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  1. Book: Inflammation and Metastasis

    Maru, Yoshiro

    2021  

    Author's details Maru, Yoshiro Department of Pharmacology, Tokyo Women's Medical University §
    Keywords Leukocytes ; microenvironment ; Pathogen sensors ; immune system ; coagulation ; Angiogenesis ; Cancer ; Inflammation ; Metastasis ; Microenvironment ; Immune system ; Coagulation
    Language English
    Size 540 p.
    Edition 2
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_11
    Format 160 x 241 x 33
    ISBN 9789811617560 ; 9811617562
    Database PDA

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  2. Book: Inflammation and metastasis

    Maru, Yoshiro

    2016  

    Author's details Yoshiro Maru
    Keywords Leukocytes ; Inflammation ; Metastasis ; Angiogenesis ; Microenvironment ; Immune system ; Pathogen sensors ; Coagulation
    Language English
    Size X, 440 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT018981531
    ISBN 978-4-431-56022-7 ; 9784431560241 ; 4-431-56022-X ; 4431560246
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1847 available for loan (reading room) Lesesaal EG

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  3. Book ; Online ; E-Book: Inflammation and metastasis

    Maru, Yoshirō

    2021  

    Author's details Yoshiro Maru
    Keywords Inflammation ; Metastasis ; Cancer/Molecular aspects ; Càncer
    Subject code 616.0473
    Language English
    Size 1 online resource (531 pages)
    Edition Second edition.
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-1757-0 ; 981-16-1756-2 ; 978-981-16-1757-7 ; 978-981-16-1756-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Premetastasis.

    Maru, Yoshiro

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 11

    Abstract: Sterile inflammation within primary tumor tissues can spread to distant organs that are devoid of tumor cells. This happens in a manner dependent on tumor-led secretome, before the actual metastasis occurs. The premetastatic microenvironment is ... ...

    Abstract Sterile inflammation within primary tumor tissues can spread to distant organs that are devoid of tumor cells. This happens in a manner dependent on tumor-led secretome, before the actual metastasis occurs. The premetastatic microenvironment is established in this way and is at least partly regulated by hijacking the host innate immune system. The biological manifestation of premetastasis include increased vascular permeability, cell mobilization via the blood stream, degradation of the extracellular matrix, immunosuppression, and host antineoplastic activities.
    MeSH term(s) Animals ; Humans ; Neoplasm Metastasis/pathology ; Neoplasms/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a036897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Inflammation-associated premetastatic niche formation.

    Deguchi, Atsuko / Maru, Yoshiro

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 22

    Abstract: Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory "seed-and-soil." Both cancer cell-intrinsic properties ("seed") and fertile microenvironment ("soil") are essential for metastasis ... ...

    Abstract Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory "seed-and-soil." Both cancer cell-intrinsic properties ("seed") and fertile microenvironment ("soil") are essential for metastasis formation. To date, accumulating evidences supported the theory using mouse models. The formation of a premetastatic niche has been widely accepted as an accel for metastasis. Similar to tumor microenvironment, various types of cells, such as immune cells, endothelial cells, and fibroblasts are involved in premetastatic niche formation. We have discovered that primary tumors hijack Toll-like receptor 4 (TLR4) signaling to establish a premetastatic niche in the lung by utilizing the endogenous ligands. In this review, we discuss the mechanisms that underlie inflammation-associated premetastatic niche formation upon metastasis, focusing especially on myeloid cells and macrophages as the cells executing and mediating complicated processes.
    Language English
    Publishing date 2022-07-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00208-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Editorial: Anti inflammatory Treatment for Seemingly Non-inflammatory Disorders-Part 2.

    Maru, Yoshiro

    Endocrine, metabolic & immune disorders drug targets

    2015  Volume 15, Issue 3, Page(s) 170

    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2015-09-01
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/187153031503150827163933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Anti-inflammatory Treatment for Seemingly Non-inflammatory Disorders. Editorial.

    Maru, Yoshiro

    Endocrine, metabolic & immune disorders drug targets

    2015  Volume 15, Issue 2, Page(s) 82

    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Molecular Targeted Therapy ; Signal Transduction/drug effects
    Chemical Substances Anti-Inflammatory Agents ; Inflammation Mediators
    Language English
    Publishing date 2015-05-28
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/187153031502150522123335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Eph/Ephrin Signaling in the Tumor Microenvironment.

    Ieguchi, Katsuaki / Maru, Yoshiro

    Advances in experimental medicine and biology

    2020  Volume 1270, Page(s) 45–56

    Abstract: The Eph/ephrin system plays a vital role in diverse physiological events such as neurogenesis, vasculogenesis, and cell adhesion. Expression analysis of mRNA and protein in clinical samples revealed the involvement of the Eph/ephrin system in ... ...

    Abstract The Eph/ephrin system plays a vital role in diverse physiological events such as neurogenesis, vasculogenesis, and cell adhesion. Expression analysis of mRNA and protein in clinical samples revealed the involvement of the Eph/ephrin system in tumorigenesis, Alzheimer's disease, and atherosclerosis. Therefore, the Eph/ephrin system is considered a promising therapeutic target. However, no molecularly targeted drug against Ephs and ephrins is being used in the clinic thus far.Tumors are composed of various types of cells, including fibroblasts, immune cells, and endothelial cells. Recent studies showed the contribution of these cells to tumor growth, tumor progression, drug resistance, and metastasis. In this chapter, we discuss the role of Eph/ephrin system in the tumor microenvironment and describe its functions in tumor initiation, angiogenesis, cancer stem cell, tumor immunity, and also the metastatic environment.
    MeSH term(s) Ephrins/genetics ; Ephrins/metabolism ; Humans ; Neoplasms/metabolism ; Receptors, Eph Family/metabolism ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Ephrins ; Receptors, Eph Family (EC 2.7.10.1)
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-47189-7_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The lung metastatic niche.

    Maru, Yoshiro

    Journal of molecular medicine (Berlin, Germany)

    2015  Volume 93, Issue 11, Page(s) 1185–1192

    Abstract: Cancer cells that succeed in forming lung metastases need to survive in a foreign microenvironment and to protect themselves against immune surveillance. Lung metastatic niches facilitate this process. They can develop as pre-metastatic niches by ... ...

    Abstract Cancer cells that succeed in forming lung metastases need to survive in a foreign microenvironment and to protect themselves against immune surveillance. Lung metastatic niches facilitate this process. They can develop as pre-metastatic niches by inflammatory events that are provoked by primary tumors before tumor cell arrival, and/or they can be post-formed by reciprocal signaling between metastasizing tumor cells and local non-tumor cells. Primary tumor-derived factors induce expression of chemokines in the lungs to which bone marrow-derived myeloid cells are recruited. These cells work in concert with lung-specific resident cells to establish pre-metastatic niches. The role of the endogenous TLR4-dependent innate immune system in pre-metastatic niche formation illustrates this point. During lung infection, endotoxin induces inflammation by increasing vascular permeability and leukocyte mobilization to the lungs through the endotoxin receptor TLR4 that is expressed in endothelial cells and leukocytes, respectively. This innate immune system can be hijacked by primary tumors to generate a pre-metastatic niche. Specifically, primary tumor-produced chemokine CCL2 works in an endocrine manner to induce pulmonary overexpression of endogenous TLR4 ligands such as S100A8 and SAA3 resulting in lung inflammation similar to that caused by endotoxin. An endotoxin analog Eritoran inhibits pre-metastatic niche formation in this system.
    MeSH term(s) Humans ; Immunologic Surveillance ; Lung/immunology ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Neoplasm Metastasis/immunology ; Neoplasm Metastasis/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2015-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-015-1355-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.36: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Roles of EphA1/A2 and ephrin-A1 in cancer.

    Ieguchi, Katsuaki / Maru, Yoshiro

    Cancer science

    2019  Volume 110, Issue 3, Page(s) 841–848

    Abstract: The biological functions of the Eph/ephrin system have been intensively investigated and well documented so far since its discovery in 1987. Although the Eph/ephrin system has been implicated in pathological settings such as Alzheimer's disease and ... ...

    Abstract The biological functions of the Eph/ephrin system have been intensively investigated and well documented so far since its discovery in 1987. Although the Eph/ephrin system has been implicated in pathological settings such as Alzheimer's disease and cancer, the molecular mechanism of the Eph/ephrin system in those diseases is not well understood. Especially in cancer, recent studies have demonstrated that most of Eph and ephrin are up- or down-regulated in various types of cancer, and have been implicated in tumor progression, tumor malignancy, and prognosis. However, they lack consistency and are in controversy. The localization patterns of EphA1 and EphA2 in mouse lungs are very similar, and both knockout mice showed similar phenotypes in the lungs. Ephrin-A1 that is a membrane-anchored ligand for EphAs was co-localized with EphA1 and EphA2 in lung vascular endothelial cells. We recently uncovered the molecular mechanism of ephrin-A1-induced lung metastasis by understanding the physiological function of ephrin-A1 in lungs. This review focuses on the function of EphA1, EphA2, and ephrin-A1 in tumors and an establishment of pre-metastatic microenvironment in the lungs.
    MeSH term(s) Animals ; Down-Regulation/physiology ; Endothelial Cells/metabolism ; Ephrin-A1/metabolism ; Humans ; Lung Neoplasms/metabolism ; Prognosis ; Receptor, EphA2/metabolism ; Up-Regulation/physiology
    Chemical Substances Ephrin-A1 ; Receptor, EphA2 (EC 2.7.10.1)
    Language English
    Publishing date 2019-02-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1347-9032
    ISSN (online) 1349-7006
    ISSN 1347-9032
    DOI 10.1111/cas.13942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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