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  1. Article ; Online: Nebulizer systems: a new frontier for therapeutics and targeted delivery.

    Khairnar, Sakshi V / Jain, Divya D / Tambe, Srushti M / Chavan, Yashashri R / Amin, Purnima D

    Therapeutic delivery

    2021  Volume 13, Issue 1, Page(s) 31–49

    Abstract: Drug delivery via the pulmonary route is a cornerstone in the pharmaceutical sector as an alternative to oral and parenteral administration. Nebulizer inhalation treatment offers multiple drug administration, easily employed with tidal breathing, ... ...

    Abstract Drug delivery via the pulmonary route is a cornerstone in the pharmaceutical sector as an alternative to oral and parenteral administration. Nebulizer inhalation treatment offers multiple drug administration, easily employed with tidal breathing, suitable for children and elderly, can be adapted for severe patients and visible spray ensures patient satisfaction. This review discusses the operational and mechanical characteristics of nebulizer delivery devices in terms of aerosol production processes, their usage, benefits and drawbacks that are currently shaping the contemporary landscape of inhaled drug delivery. With the advent of particle engineering, novel inhaled nanosystems can be successfully developed to increase lung deposition and decrease pulmonary clearance. The above-mentioned advances might pave the path for treating a life-threatening disorder like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is also discussed in the current state of the art.
    MeSH term(s) Administration, Inhalation ; Aerosols ; Aged ; Bronchodilator Agents ; COVID-19 ; Child ; Drug Delivery Systems ; Equipment Design ; Humans ; Lung ; Nebulizers and Vaporizers ; SARS-CoV-2
    Chemical Substances Aerosols ; Bronchodilator Agents
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2041-6008
    ISSN (online) 2041-6008
    DOI 10.4155/tde-2021-0070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive medicinal metabolites from

    Sakshi, Chavan / Harikrishnan, A / Jayaraman, Selvakumar / Choudhury, Ahana Roy / Veena, V

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 11, Page(s) 5175–5188

    Abstract: Momordica ... ...

    Abstract Momordica dioica
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Catechin ; Comorbidity ; Humans ; Hypoglycemic Agents/pharmacology ; Molecular Docking Simulation ; Momordica/metabolism ; Quercetin/pharmacology ; SARS-CoV-2 ; Triterpenes ; Viral Nonstructural Proteins/chemistry
    Chemical Substances Antiviral Agents ; Hypoglycemic Agents ; Triterpenes ; Viral Nonstructural Proteins ; Catechin (8R1V1STN48) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1868340
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  3. Article: Improvement in the Quality of Life of a Patient of Ectodermal Dysplasia with Reconstructive Surgeries.

    Deo, Kirti / Sharma, Yugal K / Shah, Bhavika / Kothari, Preeti / Chavan, Dhanraj / Sitaniya, Sakshi / Gupta, Aayush

    Journal of cutaneous and aesthetic surgery

    2019  Volume 12, Issue 4, Page(s) 244–247

    Abstract: Ectodermal dysplasias are a complex group of heterogenous, heritable disorders entailing two or more developmental abnormalities in ectodermal structures, such as hair, teeth, nails, and/or sweat glands. The most common subtype of these disorders is X- ... ...

    Abstract Ectodermal dysplasias are a complex group of heterogenous, heritable disorders entailing two or more developmental abnormalities in ectodermal structures, such as hair, teeth, nails, and/or sweat glands. The most common subtype of these disorders is X-linked hypohidrotic that significantly impairs the quality of life of its sufferers. A 15-year-old boy, who sought the treatment for protuberant lips, saddle nose, dental anomalies, fine sparse hair, decreased sweating, intolerance to heat and photosensitivity, experienced dramatic improvement in his quality of life and confidence with aesthetic correction comprising autologous fat grafting, rhinoplasty, lip reduction, microblading and comprehensive prosthodontic and orthodontic treatments undertaken in collaboration with dental and plastic surgery departments and expert psychological counseling.
    Language English
    Publishing date 2019-12-20
    Publishing country India
    Document type Case Reports
    ZDB-ID 2461107-4
    ISSN 0974-5157 ; 0974-2077
    ISSN (online) 0974-5157
    ISSN 0974-2077
    DOI 10.4103/JCAS.JCAS_17_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain.

    Yao, Zizhen / van Velthoven, Cindy T J / Kunst, Michael / Zhang, Meng / McMillen, Delissa / Lee, Changkyu / Jung, Won / Goldy, Jeff / Abdelhak, Aliya / Baker, Pamela / Barkan, Eliza / Bertagnolli, Darren / Campos, Jazmin / Carey, Daniel / Casper, Tamara / Chakka, Anish Bhaswanth / Chakrabarty, Rushil / Chavan, Sakshi / Chen, Min /
    Clark, Michael / Close, Jennie / Crichton, Kirsten / Daniel, Scott / Dolbeare, Tim / Ellingwood, Lauren / Gee, James / Glandon, Alexandra / Gloe, Jessica / Gould, Joshua / Gray, James / Guilford, Nathan / Guzman, Junitta / Hirschstein, Daniel / Ho, Windy / Jin, Kelly / Kroll, Matthew / Lathia, Kanan / Leon, Arielle / Long, Brian / Maltzer, Zoe / Martin, Naomi / McCue, Rachel / Meyerdierks, Emma / Nguyen, Thuc Nghi / Pham, Trangthanh / Rimorin, Christine / Ruiz, Augustin / Shapovalova, Nadiya / Slaughterbeck, Cliff / Sulc, Josef / Tieu, Michael / Torkelson, Amy / Tung, Herman / Cuevas, Nasmil Valera / Wadhwani, Katherine / Ward, Katelyn / Levi, Boaz / Farrell, Colin / Thompson, Carol L / Mufti, Shoaib / Pagan, Chelsea M / Kruse, Lauren / Dee, Nick / Sunkin, Susan M / Esposito, Luke / Hawrylycz, Michael J / Waters, Jack / Ng, Lydia / Smith, Kimberly A / Tasic, Bosiljka / Zhuang, Xiaowei / Zeng, Hongkui

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The mammalian brain is composed of millions to billions of cells that are organized into numerous cell types with specific spatial distribution patterns and structural and functional properties. An essential step towards understanding brain function is ... ...

    Abstract The mammalian brain is composed of millions to billions of cells that are organized into numerous cell types with specific spatial distribution patterns and structural and functional properties. An essential step towards understanding brain function is to obtain a parts list, i.e., a catalog of cell types, of the brain. Here, we report a comprehensive and high-resolution transcriptomic and spatial cell type atlas for the whole adult mouse brain. The cell type atlas was created based on the combination of two single-cell-level, whole-brain-scale datasets: a single-cell RNA-sequencing (scRNA-seq) dataset of ~7 million cells profiled, and a spatially resolved transcriptomic dataset of ~4.3 million cells using MERFISH. The atlas is hierarchically organized into five nested levels of classification: 7 divisions, 32 classes, 306 subclasses, 1,045 supertypes and 5,200 clusters. We systematically analyzed the neuronal, non-neuronal, and immature neuronal cell types across the brain and identified a high degree of correspondence between transcriptomic identity and spatial specificity for each cell type. The results reveal unique features of cell type organization in different brain regions, in particular, a dichotomy between the dorsal and ventral parts of the brain: the dorsal part contains relatively fewer yet highly divergent neuronal types, whereas the ventral part contains more numerous neuronal types that are more closely related to each other. We also systematically characterized cell-type specific expression of neurotransmitters, neuropeptides, and transcription factors. The study uncovered extraordinary diversity and heterogeneity in neurotransmitter and neuropeptide expression and co-expression patterns in different cell types across the brain, suggesting they mediate a myriad of modes of intercellular communications. Finally, we found that transcription factors are major determinants of cell type classification in the adult mouse brain and identified a combinatorial transcription factor code that defines cell types across all parts of the brain. The whole-mouse-brain transcriptomic and spatial cell type atlas establishes a benchmark reference atlas and a foundational resource for deep and integrative investigations of cell type and circuit function, development, and evolution of the mammalian brain.
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.06.531121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain.

    Yao, Zizhen / van Velthoven, Cindy T J / Kunst, Michael / Zhang, Meng / McMillen, Delissa / Lee, Changkyu / Jung, Won / Goldy, Jeff / Abdelhak, Aliya / Aitken, Matthew / Baker, Katherine / Baker, Pamela / Barkan, Eliza / Bertagnolli, Darren / Bhandiwad, Ashwin / Bielstein, Cameron / Bishwakarma, Prajal / Campos, Jazmin / Carey, Daniel /
    Casper, Tamara / Chakka, Anish Bhaswanth / Chakrabarty, Rushil / Chavan, Sakshi / Chen, Min / Clark, Michael / Close, Jennie / Crichton, Kirsten / Daniel, Scott / DiValentin, Peter / Dolbeare, Tim / Ellingwood, Lauren / Fiabane, Elysha / Fliss, Timothy / Gee, James / Gerstenberger, James / Glandon, Alexandra / Gloe, Jessica / Gould, Joshua / Gray, James / Guilford, Nathan / Guzman, Junitta / Hirschstein, Daniel / Ho, Windy / Hooper, Marcus / Huang, Mike / Hupp, Madie / Jin, Kelly / Kroll, Matthew / Lathia, Kanan / Leon, Arielle / Li, Su / Long, Brian / Madigan, Zach / Malloy, Jessica / Malone, Jocelin / Maltzer, Zoe / Martin, Naomi / McCue, Rachel / McGinty, Ryan / Mei, Nicholas / Melchor, Jose / Meyerdierks, Emma / Mollenkopf, Tyler / Moonsman, Skyler / Nguyen, Thuc Nghi / Otto, Sven / Pham, Trangthanh / Rimorin, Christine / Ruiz, Augustin / Sanchez, Raymond / Sawyer, Lane / Shapovalova, Nadiya / Shepard, Noah / Slaughterbeck, Cliff / Sulc, Josef / Tieu, Michael / Torkelson, Amy / Tung, Herman / Valera Cuevas, Nasmil / Vance, Shane / Wadhwani, Katherine / Ward, Katelyn / Levi, Boaz / Farrell, Colin / Young, Rob / Staats, Brian / Wang, Ming-Qiang Michael / Thompson, Carol L / Mufti, Shoaib / Pagan, Chelsea M / Kruse, Lauren / Dee, Nick / Sunkin, Susan M / Esposito, Luke / Hawrylycz, Michael J / Waters, Jack / Ng, Lydia / Smith, Kimberly / Tasic, Bosiljka / Zhuang, Xiaowei / Zeng, Hongkui

    Nature

    2023  Volume 624, Issue 7991, Page(s) 317–332

    Abstract: The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional ... ...

    Abstract The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional properties
    MeSH term(s) Animals ; Mice ; Brain/anatomy & histology ; Brain/cytology ; Brain/metabolism ; Datasets as Topic ; Gene Expression Profiling ; In Situ Hybridization, Fluorescence ; Neural Pathways ; Neurons/classification ; Neurons/metabolism ; Neuropeptides/metabolism ; Neurotransmitter Agents/metabolism ; RNA/analysis ; Single-Cell Gene Expression Analysis ; Transcription Factors/metabolism ; Transcriptome/genetics
    Chemical Substances Neuropeptides ; Neurotransmitter Agents ; RNA (63231-63-0) ; Transcription Factors
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06812-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A randomized trial of iron- and zinc-biofortified pearl millet-based complementary feeding in children aged 12 to 18 months living in urban slums

    Mehta, Saurabh / Huey, Samantha L. / Ghugre, Padmini S. / Potdar, Ramesh D. / Venkatramanan, Sudha / Krisher, Jesse T. / Ruth, Caleb J. / Chopra, Harsha V. / Thorat, Aparna / Thakker, Varsha / Johnson, Lynn / Powis, Laura / Raveendran, Yadurshini / Haas, Jere D. / Finkelstein, Julia L. / Udipi, Shobha A. / Rajagopalan, Kripa / Research assistants / Iyer, Shobaha R. /
    Sonawane, Janhavi / Thorat, Tejashree / Bagal, Pratiksha / Pangerkar, Pranali / Kathar, Swati J. / Kadam, Priyanka / Saw, Rinki / Saw, Chinki / Saw, Lalita / Surve, Samrutthi / Majethiya, Sona / Mishra, Sonu / Rao, Bansari / Pawar, Anupriya / Shinde, Namrata / Fernandes, Monthie / Salvi, Ashwini / Cognitive function testing administrators / Devare, Komal Vilas / Sakat, Nalini / Vapilkar-Salpe, Chhaya / CSSC staff / Chavan, Sunanda / Community health workers and project clerks / Ambre, Varsha / Arde, Ragini Milind / Babrekar, Bhagyashri C. / Bhale, Anuja Sachin / Bhosale, Sakshi Samir / Devlekar, Ankita Arun / Dhanawade, Yojina / Dhotre, Vaibhavi / Faroqie, Afroz / Fernandes, Regina / Fernandes, Steffie / Ganekar, Suvarna Chandan / Ghadi, Sangeetha / Ghag, Mayuri / Hardas, Shubhada / Hiddujikar, Shanta Pundalik / Jadhav, Neelam Narayan / Jaiswal, Shivani / Jalankar, Neelam / Kadam, Suneetha / Kanade, Janvi Avadhut / Karande, Surekha Anil / Khade, Mangal / Kumbhar, Bharti Bhimrao / Lokhande, Jyothi Raghunath / Maingade, Dipika Dipak / Martal, Lakshmi / Mathkar, Prachi Pratap / Matondkar, Satyabhama Nhanu / Mestry, Kiran Ravindra / Mohite, Tripti / Naik, Akansha A. / Narkar, Namrata / Parab, Suvarna Santosh / Pendurkar, Ankita Ashok / Qamrunisa Shah, Seetamaya Saw / Shaikh, Bashirunnisa / Shaikh, Tasleem Rafique / Shaikh, Yasmin / Sheikh, Nazma / Surve, Sheetal S. / Tamble, Aditi / Tandel, Deepa / Tivrekar, Shraddha / Warang, Aswhini / Warang, Aswini / Pendurkar, Ashwini / Study physicians / Sahariah, Sirazul Ameen / Ojha, Sanjay / Feeding center managers / Auto-rickshaw drivers / Fernandes, Anthony / Kalogi, Vittal D.

    Clinical nutrition. 2022 Apr., v. 41, no. 4

    2022  

    Abstract: Biofortification of staple crops with higher levels of micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification and other interventions to target micronutrient deficiencies in low resource ... ...

    Institution Project Sabal
    Abstract Biofortification of staple crops with higher levels of micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification and other interventions to target micronutrient deficiencies in low resource settings, particularly among vulnerable populations such as children. We aimed to determine if iron- and zinc-biofortified pearl millet (FeZnPM, Dhanashakti, ICTP-8203Fe)-based complementary feeding improves nutritional status, including iron biomarkers and growth, in children living in urban slums of Mumbai. We conducted a randomized controlled trial of FeZnPM among 223 children aged 12–18 months who were not severely anemic at baseline (hemoglobin ≥9.0 g/dL). Children were randomized to receive either FeZnPM or conventional non-biofortified pearl millet (CPM) daily for 9 months. Iron status (hemoglobin, serum ferritin), plasma zinc, and anthropometric indicators (length, weight, mid-upper arm circumference, triceps and subscapular skinfolds) were evaluated at enrollment and throughout the trial. World Health Organization (WHO) anthropometric z-scores were calculated using WHO growth standards. Primary outcomes were hemoglobin and serum ferritin concentrations, and growth, defined as WHO z-scores. An intent to treat approach was used for analyses. We used the Hodges–Lehmann–Sen test to assess the change in primary outcomes between baseline and the last visit and report corresponding 95% confidence intervals. At baseline, 67.7% of children were anemic (hemoglobin <11.0 g/dL) and 59.6% were iron deficient (serum ferritin <12.0 μg/L). FeZnPM did not significantly increase iron biomarkers or improve growth, compared to CPM. In subgroup analyses, FeZnPM improved hemoglobin concentrations in male children, and in children with iron deficiency or iron depletion (serum ferritin <25.0 μg/L) at baseline, relative to CPM. Daily consumption of FeZnPM-based complementary foods did not significantly impact iron and zinc status or growth in children living in Mumbai's urban slums. However, the intervention significantly improved hemoglobin concentrations among male children and among individuals who were iron-deficient or iron-depleted at baseline. This trial is registered with Clinicaltrials.gov (ID: NCT02233764), and Clinical Trials Registry of India (ID: REF/2014/10/007731).
    Keywords Cenchrus americanus ; World Health Organization ; anemia ; arm circumference ; biofortification ; biomarkers ; blood serum ; clinical nutrition ; complementary feeding ; ferritin ; hemoglobin ; males ; nutritional status ; randomized clinical trials ; zinc ; India
    Language English
    Dates of publication 2022-04
    Size p. 937-947.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2022.02.014
    Database NAL-Catalogue (AGRICOLA)

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