Article ; Online: Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway.
2023 Volume 61, Issue 1, Page(s) 1364–1373
Abstract: Context: Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis ...
| Abstract | Context: Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood. Objective: To investigate the mechanism by which SMYA stabilizes AS plaques from the perspective of inhibiting vasa vasorum (VV) angiogenesis. Materials and methods: We used male Results: SMYA significantly attenuated cholesterol crystallization, and lipid accumulation in AS plaques, resulting in smaller plaque size (0.25 mm Discussion and conclusions: SMYA has a protective effect against AS, which may be related to its anti-VV angiogenesis in plaques, suggesting that SMYA has the potential as a novel botanical formulation in the treatment of AS. |
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| MeSH term(s) | Animals ; Male ; Mice ; Atherosclerosis/drug therapy ; beta Catenin ; Cyclin D1 ; RNA, Messenger ; Vasa Vasorum ; Wnt Signaling Pathway |
| Chemical Substances | beta Catenin ; Cyclin D1 (136601-57-5) ; RNA, Messenger ; si-miao-yong-an decoction |
| Language | English |
| Publishing date | 2023-08-31 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1440131-9 |
| ISSN | 1744-5116 ; 1388-0209 |
| ISSN (online) | 1744-5116 |
| ISSN | 1388-0209 |
| DOI | 10.1080/13880209.2023.2249061 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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