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  1. Article ; Online: Special Issue: "Drug Repurposing for Cancer Therapies".

    Xavier, Cristina P R / Palmeira, Andreia

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Cancer is one of the primary global causes of death, thus addressing cancer therapy remains a significant challenge, especially in cases where cancers exhibit resistance to treatment [ ... ]. ...

    Abstract Cancer is one of the primary global causes of death, thus addressing cancer therapy remains a significant challenge, especially in cases where cancers exhibit resistance to treatment [...].
    MeSH term(s) Humans ; Drug Repositioning ; Neoplasms/drug therapy
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Correction: Palmeira et al. Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection.

    Palmeira, Andreia / Sousa, Emília / Köseler, Aylin / Sabirli, Ramazan / Gören, Tarık / Türkçüer, İbrahim / Kurt, Özgür / Pinto, Madalena M / Vasconcelos, M Helena

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: There was an error in the original publication [ ... ]. ...

    Abstract There was an error in the original publication [...].
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment.

    Sousa, Sofia Martins / Xavier, Cristina Pinto Ribeiro / Vasconcelos, Maria Helena / Palmeira, Andreia

    Current topics in medicinal chemistry

    2023  Volume 23, Issue 13, Page(s) 1171–1195

    Abstract: Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the ... ...

    Abstract Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is timesaving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing candidates have been identified in silico screening and in vitro methodologies. One of the best examples is non-steroidal anti-inflammatory drugs (NSAIDs). Tumor-promoting inflammation is one of the hallmarks of cancer, revealing a connection between inflammatory processes and tumor progression and development. This explains why using NSAIDs in the context of neoplasia has become a topic of interest. Indeed, identifying NSAIDs with antitumor activity has become a promising strategy for finding novel cancer treatment opportunities. Indeed, several commercial anti-inflammatory drugs, including aspirin, ibuprofen, diclofenac, celecoxib, tepoxalin and cyclovalone, naproxen, and indomethacin have presented antitumor activity, and some of them are already in clinical trials for cancer treatment. However, the benefits and complications of using NSAIDs for cancer treatment must be carefully evaluated, particularly for cancer patients with no further therapeutic options available. This review article provides insight into the drug repurposing strategy and describes some of the well-known NSAIDs that have been investigated as repurposed drugs with potential anticancer activity.
    MeSH term(s) Humans ; Drug Repositioning ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Naproxen/adverse effects ; Anti-Inflammatory Agents ; Neoplasms/drug therapy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Naproxen (57Y76R9ATQ) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-28
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026623666230130150029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Photomodulation Approaches to Overcome Antimicrobial Resistance.

    Sarabando, Sofia N / Palmeira, Andreia / Sousa, Maria Emília / Faustino, Maria Amparo F / Monteiro, Carlos J P

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) ...

    Abstract Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs) containing azobenzene moieties (PHOTACs) and photocleavable protecting groups (photocaged PROTACs) are also mentioned. Furthermore, porphyrins are referenced as successful photoactive compounds in a clinical context, such as in the photodynamic therapy of tumours as well as preventing antimicrobial resistance, namely in bacteria. Porphyrins combining photoswitches and photocleavage systems are highlighted, taking advantage of both photopharmacology and photodynamic action. Finally, porphyrins with antibacterial activity are described, taking advantage of the synergistic effect of photodynamic treatment and antibiotic therapy to overcome bacterial resistance.
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Structure-Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization.

    Moreira, Joana / Loureiro, Joana B / Correia, Danilo / Palmeira, Andreia / Pinto, Madalena M / Saraiva, Lucília / Cidade, Honorina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: We previously reported that ... ...

    Abstract We previously reported that chalcone
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16101354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Targeted and Self-Adjuvated Nanoglycovaccine Candidate for Cancer Immunotherapy.

    Freitas, Rui / Ferreira, Eduardo / Miranda, Andreia / Ferreira, Dylan / Relvas-Santos, Marta / Castro, Flávia / Santos, Beatriz / Gonçalves, Martina / Quintas, Sofia / Peixoto, Andreia / Palmeira, Carlos / Silva, André M N / Santos, Lúcio Lara / Oliveira, Maria José / Sarmento, Bruno / Ferreira, José Alexandre

    ACS nano

    2024  Volume 18, Issue 14, Page(s) 10088–10103

    Abstract: Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found in healthy human tissues. This presents a valuable approach for ... ...

    Abstract Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found in healthy human tissues. This presents a valuable approach for designing targeted therapeutics, including cancer glycovaccines, which could potentially promote antigen recognition and foster the immune response to control disease spread and prevent relapse. In this study, we describe an adjuvant-free poly(lactic-
    MeSH term(s) Humans ; Lectins/metabolism ; Glycosylation ; Glycopeptides/metabolism ; Neoplasms/therapy ; Neoplasms/metabolism ; Immunotherapy/methods ; Dendritic Cells ; Nanoparticles
    Chemical Substances Lectins ; Glycopeptides
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c12487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion.

    Gaiteiro, Cristiana / Soares, Janine / Relvas-Santos, Marta / Peixoto, Andreia / Ferreira, Dylan / Paulo, Paula / Brandão, Andreia / Fernandes, Elisabete / Azevedo, Rita / Palmeira, Carlos / Freitas, Rui / Miranda, Andreia / Osório, Hugo / Prieto, Jesús / Lima, Luís / Silva, André M N / Santos, Lúcio Lara / Ferreira, José Alexandre

    Theranostics

    2022  Volume 12, Issue 7, Page(s) 3150–3177

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Alternative Splicing/genetics ; Cell Line, Tumor ; Female ; Humans ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/metabolism ; Male ; Neoplastic Stem Cells/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Small Interfering/metabolism ; Tandem Mass Spectrometry ; Urinary Bladder Neoplasms/pathology
    Chemical Substances CD44 protein, human ; Hyaluronan Receptors ; Protein Isoforms ; RNA, Small Interfering
    Language English
    Publishing date 2022-03-28
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.67409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids.

    Barbosa, Flávia / Araújo, Joana / Gonçalves, Virgínia M F / Palmeira, Andreia / Cunha, Andrea / Silva, Patrícia M A / Fernandes, Carla / Pinto, Madalena / Bousbaa, Hassan / Queirós, Odília / Tiritan, Maria Elizabeth

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Cancer is a complex disease characterized by several alterations, which confer, to the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment ... ...

    Abstract Cancer is a complex disease characterized by several alterations, which confer, to the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment failure; thus, the search for natural products or their derivatives with therapeutic action is essential. Chiral derivatives of xanthones (CDXs) have shown potential inhibitory activity against the growth of some human tumor cell lines. This work reports the screening of a library of CDXs, through viability assays, in different cancer cell lines: A375-C5, MCF-7, NCI-H460, and HCT-15. CDXs' effect was analyzed based on several parameters of cancer cells, and it was also verified if these compounds were substrates of glycoprotein-P (Pgp), one of the main mechanisms of resistance in cancer therapy. Pgp expression was evaluated in all cell lines, but no expression was observed, except for HCT-15. Also, when a humanized yeast expressing the human gene MDR1 was used, no conclusions could be drawn about CDXs as Pgp substrates. The selected CDXs did not induce significant differences in the metabolic parameters analyzed. These results show that some CDXs present promising antitumor activity, but other mechanisms should be triggered by these compounds.
    MeSH term(s) Humans ; Amino Acids ; Xanthones/pharmacology ; Xanthones/chemistry ; Cell Line, Tumor ; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics
    Chemical Substances Amino Acids ; Xanthones ; ATP Binding Cassette Transporter, Subfamily B, Member 1
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A multivalent CD44 glycoconjugate vaccine candidate for cancer immunotherapy.

    Freitas, Rui / Miranda, Andreia / Ferreira, Dylan / Relvas-Santos, Marta / Castro, Flávia / Ferreira, Eduardo / Gaiteiro, Cristiana / Soares, Janine / Cotton, Sofia / Gonçalves, Martina / Eiras, Mariana / Santos, Beatriz / Palmeira, Carlos / Correia, Margareta P / Oliveira, Maria José / Sarmento, Bruno / Peixoto, Andreia / Santos, Lúcio Lara / Silva, André M N /
    Ferreira, José Alexandre

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 367, Page(s) 540–556

    Abstract: Cancer presents a high mortality rate due to ineffective treatments and tumour relapse with progression. Cancer vaccines hold tremendous potential due to their capability to eradicate tumour and prevent relapse. In this study, we present a novel ... ...

    Abstract Cancer presents a high mortality rate due to ineffective treatments and tumour relapse with progression. Cancer vaccines hold tremendous potential due to their capability to eradicate tumour and prevent relapse. In this study, we present a novel glycovaccine for precise targeting and immunotherapy of aggressive solid tumours that overexpress CD44 standard isoform (CD44s) carrying immature Tn and sialyl-Tn (sTn) O-glycans. We describe an enzymatic method and an enrichment strategy to generate libraries of well-characterized cancer-specific CD44s-Tn and/or sTn glycoproteoforms, which mimic the heterogeneity found in tumours. We conjugated CD44-Tn-derived glycopeptides with carrier proteins making them more immunogenic, with further demonstration of the importance of this conjugation to overcome the glycopeptides' intrinsic toxicity. We have optimized the glycopeptide-protein maleimide-thiol conjugation chemistry to avoid undesirable cross-linking between carrier proteins and CD44s glycopeptides. The resulting glycovaccines candidates were well-tolerated in vivo, inducing both humoral and cellular immunity, including immunological memory. The generated antibodies exhibited specific reactivity against synthetic CD44s-Tn glycopeptides, CD44s-Tn glycoengineered cells, and human tumours. In summary, we present a promising prototype of a cancer glycovaccine for future therapeutical pre-clinical efficacy validation.
    MeSH term(s) Humans ; Vaccines, Combined ; Antigens, Tumor-Associated, Carbohydrate/chemistry ; Glycoconjugates ; Neoplasms/therapy ; Immunotherapy ; Glycopeptides/chemistry ; Cancer Vaccines ; Carrier Proteins ; Recurrence ; Hyaluronan Receptors
    Chemical Substances Vaccines, Combined ; Antigens, Tumor-Associated, Carbohydrate ; Glycoconjugates ; Glycopeptides ; Cancer Vaccines ; Carrier Proteins ; CD44 protein, human ; Hyaluronan Receptors
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.01.065
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Supramolecular Atropine Potentiometric Sensor.

    Ferreira, Catarina / Palmeira, Andreia / Sousa, Emília / Amorim, Célia G / Araújo, Alberto Nova / Montenegro, Maria Conceição

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 17

    Abstract: A supramolecular atropine sensor was developed, using cucurbit[6]uril as the recognition element. The solid-contact electrode is based on a polymeric membrane incorporating cucurbit[6]uril (CB[6]) as an ionophore, 2-nitrophenyl octyl ether as a solvent ... ...

    Abstract A supramolecular atropine sensor was developed, using cucurbit[6]uril as the recognition element. The solid-contact electrode is based on a polymeric membrane incorporating cucurbit[6]uril (CB[6]) as an ionophore, 2-nitrophenyl octyl ether as a solvent mediator, and potassium tetrakis (4-chlorophenyl) borate as an additive. In a MES-NaOH buffer at pH 6, the performance of the atropine sensor is characterized by a slope of (58.7 ± 0.6) mV/dec with a practical detection limit of (6.30 ± 1.62) × 10
    MeSH term(s) Atropine ; Electrodes ; Humans ; Ionophores ; Polymers ; Potentiometry
    Chemical Substances Ionophores ; Polymers ; Atropine (7C0697DR9I)
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21175879
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