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  1. Book ; Thesis: Überlebenszeitanalyse von Patienten mit Weichteilsarkom des Bewegungsapparates

    Langenberg, Jenny / Hofmann, Gunther O. / Hochhaus, Andreas / Delank, Karl-Stefan

    2022  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Jenny Langenberg
    Keywords Weichteilsarkom ; Überlebenszeit
    Subject Weichgewebesarkom
    Language German
    Size 111 Blätter, Diagramme, 29,5cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2022
    Note Tag der Verteidigung: 05.04.2022
    HBZ-ID HT021607236
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Ups and downs of lysosomal pH: conflicting roles of LAMP proteins?

    Handy, Jonathan / Macintosh, Gustavo C / Jenny, Andreas

    Autophagy

    2024  Volume 20, Issue 2, Page(s) 437–440

    Abstract: The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalian cell culture systems have identified novel and, at ... ...

    Abstract The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and is altered in neurodegenerative disease including Alzheimer and Parkinson. Recent reports using Drosophila and mammalian cell culture systems have identified novel and, at first sight, conflicting roles for the lysosomal associated membrane proteins (LAMPs) in the regulation of the endolysosomal system.
    MeSH term(s) Animals ; Neurodegenerative Diseases/metabolism ; Autophagy ; Lysosomes/metabolism ; Lysosomal Membrane Proteins ; Adenosine Triphosphatases/metabolism ; Drosophila/metabolism ; Hydrogen-Ion Concentration ; Vacuolar Proton-Translocating ATPases/metabolism ; Mammals/metabolism
    Chemical Substances Lysosomal Membrane Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2274253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparing the net-energy balance of standalone photovoltaic-coupled electrolysis and photoelectrochemical hydrogen production.

    Tam, Brian / Babacan, Oytun / Kafizas, Andreas / Nelson, Jenny

    Energy & environmental science

    2024  Volume 17, Issue 5, Page(s) 1677–1694

    Abstract: Photovoltaic-coupled electrolysis (PV-E) and photoelectrochemical (PEC) water splitting are two options for storing solar energy as hydrogen. Understanding the requirements for achieving a positive energy balance over the lifetime of facilities using ... ...

    Abstract Photovoltaic-coupled electrolysis (PV-E) and photoelectrochemical (PEC) water splitting are two options for storing solar energy as hydrogen. Understanding the requirements for achieving a positive energy balance over the lifetime of facilities using these technologies is important for ensuring sustainability. While neither technology has yet reached full commercialisation, they are also at very different technology readiness levels and scales of development. Here, we model the energy balance of standalone large-scale facilities to evaluate their energy return on energy invested (ERoEI) over time and energy payback time (EPBT). We find that for average input parameters based on present commercialised modules, a PV-E facility shows an EPBT of 6.2 years and ERoEI after 20 years of 2.1, which rises to approximately 3.7 with an EPBT of 2.7 years for favourable parameters using the best metrics amongst large-scale modules. The energy balance of PV-E facilities is influenced most strongly by the upfront embodied energy costs of the photovoltaic component. In contrast, the simulated ERoEI for a PEC facility made with earth abundant materials only peaks at 0.42 after 11 years and about 0.71 after 20 years for facilities with higher-performance active materials. Doubling the conversion efficiency to 10% and halving the degradation rate to 2% for a 10-year device lifetime can allow PEC facilities to achieve an ERoEI after 20 years of 2.1 for optimistic future parameters. We also estimate that recycling the materials used in hydrogen production technologies improves the energy balance by 28% and 14% for favourable-case PV-E and PEC water splitting facilities, respectively.
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2439879-2
    ISSN 1754-5706 ; 1754-5692
    ISSN (online) 1754-5706
    ISSN 1754-5692
    DOI 10.1039/d3ee02814c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preface.

    Jenny, Andreas

    Current topics in developmental biology

    2017  Volume 123, Page(s) xiii–xvi

    MeSH term(s) Animals ; Developmental Biology ; Growth and Development ; Humans ; Phosphorylation ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Signal Transduction
    Chemical Substances Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2017-02-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/S0070-2153(17)30014-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Weissbuch Landwirtschaft Schweiz

    Bosshard, Andreas / Schläpfer, Felix / Jenny, Markus

    Analysen und Vorschläge zur Reform der Agrarpolitik

    2010  

    Author's details Andreas Bosshard ; Felix Schläpfer ; Markus Jenny. Hrsg von Vision Landwirtschaft
    Keywords Schweiz ; Agrarpolitik ; Agrarreform
    Subject Landreform ; Agrarverfassung ; Landwirtschaftspolitik
    Language German
    Size 272 S., zahlr. Ill., graph. Darst., Kt., 240 mm x 170 mm
    Edition 1. Aufl.
    Publisher Haupt
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    Note Literaturverz. S. 262 - 272
    HBZ-ID HT016394786
    ISBN 978-3-258-07551-8 ; 3-258-07551-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  6. Article ; Online: Landmark-based registration of a cochlear model to a human cochlea using conventional CT scans

    Jenny Stritzel / Amir Hossein Ebrahimzadeh / Andreas Büchner / Heinrich Lanfermann / Michael Marschollek / Dominik Wolff

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 13

    Abstract: Abstract Cochlear implants can provide an advanced treatment option to restore hearing. In standard pre-implant procedures, many factors are already considered, but it seems that not all underlying factors have been identified yet. One reason is the low ... ...

    Abstract Abstract Cochlear implants can provide an advanced treatment option to restore hearing. In standard pre-implant procedures, many factors are already considered, but it seems that not all underlying factors have been identified yet. One reason is the low quality of the conventional computed tomography images taken before implantation, making it difficult to assess these parameters. A novel method is presented that uses the Pietsch Model, a well-established model of the human cochlea, as well as landmark-based registration to address these challenges. Different landmark numbers and placements are investigated by visually comparing the mean error per landmark and the registrations’ results. The landmarks on the first cochlear turn and the apex are difficult to discern on a low-resolution CT scan. It was possible to achieve a mean error markedly smaller than the image resolution while achieving a good visual fit on a cochlear segment and directly in the conventional computed tomography image. The employed cochlear model adjusts image resolution problems, while the effort of setting landmarks is markedly less than the segmentation of the whole cochlea. As a next step, the specific parameters of the patient could be extracted from the adapted model, which enables a more personalized implantation with a presumably better outcome.
    Keywords Medicine ; R ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Landmark-based registration of a cochlear model to a human cochlea using conventional CT scans.

    Stritzel, Jenny / Ebrahimzadeh, Amir Hossein / Büchner, Andreas / Lanfermann, Heinrich / Marschollek, Michael / Wolff, Dominik

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1115

    Abstract: Cochlear implants can provide an advanced treatment option to restore hearing. In standard pre-implant procedures, many factors are already considered, but it seems that not all underlying factors have been identified yet. One reason is the low quality ... ...

    Abstract Cochlear implants can provide an advanced treatment option to restore hearing. In standard pre-implant procedures, many factors are already considered, but it seems that not all underlying factors have been identified yet. One reason is the low quality of the conventional computed tomography images taken before implantation, making it difficult to assess these parameters. A novel method is presented that uses the Pietsch Model, a well-established model of the human cochlea, as well as landmark-based registration to address these challenges. Different landmark numbers and placements are investigated by visually comparing the mean error per landmark and the registrations' results. The landmarks on the first cochlear turn and the apex are difficult to discern on a low-resolution CT scan. It was possible to achieve a mean error markedly smaller than the image resolution while achieving a good visual fit on a cochlear segment and directly in the conventional computed tomography image. The employed cochlear model adjusts image resolution problems, while the effort of setting landmarks is markedly less than the segmentation of the whole cochlea. As a next step, the specific parameters of the patient could be extracted from the adapted model, which enables a more personalized implantation with a presumably better outcome.
    MeSH term(s) Humans ; Cochlea/diagnostic imaging ; Cochlea/surgery ; Cochlear Implantation/methods ; Cochlear Implants ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50632-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surgical outcomes of laser in situ keratomileusis (LASIK) in patients with stable systemic disease.

    Saad, Amr / Narr, Jenny / Frings, Andreas / Steinberg, Johannes / Katz, Toam / Linke, Stephan Johannes

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 119

    Abstract: Purpose: To evaluate the surgical outcome in terms of safety, efficacy, predictability, and retreatment rate of LASIK surgery in patients with controlled systemic diseases in comparison with healthy individuals.: Methods: The retrospective study ... ...

    Abstract Purpose: To evaluate the surgical outcome in terms of safety, efficacy, predictability, and retreatment rate of LASIK surgery in patients with controlled systemic diseases in comparison with healthy individuals.
    Methods: The retrospective study included data from 1936 eyes of 976 patients with stable systemic diseases who underwent LASIK surgery between January 2016 and June 2019. The safety, efficacy, predictability of the surgery, and retreatment rate were evaluated in comparison with a control group comprising 1951 patients. The study was approved by the local ethics committee and adhered to the principles of the Declaration of Helsinki. Statistical analysis was performed using R team and the level of statistical significance was set at p < 0.05.
    Results: All treatment groups demonstrated high safety and efficacy indices after LASIK surgery. Furthermore, the study arms demonstrated comparable predictability and retreatment rates to the control group in nearly all cases. Retreatment rates were significantly higher in the rheumatoid arthritis group (p = 0.03), while safety indices were significantly lower in the hay fever group compared to the control group (p = 0.004). No intra- or postoperative sight-threatening complications were documented.
    Conclusion: Our findings suggest that selected patients with stable systemic conditions can safely undergo LASIK surgery and achieve comparable outcomes to healthy individuals. Further research is needed to better understand the treatment outcomes in this challenging patient population.
    MeSH term(s) Humans ; Keratomileusis, Laser In Situ/adverse effects ; Visual Acuity ; Retrospective Studies ; Treatment Outcome ; Eye ; Postoperative Complications/etiology ; Refraction, Ocular ; Lasers, Excimer
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-02956-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synthesis, characterization, and biomedical evaluation of ethylene-bridged tetra-NHC Pd(ii), Pt(ii) and Au(iii) complexes, with apoptosis-inducing properties in cisplatin-resistant neuroblastoma cells.

    Büchele, Wolfgang R E / Schlachta, Tim P / Gebendorfer, Andreas L / Pamperin, Jenny / Richter, Leon F / Sauer, Michael J / Prokop, Aram / Kühn, Fritz E

    RSC advances

    2024  Volume 14, Issue 15, Page(s) 10244–10254

    Abstract: Synthesis and characterization of the first two cyclic ethylene-bridged tetradentate NHC ligands, with an unsaturated (imidazole) and saturated backbone (2-imidazoline), are described. Complexes of both ligands containing palladium(ii) have been obtained. ...

    Abstract Synthesis and characterization of the first two cyclic ethylene-bridged tetradentate NHC ligands, with an unsaturated (imidazole) and saturated backbone (2-imidazoline), are described. Complexes of both ligands containing palladium(ii) have been obtained. For platinum(ii) and gold(iii), only the unsaturated tetracarbene complexes could be isolated. The attempts to synthesize a methylene-bridged 2-imidazoline macrocycle are also described. Furthermore, a novel bisimidazolinium ligand precursor and its open-chain Pd
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01195c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Respiratory motion modelling for MR-guided lung cancer radiotherapy: model development and geometric accuracy evaluation.

    Eiben, Björn / Bertholet, Jenny / Tran, Elena H / Wetscherek, Andreas / Shiarli, Anna-Maria / Nill, Simeon / Oelfke, Uwe / McClelland, Jamie R

    Physics in medicine and biology

    2024  Volume 69, Issue 5

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Magnetic Resonance Imaging/methods ; Motion ; Imaging, Three-Dimensional ; Respiration ; Radiotherapy, Image-Guided/methods
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad222f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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