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  1. Article ; Online: Palatoglossus muscle involvement in oropharynx Carcinoma: A pitfall in the T4 category definition of the 8th edition of the TNM staging system?

    Tirelli, Giancarlo / Boscolo-Rizzo, Paolo

    Oral oncology

    2023  Volume 147, Page(s) 106627

    MeSH term(s) Humans ; Neoplasm Staging ; Oropharyngeal Neoplasms/pathology ; Prognosis ; Carcinoma ; Muscles/pathology ; Retrospective Studies
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106627
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  2. Article ; Online: ENT symptoms in acute COVID-19: a narrative review.

    Tirelli, Giancarlo / Boscolo-Rizzo, Paolo

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2022  Volume 42, Issue Suppl. 1, Page(s) S14–S19

    MeSH term(s) COVID-19 ; Humans
    Language English
    Publishing date 2022-06-28
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-suppl.1-42-2022-02
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  3. Article ; Online: Otolaryngologic manifestations of the ongoing outbreak of human monkeypox: ENT specialists should be on the alert.

    Boscolo-Rizzo, Paolo / Hopkins, Claire / Vaira, Luigi A

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5975–5976

    MeSH term(s) Humans ; Mpox (monkeypox)/epidemiology ; Otolaryngology ; Otolaryngologists ; Disease Outbreaks ; Pharynx
    Language English
    Publishing date 2022-08-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07601-6
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  4. Article ; Online: Smell and taste dysfunction after covid-19.

    Boscolo-Rizzo, Paolo / Polesel, Jerry / Vaira, Luigi A

    BMJ (Clinical research ed.)

    2022  Volume 378, Page(s) o1653

    MeSH term(s) COVID-19 ; Humans ; Prognosis ; SARS-CoV-2 ; Smell ; Taste Disorders/etiology
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o1653
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  5. Article ; Online: Cochlear implant cost analysis in adults: a European narrative review.

    Gatto, Annalisa / Tofanelli, Margherita / Valentinuz, Giorgio / Mascherin, Anna / Costariol, Ludovica / Rizzo, Serena / Borsetto, Daniele / Boscolo-Rizzo, Paolo / Tirelli, Giancarlo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose: The aim of this study was to provide an updated European narrative review spanning the last decade, focusing on the cost-effectiveness of cochlear implants (CIs) for adults with severe to profound post-lingual hearing loss.: Methods: This ... ...

    Abstract Purpose: The aim of this study was to provide an updated European narrative review spanning the last decade, focusing on the cost-effectiveness of cochlear implants (CIs) for adults with severe to profound post-lingual hearing loss.
    Methods: This review encompasses both prospective and retrospective approaches, as well as cross-sectional and longitudinal trials conducted on CIs in adults. All studies related to European countries (Austria, Germany, Switzerland, the Netherlands, Sweden, the UK and Poland) were conducted in English and were published between 2012 and June 2023.
    Results: Nine studies were included in the analysis. The patients' ages ranged from 18 years to over 67 years, with sample sizes ranging from 20 to 100 patients; two of these studies were focused on single-sided deafness in adults. The Markov model was identified as the most commonly utilized analysis method.
    Conclusions: This review identified a general consensus on CI cost-effectiveness, despite substantial variability among countries in factors such as observation time horizons, cost-effectiveness thresholds, methods of cost collection, discount rates, CI eligibility criteria and country-specific health systems. Generally, CIs yield positive societal benefits for working-age individuals, potentially less for seniors. Early unilateral CI enhances cost-effectiveness, highlighting the importance of prompt candidate identification. A consistent undersupply of CIs relative to the percentage of potential recipients emerged across countries. Therefore, further investigation into subcategories such as single-sided deafness is warranted, along with country-specific cost analyses. Emphasizing the significance of detailed information on health systems and associated costs and benefits is crucial for facilitating comparisons across different settings.
    Language English
    Publishing date 2024-03-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08591-3
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  6. Article ; Online: Orthonasal and retronasal odor identification in patients with parosmia.

    Li, Shubin / Boscolo-Rizzo, Paolo / Uderzo, Francesco / Tirelli, Giancarlo / Whitcroft, Katherine L / Hummel, Thomas

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 11, Page(s) 4933–4938

    Abstract: ... without parosmia, parosmic patients performed worse in odor identification for both orthonasal (F = 4.94, p = 0.03 ... and retronasal tests (F = 11.95, p < 0.01). However, an interaction effect between route of odor ... identification (orthonasal or retronasal) and parosmia status was found (F = 4.67, p = 0.03): patients ...

    Abstract Objective: To compare retronasal and orthonasal perception in parosmic COVID-19 patients, in order to determine whether COVID-19 has a differential effect on these functions.
    Methods: Using the Sniffin Sticks test battery orthonasal function was examined for odor threshold, discrimination and identification. Retronasal function was assessed using 20 tasteless aromatized powders. Gustatory function was measured using the Taste Strips test.
    Results: This study included 177 patients (127 women, 50 men; mean age 45 years), of whom 127 (72%) were hyposmic and 50 (28%) normosmic. Compared to patients without parosmia, parosmic patients performed worse in odor identification for both orthonasal (F = 4.94, p = 0.03) and retronasal tests (F = 11.95, p < 0.01). However, an interaction effect between route of odor identification (orthonasal or retronasal) and parosmia status was found (F = 4.67, p = 0.03): patients with parosmia had relatively lower retronasal scores than patients without parosmia.
    Conclusion: Our results suggest that COVID-19 may affect the olfactory mucosa differently along the anterior-posterior axis, thereby possibly contributing to the pathophysiology of parosmia. Patients with parosmia also exhibit a higher degree of impairment when odors are presented through the retronasal route during eating and drinking.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Odorants ; Smell/physiology ; COVID-19 ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology
    Language English
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08072-z
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  7. Article ; Online: Post-viral olfactory loss and parosmia.

    Liu, Zhen Yu / Vaira, Luigi Angelo / Boscolo-Rizzo, Paolo / Walker, Abigail / Hopkins, Claire

    BMJ medicine

    2023  Volume 2, Issue 1, Page(s) e000382

    Abstract: The emergence of SARS-CoV-2 has brought olfactory dysfunction to the forefront of public awareness, because up to half of infected individuals could develop olfactory dysfunction. Loss of smell-which can be partial or total-in itself is debilitating, but ...

    Abstract The emergence of SARS-CoV-2 has brought olfactory dysfunction to the forefront of public awareness, because up to half of infected individuals could develop olfactory dysfunction. Loss of smell-which can be partial or total-in itself is debilitating, but the distortion of sense of smell (parosmia) that can occur as a consequence of a viral upper respiratory tract infection (either alongside a reduction in sense of smell or as a solo symptom) can be very distressing for patients. Incidence of olfactory loss after SARS-CoV-2 infection has been estimated by meta-analysis to be around 50%, with more than one in three who will subsequently report parosmia. While early loss of sense of smell is thought to be due to infection of the supporting cells of the olfactory epithelium, the underlying mechanisms of persistant loss and parosmia remain less clear. Depletion of olfactory sensory neurones, chronic inflammatory infiltrates, and downregulation of receptor expression are thought to contribute. There are few effective therapeutic options, so support and olfactory training are essential. Further research is required before strong recommendations can be made to support treatment with steroids, supplements, or interventions applied topically or injected into the olfactory epithelium in terms of improving recovery of quantitative olfactory function. It is not yet known whether these treatments will also achieve comparable improvements in parosmia. This article aims to contextualise parosmia in the setting of post-viral olfactory dysfunction, explore some of the putative molecular mechanisms, and review some of the treatment options available.
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-0413
    ISSN (online) 2754-0413
    DOI 10.1136/bmjmed-2022-000382
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  8. Article ; Online: Post-thyroidectomy dysphonia and swallowing symptoms: The role of cricopharyngeal sphincter.

    Vaira, Luigi A / Saussez, Sven / Maniaci, Antonino / Boscolo-Rizzo, Paolo / Hans, Stephane / Lechien, Jerome R

    American journal of otolaryngology

    2023  Volume 44, Issue 4, Page(s) 103910

    MeSH term(s) Humans ; Dysphonia/etiology ; Deglutition ; Thyroidectomy/adverse effects ; Voice Disorders ; Deglutition Disorders/etiology
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.103910
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  9. Article ; Online: A narrative review of the management of pars flaccida tympanic membrane retractions without cholesteatoma.

    Bateman, Laura / Borsetto, Daniele / Boscolo-Rizzo, Paolo / Mochloulis, George / Vijendren, Ananth

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2023  Volume 48, Issue 6, Page(s) 799–808

    Abstract: Objective: Review the effectiveness of surgical and non-surgical management strategies for isolated pars flaccida and combined pars tensa and flaccida tympanic membrane retractions in preventing progression or recurrence, improving hearing and ... ...

    Abstract Objective: Review the effectiveness of surgical and non-surgical management strategies for isolated pars flaccida and combined pars tensa and flaccida tympanic membrane retractions in preventing progression or recurrence, improving hearing and preventing development of cholesteatoma.
    Design: Narrative review.
    Setting: ENT and otology services worldwide.
    Participants: Patients with non-cholesteatoma tympanic membrane retractions.
    Main ouctome measure: Changes in retraction (progression or resolution, or development of a known sequela such as perforation).
    Results: Eight full text papers are included: three randomised controlled trials and five case series or cohort studies of more than five patients (a total of 238 ears). Data exists for the use of conservative management, ventilation tubes, laser tympanoplasty, cartilage and fascia tympanoplasty, lateral attic reconstruction as well as mastoid procedures.
    Conclusion: Few high-quality studies on the management of isolated and combined pars flaccida retractions exist. For isolated pars flaccida retractions deemed to require surgical intervention, this review suggests that lateral attic reconstruction and cartilage tympanoplasty carries least risk of recurrence.
    Language English
    Publishing date 2023-07-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.14085
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  10. Article ; Online: The importance of identifying risk factors for the persistence of COVID-19 related olfactory disorders.

    Vaira, Luigi Angelo / De Riu, Giacomo / Mayo-Yáñez, Miguel / Boscolo-Rizzo, Paolo / Lechien, Jerome R

    American journal of otolaryngology

    2023  Volume 45, Issue 2, Page(s) 104114

    MeSH term(s) Humans ; COVID-19/complications ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; SARS-CoV-2 ; Risk Factors ; Smell ; Taste Disorders/etiology
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104114
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