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Book ; Online: Ippocrate e gli altri

Manetti, Daniela / Perilli, Lorenzo / Roselli, Amneris

(Collection de l'École française de Rome)

2021

Series title	Collection de l'École française de Rome
Keywords	Ancient history: to c 500 CE ; medicina greca ; medicina romana ; Ippocrate
Language	0\|i
Size	1 Online-Ressource
Publisher	Publications de l'École française de Rome
Publishing place	Rome
Document type	Book ; Online
Note	Italian ; Open Access
HBZ-ID	HT021616091
ISBN	9782728315055 ; 2728315051
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Strategies for Complex Reoperative Aortic Arch Reconstruction in Patients With Congenital Heart Disease.

Frankel, William C / Roselli, Eric E

Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual

2022 Volume 26, Page(s) 81–88

Abstract: Aortic dilation is common in patients with congenital heart disease including those with a bicuspid aortic valve, connective tissue disease, coarctation of the aorta, and conotruncal defects. In addition, neo-aortic dilation has been described in ... ...

Abstract	Aortic dilation is common in patients with congenital heart disease including those with a bicuspid aortic valve, connective tissue disease, coarctation of the aorta, and conotruncal defects. In addition, neo-aortic dilation has been described in patients after aortic reconstruction including the Norwood procedure, the arterial switch operation, and the Ross procedure. Although aortic catastrophe is rare in patients with congenital heart disease, common pathologic endpoints in these patients likely manifest with similar aortic tissue behavior. A lifelong care model with similar indications for surveillance and prophylactic repair to other more common aortopathies is therefore warranted. Still, reoperative aortic arch reconstruction in these patients is often a complex and high-risk endeavor, and in all cases, a tailored and adaptable plan ensuring adequate myocardial and cerebral protection with appropriate rescue measures is paramount. A surgical team taking on these challenging cases should possess an armamentarium of open, hybrid, and endovascular techniques which can be individualized to a patient's unique anatomy, surgical history, and concomitant lesions as well as the team's measured outcomes and experience.
MeSH term(s)	Humans ; Aorta, Thoracic/surgery ; Aorta, Thoracic/abnormalities ; Aortic Valve/surgery ; Heart Valve Diseases/complications ; Heart Valve Diseases/surgery ; Heart Defects, Congenital/surgery ; Aortic Coarctation/surgery ; Aortic Diseases/complications ; Aortic Diseases/surgery ; Endovascular Procedures
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1425449-9
ISSN	1876-4665 ; 1092-9126
ISSN (online)	1876-4665
ISSN	1092-9126
DOI	10.1053/j.pcsu.2022.12.006
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Article ; Online: Neurobiology of gender identity and sexual orientation.

Roselli, C E

Journal of neuroendocrinology

2017 Volume 30, Issue 7, Page(s) e12562

Abstract: Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, although not always. The present review discusses the ... ...

Abstract	Sexual identity and sexual orientation are independent components of a person's sexual identity. These dimensions are most often in harmony with each other and with an individual's genital sex, although not always. The present review discusses the relationship of sexual identity and sexual orientation to prenatal factors that act to shape the development of the brain and the expression of sexual behaviours in animals and humans. One major influence discussed relates to organisational effects that the early hormone environment exerts on both gender identity and sexual orientation. Evidence that gender identity and sexual orientation are masculinised by prenatal exposure to testosterone and feminised in it absence is drawn from basic research in animals, correlations of biometric indices of androgen exposure and studies of clinical conditions associated with disorders in sexual development. There are, however, important exceptions to this theory that have yet to be resolved. Family and twin studies indicate that genes play a role, although no specific candidate genes have been identified. Evidence that relates to the number of older brothers implicates maternal immune responses as a contributing factor for male sexual orientation. It remains speculative how these influences might relate to each other and interact with postnatal socialisation. Nonetheless, despite the many challenges to research in this area, existing empirical evidence makes it clear that there is a significant biological contribution to the development of an individual's sexual identity and sexual orientation.
MeSH term(s)	Animals ; Brain/physiology ; Female ; Gender Identity ; Humans ; Male ; Sex Differentiation/physiology ; Sexual Partners ; Sexuality/physiology
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.12562
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Article: A roadmap for the implementation of a renewable energy community.

Esposito, Paolo / Marrasso, Elisa / Martone, Chiara / Pallotta, Giovanna / Roselli, Carlo / Sasso, Maurizio / Tufo, Massimiliano

Heliyon

2024 Volume 10, Issue 7, Page(s) e28269

Abstract: Environmental problems due to climate change, that have been affecting our planet for years, are the main issues which prompted European Union to establish the ambitious target of achieving carbon neutrality by 2050. This occurrence encouraged all Member ...

Abstract	Environmental problems due to climate change, that have been affecting our planet for years, are the main issues which prompted European Union to establish the ambitious target of achieving carbon neutrality by 2050. This occurrence encouraged all Member States to undergo significant changes of their energy sectors, favouring the extensive use of renewable energy sources. In this scenario, the European Union introduced Renewable Energy Communities, innovative energy systems based on a new model of renewable energy production, consumption and sharing, guaranteeing environmental, economic, energy and social benefits. The objective of this paper is twofold: firstly, to examine the regulatory framework of Member States and, secondly, to present a standardized procedure for the implementation of a Renewable Energy Community, an aspect not yet covered in scientific literature. The roadmap includes four main phases: a feasibility study involving an energy analysis of end users' consumption and a general assessment; the aggregation of members as producers, consumers or prosumers forming a legal entity, considering different funding opportunities; the operating phase, involving plant construction and project validation by national authorities; the technical and economic management phase. The dynamic structure of the roadmap allows for adjustments to accommodate different regulatory contexts, member typologies and project aim.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28269
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Article: Time-evolution and forecasting of environmental and energy performance of electricity production system at national and at bidding zone level

Ceglia, F. / Marrasso, E. / Roselli, C. / Sasso, M.

Energy conversion and management. 2022 Aug. 01, v. 265

2022

Abstract: The electricity generation system has faced exceptional change lately because of several aspects: the electrification of heating and transport sectors, the spread of distributed energy generation, and the increase of renewable share in the electricity ... ...

Abstract	The electricity generation system has faced exceptional change lately because of several aspects: the electrification of heating and transport sectors, the spread of distributed energy generation, and the increase of renewable share in the electricity production mix. All these factors have contributed to exacerbate the variability of power system operation. This work aims to present hourly data analysis of the electricity production (from fossil fuels and renewables) at the country level (Italy) and at the bidding zone level in the period 2015–2019. Based on different time-resolution, several datasets have been examined and a reproducible method has been defined to overcome the temporal resolution misalignment. Subsequently, the data has been used to define and calculate the time-dependent energy efficiency and environmental indicators for the electricity system with an hourly timestep both for Italy and related bidding zones. The results have demonstrated that these parameters are extremely variable year by year and hour by hour both at the national and bidding zones level. For example, one of the analysed energy efficiency indicators referred to Italy ranges from 0.4 in the hours in which the renewable share is lower than 10% to 1.8 when the renewable share reaches 80%. At the bidding zone level, the electric efficiency indicators, and carbon dioxide emission factor for electricity show a pattern depending on the specific electricity production mix in each zone evidencing a great difference compared to outcomes related to the whole of Italy. The findings of this work evidence the need of accurate knowledge of these operational indexes in the evaluation of electric-driven energy conversion systems performance, energy planning, and in the improvements of electricity market efficiency.
Keywords	carbon dioxide ; data collection ; electricity ; electricity generation ; emissions factor ; energy efficiency ; markets ; Italy
Language	English
Dates of publication	2022-0801
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2022.115772
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Assessing the influence of time-dependent power grid efficiency indicators on primary energy savings and economic incentives for high-efficiency cogeneration

Ceglia, F. / Marrasso, E. / Pallotta, G. / Roselli, C. / Sasso, M.

Energy. 2023 May 29, p.127969-

2023 , Page(s) 127969–

Abstract: In Italy, the economic support scheme for high-efficiency cogeneration annually provides tradable White Certificates to new constructed or refurbished high-efficiency cogeneration plants over a period of 10 years, proportionally to their annual primary ... ...

Abstract	In Italy, the economic support scheme for high-efficiency cogeneration annually provides tradable White Certificates to new constructed or refurbished high-efficiency cogeneration plants over a period of 10 years, proportionally to their annual primary energy saving. In contrast to the legislation currently in force, which assumes the power grid efficiency constant, this paper aims at assessing the adoption of a time-dependent approach, based on the use of the thermoelectric-based power grid efficiency, for evaluating the primary energy saving ensured by high-efficiency cogeneration as well as the relating economic incentives. The case study being analysed includes two 5.5 kWₑₗ micro-cogenerators installed in Naples (South Italy). Beyond the conventional, three scenarios have been outlined, depending on the time accuracy adopted (yearly, monthly and hourly basis). Starting from 2016, the scenarios have been replicated over the ten-year incentive period. In particular, the annual average thermoelectric-based power grid efficiency has been forecasted from 2021 to 2025. Following the innovative approach proposed in this study, the White Certificates would have increased by 9.2% in 2016, by 6.1% in 2017 and by 6.1% in 2018 too, thus fostering the achievement of the targets about high-efficiency cogeneration at national level.
Keywords	case studies ; laws and regulations ; primary energy ; Italy ; High efficiency cogeneration ; Primary energy savings ; Energy efficiency ; White certificates ; Economic incentives ; Time-dependent power grid efficiency
Language	English
Dates of publication	2023-0529
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.127969
Database	NAL-Catalogue (AGRICOLA)

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Article: Double Valve Replacement in a Patient With Hunter Syndrome.

Keshavamurthy, Suresh / Duncan, Andra / Kumar, Akshay / Trombetta, Carlos / Rodriguez, Rene / Tan, Carmela / Roselli, Eric

Cureus

2022 Volume 14, Issue 9, Page(s) e28961

Abstract: Hunter syndrome is a rare disorder in which affected patients have significant airway abnormalities (macroglossia, small mouth opening, and supraglottic narrowing) that complicate their management. Deposition of glycosaminoglycans in the heart leads to ... ...

Abstract	Hunter syndrome is a rare disorder in which affected patients have significant airway abnormalities (macroglossia, small mouth opening, and supraglottic narrowing) that complicate their management. Deposition of glycosaminoglycans in the heart leads to cardiomyopathy, and cardiac valve dysplasia that can lead to valvular stenosis or regurgitation or both, necessitating valve replacement. Management of patients with Hunter syndrome is complex and needs a multidisciplinary team approach. Mechanical valve replacement is a suitable treatment option.
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.28961
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Article ; Online: Obesity and Breast Cancer: Interaction or Interference with the Response to Therapy?

Riondino, Silvia / Formica, Vincenzo / Valenzi, Elena / Morelli, Cristina / Flaminio, Valeria / Portarena, Ilaria / Torino, Francesco / Roselli, Mario

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 1, Page(s) 1220–1231

Abstract: Background: Aromatase inhibitors (AI) are widely used for treating hormone-sensitive breast cancer (BC). Obesity, however, due to aromatase-mediated androgen conversion into estradiol in the peripheral adipose tissue, might impair AI inhibitory capacity. ...

Abstract	Background: Aromatase inhibitors (AI) are widely used for treating hormone-sensitive breast cancer (BC). Obesity, however, due to aromatase-mediated androgen conversion into estradiol in the peripheral adipose tissue, might impair AI inhibitory capacity. We aimed at identifying a cut-off of body mass index (BMI) with significant prognostic impact, in a cohort of stage I-II BC patients on systemic adjuvant therapy with AI. Methods: we retrospectively evaluated routinely collected baseline parameters. The optimal BMI cut-off affecting disease-free survival (DFS) in AI-treated BC patients was identified through maximally selected rank statistics; non-linear association between BMI and DFS in the AI cohort was assessed by hazard-ratio-smoothed curve analysis using BMI as continuous variable. The impact of the BMI cut-off on survival outcomes was estimated through Kaplan−Meier plots, with log-rank test and hazard ratio estimation comparing patient subgroups. Results: A total of 319 BC patients under adjuvant endocrine therapy and/or adjuvant chemotherapy were included. Curve-fitting analysis showed that for a BMI cut-off >29 in AI-treated BC patients (n = 172), DFS was increasingly deteriorating and that the impact of BMI on 2-year DFS identified a cut-off specific only for the cohort of postmenopausal BC patients under adjuvant therapy with AI. Conclusion: in radically resected hormone-sensitive BC patients undergoing neoadjuvant or adjuvant chemotherapy and treated with AI, obesity represents a risk factor for recurrence, with a significantly reduced 2-year DFS.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Retrospective Studies ; Aromatase Inhibitors/therapeutic use ; Obesity/complications ; Obesity/drug therapy ; Hormones/therapeutic use
Chemical Substances	Aromatase Inhibitors ; Hormones
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30010094
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Article ; Online: Ascending Aortic Endograft and Thoracic Aortic Deformation After Ascending Thoracic Endovascular Aortic Repair.

Suh, Ga-Young K / Bondesson, Johan / Zhu, Yufei D / Nilson, Michael C / Roselli, Eric E / Cheng, Christopher P

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2023 , Page(s) 15266028231168351

Abstract: Purpose: We aim to quantify multiaxial cardiac pulsatility-induced deformation of the thoracic aorta after ascending thoracic endovascular aortic repair (TEVAR) as a part of the GORE ARISE Early Feasibility Study.: Materials and methods: Fifteen ... ...

Abstract	Purpose: We aim to quantify multiaxial cardiac pulsatility-induced deformation of the thoracic aorta after ascending thoracic endovascular aortic repair (TEVAR) as a part of the GORE ARISE Early Feasibility Study. Materials and methods: Fifteen patients (7 females and 8 males, age 73±9 years) with ascending TEVAR underwent computed tomography angiography with retrospective cardiac gating. Geometric modeling of the thoracic aorta was performed; geometric features including axial length, effective diameter, and centerline, inner surface, and outer surface curvatures were quantified for systole and diastole; and pulsatile deformations were calculated for the ascending aorta, arch, and descending aorta. Results: From diastole to systole, the ascending endograft exhibited straightening of the centerline (0.224±0.039 to 0.217±0.039 cm Conclusion: Compared with the native ascending aorta (from prior literature), ascending TEVAR damps axial and bending pulsatile deformations of the ascending aorta similar to how descending TEVAR damps descending aortic deformations, while diametric deformations are damped to a greater extent. Downstream diametric and bending pulsatility of the native descending aorta was muted compared with that in patients without ascending TEVAR (from prior literature). Deformation data from this study can be used to evaluate the mechanical durability of ascending aortic devices and inform physicians about the downstream effects of ascending TEVAR to help predict remodeling and guide future interventional strategies. Clinical impact: This study quantified local deformations of both stented ascending and native descending aortas to reveal the biomechanical impact of ascending TEVAR on the entire thoracic aorta, and reported that the ascending TEVAR muted cardiac-induced deformation of the stented ascending aorta and native descending aorta. Understanding of in vivo deformations of the stented ascending aorta, aortic arch and descending aorta can inform physicians about the downstream effects of ascending TEVAR. Notable reduction of compliance may lead to cardiac remodeling and long-term systemic complications. This is the first report which included dedicated deformation data regarding ascending aortic endograft from clinical trial.
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028231168351
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Article ; Online: Multifocal disease progression and subsequent intervention in patients with actin alpha-2 variants: A single-center experience.

Maigrot, Jean-Luc A / Vargo, Patrick R / Kramer, Benjamin / Rigelsky, Christina / Ghobrial, Joanna / Zahka, Kenneth / Najm, Hani / Roselli, Eric E

The Journal of thoracic and cardiovascular surgery

2023

Abstract: Objectives: To describe patient characteristics and indications for surgical intervention, reoperation, and outcomes in patients with actin alpha-2 (ACTA2) variants.: Methods: A single-center retrospective cohort study with prospective follow-up was ... ...

Abstract	Objectives: To describe patient characteristics and indications for surgical intervention, reoperation, and outcomes in patients with actin alpha-2 (ACTA2) variants. Methods: A single-center retrospective cohort study with prospective follow-up was performed for 38 patients with an ACTA2 variant. Results: From 1999 to 2020, 26 (70%) patients underwent surgery; 11 remain under surveillance (mean follow-up, 7.5 ± 5 years). Median age at index operation was 42 (range, 10-69) years, with 4 pediatric cases. Thoracic aortic aneurysm was present in 19 (73%) patients (mean adult max diameter, 5.2 ± 0.8 cm; pediatric z score, 10.7 ± 5.4). Aortic dissection was present in 13 (50%) patients, with 4 (15%) having type A dissection. Operations included replacement of the aortic root in 16 (17%), ascending aorta in 20 (77%), and aortic arch in 14 (54%) patients. Four (15%) patients had coronary artery disease, and 2 (7.7%) underwent concomitant coronary artery bypass grafting. There was no operative mortality, stroke, reoperation for bleeding, or dialysis-dependent renal failure; One (3.8%) patient developed acute on chronic kidney injury. Three patients (12%) required prolonged ventilation. Eleven (42%) patients underwent 26 reoperations, median time 45 (range, 4-147) months, including 5 open thoracoabdominal aneurysm repairs. Conclusions: Patients with ACTA2 variants frequently develop aortic aneurysm and are at risk of aortic dissection and coronary artery disease. However, age at diagnosis and symptoms at presentation are highly variable. Multiple operations are often required for disease management, particularly after dissection. Close monitoring and timely intervention are important in mitigating disease progression and improving outcomes.
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2023.11.052
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