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  1. Article ; Online: The Development of a Sulfamate-Tethered Aza-Michael Cyclization Allows for the Preparation of (-)-Negamycin

    Joshi, Harshit / Nirpal, Appasaheb K / Paul, Debobrata / Kelley, Steven P / Mague, Joel T / Sathyamoorthi, Shyam

    The Journal of organic chemistry

    2024  Volume 89, Issue 8, Page(s) 5911–5916

    Abstract: We present the first examples of intramolecular aza-Michael cyclizations of sulfamates and ...

    Abstract We present the first examples of intramolecular aza-Michael cyclizations of sulfamates and sulfamides onto pendant α,β-unsaturated esters, thioesters, amides, and nitriles. Stirring the substrate with catalytic quantities of the appropriate base delivers the product in good yield and excellent diastereoselectivity. The reactions are operationally simple, can be performed open to air, and are tolerant of a variety of important functional groups. We highlight the utility of this technology by using it in the preparation of a (-)-negamycin derivative.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.4c00604
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  2. Article ; Online: An interview with Michael Samuel - Tumour Microenvironment Laboratory, Centre for Cancer Biology, SA Pathology and University of South Australia.

    Samuel, Michael S / Van, Lena / Trevorrow, Paul

    Cytoskeleton (Hoboken, N.J.)

    2023  Volume 80, Issue 3-4, Page(s) 58–59

    MeSH term(s) Humans ; Tumor Microenvironment ; Neoplasms ; Australia ; Biology
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Interview
    ZDB-ID 2534372-5
    ISSN 1949-3592 ; 1949-3584
    ISSN (online) 1949-3592
    ISSN 1949-3584
    DOI 10.1002/cm.21744
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1840: Show issues Location:
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  3. Article ; Online: Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains.

    Williams, Tyrell J / Jeevarathinam, Ananthakrishnan S / Jivan, Faraz / Baldock, Victoria / Kim, Paul / McShane, Michael J / Alge, Daniel L

    Journal of materials chemistry. B

    2023  Volume 11, Issue 8, Page(s) 1749–1759

    Abstract: Continuous glucose monitoring (CGM) devices have the potential to lead to better disease management and improved outcomes in patients with diabetes. Chemo-optical glucose sensors offer a promising, accurate, long-term alternative to the current CGMs that ...

    Abstract Continuous glucose monitoring (CGM) devices have the potential to lead to better disease management and improved outcomes in patients with diabetes. Chemo-optical glucose sensors offer a promising, accurate, long-term alternative to the current CGMs that require frequent calibration and replacement. Recently, we have proposed glucose sensor designs using phosphorescence lifetime-based measurement of chemo-optical glucose sensing microdomains embedded within alginate hydrogels. Due to the poor long-term stability of calcium-crosslinked alginate, we propose poly(ethylene glycol) (PEG) hydrogels synthesized
    MeSH term(s) Humans ; Glucose ; Calcium ; Blood Glucose Self-Monitoring ; Blood Glucose ; Biocompatible Materials/chemistry ; Sulfhydryl Compounds ; Hydrogels/chemistry ; Polyethylene Glycols/chemistry ; Biosensing Techniques ; Alginates/chemistry
    Chemical Substances Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP) ; Blood Glucose ; Biocompatible Materials ; Sulfhydryl Compounds ; Hydrogels ; Polyethylene Glycols (3WJQ0SDW1A) ; Alginates
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb02339c
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  4. Article ; Online: Michael Soulé (1936-2020).

    Inouye, David W / Ehrlich, Paul R

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6505, Page(s) 777

    MeSH term(s) Conservation of Natural Resources/history ; History, 20th Century ; History, 21st Century ; Natural History/history ; United States
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abd6925
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  5. Article ; Online: Interview with the Hon. Dr Michael Wooldridge

    Michael Wooldridge / Paul Grogan

    Public Health Research & Practice, Vol 30, Iss

    tobacco control was the best buy in health then and it’s still the best buy now

    2020  Volume 3

    Abstract: ... sponsorship of international sporting events. The Honourable Dr Michael Wooldridge, Minister for Health ...

    Abstract The late 1990s marked a turning point for tobacco control in Australia. In March 1996, the Liberal-National Coalition won government after 13 years of Labor rule. Prime Minister John Howard had campaigned on cutting expenditure, and had long been a proponent of small government and the private sector. Yet within 2 years of taking office, the Howard Government funded Australia’s first big budget National Tobacco Campaign and commenced a review of the Tobacco Advertising Prohibition Act 1992 to phase out industry sponsorship of international sporting events. The Honourable Dr Michael Wooldridge, Minister for Health from 1996 to his retirement from politics in 2001, reflects on how these reforms to tobacco control were achieved and how the public health community can best engage with policy makers to advocate for reform. He stresses the importance of public health not being defined by ideology, and that politicians must be scientifically well informed and supported in doing what is in the nation’s best interest for public health. He assesses the current state of play and argues more investment in tobacco control is needed today, suggesting it remains the “best buy” in health.
    Keywords tobacco control ; australia ; politics ; Public aspects of medicine ; RA1-1270
    Subject code 340
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Sax Institute
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Literary Pediatric Retina Fellowship With Michael T. Trese, MD.

    Wood, Edward H / Moshfeghi, Darius M / Capone, Antonio / Williams, George A / Blumenkranz, Mark S / Sieving, Paul A / Harper, Clio Armitage / Hartnett, M Elizabeth / Drenser, Kimberly A

    Ophthalmic surgery, lasers & imaging retina

    2023  Volume 54, Issue 12, Page(s) 701–712

    Abstract: Michael T. Trese, MD (1946-2022), a vitreoretinal surgeon, made significant contributions ...

    Abstract Michael T. Trese, MD (1946-2022), a vitreoretinal surgeon, made significant contributions to the field of retina. Although most known for his work in pediatric retina surgery, he was a pioneer in areas such as medical retina, translational research, and telemedicine. This article reviews his major contributions to spread his knowledge more widely to vitreoretinal trainees and specialists. We discuss six areas where Trese made a lasting impact: lens-sparing vitrectomy, familial exudative vitreoretinopathy, congenital X-linked retinoschisis, autologous plasmin enzyme, regenerative medicine, and telemedicine.
    MeSH term(s) Male ; Child ; Humans ; Fellowships and Scholarships ; Retina/surgery ; Familial Exudative Vitreoretinopathies/surgery ; Vitreous Body ; Retinoschisis/surgery ; Vitrectomy/methods
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20231020-01
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    Zs.A 756: Show issues Location:
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  7. Article: 'Introducing Michael Gove to

    Michael Garrett, Paul

    British journal of social work

    2015  Volume 46, Issue 4, Page(s) 873–889

    Abstract: In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition ...

    Abstract In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.
    Language English
    Publishing date 2015-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2012767-4
    ISSN 1468-263X ; 0045-3102
    ISSN (online) 1468-263X
    ISSN 0045-3102
    DOI 10.1093/bjsw/bcv024
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  8. Article: Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(

    Chaheine, Christian M / Song, Conner J / Gladen, Paul T / Romo, Daniel

    Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals

    2022  Volume 98, Page(s) 194–226

    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2247669-6
    ISSN 0078-6209
    ISSN 0078-6209
    DOI 10.15227/orgsyn.098.0194
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  9. Article: James Michael Evans

    Evans, Paul

    Veterinary record. 2020 Feb., v. 186, no. 7

    2020  

    Abstract: After working in a successful small animal practice, he joined the pharmaceutical industry. He became an author of books for pet owners and the profession, and set up the Pet Health Counsellor programme. ...

    Abstract After working in a successful small animal practice, he joined the pharmaceutical industry. He became an author of books for pet owners and the profession, and set up the Pet Health Counsellor programme.
    Keywords occupations ; pharmaceutical industry ; small animal practice
    Language English
    Dates of publication 2020-02
    Size p. 225.
    Publishing place BMJ Publishing Group Limited
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1136/vr.m683
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3145: Show issues

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  10. Article ; Online: Aza-Michael Addition in Explicit Solvent: A Relative Energy Gradient-Interacting Quantum Atoms Study.

    Cador, Aël / Tognetti, Vincent / Joubert, Laurent / Popelier, Paul L A

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2023  Volume 24, Issue 24, Page(s) e202300529

    Abstract: Aza-Michael additions are key reactions in organic synthesis. We investigate, from a theoretical ...

    Abstract Aza-Michael additions are key reactions in organic synthesis. We investigate, from a theoretical and computational point of view, several examples ranging from weak to strong electrophiles in dimethylsulfoxide treated as explicit solvent. We use the REG-IQA method, which is a quantum topological energy decomposition (Interacting Quantum Atoms, IQA) coupled to a chemical-interpretation calculator (Relative Energy Gradient, REG). We focus on the rate-limiting addition step in order to unravel the different events taking place in this step, and understand the influence of solvent on the reaction, with an eye on predicting the Mayr electrophilicity. For the first time, a link is established between an REG-IQA analysis and experimental values.
    Language English
    Publishing date 2023-11-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2025223-7
    ISSN 1439-7641 ; 1439-4235
    ISSN (online) 1439-7641
    ISSN 1439-4235
    DOI 10.1002/cphc.202300529
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