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Article ; Online: Surveillance Following Acute Type A Aortic Dissection: The Need for Long-Term Clinical Oversight.

Puthumana, Jyothy / Vassallo, Patricia / Hoel, Andrew / Malaisrie, S Chris / Mehta, Christopher

Journal of the American College of Cardiology

2022 Volume 79, Issue 10, Page(s) e205

MeSH term(s)	Aneurysm, Dissecting/diagnostic imaging ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Humans
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2021.11.063
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Neighborhood Socioeconomic Status and Readmission in Acute Type A Aortic Dissection Repair.

Liu, Tom / Devlin, Paul J / Whippo, Beth / Vassallo, Patricia / Hoel, Andrew / Pham, Duc Thinh / Johnston, Douglas R / Chris Malaisrie, Sukit / Mehta, Christopher K

The Journal of surgical research

2024 Volume 296, Page(s) 772–780

Abstract: Introduction: We examined the association of socioeconomic status as defined by median household income quartile (MHIQ) with mortality and readmission patterns following open repair of acute type A aortic dissection (ATAAD) in a nationally ... ...

Abstract	Introduction: We examined the association of socioeconomic status as defined by median household income quartile (MHIQ) with mortality and readmission patterns following open repair of acute type A aortic dissection (ATAAD) in a nationally representative registry. Methods: Adults who underwent open repair of ATAAD were selected using the US Nationwide Readmissions Database and stratified by MHIQ. Patients were selected based on diagnostic and procedural codes. The primary endpoint was 30-d readmission. Results: Between 2016 and 2019, 10,288 individuals (65% male) underwent open repair for ATAAD. Individuals in the lowest income quartile were younger (median: 60 versus 64, P < 0.05) but had greater Elixhauser comorbidity burden (5.9 versus 5.7, P < 0.05). Across all groups, in-hospital mortality was approximately 15% (P = 0.35). On multivariable analysis adjusting for baseline comorbidity burden, low socioeconomic status was associated with increased readmission at 90 d, but not at 30 d. Concomitant renal disease (odds ratio [OR], 1.68; P < 0.001), pulmonary disease (OR, 1.26; P < 0.001), liver failure (OR 1.2, P = 0.04), and heart failure (OR, 1.17; P < 0.001) were all associated with readmission at 90 d. The primary indication for readmission was most commonly cardiac (33%), infectious (16.5%), and respiratory (9%). Conclusions: In patients who undergo surgery for ATAAD, lower MHIQ was associated with higher odds of readmission following open repair. While early readmission for individuals living in the lowest income communities is likely attributable to greater baseline comorbidity burden, we observed that 90-d readmission rates are associated with lower MHIQ regardless of comorbidity burden. Further investigation is required to determine which patient-level and system-level interventions are needed to reduce readmissions in the immediate postoperative period for resource poor areas.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Patient Readmission ; Risk Factors ; Comorbidity ; Social Class ; Aortic Dissection/epidemiology ; Aortic Dissection/surgery ; Retrospective Studies
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.12.049
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Zs.A 178: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Article ; Online: Implementation of a direct-to-operating room aortic emergency transfer program: Expedited management of type A aortic dissection.

Mehta, Christopher K / Chiu, Stephen / Hoel, Andrew W / Vassallo, Patricia / Whippo, Beth / Andrei, Adin Cristian / Schmidt, Michael J / Pham, Duc Thinh / Johnston, Douglas R / Churyla, Andrei / Malaisrie, S Chris

The American journal of emergency medicine

2023 Volume 70, Page(s) 113–118

Abstract: Introduction: Type A Aortic Dissection (TAAD) is a surgical emergency with a time-dependent rate of mortality. We hypothesized that a direct-to-operating room (DOR) transfer program for patients with TAAD would reduce time to intervention.: Methods: ... ...

Abstract	Introduction: Type A Aortic Dissection (TAAD) is a surgical emergency with a time-dependent rate of mortality. We hypothesized that a direct-to-operating room (DOR) transfer program for patients with TAAD would reduce time to intervention. Methods: A DOR program was started at an urban tertiary care hospital in February 2020. We performed a retrospective study of adult patients undergoing treatment for TAAD before (n = 42) and after (n = 84) implementation of DOR. Expected mortality was calculated using the International Registry of Acute Aortic Dissection risk prediction model. Results: Median time from acceptance of transfer from emergency physician to operating room arrival was 1.37 h (82 min) faster in DOR compared to pre-DOR (1.93 h vs 3.30 h, p < 0.001). Median time from arrival to operating room was 1.14 h (72 min) faster after DOR compared to pre-DOR (0.17 h vs 1.31 h, p < 0.001). In-hospital mortality was 16.2% in pre-DOR, with an observed-to-expected (O/E) ratio of 1.03 (p = 0.24) and 12.0% in the DOR group, with an O/E ratio of 0.59 (p < 0.001). Conclusion: Creation of a DOR program resulted in decreased time to intervention. This was associated with a decrease in observed-to-expected operative mortality. The transfer of patients with acute type A aortic dissection to centers with direct-to-OR programs may result in decreased time from diagnosis to surgery.
MeSH term(s)	Adult ; Humans ; Operating Rooms ; Retrospective Studies ; Aortic Dissection/surgery ; Aorta/surgery ; Hospital Mortality ; Treatment Outcome
Chemical Substances	1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose (80321-89-7)
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.05.036
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Zs.A 2005: Show issues

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Article ; Online: Potential benefits of egg white hydrolysate in the prevention of Hg-induced dysfunction in adipose tissue.

Rizzetti, Danize Aparecida / Corrales, Patricia / Uranga-Ocio, José Antonio / Medina-Gómez, Gema / Peçanha, Franck Maciel / Vassallo, Dalton Valentim / Miguel, Marta / Wiggers, Giulia Alessandra

Food & function

2022 Volume 13, Issue 11, Page(s) 5996–6007

Abstract: ... ...

Abstract	Aim
MeSH term(s)	Adiponectin/genetics ; Adiponectin/metabolism ; Adipose Tissue ; Adipose Tissue, White/metabolism ; Animals ; Antioxidants/pharmacology ; Egg White ; Glucose/metabolism ; Insulins/metabolism ; Insulins/pharmacology ; Leptin/metabolism ; Lipids/pharmacology ; Mercury/metabolism ; Mercury/pharmacology ; PPAR alpha/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar
Chemical Substances	Adiponectin ; Antioxidants ; Insulins ; Leptin ; Lipids ; PPAR alpha ; PPAR gamma ; RNA, Messenger ; Mercury (FXS1BY2PGL) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo00561a
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Article: New Insight on the Bioactivity of

Faraone, Immacolata / Lela, Ludovica / Ponticelli, Maria / Gorgoglione, Domenico / De Biasio, Filomena / Valentão, Patricia / Andrade, Paula B / Vassallo, Antonio / Caddeo, Carla / Falabella, Roberto / Ostuni, Angela / Milella, Luigi

Pharmaceutics

2022 Volume 14, Issue 6

Abstract: Food extract's biological effect and its improvement using nanotechnologies is one of the challenges of the last and the future decades; for this reason, the antioxidant effect of scarlet eggplant extract liposomal incorporation was investigated. Scarlet ...

Abstract	Food extract's biological effect and its improvement using nanotechnologies is one of the challenges of the last and the future decades; for this reason, the antioxidant effect of scarlet eggplant extract liposomal incorporation was investigated. Scarlet eggplant (
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14061168
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Article ; Online: Emerging from the Pandemic: AAIM Recommendations for Internal Medicine Residency and Fellowship Interview Standards.

Luther, Vera P / Wininger, David A / Lai, Cindy J / Dao, Anthony / Garcia, Maria M / Harper, Whitney / Chow, Timothy M / Correa, Ricardo / Gay, Lindsey J / Fettig, Lyle / Dalal, Bhavin / Vassallo, Patricia / Barczi, Steven / Sweet, Michelle

The American journal of medicine

2022 Volume 135, Issue 10, Page(s) 1267–1272

MeSH term(s)	Education, Medical, Graduate ; Fellowships and Scholarships ; Humans ; Internship and Residency ; Pandemics
Language	English
Publishing date	2022-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.07.001
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Ua VI Zs.289: Show issues

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Article ; Online: Metabolic Syndrome: An Evolving Clinical Construct.

Vassallo, Patricia / Driver, Steven L / Stone, Neil J

Progress in cardiovascular diseases

2016 Volume 59, Issue 2, Page(s) 172–177

Abstract: Metabolic syndrome (MetS), a clustering of metabolic risk factors, identifies individuals at increased risk of diabetes and cardiovascular disease (CVD). Measurement of waist circumference, high-density lipoprotein-cholesterol, triglycerides, blood ... ...

Abstract	Metabolic syndrome (MetS), a clustering of metabolic risk factors, identifies individuals at increased risk of diabetes and cardiovascular disease (CVD). Measurement of waist circumference, high-density lipoprotein-cholesterol, triglycerides, blood pressure and fasting blood glucose are easily obtained in the clinic. At any level of low-density lipoprotein-cholesterol, presence of MetS increases the risk of adverse CVD outcomes including bothatherosclerotic CVD and atrial fibrillation. The MetS construct should focus the clinician on recommending behavioral lifestyle modification as this improves all of its components. The challenge, however, has been the lack of a standardized approach to achieve effective and sustained lifestyle modification in clinical practice. We briefly review various approaches useful to the clinician in counseling such patients. These include group lifestyle programs and emerging mobile technology. Technology alone may not be sufficient, but as an adjunct has the promise to improve low rates of behavioral change currently seen with traditional programs.
MeSH term(s)	Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/prevention & control ; Health Promotion/methods ; Health Promotion/organization & administration ; Healthy Lifestyle ; Humans ; Inventions ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/prevention & control ; Metabolic Syndrome/psychology ; Risk Reduction Behavior
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2016.07.012
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Zs.A 229: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Valve-sparing versus valve-replacing aortic root replacement in patients with aortic root aneurysm.

Malaisrie, S Chris / Kislitsina, Olga N / Wilsbacher, Lisa / Mendelson, Marla / Puthumana, Jyothy J / Vassallo, Patricia / Kruse, Jane / Andrei, Adin-Cristian / McCarthy, Patrick M

Journal of cardiac surgery

2022 Volume 37, Issue 7, Page(s) 1947–1956

Abstract: Background: Valve-sparing aortic root replacement (VSARR) is an alternative to valve-replacing aortic root replacement (VRARR) with valved-conduits based on recent guidelines for clinical practice. This study investigated outcomes of these two ... ...

Abstract	Background: Valve-sparing aortic root replacement (VSARR) is an alternative to valve-replacing aortic root replacement (VRARR) with valved-conduits based on recent guidelines for clinical practice. This study investigated outcomes of these two procedures in patients with nonstenotic valves. Methods: Between January 7, 2007 and June 30, 2019, 475 patients with aortic root aneurysm without aortic stenosis underwent VSARR (151) or VRARR (324) techniques. Propensity score-matching (PSM) was used to alleviate confounding. Endpoints were 30-day mortality, 8-year survival and reoperation, aortic regurgitation, and valve gradients. Results: PSM created 69 pairs of patients with a mean age 52 ± 13 years (10.1% Marfan syndrome, 34.8% bicuspid aortic valve). There was no statistically significant difference in major perioperative morbidity or 30-day mortality (0% VSARR vs. 1.4% VRARR; p = 0.316). Overall survival was significantly higher (p = 0.025) in the VSARR group versus the VRARR group (8-year estimates 100% vs. 88.9%, respectively), while freedom from valve reoperation was similar (p = 0.97, 8-year estimates 90.9% vs. 96.7%, respectively). Freedom from > moderate-severe AR was not significantly different (p = 0.08, 8-year estimates 90.0% VSARR group vs. 100% VRARR), but mean valve gradients at last follow-up were better in the VSARR group (5.9 vs. 13.2 mmHg, p < 0.001). Conclusions: VSARR is a safe operation in patients with aortic root aneurysm and nonstenotic aortic valves in the hands of experienced surgeons. Freedom from reoperation is similar and the mode of aortic valve failure differs between the two groups.
MeSH term(s)	Adult ; Aged ; Aortic Aneurysm, Thoracic/surgery ; Aortic Valve/surgery ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Heart Valve Prosthesis Implantation/methods ; Humans ; Middle Aged ; Reoperation ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.16473
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Zs.A 2221: Show issues

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Article: Potential benefits of egg white hydrolysate in the prevention of Hg-induced dysfunction in adipose tissue

Rizzetti, Danize Aparecida / Corrales, Patricia / Uranga-Ocio, José Antonio / Medina-Gómez, Gema / Peçanha, Franck Maciel / Vassallo, Dalton Valentim / Miguel, Marta / Wiggers, Giulia Alessandra

Food & function. 2022 June 6, v. 13, no. 11

2022

Abstract: Aim: To investigate the effects of egg white hydrolysate (EWH) on the lipid and glycemic metabolism disruption in the white adipose tissue (WAT) dysfunction induced by mercury (Hg). Experimental: Wistar rats were treated for 60 days: control (saline, ... ...

Abstract	Aim: To investigate the effects of egg white hydrolysate (EWH) on the lipid and glycemic metabolism disruption in the white adipose tissue (WAT) dysfunction induced by mercury (Hg). Experimental: Wistar rats were treated for 60 days: control (saline, intramuscular – i.m.); hydrolysate (EWH, gavage, 1 g kg⁻¹ day⁻¹); mercury (HgCl₂, i.m., 1ˢᵗ dose 4.6 μg kg⁻¹, subsequent doses 0.07 μg kg⁻¹ day⁻¹) and hydrolysate-mercury (EWH-HgCl₂). Hg level and histological analyses were performed in epididymal WAT (eWAT), pancreas and liver. GRP78, CHOP, PPARα, PPARγ, leptin, adiponectin, and CD11 mRNA expressions were analyzed in eWAT. The plasma lipid profile, glucose, and insulin levels were measured. Antioxidant status was also evaluated in the plasma and liver. Results: EWH intake prevented the reduced eWAT weight, adipocyte size, insulin levels, and antioxidant defenses and the increased glucose and triglyceride levels induced by Hg exposure; hepatic glutathione levels were higher in rats co-treated with EWH. The increased mRNA expression of CHOP, PPARα, and leptin induced by Hg was reduced in co-treated rats. EWH did not modify the elevated mRNA expression of GRP78, PPARγ and adiponectin in Hg-treated rats. Increased levels of Hg were found in the liver; the co-treatment did not alter this parameter. EWH prevented the morphological and metabolic disorder induced by Hg, by improving antioxidant defenses, inactivating pro-apoptotic pathways and normalizing the mRNA expression of PPARs and adipokines. Its effects enabled an increase in insulin levels and a normal balance between the fat storage and expenditure mechanisms in WAT. Conclusions: EWH may have potential benefits in the prevention and management of Hg-related metabolic disorders.
Keywords	adipocytes ; adiponectin ; antioxidants ; apoptosis ; blood lipids ; egg albumen ; epididymis ; gene expression ; glucose ; glutathione ; histology ; hydrolysates ; insulin ; leptin ; lipid composition ; liver ; mercury ; metabolic diseases ; metabolism ; pancreas ; triacylglycerols ; white adipose tissue
Language	English
Dates of publication	2022-0606
Size	p. 5996-6007.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo00561a
Database	NAL-Catalogue (AGRICOLA)

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Z 7872: Show issues

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Article ; Online: Noninvasive Morphologic and Hemodynamic Evaluation of Type B Aortic Dissection: State of the Art and Future Perspectives.

Zilber, Zachary A / Boddu, Aayush / Malaisrie, S Chris / Hoel, Andrew W / Mehta, Christopher K / Vassallo, Patricia / Burris, Nicholas S / Roldán-Alzate, Alejandro / Collins, Jeremy D / François, Christopher J / Allen, Bradley D

Radiology. Cardiothoracic imaging

2021 Volume 3, Issue 3, Page(s) e200456

Abstract: Stanford type B aortic dissection (TBAD) is associated with relatively high rates of morbidity and mortality, and appropriate treatment selection is important for optimizing patient outcomes. Depending on individualized risk factors, clinical ... ...

Abstract	Stanford type B aortic dissection (TBAD) is associated with relatively high rates of morbidity and mortality, and appropriate treatment selection is important for optimizing patient outcomes. Depending on individualized risk factors, clinical presentation, and imaging findings, patients are generally stratified to optimal medical therapy anchored by antihypertensives or thoracic endovascular aortic repair (TEVAR). Using standard anatomic imaging with CT or MRI, several high-risk features including aortic diameter, false lumen (FL) features, size of entry tears, involvement of major aortic branch vessels, or evidence of visceral malperfusion have been used to select patients likely to benefit from TEVAR. However, even with these measures, the number needed to treat for TEVAR remains, and improved risk stratification is needed. Increasingly, the relationship between FL hemodynamics and adverse aortic remodeling in TBAD has been studied, and evolving noninvasive techniques can measure numerous FL hemodynamic parameters that may improve risk stratification. In addition to summarizing the current clinical state of the art for morphologic TBAD evaluation, this review provides a detailed overview of noninvasive methods for TBAD hemodynamics characterization, including computational fluid dynamics and four-dimensional flow MRI.
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.2021200456
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