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  1. Article ; Online: Valid but Undervalued.

    Li, Ji-Peng Olivia / Keane, Pearse A / Thomas, Peter

    JAMA ophthalmology

    2022  Volume 140, Issue 5, Page(s) 471

    Language English
    Publishing date 2022-03-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2022.0549
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  2. Article ; Online: Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine.

    Phylactou, Maria / Li, Ji-Peng Olivia / Larkin, Daniel F P

    The British journal of ophthalmology

    2021  Volume 105, Issue 7, Page(s) 893–896

    Abstract: Aim: We report two cases of endothelial corneal allograft rejection following immunisation with SARS-CoV-2 messenger RNA (mRNA) vaccine BNT162b2 and describe the implications for management of transplant recipients postvaccination for COVID-19.: ... ...

    Abstract Aim: We report two cases of endothelial corneal allograft rejection following immunisation with SARS-CoV-2 messenger RNA (mRNA) vaccine BNT162b2 and describe the implications for management of transplant recipients postvaccination for COVID-19.
    Methods: A 66-year-old woman with Fuchs endothelial corneal dystrophy (FECD) and a unilateral Descemet's membrane endothelial keratoplasty (DMEK) transplant received COVID-19 mRNA vaccine BNT162b2 14 days post-transplant. Seven days later, she presented with symptoms and signs of endothelial graft rejection. An 83-year-old woman with bilateral DMEK transplants for FECD 3 and 6 years earlier developed simultaneous acute endothelial rejection in both eyes, 3 weeks post second dose of COVID-19 mRNA vaccine BNT162b2. Rejection in both cases was treated successfully with topical corticosteroids.
    Conclusions: We believe this is the first report of temporal association between corneal transplant rejection following immunisation against COVID-19 and the first report of DMEK rejection following any immunisation. We hypothesise that the allogeneic response may have been initiated by the host antibody response following vaccination. Clinicians and patients should be aware of the potential of corneal graft rejection associated with vaccine administration and may wish to consider vaccination in advance of planned non-urgent keratoplasties. Patients should be counselled on the symptoms and signs that require urgent review to allow early treatment of any confirmed rejection episode.
    MeSH term(s) Administration, Ophthalmic ; Aged ; Aged, 80 and over ; Allografts ; Anterior Eye Segment/diagnostic imaging ; BNT162 Vaccine ; COVID-19/genetics ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Descemet Stripping Endothelial Keratoplasty ; Dexamethasone/therapeutic use ; Endothelium, Corneal/diagnostic imaging ; Endothelium, Corneal/pathology ; Female ; Fuchs' Endothelial Dystrophy/surgery ; Glucocorticoids/therapeutic use ; Graft Rejection/diagnostic imaging ; Graft Rejection/drug therapy ; Graft Rejection/etiology ; Humans ; Immunization/adverse effects ; Intraocular Pressure/physiology ; Microscopy, Confocal ; Ophthalmic Solutions ; RNA, Messenger/genetics ; SARS-CoV-2/genetics ; Slit Lamp Microscopy ; Tomography, Optical Coherence ; Visual Acuity/physiology
    Chemical Substances COVID-19 Vaccines ; Glucocorticoids ; Ophthalmic Solutions ; RNA, Messenger ; Dexamethasone (7S5I7G3JQL) ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2021-319338
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  3. Article ; Online: Reply to Comment on: Personalized model to predict keratoconus progression from demographic, topographic and genetic data.

    Maile, Howard P / Li, Ji-Peng Olivia / Pontikos, Nikolas / Gore, Daniel M / Tuft, Stephen J

    American journal of ophthalmology

    2022  Volume 249, Page(s) 193

    MeSH term(s) Humans ; Keratoconus/diagnosis ; Keratoconus/genetics ; Cornea ; Corneal Topography ; Demography
    Language English
    Publishing date 2022-11-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2022.11.006
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  4. Article ; Online: Visual Acuity Apps for Rapid Integration in Teleconsultation Services in all Resource Settings: A Review.

    Kawamoto, Ken / Stanojcic, Nick / Li, Ji-Peng Olivia / Thomas, Peter B M

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2021  Volume 10, Issue 4, Page(s) 350–354

    Abstract: Purpose: There is a need for a simple and accurate way to assess visual acuity in telemedicine consultations in ophthalmology and other related specialties.: Design: We surveyed visual acuity testing apps available that allow patients to measure ... ...

    Abstract Purpose: There is a need for a simple and accurate way to assess visual acuity in telemedicine consultations in ophthalmology and other related specialties.
    Design: We surveyed visual acuity testing apps available that allow patients to measure their own acuity, focusing on freely accessible resources suitable for all resource settings.
    Methods: A systematic search was performed for visual acuity testing apps on 2 major platforms: Google Play Store (Google, CA, USA) and Apple App Store (Apple, CA, USA).
    Results: Sixteen apps (67%) tested near vision, 5 apps (21%) tested distance vision, and 3 apps (13%) offered options for both near and distance vision testing. Of the 24 apps, 5 (21%) offered a method of calibration of optotype size. Three apps (13%) demonstrated evidence of clinical validation. Only 3 apps fulfilled our criteria for suitability for clinical practice.
    Conclusions: We have recommended 3 apps that may be quickly integrated into clinical practice in both ophthalmic and non-ophthalmic all resource settings.
    MeSH term(s) Humans ; Mobile Applications ; Ophthalmology ; Remote Consultation ; Visual Acuity
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0000000000000384
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  5. Article ; Online: AI papers in ophthalmology made simple.

    Jeon, Sohee / Liu, Yun / Li, Ji-Peng Olivia / Webster, Dale / Peng, Lily / Ting, Daniel

    Eye (London, England)

    2020  Volume 34, Issue 11, Page(s) 1947–1949

    MeSH term(s) Artificial Intelligence ; Bibliometrics ; Humans ; Ophthalmology
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Editorial
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-0929-6
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  6. Article: Corneal astigmatic outcomes after femtosecond laser-assisted cataract surgery combined with surface penetrating arcuate keratotomies.

    Stanojcic, Nick / O'Brart, David / Hull, Chris / Wagh, Vijay / Azan, Elodie / Bhogal, Mani / Robbie, Scott / Li, Ji-Peng Olivia

    International journal of ophthalmology

    2023  Volume 16, Issue 7, Page(s) 1084–1092

    Abstract: Aim: To evaluate corneal astigmatic outcomes of femtosecond laser-assisted arcuate keratotomies (FAKs) combined with femtosecond-laser assisted cataract surgery (FLACS) over 12mo follow-up.: Methods: Totally 145 patients with bilateral cataracts and ... ...

    Abstract Aim: To evaluate corneal astigmatic outcomes of femtosecond laser-assisted arcuate keratotomies (FAKs) combined with femtosecond-laser assisted cataract surgery (FLACS) over 12mo follow-up.
    Methods: Totally 145 patients with bilateral cataracts and no ocular co-morbidities were recruited to a single-centre, single-masked, prospective randomized controlled trial (RCT) comparing two monofocal hydrophobic acrylic intraocular lenses. Eyes with corneal astigmatism (CA) of >0.8 dioptres (D) received unpaired, unopened, surface penetrating FAKs at the time of FLACS. Visual acuity, subjective refraction and Scheimpflug tomography were recorded at 1, 6, and 12mo. Alpins vectoral analyses were performed.
    Results: Fifty-one patients (61 eyes), mean age 68.2±9.6y [standard deviation (SD)], received FAKs. Sixty eyes were available for analysis, except at 12mo when 59 attended. There were no complications due to FAKs. Mean pre-operative CA was 1.13±0.20 D. There was a reduction of astigmatism at all post-operative visits (residual CA 1mo: 0.85±0.42 D,
    Conclusion: Unpaired unopened penetrating FAKs combined with on-axis phacoemulsification are safe but minimally effective. CA is largely under-corrected in this cohort using an existing unmodified nomogram. The effect of arcuate keratotomies on CA remained stable over 12mo.
    Language English
    Publishing date 2023-07-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2023.07.13
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  7. Article ; Online: A comparison of keratoconus progression following collagen cross-linkage using standard or personalised keratometry thresholds.

    Li, Ji-Peng Olivia / Maile, Howard P / Bunce, Catey / Kandakji, Lynn / Leucci, Marcello T / Allan, Bruce D / Tuft, Stephen J / Pontikos, Nikolas / Gore, Daniel M

    Eye (London, England)

    2024  

    Abstract: Objective: To define how estimates of keratoconus progression following collagen cross-linking (CXL) vary according to the parameter selected to measure corneal shape.: Materials and methods: We estimated progression following CXL in 1677 eyes. We ... ...

    Abstract Objective: To define how estimates of keratoconus progression following collagen cross-linking (CXL) vary according to the parameter selected to measure corneal shape.
    Materials and methods: We estimated progression following CXL in 1677 eyes. We compared standard definitions of keratoconus progression based on published thresholds for Kmax, front K2, or back K2, or progression of any two of these three parameters, with the option of an increased threshold for Kmax values ≥ 55D. As corneal thickness reduces unpredictably after CXL, it was excluded from the principal analysis. We then repeated the analysis using novel adaptive estimates of progression for Kmax, front K2, or back K2, developed separately using 6463 paired readings from keratoconus eyes, with a variation of the Bland-Altman method to determine the 95% regression-based limits of agreement (LoA). We created Kaplan-Meier survival plots for both standard and adaptive thresholds. The primary outcome was progression five years after a baseline visit 9-15 months following CXL.
    Results: Progression rates were 8% with a standard (≥ 1.5D) threshold for K2 or 6% with the static multi-parameter definition. With a ≥ 1D threshold for Kmax, the progression was significantly higher at 29%. With adaptive Kmax or K2, the progression rates were similar (20%) but less than with the adaptive multi-parameter method (22%).
    Conclusions: Estimates of keratoconus progression following CXL vary widely according to the reference criteria. Using adaptive thresholds (LoA) to define the repeatability of keratometry gives estimates for progression that are markedly higher than with the standard multi-parameter method.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-024-02994-6
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  8. Article ; Online: Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear.

    Li, Ji-Peng Olivia / Lam, Dennis Shun Chiu / Chen, Youxin / Ting, Daniel Shu Wei

    The British journal of ophthalmology

    2020  Volume 104, Issue 3, Page(s) 297–298

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/transmission ; Eye/virology ; Eye Protective Devices ; Humans ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-02-19
    Publishing country England
    Document type Editorial
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2020-315994
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  9. Article: CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing.

    Aiello, Francesco / Gallo Afflitto, Gabriele / Li, Ji-Peng Olivia / Martucci, Alessio / Cesareo, Massimo / Nucci, Carlo

    Journal of clinical medicine

    2020  Volume 9, Issue 12

    Abstract: The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of ... ...

    Abstract The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the regulation of tissue repair and fibrosis, neo-angiogenesis and pain perception. This review aims to summarize all the available data on ECS expression and its function in ocular surface structures to provide a specific insight concerning its modulation in dry eye disease, and to propose directions for future research.
    Language English
    Publishing date 2020-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9124036
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  10. Article ; Online: Digital Transformation in Ophthalmic Clinical Care During the COVID-19 Pandemic.

    Kim, Soyang Ella / Logeswaran, Abison / Kang, Swan / Stanojcic, Nick / Wickham, Louisa / Thomas, Peter / Li, Ji-Peng Olivia

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2021  Volume 10, Issue 4, Page(s) 381–387

    Abstract: Abstract: COVID-19 has placed unprecedented pressure on health systems globally, whereas simultaneously stimulating unprecedented levels of transformation. Here, we review digital adoption that has taken place during the pandemic to drive improvements ... ...

    Abstract Abstract: COVID-19 has placed unprecedented pressure on health systems globally, whereas simultaneously stimulating unprecedented levels of transformation. Here, we review digital adoption that has taken place during the pandemic to drive improvements in ophthalmic clinical care, with a specific focus on out-of-hospital triage and services, clinical assessment, patient management, and use of electronic health records. We show that although there have been some successes, shortcomings in technology infrastructure prepandemic became only more apparent and consequential as COVID-19 progressed. Through our review, we emphasize the need for clinicians to better grasp and harness key technology trends such as telecommunications and artificial intelligence, so that they can effectively and safely shape clinical practice using these tools going forward.
    MeSH term(s) Artificial Intelligence ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Technology ; Telemedicine
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0000000000000407
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