/surgery ; Mandible/surgery ; Maxilla ; Middle Aged ; Molar ; Orthodontic Anchorage Procedures/methods ; Orthodontic Appliances, Fixed ; Orthognathic Surgical Procedures/methods ; Radiography, Dental ; Tooth Movement Techniques ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-04-25
Publishing country	France
Document type	Case Reports ; Journal Article
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2019.03.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps.

Varela-Rey, Iria / de la Iglesia, Daniel / San Bruno-Ruz, Alba / Mejuto-Fernández, Rafael / Monteserín-Ron, Luzdivina / López-Diaz, Javier / García-Salom, Pedro / González-Cantalapiedra, Antonio / Manuel Brea, Jose / Piña-Márquez, Rocío / Díaz-Tomé, Victoria / González-Barcia, Miguel / Zarra-Ferro, Irene / Mondelo-García, Cristina / Dominguez-Muñoz, J Enrique / Otero-Espinar, Francisco J / Fernández-Ferreiro, Anxo

International journal of pharmaceutics

2023 Volume 635, Page(s) 122706

Abstract: Background and aims: Submucosal injection agents are widely used solutions in gastric polyp resection techniques. Currently, many different solutions are used in clinical practice, but most are not authorised for this use or are not biopharmaceutical ... ...

Abstract	Background and aims: Submucosal injection agents are widely used solutions in gastric polyp resection techniques. Currently, many different solutions are used in clinical practice, but most are not authorised for this use or are not biopharmaceutical characterised. The objective of this multidisciplinary work is to test the efficacy of a novel thermosensitive hydrogel designed specifically for this indication. Methods: A mixture design of various components (Pluronic®, hyaluronic acid and sodium alginate) was carried out to select the combination with optimal properties for this use. Three final thermosensitive hydrogels were selected on which biopharmaceutical characterisation was performed and stability and biocompatibility were analysed. Efficacy in maintaining elevation was tested ex vivo on pig mucosa and in vivo in pigs RESULTS: The mixture design allowed selection of the ideal combinations of agents for the characteristics sought. The thermosensitive hydrogels studied showed high values of hardness and viscosity at 37 °C, maintaining good syringeability. One of them demonstrated superiority in maintaining polyp elevation in the ex vivo assay and non-inferiority in the in vivo assay. Conclusion: The thermosensitive hydrogel specifically designed for this use is promising both for its biopharmaceutical characteristics and for its demonstrated efficacy. This study lays the foundation for evaluating the hydrogel in humans.
MeSH term(s)	Humans ; Animals ; Swine ; Hydrogels ; Biological Products ; Temperature ; Poloxamer ; Mucous Membrane
Chemical Substances	Hydrogels ; Biological Products ; Poloxamer (106392-12-5)
Language	English
Publishing date	2023-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.122706
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1409: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Endoscopic Pancreatic Drainage Improves Exocrine Pancreatic Function in Patients With Unresectable Pancreatic Cancer: A Double-Blind, Prospective, Randomized, Single-Center, Interventional Study.

Domínguez-Muñoz, J Enrique / de la Iglesia-García, Daniel / Nieto-García, Laura / Álvarez-Castro, Ana / San Bruno-Ruz, Alba / Monteserín-Ron, Luz / López-Díaz, Javier / Iglesias-García, Julio

Pancreas

2021 Volume 50, Issue 5, Page(s) 679–684

Abstract: Objectives: Exocrine pancreatic insufficiency is a frequent and clinically relevant complication of pancreatic cancer probably secondary to pancreatic duct obstruction. We aimed at evaluating the impact of endoscopic pancreatic drainage on pancreatic ... ...

Abstract	Objectives: Exocrine pancreatic insufficiency is a frequent and clinically relevant complication of pancreatic cancer probably secondary to pancreatic duct obstruction. We aimed at evaluating the impact of endoscopic pancreatic drainage on pancreatic function in patients with unresectable pancreatic cancer. Methods: A double-blind, prospective, randomized, single-center, interventional study was designed. Patients undergoing endoscopic retrograde cholangiopancreatography for jaundice secondary to unresectable pancreatic cancer were randomized to biliary drainage (group A) or biliopancreatic drainage (group B). Pancreatic function was evaluated by 13C-mixed triglyceride breath test before and 2 weeks after endoscopic retrograde cholangiopancreatography. Breath test result is expressed as 13C-cumulative recovery rate. Abdominal symptoms and nutritional markers were evaluated as secondary outcomes. Results: Twenty patients were included. Sixteen patients had exocrine pancreatic insufficiency, and 13 completed the study (7 in group A and 6 in group B). The median absolute improvement of 13C-cumulative recovery rate was of 23.75% (interquartile range, 9.62-31.74) after biliopancreatic drainage compared with -1.92% (interquartile range, -4.17 to 13.92) after biliary drainage (P = 0.015). Nutritional markers improved after biliopancreatic drainage, but not after biliary drainage. Conclusions: Biliopancreatic and not biliary endoscopic drainage is associated with a significant improvement of exocrine pancreatic function in patients with unresectable pancreatic cancer.
MeSH term(s)	Aged ; Aged, 80 and over ; Breath Tests ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Double-Blind Method ; Drainage/adverse effects ; Exocrine Pancreatic Insufficiency/diagnosis ; Exocrine Pancreatic Insufficiency/physiopathology ; Exocrine Pancreatic Insufficiency/therapy ; Female ; Humans ; Male ; Middle Aged ; Pancreas, Exocrine/pathology ; Pancreas, Exocrine/physiopathology ; Pancreatic Function Tests ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/physiopathology ; Pancreatic Neoplasms/therapy ; Prospective Studies ; Recovery of Function ; Spain ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001817
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2160: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Fulminant myocarditis following SARS-CoV-2 mRNA vaccination rescued with venoarterial ECMO: A report of two cases.

Vila-Olives, Rosa / Uribarri, Aitor / Martínez-Martínez, María / Argudo, Eduard / Bonilla, Camilo / Chiscano, Luis / Herrador, Lorena / Gabaldón, Alejandra / Irene Buera / Vidal, Maria / De la Iglesia, Ana / Díaz, Maria Ángeles / López, Elena / Font, Marta / Barrabés, Jose A / Riera, Jordi / Ferreira-González, Ignacio / Ferrer, Ricard

Perfusion

2023 , Page(s) 2676591231170480

Abstract: Introduction: Cases of myocarditis after COVID-19 messenger RNA (mRNA) vaccines administration have been reported. Although the majority follow a mild course, fulminant presentations may occur. In these cases, cardiopulmonary support with venoarterial ... ...

Abstract	Introduction: Cases of myocarditis after COVID-19 messenger RNA (mRNA) vaccines administration have been reported. Although the majority follow a mild course, fulminant presentations may occur. In these cases, cardiopulmonary support with venoarterial extracorporeal membrane oxygenation (V-A ECMO) may be needed. Results: We present two cases supported with V-A ECMO for refractory cardiogenic shock due to myocarditis secondary to a mRNA SARS-CoV2 vaccine. One of the cases was admitted for out-of-hospital cardiac arrest. In both, a peripheral V-A ECMO was implanted in the cath lab using the Seldinger technique. An intra-aortic balloon pump was needed in one case for left ventricle unloading. Support could be successfully withdrawn in a mean of five days. No major bleeding or thrombosis complications occurred. Whereas an endomyocardial biopsy was performed in both, a definite microscopic diagnosis just could be reached in one of them. Treatment was the same, using 1000mg of methylprednisolone/day for three days. A cardiac magnetic resonance was performed ten days after admission, showing a significant improvement of the left ventricular ejection fraction and diffuse oedema and subepicardial contrast intake in different segments. Both cases were discharged fully recovered, with CPC 1. Conclusions: COVID-19 vaccine-associated fulminant myocarditis has a high morbidity and mortality but presents a high potential for recovery. V-A ECMO should be established in cases with refractory cardiogenic shock during the acute phase.
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/02676591231170480
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2424: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Increased Risk of Mortality Associated With Pancreatic Exocrine Insufficiency in Patients With Chronic Pancreatitis.

de la Iglesia-Garcia, Daniel / Vallejo-Senra, Nicolau / Iglesias-Garcia, Julio / López-López, Andrea / Nieto, Laura / Domínguez-Muñoz, J Enrique

Journal of clinical gastroenterology

2017 Volume 52, Issue 8, Page(s) e63–e72

Abstract: Background: Pancreatic exocrine insufficiency (PEI) is a common serious complication in chronic pancreatitis (CP); however, little is known about its effect on mortality in these patients. In this study, we assessed the mortality risk of PEI in patients ...

Abstract	Background: Pancreatic exocrine insufficiency (PEI) is a common serious complication in chronic pancreatitis (CP); however, little is known about its effect on mortality in these patients. In this study, we assessed the mortality risk of PEI in patients with CP. Study: A prospective, longitudinal cohort study conducted in patients with CP under long-term follow-up. CP and PEI were diagnosed using pancreatic imaging and the C-labeled mixed triglyceride breath test, respectively. Multivariate analysis was performed to evaluate the impact of PEI and other clinical features on mortality risk. Results: Patients (N=430) were analyzed (79.1% male; mean age, 47.8 y) during a mean follow-up of 8.6±4.6 years. PEI prevalence was 29.3% and mortality was 10.9%. Most frequent causes of death were cancer (40.4%), infection (21.3%), and acute cardiovascular event (14.9%). Multivariate analyses showed associations between increased mortality and presence of PEI [hazard ratio (HR), 2.59; 95% confidence interval (CI), 1.42-4.71; P<0.003], liver cirrhosis (HR, 3.87; 95% CI, 1.95-7.69; P<0.001), age at diagnosis (HR, 1.05; 95% CI, 1.03-1.09; P<0.001), toxic etiology of CP (HR, 3.11; 95% CI, 1.11-8.70; P<0.05) and respiratory comorbidity (HR, 2.19; 95% CI, 1.12-4.31; P<0.03). Nutritional markers were significantly lower in patients with PEI versus those without PEI (P<0.001) and in those who died versus survivors (P<0.001). Conclusions: PEI was a significant independent risk factor for mortality in patients with CP. These results support further research into the optimal treatment of PEI to reduce mortality in this population.
MeSH term(s)	Adult ; Biomarkers/analysis ; Comorbidity ; Exocrine Pancreatic Insufficiency/etiology ; Exocrine Pancreatic Insufficiency/mortality ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/mortality ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2017-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000000917
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1523: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Endoscopic drainage with local infusion of antibiotics to avoid necrosectomy of infected walled-off necrosis.

Lariño-Noia, Jose / de la Iglesia-García, Daniel / González-Lopez, Jaime / Díaz-Lopez, Javier / Macías-García, Fernando / Mejuto, Rafael / Quiroga, Adriano / Mauriz, Violeta / Jardí, Andrea / Iglesias-García, Julio / Domínguez-Muñoz, J Enrique

Surgical endoscopy

2020 Volume 35, Issue 2, Page(s) 644–651

Abstract: Background: Current treatment of infected pancreatic necrosis (IPN) follows a step-up approach. Our group designed a step-up protocol that associates endoscopic drainage with local infusion of antibiotics through transmural nasocystic catheter. Aim of ... ...

Abstract	Background: Current treatment of infected pancreatic necrosis (IPN) follows a step-up approach. Our group designed a step-up protocol that associates endoscopic drainage with local infusion of antibiotics through transmural nasocystic catheter. Aim of our study was to evaluate our step-up protocol for IPN in terms of proportion of patients avoiding necrosectomy. Methods: Retrospective analysis of patients admitted with acute pancreatitis (AP) between January 2015 and December 2018. The number of patients who responded to each therapeutic step were analysed: step 1, systemic antibiotics; step 2, endoscopic transmural drainage and local infusion of antibiotics; step 3, endoscopic necrosectomy. Results: 1158 patients with AP were included. 110 patients (8.4%) suffered from necrotising pancreatitis; 48 of them had IPN (42.6% of necrotising pancreatitis) and were treated with systemic antibiotics. Nineteen patients (39.6% of IPN) responded and did not required any invasive therapy. Six patients with IPN on systemic antibiotics died within the first 4 weeks of disease before step 2 could be applied. Urgent surgical necrosectomy in the first 4 weeks was performed in three additional patients. Endoscopic drainage and local antibiotic therapy was performed in the remaining 20 patients; 9 (45% of them) did well and 9 patients underwent necrosectomy (18.7% of IPN). Two patients died on drainage. Overall mortality of the total cohort of AP was 2.53% CONCLUSIONS: Addition of local infusion of antibiotics to endoscopic drainage avoids the need of necrosectomy in half of patients with IPN not responding to systemic antibiotics.
MeSH term(s)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Drainage/methods ; Endoscopy, Digestive System/methods ; Female ; Humans ; Intraabdominal Infections/mortality ; Intraabdominal Infections/surgery ; Intraabdominal Infections/therapy ; Male ; Middle Aged ; Pancreatectomy ; Pancreatitis, Acute Necrotizing/mortality ; Pancreatitis, Acute Necrotizing/surgery ; Pancreatitis, Acute Necrotizing/therapy ; Retrospective Studies ; Stents ; Treatment Outcome ; Ultrasonography, Interventional/methods
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-020-07428-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2214: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Predictive factors of COVID-19 in patients with negative RT-qPCR.

López de la Iglesia, J / Fernández-Villa, T / Rivero, A / Carvajal, A / Bay Simon, E / Martínez Martínez, M / Argüello, H / Puente, H / Fernández Vázquez, J P

Semergen

2020 Volume 46 Suppl 1, Page(s) 6–11

Abstract: Objective: To evaluate the factors associated with false negatives in RT-qPCR in patients with mild-moderate symptoms of COVID-19.: Materials and methods: This was a cross-sectional study that used a random sample of non-hospitalized patients from ... ...

Abstract	Objective: To evaluate the factors associated with false negatives in RT-qPCR in patients with mild-moderate symptoms of COVID-19. Materials and methods: This was a cross-sectional study that used a random sample of non-hospitalized patients from the primary care management division of the Healthcare Area of Leon (58 RT-qPCR-positive cases and 52 RT-qPCR-negative cases). Information regarding symptoms was collected and all patients were simultaneously tested using two rapid diagnostic tests - RDTs (Combined - cRDT and Differentiated - dRDT). The association between symptoms and SARS-CoV-2 infection was evaluated by non-conditional logistic regression, with estimation of Odds Ratio. Results: A total of 110 subjects were studied, 52% of whom were women (mean age: 48.2±11.0 years). There were 42.3% of negative RT-qPCRs that were positive in some RDTs. Fever over 38°C (present in 35.5% of cases) and anosmia (present in 41.8%) were the symptoms most associated with SARS-CoV-2 infection, a relationship that remained statistically significant in patients with negative RT-qPCR and some positive RDT (aOR=6.64; 95%CI=1.33-33.13 and aOR=19.38; 95% CI=3.69-101.89, respectively). Conclusions: RT-qPCR is the technique of choice in the diagnosis of SARS-CoV-2 infection, but it is not exempt from false negatives. Our results show that patients who present mild or moderate symptoms with negative RT-qPCR, but with fever and/or anosmia, should be considered as suspicious cases and should be evaluated with other diagnostic methods.
MeSH term(s)	Adult ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Cross-Sectional Studies ; False Negative Reactions ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Predictive Value of Tests
Keywords	covid19
Language	English
Publishing date	2020-06-23
Publishing country	Spain
Document type	Journal Article
ISSN	1578-8865
ISSN (online)	1578-8865
DOI	10.1016/j.semerg.2020.06.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Sex-bias in the diagnosis of malnutrition in the elderly: a pilot study.

Molina-Luque, Rafael / Muñoz Díaz, Belén / Romero-Saldaña, Manuel / Martínez de la Iglesia, Jorge / Aguilera-López, María Dolores / Molina-Recio, Guillermo

Women & health

2020 Volume 61, Issue 2, Page(s) 121–132

Abstract: ... Youden´s index (J). None of the variables studied showed high precision in the diagnosis of malnutrition ... in their validity indexes. The number of lymphocytes was more accurate in women (J = 0.58), being the muscular ... circumference of the arm the best in men (J = 0.8). Regarding MNA, the Long Form version showed higher ...

Abstract	This research aimed to show that using different cutoff points for women and men in nutritional assessment through the Mini Nutritional Assessment (MNA) and different anthropometric variables, improves the diagnostic accuracy of malnutrition among people over 65 years. A cross-sectional study was carried out in a sample of 240 patients of 65 to 104 years in Córdoba (Spain) between 2013 and 2015. Excluded were those with disabling diseases that prevented informed consent. We assessed Nutritional status using the MNA and the Chang Method (Gold Standard). Global cut points per sex were determined for each independent variable using Receiver Operating Characteristic curves, choosing the best of each according to the highest Youden´s index (J). None of the variables studied showed high precision in the diagnosis of malnutrition in the elderly. Different cutoff points were found for all variables by sex, as well as variations in their validity indexes. The number of lymphocytes was more accurate in women (J = 0.58), being the muscular circumference of the arm the best in men (J = 0.8). Regarding MNA, the Long Form version showed higher sensitivity (S) in women (S = 76%) and short versions in men (S = 71% and 59%) at different cutoff points. The introduction of the sex variable seems determinant to achieve a more accurate diagnostic of malnutrition, avoiding biases derivate from a global study without considering its effect in the development of diseases.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Nutrition Assessment ; Nutritional Status ; Pilot Projects
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603396-9
ISSN	1541-0331 ; 0363-0242
ISSN (online)	1541-0331
ISSN	0363-0242
DOI	10.1080/03630242.2020.1834057
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2265: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito