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Article ; Online: Oncodermatology: Advancing the Science and Care of Cancer Patients and Survivors.

Bang, Alexander S / Anadkat, Milan J / Choi, Jennifer N / LeBoeuf, Nicole R / Jung, Jae Y / Markova, Alina / Gordon, Allison / Rossi, Anthony M / Noor, Sarah J / Sibaud, Vincent / Lacouture, Mario E

American journal of clinical dermatology

2022 Volume 23, Issue 4, Page(s) 587–589

MeSH term(s)	Humans ; Neoplasms/therapy ; Survivors
Language	English
Publishing date	2022-07-05
Publishing country	New Zealand
Document type	Letter
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-022-00705-z
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Article ; Online: Preparedness for COVID-19: in situ simulation to enhance infection control systems in the intensive care unit.

Choi, Gordon Y S / Wan, Winnie T P / Chan, Albert K M / Tong, Sau K / Poon, Shing T / Joynt, Gavin M

British journal of anaesthesia

2020 Volume 125, Issue 2, Page(s) e236–e239

MeSH term(s)	COVID-19 ; Coronavirus Infections/therapy ; Critical Care/methods ; Disinfection ; Humans ; Infection Control/methods ; Intensive Care Units ; Nurses ; Pandemics ; Physicians ; Pneumonia, Viral/therapy ; Quality Improvement ; Simulation Training/methods
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	England
Document type	Letter
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2020.04.001
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Article: Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus.

Krustev, Eugene / Hanly, John G / Chin, Ricky / Buhler, Katherine A / Urowitz, Murray B / Gordon, Caroline / Bae, Sang-Cheol / Romero-Diaz, Juanita / Sánchez-Guerrero, Jorge / Bernatsky, Sasha / Wallace, Daniel J / Isenberg, David / Rahman, Anisur / Merrill, Joan T / Fortin, Paul R / Gladman, Dafna D / Bruce, Ian N / Petri, Michelle A / Ginzler, Ellen M /

Lupus science & medicine

2024 Volume 11, Issue 1

Abstract: Background: Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We ... ...

Abstract	Background: Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort. Methods: Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up. Results: Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study: 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1). Conclusion: Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis.
MeSH term(s)	Female ; Humans ; Male ; Autoantibodies ; Biomarkers ; Kinesins ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis
Chemical Substances	Autoantibodies ; Biomarkers ; KIF20B protein, human (EC 3.6.1.-) ; Kinesins (EC 3.6.4.4)
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2023-001139
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Article: Preparedness for COVID-19: in situ simulation to enhance infection control systems in the intensive care unit

Choi, Gordon Y S / Wan, Winnie T P / Chan, Albert K M / Tong, Sau K / Poon, Shing T / Joynt, Gavin M

Br J Anaesth

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #99938
Database	COVID19

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Article ; Online: Speckle-free holography with partially coherent light sources and camera-in-the-loop calibration.

Peng, Yifan / Choi, Suyeon / Kim, Jonghyun / Wetzstein, Gordon

Science advances

2021 Volume 7, Issue 46, Page(s) eabg5040

Abstract: Computer-generated holography (CGH) holds transformative potential for a wide range of applications, including direct-view, virtual and augmented reality, and automotive display systems. While research on holographic displays has recently made impressive ...

Abstract	Computer-generated holography (CGH) holds transformative potential for a wide range of applications, including direct-view, virtual and augmented reality, and automotive display systems. While research on holographic displays has recently made impressive progress, image quality and eye safety of holographic displays are fundamentally limited by the speckle introduced by coherent light sources. Here, we develop an approach to CGH using partially coherent sources. For this purpose, we devise a wave propagation model for partially coherent light that is demonstrated in conjunction with a camera-in-the-loop calibration strategy. We evaluate this algorithm using light-emitting diodes (LEDs) and superluminescent LEDs (SLEDs) and demonstrate improved speckle characteristics of the resulting holograms compared with coherent lasers. SLEDs in particular are demonstrated to be promising light sources for holographic display applications, because of their potential to generate sharp and high-contrast two-dimensional (2D) and 3D images that are bright, eye safe, and almost free of speckle.
Language	English
Publishing date	2021-11-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abg5040
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Article ; Online: Performance of six birth-weight and estimated-fetal-weight standards for predicting adverse perinatal outcome: a 10-year nationwide population-based study.

Choi, S K Y / Gordon, A / Hilder, L / Henry, A / Hyett, J A / Brew, B K / Joseph, F / Jorm, L / Chambers, G M

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2020 Volume 58, Issue 2, Page(s) 264–277

Abstract: Objective: To evaluate three birth-weight (BW) standards (Australian population-based, Fenton and INTERGROWTH-21: Methods: This was a nationwide population-based study conducted on a total of 2.4 million singleton births that occurred from 24 + 0 to ... ...

Abstract	Objective: To evaluate three birth-weight (BW) standards (Australian population-based, Fenton and INTERGROWTH-21 Methods: This was a nationwide population-based study conducted on a total of 2.4 million singleton births that occurred from 24 + 0 to 40 + 6 weeks' gestation between 2004 and 2013 in Australia. The performance of the growth charts was evaluated according to SGA and LGA classification, and relative risk (RR) and diagnostic accuracy based on the areas under the receiver-operating-characteristics curves (AUCs) for stillbirth, neonatal death, perinatal death, composite morbidity and a composite of perinatal death and morbidity outcomes. The analysis was stratified according to gestational age at delivery (< 37 + 0 vs ≥ 37 + 0 weeks). Results: Following exclusions, 2 392 782 singleton births were analyzed. There were significant differences in the SGA and LGA classification and risk of adverse outcomes between the six BW and EFW standards evaluated. For the term group, compared with the other standards, the INTERGROWTH-21 Conclusions: This study addresses the recurrent problem of identifying fetuses at risk of morbidity and perinatal mortality associated with growth disorders and provides new insights into the applicability of international growth standards. Our findings of marked variation in classification and the similarly poor performance of prescriptive international standards and the other commonly used standards raise questions about whether the prescriptive international standards that were constructed for universal adoption are indeed applicable to a multiethnic population such as that of Australia. Thus, caution is needed when adopting universal standards for clinical and epidemiological use. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.
MeSH term(s)	Australia ; Birth Weight ; Female ; Fetal Growth Retardation/diagnostic imaging ; Fetal Weight ; Humans ; Infant, Small for Gestational Age ; Predictive Value of Tests ; Pregnancy ; Reference Values ; Ultrasonography, Prenatal
Language	English
Publishing date	2020-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.22151
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Article ; Online: Preparedness for COVID-19

Choi, Gordon Y.S. / Wan, Winnie T.P. / Chan, Albert K.M. / Tong, Sau K. / Poon, Shing T. / Joynt, Gavin M.

British Journal of Anaesthesia

in situ simulation to enhance infection control systems in the intensive care unit

2020 Volume 125, Issue 2, Page(s) e236–e239

Keywords	Anesthesiology and Pain Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2020.04.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical implications of LDH isoenzymes in hemolysis and continuous-flow left ventricular assist device-induced thrombosis.

Gordon, Jonathan S / Wood, Chelsey T / Luc, Jessica G Y / Watson, Ryan A / Maynes, Elizabeth J / Choi, Jae Hwan / Morris, Rohinton J / Massey, Howard Todd / Throckmorton, Amy L / Tchantchaleishvili, Vakhtang

Artificial organs

2019 Volume 44, Issue 3, Page(s) 231–238

Abstract: Pump-induced thrombosis continues to be a major complication of continuous-flow left ventricular assist devices (CF-LVADs), which increases the risks of thromboembolic stroke, peripheral thromboembolism, reduced pump flow, pump failure, cardiogenic shock, ...

Abstract	Pump-induced thrombosis continues to be a major complication of continuous-flow left ventricular assist devices (CF-LVADs), which increases the risks of thromboembolic stroke, peripheral thromboembolism, reduced pump flow, pump failure, cardiogenic shock, and death. This is confounded by the fact that there is currently no direct measure for a proper diagnosis during pump support. Given the severity of this complication and its required treatment, the ability to accurately differentiate CF-LVAD pump thrombosis from other complications is vital. Hemolysis measured by elevated lactate dehydrogenase (LDH) enzyme levels, when there is clinical suspicion of pump-induced thrombosis, is currently accepted as an important metric used by clinicians for diagnosis; however, LDH is a relatively nonspecific finding. LDH exists as five isoenzymes in the body, each with a unique tissue distribution. CF-LVAD pump thrombosis has been associated with elevated serum LDH-1 and LDH-2, as well as decreased LDH-4 and LDH-5. Herein, we review the various isoenzymes of LDH and their utility in differentiating hemolysis seen in CF-LVAD pump thrombosis from other physiologic and pathologic conditions as reported in the literature.
MeSH term(s)	Animals ; Heart-Assist Devices/adverse effects ; Hemolysis ; Humans ; Isoenzymes/blood ; L-Lactate Dehydrogenase/blood ; Thrombosis/blood ; Thrombosis/etiology ; Thrombosis/pathology
Chemical Substances	Isoenzymes ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2019-10-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13565
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Article: Quantitative analysis of debris-flow flexible barrier capacity from momentum and energy perspectives

Song, D / C.E. Choi / Gordon G.D. Zhou / Min Xu / S. Li / Y. Zheng

Engineering geology. 2019 Mar. 09, v. 251

2019

Abstract: In-depth understanding of debris-structure interaction is hindered by a lack of physical data of debris flow impacting structures. This study reports a set of centrifuge experiments investigating the impact load exerted by debris flow on rigid and ... ...

Abstract	In-depth understanding of debris-structure interaction is hindered by a lack of physical data of debris flow impacting structures. This study reports a set of centrifuge experiments investigating the impact load exerted by debris flow on rigid and flexible barriers. A combination of high-speed imagery and load-displacement sensors enabled a comprehensive grasp of the impact details, including flow depth, velocity, impact pressure, bending moment, and cable force-elongation of flexible barrier. Test results reveal that the debris-structure interaction plays a major role in the energy dissipation and impact load reconstruction. The built-up of static load behind the barrier occurs simultaneously with the grow-up of impact force. As a result, the momentum flux of incoming flow is not merely a surrogate of the impact force. A quantitative analysis from the energy perspective has been conducted. Under the experimental conditions of this study, debris flow impact results in over 90% of debris energy dissipated through the internal and boundary shearing, leaving <10% absorbed by the flexible barrier. Findings from the energy and momentum perspectives could facilitate the optimization of flexible barriers in mitigation of debris flow hazards.
Keywords	energy ; impact load ; mass movement ; momentum ; quantitative analysis ; static load
Language	English
Dates of publication	2019-0309
Size	p. 81-92.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0013-7952
DOI	10.1016/j.enggeo.2019.02.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Unfiltered holography: optimizing high diffraction orders without optical filtering for compact holographic displays.

Gopakumar, Manu / Kim, Jonghyun / Choi, Suyeon / Peng, Yifan / Wetzstein, Gordon

Optics letters

2021 Volume 46, Issue 23, Page(s) 5822–5825

Abstract: Computer-generated holography suffers from high diffraction orders (HDOs) created from pixelated spatial light modulators, which must be optically filtered using bulky optics. Here, we develop an algorithmic framework for optimizing HDOs without optical ... ...

Abstract	Computer-generated holography suffers from high diffraction orders (HDOs) created from pixelated spatial light modulators, which must be optically filtered using bulky optics. Here, we develop an algorithmic framework for optimizing HDOs without optical filtering to enable compact holographic displays. We devise a wave propagation model of HDOs and use it to optimize phase patterns, which allows HDOs to contribute to forming the image instead of creating artifacts. The proposed method significantly outperforms previous algorithms in an unfiltered holographic display prototype.
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.442851
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