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Article ; Online: Assessment of a feed additive consisting of RRR-alpha-tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (Specialty Ingredients (Europe) B.V. and Vitae Caps S.A.).

Bampidis, Vasileios / Azimonti, Giovanna / Bastos, Maria de Lourdes / Christensen, Henrik / Dusemund, Birgit / Fašmon Durjava, Mojca / Kouba, Maryline / López-Alonso, Marta / López Puente, Secundino / Marcon, Francesca / Mayo, Baltasar / Pechová, Alena / Petkova, Mariana / Ramos, Fernando / Sanz, Yolanda / Villa, Roberto Edoardo / Woutersen, Ruud / Bories, Georges / Gropp, Jürgen /

Anguita, Montserrat / Galobart, Jaume / Holczknecht, Orsolya / Manini, Paola / Tarrés-Call, Jordi / Pettenati, Elisa / Vettori, Maria Vittoria / Pizzo, Fabiola

EFSA journal. European Food Safety Authority

2021 Volume 19, Issue 4, Page(s) e06532

Abstract: Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of RRR-alpha- ...

Abstract	Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of RRR-alpha-tocopheryl acetate (vitamin E) as a feed additive for all animal species. The applicant provided data demonstrating that the additive currently in the market complies with the conditions of authorisation. The FEEDAP Panel confirms that the use of RRR-alpha-tocopheryl acetate under the current authorised conditions of use is safe for the target species, the consumers and the environment. No concern for user safety is expected from the use of the active substance; however, due to the lack of information, the FEEDAP Panel is not able to conclude on its skin sensitisation potential. To draw conclusions on the safety for the user of the final formulated additives, specific studies would be required. There is no need to assess the efficacy of RRR-alpha-tocopheryl acetate in the context of the renewal of the authorisation.
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2021.6532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; E-Book: Devita, Hellman, and Rosenberg's cancer

DeVita, Vincent T. / Lawrence, Theodore S. / Rosenberg, Steven A.

principles & practice of oncology : primer of the molecular biology of cancer

2021

Title variant	Cancer ; Primer of the molecular biology of cancer
Author's details	Vincent T. DeVita, Jr., Theodore S. Lawrence, Steven A. Rosenberg editors
Keywords	Electronic books ; Neoplasms / etiology ; Neoplasms / genetics ; Neoplasms / physiopathology ; Molecular Biology / methods
Language	English
Size	1 Online-Ressource (1011 Seiten), Illustrationen, Diagramme
Edition	Third edition
Publisher	Wolters Kluwer
Publishing place	Philadelphia
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020914691
ISBN	978-1-975149-13-0 ; 9781975149116 ; 1-975149-13-0 ; 1975149114
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Implementing Brazil’s Forest Code: a vital contribution to securing forests and conserving biodiversity

Brock, Rebecca Catherine / Arnell, Andy / Simonson, Will / Soterroni, Aline C / Mosnier, Aline / Ramos, Fernando / Ywata de Carvalho, Alexandre Xavier / Camara, Gilberto / Pirker, Johannes / Obersteiner, Michael / Kapos, Valerie

Biodiversity and conservation. 2021 May, v. 30, no. 6

2021

Abstract: Meeting Brazil’s ambitious national commitments on both climate change mitigation and ... biodiversity conservation depends on securing its reserves of forest carbon and biodiversity. Brazil’s ‘Forest Code’ is ... s 2012 revision have yet been implemented and some are facing new challenges. Using modelled ...

Abstract	Meeting Brazil’s ambitious national commitments on both climate change mitigation and biodiversity conservation depends on securing its reserves of forest carbon and biodiversity. Brazil’s ‘Forest Code’ is a key tool to reconcile environmental preservation and agricultural production; it limits deforestation and requires forest restoration in illegally deforested areas. However, not all provisions of the law’s 2012 revision have yet been implemented and some are facing new challenges. Using modelled land use change projections for the whole of the country, we show that full implementation and enforcement of the law has the potential to contribute to conserving biodiversity. Biodiversity outcomes will be especially positive if (i) deforested areas are restored in ways that support recolonization by native species and (ii) additional measures are implemented to protect native vegetation in areas like Caatinga dry forests and Cerrado savannas, which may experience added pressure displaced from other regions by Forest Code implementation.
Keywords	biodiversity ; biodiversity conservation ; caatinga ; carbon ; cerrado ; climate change ; deforestation ; forest restoration ; indigenous species ; land use change ; Brazil
Language	English
Dates of publication	2021-05
Size	p. 1621-1635.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2000787-5
ISSN	1572-9710 ; 0960-3115
ISSN (online)	1572-9710
ISSN	0960-3115
DOI	10.1007/s10531-021-02159-x
Database	NAL-Catalogue (AGRICOLA)

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Book: Cancer

DeVita, Vincent T. / Lawrence, Theodore S. / Rosenberg, Steven A.

principles & practice of oncology ; primer of the molecular biology of cancer

(Oncology)

2015

Author's details	editors Vincent T. DeVita, Jr., MD, Amy & Joseph Perella Professor of Medicine, Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale-New Haven, Professor of Epidemiology and Public Health, Yale University School of Public Health, New Haven, Connecticut, Theodore S. Lawrence, MD, PhD, Isadore Lampe Professor and Chair, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, Steven A. Rosenberg, MD, PhD, Chief, Surgery Branch, National Cancer Institute, National Institutes of Health, Professor of Surgery, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland, Professor of Surgery, George Washington University School of Medicine, Washington, District of Columbia; with 82 contributin authors
Series title	Oncology
Keywords	Molecular Biology / methods ; Neoplasms / physiopathology ; Neoplasms / genetics ; Neoplasms / etiology
Language	English
Size	xiv, 519 Seiten, Illustrationen, Diagramme, 26 cm
Edition	Second edition
Publisher	Wolters Kluwer
Publishing place	Philadelphia
Publishing country	United States
Document type	Book
Accompanying material	Zugang zu Online-Ausgabe über Code
HBZ-ID	HT019137075
ISBN	978-1-4963-1063-7 ; 1-4963-1063-2
Database	Catalogue ZB MED Medicine, Health

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2016 A 2580	available for loan (reading room)	Lesesaal EG

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Article ; Online: Examining interpregnancy intervals and maternal and perinatal health outcomes using U.S. vital records: Important considerations for analysis and interpretation.

Thoma, Marie E / De Silva, Dane A / MacDorman, Marian F

Paediatric and perinatal epidemiology

2018 Volume 33, Issue 1, Page(s) O60–O72

Abstract: ... of the National Vital Statistics System and recent changes to the national birth certificate data file, which have ... examining the association of IPI with maternal and perinatal data using vital records should consider ...

Abstract	Background: Numerous studies use birth certificate data to examine the association between interpregnancy interval (IPI) and maternal and perinatal health outcomes. Substantive changes from the latest birth certificate revision have implications for examining this relationship. Methods: We provide an overview of the National Vital Statistics System and recent changes to the national birth certificate data file, which have implications for assessing IPI and perinatal health outcomes. We describe the calculation of IPI using birth certificate information and related measurement issues. Missing IPI values by maternal age, race and education using 2016 birth certificate data were also compared. Finally, we review and summarise data quality studies of select covariate and outcome variables (sociodemographic, maternal health and health behaviours, and infant health) conducted after the most recent 2003 birth certificate revision. Results: Substantive changes to data collection, dissemination and quality have occurred since the 2003 revision. These changes impact IPI measurement, trends and associations with perinatal health outcomes. Missing values of IPI were highest for older ages, lower education and non-Hispanic black women. Minimal differences were found when comparing IPI using different gestational age measures. Recent data quality studies pointed to substantial variation in data quality by item and across states. Conclusion: Future studies examining the association of IPI with maternal and perinatal data using vital records should consider these aspects of the data in their research plan, sensitivity analyses and interpretation of findings.
MeSH term(s)	Birth Certificates ; Birth Intervals/statistics & numerical data ; Continental Population Groups/statistics & numerical data ; Data Accuracy ; Educational Status ; Female ; Humans ; Infant Health/statistics & numerical data ; Infant, Newborn ; Maternal Age ; Pregnancy ; Pregnancy Outcome/epidemiology ; United States/epidemiology
Language	English
Publishing date	2018-10-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639089-4
ISSN	1365-3016 ; 0269-5022 ; 1353-663X
ISSN (online)	1365-3016
ISSN	0269-5022 ; 1353-663X
DOI	10.1111/ppe.12520
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Article ; Online: Target identification by structure-based computational approaches: Recent advances and perspectives.

De Vita, Simona / Chini, Maria Giovanna / Bifulco, Giuseppe / Lauro, Gianluigi

Bioorganic & medicinal chemistry letters

2023 Volume 83, Page(s) 129171

Abstract: ... a boost, especially in the target identification step. Finding the biological partner(s) for new or ...

Abstract	The use of computational techniques in the early stages of drug discovery has recently experienced a boost, especially in the target identification step. Finding the biological partner(s) for new or existing synthetic and/or natural compounds by "wet" approaches may be challenging; therefore, preliminary in silico screening is even more recommended. After a brief overview of some of the most known target identification techniques, recent advances in structure-based computational approaches for target identification are reported in this digest, focusing on Inverse Virtual Screening and its recent applications. Moreover, future perspectives concerning the use of such methodologies, coupled or not with other approaches, are analyzed.
MeSH term(s)	Drug Discovery/methods ; Computational Biology
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2023.129171
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Book: DeVita, Hellman, and Rosenberg's cancer

DeVita, Vincent T. / Lawrence, Theodore S. / Rosenberg, Steven A.

principles and practice of oncology

2023

Title variant	Cancer
Author's details	editors, Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A. Rosenberg
Keywords	Neoplasms / genetics ; Neoplasms / physiopathology ; Molecular Biology / methods ; Oncology
Subject code	616.994
Language	English
Size	xxx, 1880, I-48 Seiten, Illustrationen, Diagramme, 28 cm
Edition	12 edition
Publisher	Wolters Kluwer
Publishing place	Philadelphia
Publishing country	United States
Document type	Book
Accompanying material	Zugang zu eBook über Code
HBZ-ID	HT021729117
ISBN	978-1-9751-8474-2 ; 1-9751-8474-2
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2023 A 422	available for loan (reading room)	Lesesaal EG
Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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Article: Breeding effects on durum wheat traits detected using GWAS and haplotype block analysis.

Taranto, F / Esposito, S / Fania, F / Sica, R / Marzario, S / Logozzo, G / Gioia, T / De Vita, P

Frontiers in plant science

2023 Volume 14, Page(s) 1206517

Abstract: Introduction: The recent boosting of genomic data in durum wheat (: Methods: Within this motivation context, 123 durum wheat accessions, classified into three groups: landraces (LR), ancient (OC) and modern cultivars (MC), were evaluated in two ... ...

Abstract	Introduction: The recent boosting of genomic data in durum wheat ( Methods: Within this motivation context, 123 durum wheat accessions, classified into three groups: landraces (LR), ancient (OC) and modern cultivars (MC), were evaluated in two locations, for 34 agronomic traits, including UPOV descriptors, to assess the impact of changes that occurred during modern breeding. Results: The association mapping analysis, performed with 4,241 SNP markers and six multi-locus-GWAS models, revealed 28 reliable Quantitative Trait Nucleotides (QTNs) related to plant morphology and kernel-related traits. Some important genes controlling flowering time and plant height were in linkage disequilibrium (LD) decay with QTNs identified in this study. A strong association for yellow berry was found on chromosome 6A ( Discussion: Our findings pave new ways to support the phenotypic characterization necessary for variety registration by using a panel of cost-effectiveness SNP markers associated also to the UPOV descriptors. Moreover, the panel of associated SNPs might represent a reservoir of favourable alleles to use in durum wheat breeding and genetics.
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1206517
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Article ; Online: An extremely rare serovar of Salmonella enterica (Yopougon) discovered in a Western Whip Snake (Hierophis viridiflavus) from Montecristo Island, Italy: case report and review.

De Bene, Andrea Francesco / Russini, Valeria / Corradini, Carlo / Vita, Silvia / Pecchi, Sabrina / De Marchis, Maria Laura / Terracciano, Giuliana / Focardi, Claudia / Montemaggiori, Alessandro / Zuffi, Marco Alberto Luca / Weill, François-Xavier / Bossù, Teresa

Archives of microbiology

2024 Volume 206, Issue 1, Page(s) 49

Abstract: ... To our knowledge, S. enterica serovar Yopougon was previously isolated only once 34 years earlier in Ivory Coast ... the phylogenetic comparison with the previously isolated S. enterica serovar Yopougon strain of human origin and ...

Abstract	Reptiles, including snakes, can be asymptomatically infected with multiple pathogen microorganisms, including Salmonella spp., which is considered an important concern for public and animal health. Small and uninhabited isles are quite ecologically different from mainland and represent interesting fields of study, to discover unexpected biological and microbiological aspects of their wild inhabitants. This work reports the presence of the very rare Salmonella enterica serovar Yopougon, isolated in a carcass of a native wild snake (Hierophis viridiflavus) from an Italian uninhabited island of Mediterranean Sea, Montecristo. To our knowledge, S. enterica serovar Yopougon was previously isolated only once 34 years earlier in Ivory Coast, from a human fecal sample. In the present study, we present the genomic characterization of the new isolate, the phylogenetic comparison with the previously isolated S. enterica serovar Yopougon strain of human origin and with other sequences available in public databases. In addition, an extensive review of available data in the literature and from our case history is provided. Our finding represents an example of the ability of some pathogens to travel for very long distances within their hosts and then to infect others, even from different taxa.
MeSH term(s)	Animals ; Humans ; Italy ; Phylogeny ; Salmonella enterica/genetics ; Serogroup ; Snakes
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03772-w
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Zs.A 805: Show issues

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Article ; Online: Treatment-As-Usual Control Groups in Brief Alcohol Intervention Trials: A Systematic Review and Meta-Analysis.

Scharer, Jacob L / Funderburk, Jennifer S / De Vita, Martin J / Rother, Yvette / Maisto, Stephen A

Journal of studies on alcohol and drugs

2022 Volume 83, Issue 6, Page(s) 934–943

Abstract: Objective: Brief alcohol interventions (BAIs) are evidence-based practices that can help reduce hazardous drinking among patients in medical settings. However, descriptions of the treatment-as-usual (TAU) control groups that BAIs are compared to in ... ...

Abstract	Objective: Brief alcohol interventions (BAIs) are evidence-based practices that can help reduce hazardous drinking among patients in medical settings. However, descriptions of the treatment-as-usual (TAU) control groups that BAIs are compared to in clinical trials often lack clarity and detail. This systematic review and meta-analysis quantified and compared descriptions of intervention and TAU control arms within reports of randomized controlled trials and examined whether treatment effects were affected by level of detail in narrative descriptions. Method: A systematic literature search to identify eligible articles was performed. Studies were rated on methodological quality, and the Template for Intervention Description and Replication (TIDieR) checklist was used to rate the level of clarity and detail included in descriptions of the intervention and TAU conditions in eligible articles. Data were extracted from articles for use in meta-analysis and meta-regression. Results: Twenty-one studies met inclusion criteria. Across the studies, TIDieR ratings for intervention arms were higher than ratings for control arms. BAIs were linked to reductions in drinks per week, heavy drinking episodes, and alcohol consequences over time when compared with TAU. TIDieR ratings for control groups were significantly associated with larger treatment effects on drinks per week and alcohol consequences but were not significant for heavy drinking episodes. Conclusions: This meta-analysis reiterated the effectiveness of BAIs in medical settings. Yet the lack of clarity in TAU descriptions raises concerns regarding the validity of BAI trials, suggesting need for more detailed reporting and use of the TIDieR guidelines for support.
MeSH term(s)	Humans ; Control Groups ; Ethanol ; Research Design
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-12-10
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2266450-6
ISSN	1938-4114 ; 1934-2683 ; 1937-1888 ; 0096-882X
ISSN (online)	1938-4114 ; 1934-2683
ISSN	1937-1888 ; 0096-882X
DOI	10.15288/jsad.21-00260
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