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  1. Article ; Online: Future Perspectives in the Diagnosis and Treatment of Sepsis and Septic Shock.

    Karampela, Irene / Fragkou, Paraskevi C

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 7

    Abstract: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, represents the primary cause of death due to infection [ ... ]. ...

    Abstract Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, represents the primary cause of death due to infection [...].
    MeSH term(s) Humans ; Sepsis/diagnosis ; Sepsis/therapy ; Shock, Septic/diagnosis ; Shock, Septic/therapy
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58070844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Future Perspectives in the Diagnosis and Treatment of Sepsis and Septic Shock

    Irene Karampela / Paraskevi C. Fragkou

    Medicina, Vol 58, Iss 7, p

    2022  Volume 844

    Abstract: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, represents the primary cause of death due to infection [.] ...

    Abstract Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, represents the primary cause of death due to infection [.]
    Keywords n/a ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pupillary light response abnormalities in Miller Fisher syndrome.

    Vrettou, Charikleia S / Fragkou, Paraskevi C / Trigkidis, Kyriakos / Charalampaki, Elpida

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1406–1407

    MeSH term(s) Humans ; Miller Fisher Syndrome/diagnosis ; Light ; Pupil
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07222-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Serious complications of COVID-19 vaccines: A mini-review.

    Fragkou, Paraskevi C / Dimopoulou, Dimitra

    Metabolism open

    2021  Volume 12, Page(s) 100145

    Abstract: Τhe most promising approach of fighting COVID-19 and restraining the course of this pandemic is indisputably the universal vaccination of the population with safe and effective vaccines. However, besides the common and usually mild side effects of the ... ...

    Abstract Τhe most promising approach of fighting COVID-19 and restraining the course of this pandemic is indisputably the universal vaccination of the population with safe and effective vaccines. However, besides the common and usually mild side effects of the authorized vaccines, some rare, major adverse reactions are increasingly being reported worldwide during the post marketing surveillance phase of vaccines' circulation, such as anaphylaxis, vaccine-induced thrombotic thrombocytopenia, myopericarditis and Guillain-Barré syndrome. Despite rare cases with complications from COVID-19 vaccines, the net benefit-risk ratio shows a clearly favorable balance towards COVID-19 vaccination for all age and sex groups. Vaccine adverse events should be identified early and monitored closely. As many aspects of these adverse effects remain still obscure for the medical community and the relevant stakeholders, it is also highly important to be promptly reported. Nonetheless, these complications should not constitute a reason to change the vaccine policy and further studies are needed to alleviate concerns and reluctance to COVID-19 vaccinations.
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2021.100145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Immune response to respiratory viruses and respiratory viral infections in susceptible populations.

    Fragkou, Paraskevi C / Dimopoulou, Dimitra / De Angelis, Giulia / Menchinelli, Giulia / Chemaly, Roy F / Skevaki, Chrysanthi

    Frontiers in medicine

    2023  Volume 10, Page(s) 1330265

    Language English
    Publishing date 2023-11-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1330265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review.

    Vrettou, Charikleia S / Fragkou, Paraskevi C / Mallios, Ioannis / Barba, Chrysanthi / Giannopoulos, Charalambos / Gavrielatou, Evdokia / Dimopoulou, Ioanna

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Pupillometry, an integral component of neurological examination, serves to evaluate both pupil size and reactivity. The conventional manual assessment exhibits inherent limitations, thereby necessitating the development of portable automated infrared ... ...

    Abstract Pupillometry, an integral component of neurological examination, serves to evaluate both pupil size and reactivity. The conventional manual assessment exhibits inherent limitations, thereby necessitating the development of portable automated infrared pupillometers (PAIPs). Leveraging infrared technology, these devices provide an objective assessment, proving valuable in the context of brain injury for the detection of neuro-worsening and the facilitation of patient monitoring. In cases of mild brain trauma particularly, traditional methods face constraints. Conversely, in severe brain trauma scenarios, PAIPs contribute to neuro-prognostication and non-invasive neuromonitoring. Parameters derived from PAIPs exhibit correlations with changes in intracranial pressure. It is important to acknowledge, however, that PAIPs cannot replace invasive intracranial pressure monitoring while their widespread adoption awaits robust support from clinical studies. Ongoing research endeavors delve into the role of PAIPs in managing critical neuro-worsening in brain trauma patients, underscoring the non-invasive monitoring advantages while emphasizing the imperative for further clinical validation. Future advancements in this domain encompass sophisticated pupillary assessment tools and the integration of smartphone applications, emblematic of a continually evolving landscape.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial for Special Issue "Multidrug-Resistant Pathogens".

    Koulenti, Despoina / Fragkou, Paraskevi C / Tsiodras, Sotirios

    Microorganisms

    2020  Volume 8, Issue 9

    Abstract: The era of injudicious use of antibiotics in both humans and animals has led to the selection of multidrug-resistant (MDR) pathogens, which in turn has left the medical community with limited therapeutic options [ ... ]. ...

    Abstract The era of injudicious use of antibiotics in both humans and animals has led to the selection of multidrug-resistant (MDR) pathogens, which in turn has left the medical community with limited therapeutic options [...].
    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8091383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Early Life Nutrition on Children's Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome.

    Fragkou, Paraskevi C / Karaviti, Dareilena / Zemlin, Michael / Skevaki, Chrysanthi

    Frontiers in immunology

    2021  Volume 12, Page(s) 644269

    Abstract: The first 1000 days of life, including the intrauterine period, are regarded as a fundamental stepping stone for the development of a human. Unequivocally, nutrition during this period plays a key role on the proper development of a child, both directly ... ...

    Abstract The first 1000 days of life, including the intrauterine period, are regarded as a fundamental stepping stone for the development of a human. Unequivocally, nutrition during this period plays a key role on the proper development of a child, both directly through the intake of essential nutrients and indirectly by affecting the composition of the gut microbiota. The gut microbiota, including bacteria, viruses, fungi, protists and other microorganisms, is a highly modifiable and adaptive system that is influenced by diet, lifestyle, medicinal products and the environment. Reversely, it affects the immune system in multiple complex ways. Many noncommunicable diseases (NCDs) associated with dysbiosis are "programmed" during childhood. Nutrition is a potent determinant of the children's microbiota composition and maturation and, therefore, a strong determinant of the NCDs' programming. In this review we explore the interplay between nutrition during the first 1000 days of life, the gut microbiota, virome and mycobiome composition and the development of NCDs.
    MeSH term(s) Child ; Child Nutritional Physiological Phenomena/immunology ; Gastrointestinal Microbiome/immunology ; Humans ; Immune System/growth & development ; Immune System/microbiology ; Mycobiome/immunology ; Noncommunicable Diseases ; Virome/immunology
    Language English
    Publishing date 2021-03-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.644269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Myeloid CD169/Siglec1: An immunoregulatory biomarker in viral disease.

    Herzog, Silva / Fragkou, Paraskevi C / Arneth, Borros M / Mkhlof, Samr / Skevaki, Chrysanthi

    Frontiers in medicine

    2022  Volume 9, Page(s) 979373

    Abstract: CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated molecular structures, which are found among various pathogenic and non- ... ...

    Abstract CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated molecular structures, which are found among various pathogenic and non-pathogenic ligands. Recent data suggest that CD169 may represent a promising new biomarker in acute respiratory and non-respiratory viral infections, such as SARS-CoV-2, Respiratory syncytial virus (RSV) and Human immunodeficiency virus (HIV). Therein lies a great potential to sufficiently differentiate viral from bacterial infection, which has been an incessant challenge in the clinical management of infectious disease. CD169 equips myeloid cells with functions, reaching far beyond pathogen elimination. In fact, CD169 seems to crosslink innate and adaptive immunity by antigen presentation and consecutive pathogen elimination, embodying a substantial pillar of immunoregulation. Yet, our knowledge about the kinetics, mechanisms of induction, signaling pathways and its precise role in host-pathogen interaction remains largely obscure. In this review, we describe the role of CD169 as a potentially novel diagnostic biomarker for respiratory viral infection by evaluating its strengths and weaknesses and considering host factors that are involved in pathogenesis of virus infection. Finally, this brief review aims to point out shortcomings of available evidence, thus, guiding future work revolving the topic.
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.979373
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  10. Article ; Online: Nosocomial pneumonia diagnosis revisited.

    Koulenti, Despoina / Zhang, Yuchi / Fragkou, Paraskevi C

    Current opinion in critical care

    2020  Volume 26, Issue 5, Page(s) 442–449

    Abstract: Purpose of review: Nosocomial pneumonia represents a significant burden even for the most resilient healthcare systems. Timely and reliable diagnosis is critical but remains a deficient field. This review critically revises the latest literature on the ... ...

    Abstract Purpose of review: Nosocomial pneumonia represents a significant burden even for the most resilient healthcare systems. Timely and reliable diagnosis is critical but remains a deficient field. This review critically revises the latest literature on the diagnosis of nosocomial pneumonia, including advances in imaging techniques, as well as the utility of rapid microbiological tests in establishing the etiological diagnosis.
    Recent findings: Studies on low radiation computed tomography (CT) and lung ultrasound (LUS) have shown promising results for early nosocomial pneumonia diagnosis; however, further data on their sensitivity and specificity are needed, especially for picking up subtle and nonspecific radiographic findings. Moreover, data supporting their superiority in pneumonia diagnosis is still limited. As for microbiological diagnosis, several culture-independent molecular diagnostic techniques have been developed, identifying both causative microorganisms as well as determinants of antimicrobial resistance, but more studies are needed to delineate their role in nosocomial pneumonia diagnosis.
    Summary: The development of nonculture dependent tests has launched a new era in microbiological nosocomial pneumonia diagnosis. These modalities along with the use of LUS and/or low radiation CT might improve the sensitivity and specificity of nosocomial pneumonia diagnosis, enhance early detection and guide the antimicrobial therapy but more studies are needed to further evaluate them and determine their role for the routine clinical practice.
    MeSH term(s) Cross Infection/diagnosis ; Healthcare-Associated Pneumonia/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Pneumonia/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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