Article ; Online: The effect of N-acetyl cysteine on the volume of uterine leiomyoma: A randomized clinical trial.
2021 Volume 154, Issue 3, Page(s) 521–525
Abstract: Objective: To conduct a clinical trial to investigate the effect of N-acetyl cysteine (NAC), a non-hormonal drug, on the volume of leiomyoma, the most common benign tumor in women.: Methods: This study is a randomized clinical trial, which was ... ...
Abstract | Objective: To conduct a clinical trial to investigate the effect of N-acetyl cysteine (NAC), a non-hormonal drug, on the volume of leiomyoma, the most common benign tumor in women. Methods: This study is a randomized clinical trial, which was performed in Semnan, Iran. Eligible women who were diagnosed with uterine leiomyoma using vaginal ultrasound were randomly assigned to receive NAC or placebo for 12 weeks. The change in the volume of Leiomyoma was considered to be the main variable in the efficacy evaluation. Reduction in the leiomyoma volume was calculated after intervention and data were entered in SPSS version 23. Results: Fifty individuals were enrolled in our study. 25 women received NAC, while 25 women took placebo. The mean volume of leiomyoma in group A was 5.71 cm Conclusion: Although this trial recommends the use of NAC as a non-hormonal drug in the treatment of leiomyoma of the uterus, the possibility of treatment failure in controlling abnormal uterine bleeding cannot be ignored. Nevertheless, we can say it is feasible and effective in the reduction of leiomyoma volume. |
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MeSH term(s) | Acetylcysteine ; Female ; Humans ; Iran ; Leiomyoma/drug therapy ; Uterine Neoplasms/drug therapy |
Chemical Substances | Acetylcysteine (WYQ7N0BPYC) |
Language | English |
Publishing date | 2021-02-23 |
Publishing country | United States |
Document type | Journal Article ; Randomized Controlled Trial |
ZDB-ID | 80149-5 |
ISSN | 1879-3479 ; 0020-7292 |
ISSN (online) | 1879-3479 |
ISSN | 0020-7292 |
DOI | 10.1002/ijgo.13611 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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