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  1. Article: Clinical frailty score as an independent predictor of outcome in COVID-19 hospitalised patients.

    Koduri, Gouri / Gokaraju, Sriya / Darda, Maria / Warrier, Vinod / Duta, Irina / Hayes, Fiona / Sayed, Iman El / Noeman-Ahmed, Yasser

    European geriatric medicine

    2021  Volume 12, Issue 5, Page(s) 1065–1073

    Abstract: Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.: Methods: Retrospective study collecting demographic and ... ...

    Abstract Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.
    Methods: Retrospective study collecting demographic and clinical characteristics of patients admitted at Southend University Hospital from 20th February to 7th May 2020.
    Results: The mean age of the cohort admitted to hospital with Covid-19 was 69.4 and 58% were over 70. Comorbidities were more frequently observed in non-survivors, whose mean Clinical Frailty Scale was significantly higher (5 vs 3) than survivors, p < 0.001. In addition, mean C-reactive protein was significantly higher.
    Conclusion: Older and frailer patients with high inflammatory markers were at risk of poor outcomes. Integrated frailty and age-based risk stratification is essential, in addition to monitoring saturation /FiO2 ratio (SFR) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes. A frailty-based risk-stratification approach, rather than age may prove more valuable when considering interventions in patients with multiple comorbidities.
    MeSH term(s) COVID-19 ; Comorbidity ; Frailty/diagnosis ; Humans ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-021-00508-1
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  2. Article ; Online: Predictors of CPAP outcome in hospitalized COVID-19 patients.

    Noeman-Ahmed, Yasser / Gokaraju, Sriya / Powrie, Duncan J / Amran, Dora A / El Sayed, Iman / Roshdy, Ashraf

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 12, Page(s) 1316–1319

    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country Australia
    Document type Letter
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13964
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4957: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Sleep-wake regularity and cardiovascular events.

    Noeman, Maryam / Sahibzada, Salman / Ahmad, Mahmood / Ahmed, Yasser

    Sleep

    2019  Volume 42, Issue 7

    MeSH term(s) Affect ; Cardiovascular Diseases ; Heart Rate ; Humans ; Sleep ; Wakefulness ; Young Adult
    Language English
    Publishing date 2019-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsz088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1475: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Anything rare is possible here: Brucellosis in London in 2012.

    Javaid, Mahvesh Rana / Farrugia, Mark / Noeman Ahmed, Yasser

    BMJ case reports

    2013  Volume 2013

    Abstract: Brucellosis is a rare zoonotic disease in the UK but endemic in parts of the world, including the Mediterranean region, South and Central America, Caribbean, Africa and Persian Gulf. Therefore, the most common routes of transmission to the UK are either ... ...

    Abstract Brucellosis is a rare zoonotic disease in the UK but endemic in parts of the world, including the Mediterranean region, South and Central America, Caribbean, Africa and Persian Gulf. Therefore, the most common routes of transmission to the UK are either through emigration or by vacationing in such endemic regions. This provides us the challenge even today, especially in the extensive multi-ethnic area of East London, in recognising the signs and symptoms of the rare disease of Brucellosis. Here, we report such a patient case of Brucellosis.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Brucellosis/diagnosis ; Brucellosis/drug therapy ; Diagnosis, Differential ; Diagnostic Imaging ; Drug Therapy, Combination ; Humans ; London ; Male ; Middle Aged ; Somalia/ethnology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2013-04-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-009178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A very sudden onset of tracheomalacia with an unknown cause.

    Javaid, Mahvesh Rana / Tan, Kai Lee / Ahmed, Yasser Noeman

    BMJ case reports

    2013  Volume 2013

    MeSH term(s) Aged ; Humans ; Male ; Tomography, X-Ray Computed ; Tracheomalacia/diagnosis ; Tracheomalacia/diagnostic imaging ; Tracheomalacia/etiology
    Language English
    Publishing date 2013-05-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-009375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predictors of CPAP outcome in hospitalised COVID-19 patients

    Ahmed, Yasser Noeman / Gokaraju, Sriya / Powrie, Duncan / Amran, Dora / El Sayed, Iman / Roshdy, Ashraf

    medRxiv

    Abstract: Introduction: Throughout March - April 2020, many patients with COVID-19 presented to Southend University Hospital with Acute Hypoxaemic Respiratory Failure (AHRF). Patients were managed in a Specialist Respiratory High Dependency Unit. We present our ... ...

    Abstract Introduction: Throughout March - April 2020, many patients with COVID-19 presented to Southend University Hospital with Acute Hypoxaemic Respiratory Failure (AHRF). Patients were managed in a Specialist Respiratory High Dependency Unit. We present our experience on the usage of continuous positive airway pressure (CPAP) therapy and possible indicators of its success in this patient group. Methods: Data from patients (n=89) requiring mechanical ventilation during the months of March to April 2020, were retrospectively collected and analysed. 37 patients received IMV (Invasive Mechanical Ventilation) without a CPAP trial beforehand. 52 patients underwent a CPAP trial, of which 21 patients successfully avoided intubation and ITU admission. Results: The 52 patients, prior to receiving CPAP had significant respiratory failure as evidenced by a low PaO2: FiO2 (PFR) (mean +/- SD 123 +/- 60 mmHg) and mean SpO2:FiO2 (SFR) (mean +/- SD: 140+/- 50). The main indicators of CPAP success were: higher SFR before and after CPAP, lower respiratory rate (RR) , lower Neutrophil to Lymphocyte ratio (NLR) and higher PFR prior to CPAP. Discussion: CPAP proved successful in 40% of COVID-19 patients presenting with AHRF. SFR, PFR, RR and NLR are predictors of such success. SFR can be used for effective real time monitoring of patients before and after CPAP to identify likelihood of success. Based on our results, we have suggested a modified CPAP management protocol in COVID-19. These findings can guide future studies and will allow improved triage of patients to either CPAP or IMV, in the event of a future COVID peak.
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.14.20130880
    Database COVID19

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  8. Article ; Online: Clinical characteristics and Outcomes of 500 patients with COVID Pneumonia : Results from a Single center (Southend University Hospital)

    Koduri, Gouri / Gokaraju, Sriya / Darda, Maria / Warrier, Vinod / Duta, Irina / Hayes, Fiona / El Sayed, Iman / Ahmed, Yasser Noeman

    medRxiv

    Abstract: Objectives To characterise the clinical features of hospitalised COVID 19 patients in a single centre during the first epidemic wave and explore potential predictive variables associated with outcomes such as mortality and the need for mechanical ... ...

    Abstract Objectives To characterise the clinical features of hospitalised COVID 19 patients in a single centre during the first epidemic wave and explore potential predictive variables associated with outcomes such as mortality and the need for mechanical ventilation, using baseline clinical parameters. Methodology We conducted a retrospective review of electronic records for demographic, clinical and laboratory data, imaging and outcomes for 500 hospitalised patients between February 20th and May 7th 2020 from Southend University Hospital, Essex, UK. Multivariate logistic regression models were used to identify risk factors relevant to outcome. Results The mean age of the cohort admitted to hospital with Covid-19, was 69.4 and 290 (58%) were over 70. The majority were Caucasians, 437 (87%) with less than 2 co-morbidities 280(56%). Most common were hypertension 186(37 %), Cardiovascular disease 178(36 %) and Diabetes 128 (26 %), represented in a larger proportion on the mortality group. Mean CFS was 4 with Non Survivors had significantly higher CFS 5 vs 3 in survivors, p<0.001. In addition, Mean CRP was significantly higher 150 vs 90, p<0.001 in Non Survivors. We observed the baseline predictors for mortality were age, CFS and CRP. Conclusions In this single centre study, older and frailer patients with more comorbidities and a higher baseline CRP and creatinine were risk factors for worse outcomes. Integrated frailty and age based risk stratification are essential, in addition to monitoring SFR (Sp02/Fi02) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.08.13.20163030
    Database COVID19

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