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Article: Evaluation of the total hydrodynamic energy loss using 4D flow MRI in a case with Fontan failure.

Odemis, Ender / Gumus, Terman / Aka, İbrahim Başar / Ozkok, Sercin / Pekkan, Kerem

2024 Volume 10, Issue 6, Page(s) e28140

Abstract: Fontan Failure (FF) is a common problem for single-ventricle patients as they reach adulthood. Although several mechanisms may cause FF, an optimized blood flow stream through the surgical conduits is essential to avoid excessive energy loss (EL). Recent ...

Abstract	Fontan Failure (FF) is a common problem for single-ventricle patients as they reach adulthood. Although several mechanisms may cause FF, an optimized blood flow stream through the surgical conduits is essential to avoid excessive energy loss (EL). Recent clinical studies showed EL is related to the quality of life, exercise capacity, and hepatic function since the single-ventricle feeds pulmonary and systemic circulation serially. 4D flow MRI effectively estimates EL in Fontan circulation and allows clinicians to compare the effectiveness of the treatment strategy concerning pre-intervention. Here, we present 26-year-old women with FF who had normal cardiac catheterization findings and were treated according to high EL definitions that are measured through 4D flow MRI.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28140
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Article: Optimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment.

Odemis, Ender / Aka, İbrahim Basar / Ali, Mhd Homam Alhaj / Gumus, Terman / Pekkan, Kerem

Frontiers in cardiovascular medicine

2024 Volume 10, Page(s) 1331206

Abstract: Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). ... ...

Abstract	Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). However, the success of PPVI depends on precise patient-specific valve sizing, the avoidance of oversizing complications, and optimal valve performance. In recent years, innovative adaptations of commercially available cardiovascular mock loops have been used to test conduits in the pulmonary position. These models are instrumental in facilitating accurate pulmonic valve sizing, mitigating the risk of oversizing, and providing insight into the valve performance before implantation. This study explored the utilization of custom-modified mock loops to implant patient-specific 3D-printed pulmonary artery geometries, thereby advancing PPVI planning and execution. Material and methods: Patient-specific 3D-printed pulmonary artery geometries of five patients who underwent PPVI using Pulsta transcatheter heart valve (THV) ® were tested in a modified ViVitro pulse duplicator system®. Various valve sizes were subjected to 10 cycles of testing at different cardiac output levels. The transpulmonary systolic and regurgitation fractions of the valves were also recorded and compared. Results: A total of 39 experiments were conducted using five different patient geometries and several different valve sizes (26, 28, 30, and 32 mm) at 3, 4, and 5 L/min cardiac output at heart rates of 70 beats per minute (bpm) and 60/40 systolic/diastolic ratios. The pressure gradients and regurgitation fractions of the tested valve sizes in the models were found to be similar to the pressure gradients and regurgitation fractions of valves used in real procedures. However, in two patients, different valve sizes showed better hemodynamic values than the actual implanted valves. Discussion: The use of 3D printing technology, electromagnetic flow meters, and the custom-modified ViVitro pulse duplicator system® in conjunction with patient-specific pulmonary artery models has enabled a comprehensive assessment of percutaneous pulmonic valve implantation performance. This approach allows for accurate valve sizing, minimization of oversizing risks, and valuable insights into hemodynamic behavior before implantation. The data obtained from this experimental setup will contribute to advancing PPVI procedures and offer potential benefits in improving patient outcomes and safety.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1331206
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Article ; Online: Working memory for time intervals: Another manifestation of the central tendency effect.

Gümüş, Gamze / Balcı, Fuat

Psychonomic bulletin & review

2023 Volume 30, Issue 6, Page(s) 2289–2295

Abstract: The relationship between working memory and time perception has been typically investigated using dual-task paradigms (e.g., testing timing performance during a concurrent task). To our knowledge, none of these studies used time intervals as the target ... ...

Abstract	The relationship between working memory and time perception has been typically investigated using dual-task paradigms (e.g., testing timing performance during a concurrent task). To our knowledge, none of these studies used time intervals as the target stimulus to be remembered. The current study investigated the working memory for time intervals by asking participants to reproduce durations they experienced at different orders in a series of experienced intervals (n-back task). One of the experiments was conducted online and the other one in the lab setting. Results showed a central tendency bias and additive elongation of time reproductions with increasing working memory load. Our results also showed that participants assigned different weights to experienced intervals based on their order of presentation (higher weight to the target interval). We conclude that the recall of intervals from working memory under high cognitive load leads to a central tendency effect, which is known to be induced by the temporal context and present particularly in aging and in those with Parkinson's disease.
MeSH term(s)	Humans ; Memory, Short-Term ; Time Perception ; Mental Recall ; Aging
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2031311-1
ISSN	1531-5320 ; 1069-9384
ISSN (online)	1531-5320
ISSN	1069-9384
DOI	10.3758/s13423-023-02324-z
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Article ; Online: Glycogen storage diseases: An update.

Gümüş, Ersin / Özen, Hasan

World journal of gastroenterology

2023 Volume 29, Issue 25, Page(s) 3932–3963

Abstract: ... organ transplantation are other treatment approaches for both disease manifestations and long-term complications ...

Abstract	Glycogen storage diseases (GSDs), also referred to as glycogenoses, are inherited metabolic disorders of glycogen metabolism caused by deficiency of enzymes or transporters involved in the synthesis or degradation of glycogen leading to aberrant storage and/or utilization. The overall estimated GSD incidence is 1 case per 20000-43000 live births. There are over 20 types of GSD including the subtypes. This heterogeneous group of rare diseases represents inborn errors of carbohydrate metabolism and are classified based on the deficient enzyme and affected tissues. GSDs primarily affect liver or muscle or both as glycogen is particularly abundant in these tissues. However, besides liver and skeletal muscle, depending on the affected enzyme and its expression in various tissues, multiorgan involvement including heart, kidney and/or brain may be seen. Although GSDs share similar clinical features to some extent, there is a wide spectrum of clinical phenotypes. Currently, the goal of treatment is to maintain glucose homeostasis by dietary management and the use of uncooked cornstarch. In addition to nutritional interventions, pharmacological treatment, physical and supportive therapies, enzyme replacement therapy (ERT) and organ transplantation are other treatment approaches for both disease manifestations and long-term complications. The lack of a specific therapy for GSDs has prompted efforts to develop new treatment strategies like gene therapy. Since early diagnosis and aggressive treatment are related to better prognosis, physicians should be aware of these conditions and include GSDs in the differential diagnosis of patients with relevant manifestations including fasting hypoglycemia, hepatomegaly, hypertransaminasemia, hyperlipidemia, exercise intolerance, muscle cramps/pain, rhabdomyolysis, and muscle weakness. Here, we aim to provide a comprehensive review of GSDs. This review provides general characteristics of all types of GSDs with a focus on those with liver involvement.
MeSH term(s)	Humans ; Glycogen Storage Disease/diagnosis ; Glycogen Storage Disease/genetics ; Glycogen Storage Disease/therapy ; Liver/metabolism ; Glycogen/metabolism ; Muscle, Skeletal/metabolism ; Genetic Therapy
Chemical Substances	Glycogen (9005-79-2)
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v29.i25.3932
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Zs.A 6039: Show issues

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Article ; Online: Evaluation of oral health-related quality of life following dental rehabilitation under general anesthesia in Turkish children with early childhood caries.

Öztürk, Gülce / Gümüş, Hüsniye

International journal of paediatric dentistry

2023 Volume 34, Issue 1, Page(s) 47–57

Abstract: ... long-term effects of DRGA on children and their families' oral health-related quality of life (OHRQoL ...

Abstract	Background: Early childhood caries (ECC) is one of the most common dental problems, which often require dental rehabilitation with general anesthesia (DRGA). Aim: To assess the short- and long-term effects of DRGA on children and their families' oral health-related quality of life (OHRQoL) in preschool children, the incidence of complications on the first day, and the factors affecting them and parental satisfaction. Design: A total of 150 children treated for ECC under DRGA were included in the study. OHRQoL was assessed on the day of DRGA, 4 weeks, and 1 year after treatment using the Early Childhood Oral Health Impact Scale (ECOHIS). The incidence of complications and parental satisfaction with DRGA were evaluated. The data were analyzed for statistical significance (p < .05). Results: In total, 134 patients were re-evaluated at the end of the fourth week and 120 at the end of the first year. The average ECOHIS scores before and after DRGA (4 weeks and 1 year) were 18.1 ± 8.5, 3.1 ± 3.9, and 5.9 ± 6.2, respectively. After DRGA, 29.2% of the children reported at least one complication. Ninety-one percent of the parents reported that they were satisfied with DRGA. Conclusion: DRGA has a positive effect on the OHRQoL of Turkish preschool children with ECC and is highly evaluated by their parents.
MeSH term(s)	Humans ; Child, Preschool ; Quality of Life ; Dental Caries Susceptibility ; Dental Caries ; Oral Health ; Parents ; Anesthesia, General ; Surveys and Questionnaires
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1070942-3
ISSN	1365-263X ; 0960-7439
ISSN (online)	1365-263X
ISSN	0960-7439
DOI	10.1111/ipd.13096
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Zs.A 3201: Show issues

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Article: The effect of internalized stigmatization on care burden in adolescent psychiatric patients and their parents.

Gümüş, Funda / Kaçan, Havva

Frontiers in psychiatry

2023 Volume 14, Page(s) 1192087

Abstract: ... 42.74 ± (11.92). When the ZBI total scores were examined in terms of sociodemographic variables, no ...

Abstract	Introduction: The purpose of this study was to determine the effect of internalized stigma perceived by adolescents with mental disorders and their families, on the burden of care on their families. Methods: The study was conducted in a descriptive and correlational desing with adolescents and their parents who applied to the child and adolescent psychiatry outpatient clinic between March 1 and June 1, 2022. A total 101 adolescents and 101 parents who met the sampling criteria and agreed to participate in the study. Only 1 parent per adolescent was included in the study. Results: It was found that the mean age of the adolescents was 15.05 ± (1.80), 57.4% were female and 56.4% were secondary school graduates, and 26.7% of the adolescents, all of whom were unemployed, were diagnosed with a mood disorder, 50.5% had received outpatient treatment previously, and 22.8% had chronic diseases. It was found that the mean age of the parents who participated in the study was 45.53 ± (6.48), 77.1% were female and 28.7% were secondary school graduates. Also, 22.8% of the parents had a chronic disease, 28.7% had a chronic disease in their family and 32.7% had another family member in need of care, and 17.0% of the parents had received training on mental disorders previously. It was found that the parents' total means ZBI score was 42.74 ± (11.92). When the ZBI total scores were examined in terms of sociodemographic variables, no significant differences were found between the groups according to the variables. There was only a weak, positive and significant relationship between the age of the parents and in the present study, it was found that adolescents with mental disorders and their families experienced internalized stigmatization and this stigmatization increased the care burden on parents. Discussion: Mental health and psychiatric nurses can facilitate this population's access to treatment by planning and implementing psychosocial interventions to reduce the internalized stigma of children and adolescents and their families.
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1192087
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Article ; Online: Research into the relationship between digital health literacy and healthy lifestyle behaviors: an intergenerational comparison.

Çetin, Murat / Gümüş, Rojan

Frontiers in public health

2023 Volume 11, Page(s) 1259412

Abstract: Introduction: Digital health literacy wields a pivotal role in individuals' health status in terms ...

Abstract	Introduction: Digital health literacy wields a pivotal role in individuals' health status in terms of seeking and choosing appropriate and accurate information, and useful services from a vast array of choices. This study is aimed at assessing the validity and reliability of the Turkish version of Digital Health Literacy Instrument (DHLI) and examining the relationship between DHL and the healthy lifestyle behaviors of participants from X, Y, and Z generations. Methods: In this study, to conduct a cross-sectional web-based survey, an online self-report questionnaire was built, and a convenience sample with a snowball approach was used. The study was conducted among 1,274 respondents aged between 18 and 64 years. Data collection tools consisted of the Personal Information Form, Lifestyle Behavior Scale II (HLBS II), and DHLI. Cultural validation and psychometric testing of DHLI, exploratory factor analysis, confirmatory factor analysis, Cronbach's alpha test, and bivariate and multivariate regression analysis were used for statistical analysis. Results: In the study, the Turkish version of the DHLI tool consisting of six dimensions proved to be valid and reliable, and deemed appropriate for use across all age groups. The average digital health literacy of the respondents was sufficient, but the mean of healthy lifestyle behavior scores was moderate. There was a positive significant relationship between the total mean scores of DHLI and HLBS. Among the subdimensions of DHLI, while the highest mean scores were in DHLI Reliability, DHLI Privacy, and DHLI Search, DHLI Navigation and DHLI Relevance showed the lowest mean scores. DHLI Reliability, DHLI Relevance, and DHLI Adding Content were statistically significant predictors of health-related behaviors of the respondents. Conclusion: The most important feature and novelty of this study is that, although the DHLI scale has been widely translated for use in many countries, it has been translated and adapted to Turkish for the first time herein. The study offers crucial evidence about Generation X, Y, and Z's DHL level and its positive relationships with health-related behaviors. Therefore, the community and its partners should lead the way in empowering individuals to understand and use online information in an effective, secure, and health-promoting manner, along with governments.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Cross-Sectional Studies ; Reproducibility of Results ; Health Literacy ; Healthy Lifestyle
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1259412
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Article ; Online: Preoperative computerized tomography screening for COVID-19 pneumonia in asymptomatic patients: experiences from two centers.

Gümüs, Terman / Kabaoglu, Zeynep Unal / Coskun, Bilgen / Kartal, Furkan / Artukoglu, Feyzi / Atasoy, Kayhan Cetin

Japanese journal of radiology

2020 Volume 39, Issue 3, Page(s) 240–245

Abstract: Purpose: The aim of this retrospective study is to evaluate the preoperative screening performance of chest CT (computerized tomography) examination to detect COVID-19 positive individuals.: Materials and methods: In this retrospective study 218 ... ...

Abstract	Purpose: The aim of this retrospective study is to evaluate the preoperative screening performance of chest CT (computerized tomography) examination to detect COVID-19 positive individuals. Materials and methods: In this retrospective study 218 adult patients who had preoperative chest CT and RT-PCR were enrolled. CT imaging results, which have been reported according to the Radiological Society of North America expert consensus on COVID-19, were collected from the picture archiving and communicating system. Demographic data, planned surgeries, and postoperative outcomes were collected from the electronic patient records. Results: One patient (0.5%) showed typical CT features for COVID-19 pneumonia; 12 patients (5.5%) were reported as indeterminate, and eight (3.7%) were reported as atypical for COVID-19 pneumonia. Only one of the three patients with positive RT-PCR had abnormalities on CT. When RT-PCR tests were taken as reference, the sensitivity, specificity, and accuracy of chest CT in showing COVID-19 infection in asymptomatic patients were 33.3%, 90.7%, and 90.0%, respectively. Conclusion: Chest CT screening for COVID-19 has a very low yield in asymptomatic preoperative patients and shows false-positive findings in 9.2% of cases, potentially leading to unnecessary postponing of the surgery.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnostic imaging ; COVID-19 Testing/methods ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Preoperative Care/methods ; Reproducibility of Results ; Retrospective Studies ; SARS-CoV-2 ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods ; Turkey ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-31
Publishing country	Japan
Document type	Journal Article ; Multicenter Study
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-020-01061-w
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Zs.A 2249: Show issues

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Article ; Online: Investigation of the effect of circadian rhythm on the performances of NBA teams.

Özdalyan, Fırat / Çene, Erhan / Gümüş, Hikmet / Açıkgöz, Osman

Chronobiology international

2024 , Page(s) 1–10

Abstract: ... its opponent's internal UTC (OB). 24985 game data were used to compare these groups in terms of 25 variables ...

Abstract	Professional athletes competing in the NBA are frequently exposed to time-zone-shifting travels. These time zone changes may cause circadian rhythm (CR) phase shifts and these shifts affect sportive performance. The aim of this study was to investigate the effects of CR phase shifts on the performance of NBA teams. 25016 regular season games across 21 consecutive seasons were included in the CR phase shift calculations. To examine the CR phase shift effect on team performance, teams were divided into three groups regarding Coordinated Universal Time (UTC): the same internal UTC as the local UTC (LS); the internal UTC ahead of the local UTC (LA); and the internal UTC behind the local UTC (LB). With a different approach, teams were divided into another three categories: the same internal UTC as its opponent's internal UTC (OS); the internal UTC ahead of its opponent's internal UTC (OA); and the internal UTC behind its opponent's internal UTC (OB). 24985 game data were used to compare these groups in terms of 25 variables. Statistical analyses were conducted separately for home and away teams. For home games, it was found that LA and OA are the most and LB is the least successful group in winning and scoring performances. For away games, it was determined that LS is the most advantageous group with the best winning percentage. These results revealed that teams from more west may have a CR advantage in regular season home games. However, it is thought that the performance of away teams depends more on travel fatigue than CR phase shifts.
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2024.2325641
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Zs.A 2068: Show issues

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Article ; Online: Human metapneumovirus infection: Diagnostic impact of radiologic imaging.

Keske, Şiran / Gümüş, Terman / Köymen, Tamer / Sandıkçı, Sunay / Tabak, Levet / Ergönül, Önder

Journal of medical virology

2019 Volume 91, Issue 6, Page(s) 958–962

Abstract: Background: Human metapneumovirus (hMPV) is a recently detected virus, which can cause mild to severe respiratory tract infections. Through this study, we aimed to detail the outcomes of hMPV infections.: Materials/methods: Between January 2012 and ... ...

Abstract	Background: Human metapneumovirus (hMPV) is a recently detected virus, which can cause mild to severe respiratory tract infections. Through this study, we aimed to detail the outcomes of hMPV infections. Materials/methods: Between January 2012 and November 2017, patients who had hMPV detected in nasopharyngeal or bronchoalveolar lavage by molecular respiratory pathogen tests were evaluated. The Food and Drug Administration cleared multiplexed-polymerase chain reaction system (Idaho Technology, Salt Lake City, UT) was used for diagnosis. Chest radiography (CR) and computed tomography (CT) were evaluated by an expert radiologist. Results: In total 100 patients were included, the mean age was 22.9 (0-87) years, and 50% were male. The hospitalization rate was 52%. Lower respiratory system infection (LRTI) was diagnosed in 44 patients with clinical findings, and in 31 patients out of 44 the radiological findings supported the diagnosis. The LRTI rate was significantly higher in adults than children (66.7%-32.8%; P = 0.001). In CR, peribronchovascular infiltration (PI) was the most common feature seen in 14 out of 18 patients and was generally bilateral (13 out of 18 patients). In CT imaging, ground-glass opacity was the most common finding seen in 11 out of 16 patients and nodular consolidation in five patients. Ribavirin was given to four patients, three of whom were severe and required respiratory support. None of the patients died of hMPV infection. Conclusions: The ground-glass opacity in CT was similar to other respiratory virus infections, and PI in CR was very common and typical; however, nodular consolidation that may mimic bacterial infection was seen in one-fourth of CT.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bronchoalveolar Lavage Fluid/virology ; Child ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Metapneumovirus/genetics ; Middle Aged ; Nasopharynx/virology ; Paramyxoviridae Infections/diagnostic imaging ; Paramyxoviridae Infections/epidemiology ; Respiratory Tract Infections/diagnostic imaging ; Respiratory Tract Infections/virology ; Turkey/epidemiology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25402
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