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Article ; Online: The effects of managerial perceptions on CSR practices and corporate financial performance

Khuong N. Mai / Phuong N.D. Nguyen / An K.T. Nguyen / Ngoc M. Tran

Entrepreneurship and Sustainability Issues, Vol 8, Iss 2, Pp 858-

an evidence from Vietnam

2020 Volume 874

Abstract: Corporate Social Responsibilities (CSR) and the related topics have evolved to be the major considerations in Western and developed countries. However, this concept as well as practical application is still new in developing nations and insufficient ... ...

Abstract	Corporate Social Responsibilities (CSR) and the related topics have evolved to be the major considerations in Western and developed countries. However, this concept as well as practical application is still new in developing nations and insufficient researches addressing CSR issues. This paper aims to fill the missing gap of managerial perceptions towards CSR practices and Corporate Financial Performance (CFP) by investigating the effects of managerial perception on CSR practices and the financial outcomes reported by the managers. Following the quantitative approach, the surveys were distributed to 869 managers currently working at Ho Chi Minh City and Binh Duong Province (Vietnam) based companies doing business in different sectors, with different sizes and industries. The collected data were processed through the factor analysis and SEM. As the results, managerial perceptions serve as the powerful forces for CSR implementation. Among the four remaining CSR domains, economic responsibility is the top contributor to CFP while legal, philanthropic and environmental dimensions showed minor impacts. Several implications are provided at the end to facilitate enterprises’ decision making process and governments’ strategy to foster the CSR adoption status domestically.
Keywords	Environmental sciences ; GE1-350 ; Technological innovations. Automation ; HD45-45.2
Subject code	690
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Entrepreneurship and Sustainability Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A simple and versatile system for the ATP-dependent assembly of chromatin.

Khuong, Mai T / Fei, Jia / Cruz-Becerra, Grisel / Kadonaga, James T

The Journal of biological chemistry

2017 Volume 292, Issue 47, Page(s) 19478–19490

Abstract: Chromatin is the natural form of DNA in the eukaryotic nucleus and is the substrate for diverse biological phenomena. The functional analysis of these processes ideally would be carried out with nucleosomal templates that are assembled with customized ... ...

Abstract	Chromatin is the natural form of DNA in the eukaryotic nucleus and is the substrate for diverse biological phenomena. The functional analysis of these processes ideally would be carried out with nucleosomal templates that are assembled with customized core histones, DNA sequences, and chromosomal proteins. Here we report a simple, reliable, and versatile method for the ATP-dependent assembly of evenly spaced nucleosome arrays. This minimal chromatin assembly system comprises the
MeSH term(s)	Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; DNA/metabolism ; Drosophila melanogaster/metabolism ; Histones/metabolism ; Humans ; Nucleoplasmins/metabolism ; Nucleosome Assembly Protein 1/metabolism ; Nucleosomes/metabolism ; Transcription Factors/metabolism
Chemical Substances	Chromatin ; Histones ; ISWI protein ; Nucleoplasmins ; Nucleosome Assembly Protein 1 ; Nucleosomes ; Transcription Factors ; Adenosine Triphosphate (8L70Q75FXE) ; DNA (9007-49-2) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2017-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M117.815365
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Article ; Online: Prenucleosomes and Active Chromatin.

Khuong, Mai T / Fei, Jia / Ishii, Haruhiko / Kadonaga, James T

Cold Spring Harbor symposia on quantitative biology

2015 Volume 80, Page(s) 65–72

Abstract: Chromatin consists of nucleosomes as well as nonnucleosomal histone-containing particles. Here we describe the prenucleosome, which is a stable conformational isomer of the nucleosome that associates with ∼80 bp DNA. Prenucleosomes are formed rapidly ... ...

Abstract	Chromatin consists of nucleosomes as well as nonnucleosomal histone-containing particles. Here we describe the prenucleosome, which is a stable conformational isomer of the nucleosome that associates with ∼80 bp DNA. Prenucleosomes are formed rapidly upon the deposition of histones onto DNA and can be converted into canonical nucleosomes by an ATP-driven chromatin assembly factor such as ACF. Different lines of evidence reveal that there are prenucleosome-sized DNA-containing particles with histones in the upstream region of active promoters. Moreover, p300 acetylates histone H3K56 in prenucleosomes but not in nucleosomes, and H3K56 acetylation is found at active promoters and enhancers. These findings therefore suggest that there may be prenucleosomes or prenucleosome-like particles in the upstream region of active promoters. More generally, we postulate that prenucleosomes or prenucleosome-like particles are present at dynamic chromatin, whereas canonical nucleosomes are at static chromatin.
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1943-4456 ; 0091-7451
ISSN (online)	1943-4456
ISSN	0091-7451
DOI	10.1101/sqb.2015.80.027300
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Article ; Online: Trends in, projections of, and inequalities in reproductive, maternal, newborn and child health service coverage in Vietnam 2000-2030: A Bayesian analysis at national and sub-national levels.

Nguyen, Phuong T / Rahman, Md Shafiur / Le, Phuong Mai / Nguyen, Huy Van / Vu, Kien Duy / Nguyen, Hoa L / Dao, An Thi Minh / Khuong, Long Quynh / Hoang, Minh Van / Gilmour, Stuart

The Lancet regional health. Western Pacific

2021 Volume 15, Page(s) 100230

Abstract: Background: To assess the reproductive, maternal, newborn and child health (RMNCH) service coverage in Vietnam with trends in 2000-2014, projections and probability of achieving targets in 2030 at national and sub-national levels; and to analyze the ... ...

Abstract	Background: To assess the reproductive, maternal, newborn and child health (RMNCH) service coverage in Vietnam with trends in 2000-2014, projections and probability of achieving targets in 2030 at national and sub-national levels; and to analyze the socioeconomic, regional and urban-rural inequalities in RMNCH service indicators. Methods: We used national population-based datasets of 44,624 households in Vietnam from 2000 to 2014. We applied Bayesian regression models to estimate the trends in and projections of RMNCH indicators and the probabilities of achieving the 2030 targets. Using the relative index, slope index, and concentration index of inequality, we examined the patterns and trends in RMNCH coverage inequality. Findings: We projected that 9 out of 17 health service indicators (53%) would likely achieve the 2030 targets at the national level, including at least one and four ANC visits, BCG immunization, access to improved water and adequate sanitation, institutional delivery, skilled birth attendance, care-seeking for pneumonia, and ARI treatment. We observed very low coverages and zero chance of achieving the 2030 targets at national and sub-national levels in early initiation and exclusive breastfeeding, family planning needs satisfied, and oral rehydration therapy. The most deprived households living in rural areas and the Northwest, Northeast, North Central, Central Highlands, and Mekong River Delta regions would not reach the 80% immunization coverage of DPT3, Polio3, Measles and full immunization. We found socioeconomic, regional, and urban-rural inequalities in all RMNCH indicators in 2014 and no change in inequalities over 15 years in the lowest-coverage indicators. Interpretation: Vietnam has made substantial progress toward UHC. By improving the government's health system reform efforts, re-allocating resources focusing on people in the most impoverished rural regions, and restructuring and enhancing current health programs, Vietnam can achieve the UHC targets and other health-related SDGs. Funding: The authors did not receive any funds for conducting this study.
Language	English
Publishing date	2021-07-30
Publishing country	England
Document type	Journal Article
ISSN	2666-6065
ISSN (online)	2666-6065
DOI	10.1016/j.lanwpc.2021.100230
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Article ; Online: Trends in, projections of, and inequalities in reproductive, maternal, newborn and child health service coverage in Vietnam 2000-2030

Phuong T. Nguyen / Md Shafiur Rahman / Phuong Mai Le / Huy Van Nguyen / Kien Duy Vu / Hoa L. Nguyen / An Thi Minh Dao / Long Quynh Khuong / Minh Van Hoang / Stuart Gilmour

The Lancet Regional Health. Western Pacific, Vol 15, Iss , Pp 100230- (2021)

A Bayesian analysis at national and sub-national levels

2021

Abstract: Summary: Background: To assess the reproductive, maternal, newborn and child health (RMNCH) service coverage in Vietnam with trends in 2000−2014, projections and probability of achieving targets in 2030 at national and sub-national levels; and to analyze ...

Abstract	Summary: Background: To assess the reproductive, maternal, newborn and child health (RMNCH) service coverage in Vietnam with trends in 2000−2014, projections and probability of achieving targets in 2030 at national and sub-national levels; and to analyze the socioeconomic, regional and urban-rural inequalities in RMNCH service indicators. Methods: We used national population-based datasets of 44,624 households in Vietnam from 2000 to 2014. We applied Bayesian regression models to estimate the trends in and projections of RMNCH indicators and the probabilities of achieving the 2030 targets. Using the relative index, slope index, and concentration index of inequality, we examined the patterns and trends in RMNCH coverage inequality. Findings: We projected that 9 out of 17 health service indicators (53%) would likely achieve the 2030 targets at the national level, including at least one and four ANC visits, BCG immunization, access to improved water and adequate sanitation, institutional delivery, skilled birth attendance, care-seeking for pneumonia, and ARI treatment. We observed very low coverages and zero chance of achieving the 2030 targets at national and sub-national levels in early initiation and exclusive breastfeeding, family planning needs satisfied, and oral rehydration therapy. The most deprived households living in rural areas and the Northwest, Northeast, North Central, Central Highlands, and Mekong River Delta regions would not reach the 80% immunization coverage of DPT3, Polio3, Measles and full immunization. We found socioeconomic, regional, and urban-rural inequalities in all RMNCH indicators in 2014 and no change in inequalities over 15 years in the lowest-coverage indicators. Interpretation: Vietnam has made substantial progress toward UHC. By improving the government's health system reform efforts, re-allocating resources focusing on people in the most impoverished rural regions, and restructuring and enhancing current health programs, Vietnam can achieve the UHC targets and other ...
Keywords	RMNCH ; Universal Health Coverage ; Vietnam ; trend ; projection ; progress ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of Multispectral Imaging in the Human Tympanic Membrane.

Tran Van, Tien / Lu Thi Thao, Mi / Bui Mai Quynh, Linh / Phan Ngoc Khuong, Cat / Huynh Quang, Linh

Journal of healthcare engineering

2020 Volume 2020, Page(s) 6219845

Abstract: Multispectral imaging has recently shown good performance in determining information about physiology, morphology, and composition of tissue. In the endoscopy field, many researches have shown the ability to apply multispectral or narrow-band images in ... ...

Abstract	Multispectral imaging has recently shown good performance in determining information about physiology, morphology, and composition of tissue. In the endoscopy field, many researches have shown the ability to apply multispectral or narrow-band images in surveying vascular structure based on the interaction of light wavelength with tissue composition. However, there has been no mention to assess the contrast between other components in the middle ear such as the tympanic membrane, malleus, and the surrounding area. Using CT, OCT, or ODT can clearly describe the tympanic membrane structure; nevertheless, these approaches are expensive, more complex, and time-consuming and are not suitable for most common middle ear diagnoses. Here, we show the potential of using the multispectral imaging technique to enhance the contrast of the tympanic membrane compared to the surrounding tissue. The optical absorption and scattering of biological tissues constituents are not the same at different wavelengths. In this pilot study, multiwavelength images of the tympanic membrane were captured by using the otoscope with LED light source at three distinct spectral regions: 450 nm, 530 nm, and 630 nm. Subsequently, analyses of the intensity images as well as the histogram of these images point out that the 630 nm illumination image features an evident contrast in the intensity of the tympanic membrane and malleus compared to the surrounding area. Analysis of such images could facilitate the boundary determination and segmentation of the tympanic membrane (TM) with high precision.
MeSH term(s)	Ear, Middle/diagnostic imaging ; Endoscopes ; Endoscopy/methods ; Equipment Design ; Female ; Hemoglobins/analysis ; Humans ; Male ; Malleus/diagnostic imaging ; Optical Fibers ; Otoscopy/methods ; Pilot Projects ; Reproducibility of Results ; Software ; Tomography, X-Ray Computed/methods ; Tympanic Membrane/diagnostic imaging ; User-Computer Interface ; Young Adult
Chemical Substances	Hemoglobins
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2020/6219845
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Article ; Online: Synthesis and Photophysical Properties of Tumor-Targeted Water-Soluble BODIPY Photosensitizers for Photodynamic Therapy.

Khuong Mai, Duy / Kang, Byungman / Pegarro Vales, Temmy / Badon, Isabel Wen / Cho, Sung / Lee, Joomin / Kim, Eunae / Kim, Ho-Joong

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 15

Abstract: The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on ... ...

Abstract	The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on three distinct cancer cell lines (human hepatoma Huh7, cervical cancer HeLa, and breast cancer MCF-7 cell lines). The halogenated BODIPY dyes exhibited a decreased fluorescence quantum yield compared to their non-halogenated counterpart, and facilitated the efficient generation of singlet oxygen species. The synthesized dyes exhibited low cytotoxicities in the dark and high photodynamic therapeutic capabilities against the treated cancer cell lines following irradiation at 530 nm. Moreover, the incorporation of lactose moieties led to an enhanced cellular uptake of the BODIPY dyes. Collectively, the results presented herein provide promising insights for the development of photodynamic therapeutic agents for cancer treatment.
MeSH term(s)	Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Boron Compounds/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Click Chemistry ; HeLa Cells ; Humans ; Lactose/chemistry ; MCF-7 Cells ; Neoplasms/metabolism ; Neoplasms/therapy ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Quantum Dots ; Singlet Oxygen/metabolism
Chemical Substances	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Boron Compounds ; Photosensitizing Agents ; Singlet Oxygen (17778-80-2) ; Lactose (J2B2A4N98G)
Language	English
Publishing date	2020-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25153340
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Article ; Online: Clinical and genetic analysis of Vietnamese patients diagnosed with early-onset Parkinson's disease.

Do, Minh Duc / Tran, Tai Ngoc / Luong, An Bac / Le, Linh Hoang Gia / Van Le, Tuan / Le, Khuong Thai / Van Vo, Niem Thanh / Le, Thuc-Nhi Nguyen / Vu, Hoang Anh / Mai, Thao Phuong

Brain and behavior

2023 Volume 13, Issue 4, Page(s) e2950

Abstract: Background: Genetic factors play a crucial role in the pathogenesis of Parkinson's disease (PD). However, no comprehensive study has described genetic alterations in Vietnamese patients diagnosed with PD. This study aimed to identify genetic causes and ... ...

Abstract	Background: Genetic factors play a crucial role in the pathogenesis of Parkinson's disease (PD). However, no comprehensive study has described genetic alterations in Vietnamese patients diagnosed with PD. This study aimed to identify genetic causes and their association with clinical phenotypes in a Vietnamese PD cohort. Methods: A total of 83 patients with early-onset PD (disease onset before the age of 50) were recruited for genetic analysis using a combination of multiplex ligation-dependent probe amplification and next-generation sequencing for a panel of 20 PD-associated genes. Results: It was found that 37 out of 83 patients carried genetic alterations, with 24 pathogenic/likely pathogenic/risk variants and 25 variants of uncertain significance. The pathogenic/likely pathogenic/risk variants were mostly detected in LRRK2, PRKN, and GBA, while the variants of uncertain significance were identified in 12 different genes that were studied. The most common genetic alteration was LRRK2 c.4883G>C (p.Arg1628Pro), and patients with PD carrying this variant were found to have a distinct phenotype. Participants carrying pathogenic/likely pathogenic/risk variants had a significantly higher rate of a family history of PD. Conclusion: These results provide a further understanding of genetic alterations associated with PD in a South-East Asian population.
MeSH term(s)	Humans ; Parkinson Disease/genetics ; Parkinson Disease/epidemiology ; Southeast Asian People ; Mutation ; Phenotype ; Genetic Predisposition to Disease
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.2950
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Article ; Online: Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2.

Theisen, Joshua W M / Gucwa, James S / Yusufzai, Timur / Khuong, Mai T / Kadonaga, James T

The Journal of biological chemistry

2013 Volume 288, Issue 10, Page(s) 7096–7104

Abstract: MeCP2 is an abundant methyl-cytosine-guanine (CG)-binding protein and transcriptional repressor. We developed a biochemical system that exhibits CG methylation-specific transcriptional repression by purified human MeCP2. MeCP2 represses transcription by ... ...

Abstract	MeCP2 is an abundant methyl-cytosine-guanine (CG)-binding protein and transcriptional repressor. We developed a biochemical system that exhibits CG methylation-specific transcriptional repression by purified human MeCP2. MeCP2 represses transcription by histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Our system appears to recreate the HDAC-independent component of MeCP2-mediated repression and occurs via inhibition of the assembly of transcription preinitiation complexes. At a ratio of approximately one molecule of MeCP2 per two methyl-CG dinucleotides, as found in mammalian neurons, the magnitude of methylation-specific repression was greater than 10-fold. Notably, the HDAC inhibitor trichostatin A had no effect on MeCP2-mediated repression with either naked DNA or chromatin templates. We designed a CG-deficient core promoter that is resistant to MeCP2-mediated repression when placed in a plasmid lacking CG dinucleotides. By using this CG-deficient reporter as a reference, we found that eight CG dinucleotides in the core promoter region are sufficient for strong methylation-specific repression by MeCP2. In contrast, MeCP2 does not repress a construct with 13 CG dinucleotides located ∼1.7 kbp upstream of the promoter. Furthermore, by analysis of C-terminally truncated MeCP2 proteins, we found that binding of MeCP2 to methyl-CG dinucleotides is not sufficient for transcriptional repression. Hence, MeCP2-mediated repression is not due to the simple steric blockage of the transcriptional machinery. These experiments suggest that MeCP2 can function as a global methyl-CG-specific, HDAC-independent repressor. This HDAC-independent mechanism of MeCP2-mediated repression may be important in cells, such as mammalian neurons, that have high levels of CG methylation and MeCP2.
MeSH term(s)	Chromatin/genetics ; Chromatin/metabolism ; DNA/genetics ; DNA/metabolism ; DNA Methylation ; Dinucleoside Phosphates/genetics ; Electrophoretic Mobility Shift Assay ; Gene Expression Regulation ; HeLa Cells ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases/metabolism ; Humans ; Hydroxamic Acids/pharmacology ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Mutation ; Promoter Regions, Genetic/genetics ; Protein Binding ; Transcription Initiation, Genetic/drug effects ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
Chemical Substances	Chromatin ; Dinucleoside Phosphates ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; Methyl-CpG-Binding Protein 2 ; cytidylyl-3'-5'-guanosine (2382-65-2) ; trichostatin A (3X2S926L3Z) ; DNA (9007-49-2) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2013-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M112.438697
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Article: ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling.

Torigoe, Sharon E / Patel, Ashok / Khuong, Mai T / Bowman, Gregory D / Kadonaga, James T

eLife

2013 Volume 2, Page(s) e00863

Abstract: Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven ... ...

Abstract	Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven chromatin assembly and chromatin remodeling in the generation of periodic nucleosome arrays. We found that chromatin remodeling-defective Chd1 motor proteins are able to catalyze ATP-dependent chromatin assembly. The resulting nucleosomes are not, however, spaced in periodic arrays. Wild-type Chd1, but not chromatin remodeling-defective Chd1, can catalyze the conversion of randomly-distributed nucleosomes into periodic arrays. These results reveal a functional distinction between ATP-dependent nucleosome assembly and chromatin remodeling, and suggest a model for chromatin assembly in which randomly-distributed nucleosomes are formed by the nucleosome assembly function of Chd1, and then regularly-spaced nucleosome arrays are generated by the chromatin remodeling activity of Chd1. These findings uncover an unforeseen level of specificity in the role of motor proteins in chromatin assembly. DOI:http://dx.doi.org/10.7554/eLife.00863.001.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Animals ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Humans ; Molecular Sequence Data ; Nucleosomes/metabolism ; Sequence Homology, Amino Acid ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Chemical Substances	Chromatin ; Nucleosomes ; Transcription Factors ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2013-08-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.00863
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