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Article ; Online: Belt and road initiative and healthy silk road: an alternative path for Pacific island countries to participate in global public health governance.

Mei, Yujie

Global health research and policy

2023 Volume 8, Issue 1, Page(s) 44

Abstract: Pacific island countries (PICs) located in a region with relatively insufficient capacity to respond to public health emergencies, establishing reliable public health cooperation is conducive to maintaining security and stability. The belt and road ... ...

Abstract	Pacific island countries (PICs) located in a region with relatively insufficient capacity to respond to public health emergencies, establishing reliable public health cooperation is conducive to maintaining security and stability. The belt and road initiative (BRI) launched by China attempts to provide a novel form of international cooperation and has supported multi-channel investment and construction. This article elucidates the history of public health cooperation between China and PICs, as well as the current situation of the BRI in the field of public health and emphasizes that there are numerous constraints in the public health cooperation between China and PICs. Given the profound impact of COVID-19 on diplomatic strategies, gradual cooperation in the field of public health may be the initial exploration of the BRI in the PICs, but it also means that the initiative must deal with challenges from geopolitical competition and cultural differences.
MeSH term(s)	Humans ; Public Health ; Pacific Islands ; COVID-19/epidemiology ; International Cooperation ; China
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Letter
ISSN	2397-0642
ISSN (online)	2397-0642
DOI	10.1186/s41256-023-00329-8
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Article ; Online: In vitro therapeutic effects and molecular mechanisms of targeted inhibition of CDK12/13 in high-grade gliomas

MEI Yanqing / HAN Yujie / WENG Wenyun / ZHANG Lei / TANG Yujie

Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 5, Pp 545-

2023 Volume 559

Abstract: Objective·To find novel and common targeting strategies for high-grade gliomas (HGGs) from the perspective of epigenetic and transcriptional modulators, test the therapeutic effect in vitro and investigate the related molecular mechanisms.Methods· ... ...

Abstract	Objective·To find novel and common targeting strategies for high-grade gliomas (HGGs) from the perspective of epigenetic and transcriptional modulators, test the therapeutic effect in vitro and investigate the related molecular mechanisms.Methods·Glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) cell lines with high malignancy and mortality in HGGs were selected for screening of targeted small molecule drug library related to epigenetic transcription and for functional genome screening based on the CRISPR-Cas9 technology. The effect of selected targeted epigenetic transcriptional modulators on growth, proliferation, and apoptosis of GBM and DIPG cell lines were then measured either by CRISPR-Cas9 knockout or treatment with targeted small molecule inhibitors of genes in vitro. Anti-tumor molecular mechanisms of the modulators in corresponding small molecule inhibitors-treated GBM and DIPG cells were explored via RNA-seq transcriptome analysis and further verified by real time quantitative PCR (RT-qPCR), Western blotting and flow cytometry.Results·Targeted small molecule drug library combined with functional genome screening for epigenetic transcriptional modulators identified CDK12/13 as the novel therapeutic targets for both GBM and DIPG. Knockout out of CDK12 by CRISPR-Cas9 in multiple GBM and DIPG cell lines significantly reduced their in vitro cellular activity. CDK12/13 inhibitors SR-4835 and THZ531 also significantly inhibited the growth of these two types of HGGs cell lines in vitro by antagonizing cell proliferation and promoting cell apoptosis. RNA-seq transcriptome analysis of GBM and DIPG cell lines after SR-4835 treatment showed that genes significantly down-regulated by CDK12/13 inhibitors in HGGs cells were mainly enriched in transcriptional regulation, DNA damage response (DDR) pathway, ubiquitin-proteasome pathway, and cell cycle. Furthermore, a series of experiments demonstrated that targeted inhibition of CDK12/13 significantly down-regulated the transcription of DDR-related genes, ...
Keywords	glioblastoma (gbm) ; diffuse intrinsic pontine glioma (dipg) ; molecular targeted therapy ; anti-tumor drug screening ; crispr-cas9 ; cdk12 ; cdk13 ; Medicine ; R
Subject code	570
Language	Chinese
Publishing date	2023-05-01T00:00:00Z
Publisher	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fluorescence quenching-based immunological probe for ticagrelor monitoring.

Zhang, Shengshuo / Cheng, Yueqing / Gao, Yujie / Zou, Yujie / Xiao, Weiling / Li, Tianyi / Li, Mei / Yu, Bowen / Dong, Jinhua

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1295406

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1295406
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Article ; Online: Bifunctional Electrocatalysts for Overall and Hybrid Water Splitting.

Quan, Li / Jiang, Hui / Mei, Guoliang / Sun, Yujie / You, Bo

Chemical reviews

2024 Volume 124, Issue 7, Page(s) 3694–3812

Abstract: Electrocatalytic water splitting driven by renewable electricity has been recognized as a promising approach for green hydrogen production. Different from conventional strategies in developing electrocatalysts for the two half-reactions of water ... ...

Abstract	Electrocatalytic water splitting driven by renewable electricity has been recognized as a promising approach for green hydrogen production. Different from conventional strategies in developing electrocatalysts for the two half-reactions of water splitting (e.g., the hydrogen and oxygen evolution reactions, HER and OER) separately, there has been a growing interest in designing and developing bifunctional electrocatalysts, which are able to catalyze both the HER and OER. In addition, considering the high overpotentials required for OER while limited value of the produced oxygen, there is another rapidly growing interest in exploring alternative oxidation reactions to replace OER for hybrid water splitting toward energy-efficient hydrogen generation. This Review begins with an introduction on the fundamental aspects of water splitting, followed by a thorough discussion on various physicochemical characterization techniques that are frequently employed in probing the active sites, with an emphasis on the reconstruction of bifunctional electrocatalysts during redox electrolysis. The design, synthesis, and performance of diverse bifunctional electrocatalysts based on noble metals, nonprecious metals, and metal-free nanocarbons, for overall water splitting in acidic and alkaline electrolytes, are thoroughly summarized and compared. Next, their application toward hybrid water splitting is also presented, wherein the alternative anodic reactions include sacrificing agents oxidation, pollutants oxidative degradation, and organics oxidative upgrading. Finally, a concise statement on the current challenges and future opportunities of bifunctional electrocatalysts for both overall and hybrid water splitting is presented in the hope of guiding future endeavors in the quest for energy-efficient and sustainable green hydrogen production.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00332
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Article ; Online: Association of lipid accumulation product and visceral adiposity index with the risk of hypertension among oil workers in Xinjiang, China.

Muheiyati, Guliman / Mei, Yujie / Tao, Ning

PeerJ

2023 Volume 11, Page(s) e15273

Abstract: Background: To explore the relationship between lipid accumulation product (LAP) and visceral adiposity index (VAI) and hypertension in oil workers and to evaluate the predictive value of hypertension by gender.: Methods: A sample of 2,312 workers ... ...

Abstract	Background: To explore the relationship between lipid accumulation product (LAP) and visceral adiposity index (VAI) and hypertension in oil workers and to evaluate the predictive value of hypertension by gender. Methods: A sample of 2,312 workers aged 18-60 years old with more than one year of service were selected by a whole-group random sampling method in six oil field bases in Karamay City, Xinjiang. Logistic regression combined with restricted cubic spline model was used to analyze the risk of hypertension in different LAP and VAI. The receiver operator characteristic curve (ROC) with different sex LAP and VAI predicting the risk of hypertension were drawn. Results: (1) There were significant differences in age, smoking, alcohol consumption, hypertension, BMI, WC, WHtR, SBP, DBP, TC, TG, HDL, LDL, FPG and Scr among different gender groups ( Conclusions: Lipid accumulation product and visceral adiposity index may be risk factors for hypertension in oil workers. LAP and VAI have certain predictive value for hypertension.
MeSH term(s)	Male ; Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Lipid Accumulation Product/physiology ; Adiposity/physiology ; Obesity, Abdominal/complications ; Hypertension/epidemiology ; China/epidemiology
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15273
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Article ; Online: Association of lipid accumulation product and visceral adiposity index with the risk of hypertension among oil workers in Xinjiang, China

Guliman Muheiyati / Yujie Mei / Ning Tao

PeerJ, Vol 11, p e

2023 Volume 15273

Abstract: Background To explore the relationship between lipid accumulation product (LAP) and visceral adiposity index (VAI) and hypertension in oil workers and to evaluate the predictive value of hypertension by gender. Methods A sample of 2,312 workers aged 18– ... ...

Abstract	Background To explore the relationship between lipid accumulation product (LAP) and visceral adiposity index (VAI) and hypertension in oil workers and to evaluate the predictive value of hypertension by gender. Methods A sample of 2,312 workers aged 18–60 years old with more than one year of service were selected by a whole-group random sampling method in six oil field bases in Karamay City, Xinjiang. Logistic regression combined with restricted cubic spline model was used to analyze the risk of hypertension in different LAP and VAI. The receiver operator characteristic curve (ROC) with different sex LAP and VAI predicting the risk of hypertension were drawn. Results (1) There were significant differences in age, smoking, alcohol consumption, hypertension, BMI, WC, WHtR, SBP, DBP, TC, TG, HDL, LDL, FPG and Scr among different gender groups (P < 0.001).The prevalence of hypertension was 10.1%, with 13.9% in men and 3.6% in women. The prevalence of hypertension with different individual characteristics was statistically significant (P < 0.05). (2) Lipid accumulation product and visceral adiposity index were positively associated with hypertension (P < 0.001). The risk of hypertension may increase with the increase of lipid accumulation product and visceral adiposity index. After adjusting for age, sex, BMI, Scr, FPG and other factors, the risk of hypertension in the fourth quartile was (OR = 5.69, 95% CI [2.72–11.8]) and (OR = 3.56, 95% CI [2.03–6.23]) compared with the first quartile of lipid accumulation product and visceral adiposity index. (3) ROC results showed: AUC values of 0.658 (95% CI [0.619–0.696]), 0.614 (95% CI [0.574–0.654]), 0.661 (95% CI [0.620–0.703]) and critical values of 43.25, 1.58, 0.13 for LAP, VAI and combined indicators in men; the AUC values of LAP, VAI and combined indicators for women were 0.787 (95% CI [0.710–0.865]), 0.732 (95% CI [0.640–0.825]), 0.792 (95% CI [0.719–0.864]) and the critical values were 35.73, 1.76 and 0.03. Restricted cubic splines showed a nonlinear ...
Keywords	Hypertension ; Visceral adiposity index ; Restricted cubic spline ; Lipid accumulation product ; Oil workers ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article: Hot-spots detection in count data by Poisson assisted smooth sparse tensor decomposition.

Zhao, Yujie / Huo, Xiaoming / Mei, Yajun

Journal of applied statistics

2022 Volume 50, Issue 14, Page(s) 2999–3029

Abstract: Count data occur widely in many bio-surveillance and healthcare applications, e.g. the numbers of new patients of different types of infectious diseases from different cities/counties/states repeatedly over time, say, daily/weekly/monthly. For this type ... ...

Abstract	Count data occur widely in many bio-surveillance and healthcare applications, e.g. the numbers of new patients of different types of infectious diseases from different cities/counties/states repeatedly over time, say, daily/weekly/monthly. For this type of count data, one important task is the quick detection and localization of hot-spots in terms of unusual infectious rates so that we can respond appropriately. In this paper, we develop a method called
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1476802-1
ISSN	1360-0532 ; 0266-4763
ISSN (online)	1360-0532
ISSN	0266-4763
DOI	10.1080/02664763.2022.2112557
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Article ; Online: Regulating Effect of Exogenous α-Ketoglutarate on Ammonium Assimilation in Poplar.

Liu, Xiaoning / Wu, Liangdan / Si, Yujia / Zhai, Yujie / Niu, Mingyi / Han, Mei / Su, Tao

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 7

Abstract: Extensive industrial activities and anthropogenic agricultural practices have led to substantial ammonia release to the environment. Although croplands can act as ammonia sinks, reduced crop production under high concentrations of ammonium has been ... ...

Abstract	Extensive industrial activities and anthropogenic agricultural practices have led to substantial ammonia release to the environment. Although croplands can act as ammonia sinks, reduced crop production under high concentrations of ammonium has been documented. Alpha-ketoglutarate (AKG) is a critical carbon source, displaying pleiotropic physiological functions. The objective of the present study is to disclose the potential of AKG to enhance ammonium assimilation in poplars. It showed that AKG application substantially boosted the height, biomass, and photosynthesis activity of poplars exposed to excessive ammonium. AKG also enhanced the activities of key enzymes involved in nitrogen assimilation: glutamine synthetase (GS) and glutamate synthase (GOGAT), elevating the content of amino acids, sucrose, and the tricarboxylic acid cycle (TCA) metabolites. Furthermore, AKG positively modulated key genes tied to glucose metabolism and ATP synthesis, while suppressing ATP-depleting genes. Correspondingly, both H
MeSH term(s)	Ammonium Compounds/pharmacology ; Ammonia ; Ketoglutaric Acids/pharmacology ; Carbon ; Nitrogen ; Adenosine Triphosphate
Chemical Substances	Ammonium Compounds ; Ammonia (7664-41-7) ; Ketoglutaric Acids ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29071425
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Article ; Online: The effects of unexpected follicular growth and ovulation in artificial cycles: a retrospective cohort study of frozen, single-blastocyst transfer.

Yin, Rusha / Dang, Yujie / Ma, Zengxiang / Sun, Mei

Fertility and sterility

2023 Volume 119, Issue 6, Page(s) 985–993

Abstract: Objective: To study the effects of unexpected follicular development and ovulation in artificial cycles (ACs) on pregnancy outcomes.: Design: A retrospective cohort study.: Setting: A university-affiliated fertility center.: Patient(s): A total ...

Abstract	Objective: To study the effects of unexpected follicular development and ovulation in artificial cycles (ACs) on pregnancy outcomes. Design: A retrospective cohort study. Setting: A university-affiliated fertility center. Patient(s): A total of 1,427 patients who underwent a single, frozen-thawed blastocyst transfer with AC regimens from January 2014 to December 2020 at a university-affiliated fertility center were included. Intervention(s): Unexpected follicular development and ovulation in ACs. Main outcome measure(s): Live birth rate (LBR), biochemical pregnancy rate, clinical pregnancy rate, and ongoing pregnancy rate. Result(s): A total of 161 patients with unexpected follicular development and ovulation in ACs (ovulation group) and 1,266 patients without growing follicles in ACs (control group) were enrolled. The patients in the ovulation group were older and had higher levels of serum follicle-stimulating hormone and lower levels of serum antimüllerian hormone. After propensity score matching, the baseline characteristics between the 2 groups were comparable and no significant difference was observed in the LBR (ovulation group, 39.0% vs. control group, 39.0%), biochemical pregnancy rate (ovulation group, 60.3% vs. control group, 58.2%), clinical pregnancy rate (ovulation group, 53.4% vs. control group, 50.7%), or ongoing pregnancy rate (ovulation group, 42.5% vs. control group, 40.4%). Moreover, the patients in the ovulation group showed a lower risk of hypertensive disorders of pregnancy (HDP) (1.6% vs. 15.3%). A subgroup analysis of women who delivered singleton live-born babies also demonstrated that unexpected follicular development and ovulation in ACs was associated with a decreased risk of HDP (adjusted odds ratio, 0.070; 95% confidence interval, 0.007-0.712) and an increased risk of large-for-gestational-age infants (adjusted odds ratio, 4.046; 95% confidence interval, 1.319-12.414). Conclusion(s): Women with unexpected follicular development and ovulation during single frozen-thawed blastocyst transfer with AC regimens had a similar LBR and a reduced risk of HDP compared with those with routine AC regimens, and singleton neonates had an increased risk of being large for gestational age.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Humans ; Female ; Retrospective Studies ; Cryopreservation ; Ovulation Induction/adverse effects ; Embryo Transfer/adverse effects ; Pregnancy Rate ; Ovulation
Language	English
Publishing date	2023-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2023.02.011
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Article ; Online: Understanding the Role of Polyvinylpyrrolidone on Ultrafine Low-Rank Coal Flotation

Qiuyu Lin / Yujie Mei / Wei Huang / Bo Zhang / Ke Liu

ACS Omega, Vol 7, Iss 12, Pp 10196-

2022 Volume 10204

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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