LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 177

Search options

  1. Article: Wilder Penfield, Sir Arthur Currie, and the Montreal Neurological Institute.

    Sadler, R Mark

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2017  Volume 45, Issue 2, Page(s) 221–226

    Abstract: Wilder Penfield and the Montreal Neurological Institute (MNI) are inextricably linked. It was Penfield's unique idea to create a building with an academic atmosphere wherein basic neuroscience and clinical care of neurological patients would benefit from ...

    Abstract Wilder Penfield and the Montreal Neurological Institute (MNI) are inextricably linked. It was Penfield's unique idea to create a building with an academic atmosphere wherein basic neuroscience and clinical care of neurological patients would benefit from interaction and mutual support. It is clear that without Penfield that there would be no MNI; however, the role of another Canadian icon, Sir Arthur Currie, in the development of the MNI has heretofore been barely mentioned. The thesis of this paper is that Currie had a critical role in the gestation of the MNI that has generally been ignored.
    MeSH term(s) Academies and Institutes/history ; Canada ; History, 19th Century ; History, 20th Century ; Humans ; Neurosurgery/history
    Language English
    Publishing date 2017-12-11
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2017.265
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Retention Rate and Efficacy of Perampanel with a Slow Titration Schedule in Adults.

    Basheikh, Mazen / Sadler, R Mark

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2020  Volume 48, Issue 1, Page(s) 105–111

    Abstract: Rationale: The manufacturer of perampanel (PER) suggests an initial adult dose of 2-4 mg/day and an upward dose titration of 2 mg at no more frequently than 1- or 2-week intervals when used with enzyme-enhancing antiepileptic drugs (AEDs) or nonenzyme- ... ...

    Abstract Rationale: The manufacturer of perampanel (PER) suggests an initial adult dose of 2-4 mg/day and an upward dose titration of 2 mg at no more frequently than 1- or 2-week intervals when used with enzyme-enhancing antiepileptic drugs (AEDs) or nonenzyme-enhancing AEDs, respectively. The general practice in our clinic is an initial dose of PER 2 mg/day and titrated by 2 mg/4 weeks to an initial target of 6 mg/day.
    Methods: Retrospective chart audit of patients starting PER in an adult epilepsy clinic between September 2013 and November 2016 with at least one 6-month follow-up visit was reviewed. Data collection included patient demographics, seizure characteristics, past and concurrent therapy, monthly seizure frequency before PER and at 6-month visit, and characteristics of PER discontinuation. Efficacy of treatment was assessed with the Engel classification and 50% responder rate.
    Results: N = 102 patients; mean age = 40 years and 54% females. Focal onset seizures 85%, generalized 13%, and unknown 2%. Median prior AED exposure = 6 (range 3-20); median concomitant AED use = 2 (range 1-5). Follow-up range was 6-37 months. The median seizure frequency/month prePER treatment was 6 (range 0-30) for focal onset seizures and 1 (range 0-6) for generalized seizures. The retention rate amongst all patients at 6 months was 78.4%. At 6-month follow-up, 36% of all patients achieved Engel class I (seizure freedom) (30.7% of patients with focal onset seizures and 63.6% with generalized epilepsy). The 50% responder rate was 52% and 82% for focal and generalized epilepsy, respectively.
    Conclusion: PER has a good retention rate when titrated slowly and thus encouraging seizure freedom results in an otherwise medically refractory epilepsy population.
    Language English
    Publishing date 2020-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2020.174
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Unilateral abdominal clonic jerking as an epileptic phenomenon.

    Patterson, Adam / Woodroffe, Stephanie / Sadler, R Mark

    Epilepsy & behavior reports

    2021  Volume 16, Page(s) 100480

    Abstract: Unilateral abdominal wall clonic seizures are a rare manifestation of epilepsy. We report three cases of focal aware seizures manifesting as unilateral abdominal clonic motor movements. Standard EEG for patients with focal motor abdominal seizures is ... ...

    Abstract Unilateral abdominal wall clonic seizures are a rare manifestation of epilepsy. We report three cases of focal aware seizures manifesting as unilateral abdominal clonic motor movements. Standard EEG for patients with focal motor abdominal seizures is often unrevealing, which can make the diagnosis difficult. We report the first case of intracranial EEG in the diagnosis of a patients with this type of semiology during a focal seizure. In the absence of an electroclinical seizure verified by video-EEG monitoring, caution should be made with the diagnosis. A careful history should be obtained to help differentiate between unilateral abdominal clonic jerking and other abdominal complaints.
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Case Reports
    ISSN 2589-9864
    ISSN (online) 2589-9864
    DOI 10.1016/j.ebr.2021.100480
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: An Unusual Todd's Phenomenon: Post-Ictal Prosopagnosia.

    George, Rebecca S / Sadler, R Mark / Clarke, David B

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2020  Volume 48, Issue 5, Page(s) 730–731

    MeSH term(s) Electroencephalography ; Humans ; Prosopagnosia ; Status Epilepticus
    Language English
    Publishing date 2020-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2020.264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Divergence between functional magnetic resonance imaging and clinical indicators of language dominance in preoperative language mapping.

    Omisade, Antonina / O'Grady, Christopher / Sadler, R Mark

    Human brain mapping

    2020  Volume 41, Issue 14, Page(s) 3867–3877

    Abstract: Accurate determination of hemispheric language dominance prior to epilepsy surgery is critically important to minimize cognitive morbidity. Functional MRI (fMRI) is a noninvasive method that is highly concordant with other clinical indicators of language ...

    Abstract Accurate determination of hemispheric language dominance prior to epilepsy surgery is critically important to minimize cognitive morbidity. Functional MRI (fMRI) is a noninvasive method that is highly concordant with other clinical indicators of language laterality, and is now commonly used to confirm language dominance. However, there is also a high frequency of divergence between fMRI findings and other clinical indices that complicate determination of dominance and surgical decision-making in individual patients. Despite this, divergent cases are rarely published or discussed. This article provides three illustrative examples to demonstrate common scenarios where fMRI may produce conflicting or otherwise difficult-to-interpret findings. We will also discuss potential reasons for divergence and propose a flow-chart to aid clinical decision making in such situations.
    MeSH term(s) Adult ; Brain Mapping/standards ; Clinical Decision-Making ; Dominance, Cerebral ; Electroencephalography ; Epilepsy/diagnostic imaging ; Epilepsy/surgery ; Female ; Humans ; Language ; Magnetic Resonance Imaging/standards ; Middle Aged ; Neuropsychological Tests/standards ; Neurosurgical Procedures/standards ; Preoperative Care/standards
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25092
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4028: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: The AO Spine RECODE-DCM International Collaborative-Establishing the Foundations for Accelerated and Patient-Centered Innovation.

    Khan, Danyal Z / Hazenbiller, Olesja / Gronlund, Toto / Sadler, Iwan / Sarewitz, Ellen B / Mowforth, Oliver / Kotter, Mark R N / Davies, Benjamin M

    Global spine journal

    2022  Volume 12, Issue 1_suppl, Page(s) 159S–171S

    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682211035381
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Water-soluble adhesive for stable long-term ambulatory EEG recordings.

    Nurse, Ewan S / Marlow, Kristan / Hennessy, Patrick J / Knight-Sadler, Rory / Nelson, Tim / Freestone, Dean R / Slater, Kyle D / Cook, Mark J

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2022  Volume 142, Page(s) 258–261

    Abstract: Objective: Conventional methods used to adhere EEG electrodes are often uncomfortable. Here, we present a polymer-based water-soluble EEG adhesive that can be maintained for up to 6 days. The primary outcome measure of this study is the median electrode ...

    Abstract Objective: Conventional methods used to adhere EEG electrodes are often uncomfortable. Here, we present a polymer-based water-soluble EEG adhesive that can be maintained for up to 6 days. The primary outcome measure of this study is the median electrode impedance at day 6.
    Methods: Impedance measurements for 841 EEG recordings using a 21 channel 10-20 configuration were remotely logged daily for 6 days after connection. A novel electrode adhesive was used to attach EEG electrodes. Patients were instructed to maintain their electrodes on day 4.
    Results: Median electrode impedances were significantly below 10kOhms for each day of recording, with a median value on day 6 of 4.18kOhms. Impedance values were significantly lower on day 5 than on day 4, demonstrating that the maintenance process can reduce impedance. Except for day 4-5, the median impedance increased each day. No significant difference was found on the first or final day between clinics or residences from areas of different geographic remoteness.
    Conclusions: EEG is able to be recorded in patients homes for 6 days with acceptable impedance and no significant effect of regionality or patients age.
    Significance: To the best of our knowledge, this is the first report in the literature of impedance data from long-term ambulatory EEG studies.
    MeSH term(s) Adhesives ; Electric Impedance ; Electrodes ; Electroencephalography/methods ; Humans ; Polymers ; Water
    Chemical Substances Adhesives ; Polymers ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-07-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2022.07.490
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Extratemporal "limbic" seizures--introductory remarks.

    Sadler, R Mark

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2009  Volume 36 Suppl 2, Page(s) S82–3

    MeSH term(s) Humans ; Limbic System/physiopathology ; Seizures/pathology
    Language English
    Publishing date 2009-08
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Performance of ChatGPT on the Situational Judgement Test-A Professional Dilemmas-Based Examination for Doctors in the United Kingdom.

    Borchert, Robin J / Hickman, Charlotte R / Pepys, Jack / Sadler, Timothy J

    JMIR medical education

    2023  Volume 9, Page(s) e48978

    Abstract: ... Overall, ChatGPT performed well, scoring 76% on the SJT but scoring full marks on only a few questions (9 ...

    Abstract Background: ChatGPT is a large language model that has performed well on professional examinations in the fields of medicine, law, and business. However, it is unclear how ChatGPT would perform on an examination assessing professionalism and situational judgement for doctors.
    Objective: We evaluated the performance of ChatGPT on the Situational Judgement Test (SJT): a national examination taken by all final-year medical students in the United Kingdom. This examination is designed to assess attributes such as communication, teamwork, patient safety, prioritization skills, professionalism, and ethics.
    Methods: All questions from the UK Foundation Programme Office's (UKFPO's) 2023 SJT practice examination were inputted into ChatGPT. For each question, ChatGPT's answers and rationales were recorded and assessed on the basis of the official UK Foundation Programme Office scoring template. Questions were categorized into domains of Good Medical Practice on the basis of the domains referenced in the rationales provided in the scoring sheet. Questions without clear domain links were screened by reviewers and assigned one or multiple domains. ChatGPT's overall performance, as well as its performance across the domains of Good Medical Practice, was evaluated.
    Results: Overall, ChatGPT performed well, scoring 76% on the SJT but scoring full marks on only a few questions (9%), which may reflect possible flaws in ChatGPT's situational judgement or inconsistencies in the reasoning across questions (or both) in the examination itself. ChatGPT demonstrated consistent performance across the 4 outlined domains in Good Medical Practice for doctors.
    Conclusions: Further research is needed to understand the potential applications of large language models, such as ChatGPT, in medical education for standardizing questions and providing consistent rationales for examinations assessing professionalism and ethics.
    Language English
    Publishing date 2023-08-07
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-3762
    ISSN 2369-3762
    DOI 10.2196/48978
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Patient, sufferer, victim, casualty or person with cervical myelopathy: let us decide our identifier.

    Boerger, Timothy F / Davies, Benjamin M / Sadler, Iwan / Sarewitz, Ellen / Kotter, Mark R N

    Integrated healthcare journal

    2020  Volume 2, Issue 1, Page(s) e000023

    Abstract: Among biomedical journals, person-first language is considered preferable to identity person-first language. However, not all populations of people with certain medical diagnoses, such as deafness, prefer person-first language. Moreover, adherence to ... ...

    Abstract Among biomedical journals, person-first language is considered preferable to identity person-first language. However, not all populations of people with certain medical diagnoses, such as deafness, prefer person-first language. Moreover, adherence to person-first language is poor among the literature on some neurological diagnoses. Therefore, it is most appropriate to consult with people with a given diagnosis regarding their preferred identifier. Here, we describe a consensus process undertaken by the REsearch objectives and COmmon Data Elements for Degenerative Cervical Myelopathy (RECODE-DCM, recode-dcm.com) steering committee members with cervical myelopathy to determine our preferred identifier.
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2399-5351
    ISSN (online) 2399-5351
    DOI 10.1136/ihj-2019-000023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top