LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 342

Search options

  1. Article ; Online: Assessing Vulnerability to Urban Heat

    Jackson Voelkel / Dana Hellman / Ryu Sakuma / Vivek Shandas

    International Journal of Environmental Research and Public Health, Vol 15, Iss 4, p

    A Study of Disproportionate Heat Exposure and Access to Refuge by Socio-Demographic Status in Portland, Oregon

    2018  Volume 640

    Abstract: Extreme urban heat is a powerful environmental stressor which poses a significant threat ... to human health and well-being. Exacerbated by the urban heat island phenomenon, heat events are expected ...

    Abstract Extreme urban heat is a powerful environmental stressor which poses a significant threat to human health and well-being. Exacerbated by the urban heat island phenomenon, heat events are expected to become more intense and frequent as climate change progresses, though we have limited understanding of the impact of such events on vulnerable populations at a neighborhood or census block group level. Focusing on the City of Portland, Oregon, this study aimed to determine which socio-demographic populations experience disproportionate exposure to extreme heat, as well as the level of access to refuge in the form of public cooling centers or residential central air conditioning. During a 2014 heat wave, temperature data were recorded using a vehicle-traverse collection method, then extrapolated to determine average temperature at the census block group level. Socio-demographic factors including income, race, education, age, and English speaking ability were tested using statistical assessments to identify significant relationships with heat exposure and access to refuge from extreme heat. Results indicate that groups with limited adaptive capacity, including those in poverty and non-white populations, are at higher risk for heat exposure, suggesting an emerging concern of environmental justice as it relates to climate change. The paper concludes by emphasizing the importance of cultural sensitivity and inclusion, in combination with effectively distributing cooling centers in areas where the greatest burden befalls vulnerable populations.
    Keywords urban heat ; vulnerability ; environmental justice ; heat exposure ; resilience ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: The effect of speed limit reductions in urban areas on cyclists' injuries in collisions with cars.

    Isaksson-Hellman, Irene / Töreki, Josefin

    Traffic injury prevention

    2019  Volume 20, Issue sup3, Page(s) 39–44

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Acceleration ; Accidents, Traffic/statistics & numerical data ; Automobiles/statistics & numerical data ; Bicycling/injuries ; Deceleration ; Environmental Exposure/statistics & numerical data ; Female ; Humans ; Insurance ; Male ; Risk Factors ; Sweden ; Wounds and Injuries/epidemiology
    Language English
    Publishing date 2019-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2089818-6
    ISSN 1538-957X ; 1538-9588
    ISSN (online) 1538-957X
    ISSN 1538-9588
    DOI 10.1080/15389588.2019.1680836
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Assessing Vulnerability to Urban Heat: A Study of Disproportionate Heat Exposure and Access to Refuge by Socio-Demographic Status in Portland, Oregon.

    Voelkel, Jackson / Hellman, Dana / Sakuma, Ryu / Shandas, Vivek

    International journal of environmental research and public health

    2018  Volume 15, Issue 4

    Abstract: Extreme urban heat is a powerful environmental stressor which poses a significant threat ... to human health and well-being. Exacerbated by the urban heat island phenomenon, heat events are expected ...

    Abstract Extreme urban heat is a powerful environmental stressor which poses a significant threat to human health and well-being. Exacerbated by the urban heat island phenomenon, heat events are expected to become more intense and frequent as climate change progresses, though we have limited understanding of the impact of such events on vulnerable populations at a neighborhood or census block group level. Focusing on the City of Portland, Oregon, this study aimed to determine which socio-demographic populations experience disproportionate exposure to extreme heat, as well as the level of access to refuge in the form of public cooling centers or residential central air conditioning. During a 2014 heat wave, temperature data were recorded using a vehicle-traverse collection method, then extrapolated to determine average temperature at the census block group level. Socio-demographic factors including income, race, education, age, and English speaking ability were tested using statistical assessments to identify significant relationships with heat exposure and access to refuge from extreme heat. Results indicate that groups with limited adaptive capacity, including those in poverty and non-white populations, are at higher risk for heat exposure, suggesting an emerging concern of environmental justice as it relates to climate change. The paper concludes by emphasizing the importance of cultural sensitivity and inclusion, in combination with effectively distributing cooling centers in areas where the greatest burden befalls vulnerable populations.
    MeSH term(s) Adult ; Aged ; Cities ; Climate Change ; Environmental Exposure/adverse effects ; Environmental Exposure/statistics & numerical data ; Health Status Disparities ; Heat Stress Disorders/etiology ; Heat Stress Disorders/prevention & control ; Hot Temperature/adverse effects ; Humans ; Middle Aged ; Oregon ; Residence Characteristics ; Socioeconomic Factors ; Urban Health ; Vulnerable Populations ; Young Adult
    Language English
    Publishing date 2018-03-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph15040640
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: The impact of adverse childhood experiences on an urban pediatric population.

    Burke, Nadine J / Hellman, Julia L / Scott, Brandon G / Weems, Carl F / Carrion, Victor G

    Child abuse & neglect

    2011  Volume 35, Issue 6, Page(s) 408–413

    Abstract: ... in youth in a low-income, urban community.: Study design: Data from a retrospective chart review of 701 ... categories in this urban population. Exposure to 4 or greater ACE categories was associated with increased ... from this study demonstrate the need both for screening of ACEs among youth in urban areas and for developing ...

    Abstract Objective: The goal of this study was to investigate the adverse childhood experiences (ACEs) in youth in a low-income, urban community.
    Study design: Data from a retrospective chart review of 701 subjects from the Bayview Child Health Center in San Francisco are presented. Medical chart documentation of ACEs as defined in previous studies were coded and each ACE criterion endorsed by a traumatic event received a score of 1 (range=0-9). This study reports on the prevalence of various ACE categories in this population, as well as the association between ACE score and two pediatric problems: learning/behavior problems and body mass index (BMI)≥85% (i.e., overweight or obese).
    Results: The majority of subjects (67.2%, N=471) had experienced 1 or more categories of adverse childhood experiences (ACE≥1) and 12.0% (N=84) had experienced 4 or more ACEs (ACE≥4). Increased ACE scores correlated with increased risk of learning/behavior problems and obesity.
    Conclusions: There was a significant prevalence of endorsed ACE categories in this urban population. Exposure to 4 or greater ACE categories was associated with increased risk for learning/behavior problems, as well as obesity.
    Practice implications: Results from this study demonstrate the need both for screening of ACEs among youth in urban areas and for developing effective primary prevention and intervention models.
    MeSH term(s) Adolescent ; Child ; Child Abuse/psychology ; Child Abuse/statistics & numerical data ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Learning Disabilities/epidemiology ; Learning Disabilities/psychology ; Logistic Models ; Male ; Medical Records ; Obesity/epidemiology ; Obesity/psychology ; Parent-Child Relations ; Poverty ; Retrospective Studies ; Risk Factors ; San Francisco/epidemiology ; Urban Population ; Young Adult
    Language English
    Publishing date 2011-06-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2011.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Evaluation of Extracellular Matrix Remodeling in Full-thickness Skin Grafts in Mice.

    Tjust, Anton Erik / Hellman, Urban / Giannopoulos, Antonios / Winsnes, Annika / Strigård, Karin / Gunnarsson, Ulf

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2024  Volume 72, Issue 2, Page(s) 79–94

    Abstract: Abdominal hernia is a protruding weakness in the abdominal wall. It affects abdominal strength and life quality and can lead to complications due to intestinal entrapment. Autologous full-thickness skin graft (FTSG) has recently become an alternative ... ...

    Abstract Abdominal hernia is a protruding weakness in the abdominal wall. It affects abdominal strength and life quality and can lead to complications due to intestinal entrapment. Autologous full-thickness skin graft (FTSG) has recently become an alternative material for reinforcement in the surgical repair of large abdominal hernias instead of synthetic mesh. FTSG eventually integrates with the abdominal wall, but the long-term fate of the graft itself is not fully understood. This has implications as to how these grafts should be optimally used and handled intraoperatively. This study investigates the remodeling of FTSG in either the onlay or the intraperitoneal position 8 weeks after FTSG transplantation in an experimental mouse model. There was a significant presence of fibroblasts, indicated by vimentin and S100A4 staining, but there were significant variations among animals as to how much of the graft had been remodeled into dense connective tissue. This correlated significantly with the proportion of vimentin-positive cells in the dense connective tissue. We also found that collagen hybridizing peptide staining intensity, a marker of active remodeling, was significantly associated with the proportion of S100A4-positive cells in the dense connective tissue of the FTSG.
    MeSH term(s) Animals ; Mice ; Skin Transplantation ; Vimentin ; Abdominal Wall/surgery ; Disease Models, Animal ; Extracellular Matrix
    Chemical Substances Vimentin
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/00221554231225995
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Urban Indian voices: a community-based participatory research health and needs assessment.

    Johnson, Chad V / Bartgis, Jami / Worley, Jody A / Hellman, Chad M / Burkhart, Russell

    American Indian and Alaska native mental health research (Online)

    2010  Volume 17, Issue 1, Page(s) 49–70

    Abstract: ... to identify urban (Tulsa, OK) American Indian (AI) strengths and needs. Six hundred fifty AIs (550 adults and ...

    Abstract This community-based participatory research (CBPR) project utilized a mixed-methods survey design to identify urban (Tulsa, OK) American Indian (AI) strengths and needs. Six hundred fifty AIs (550 adults and 100 youth) were surveyed regarding their attitudes and beliefs about their community. These results were used in conjunction with other community research efforts to inform program development, support proposals for external funding, and develop a comprehensive service system model to be implemented in the community.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Community-Based Participatory Research/organization & administration ; Community-Based Participatory Research/statistics & numerical data ; Female ; Health Promotion/organization & administration ; Health Status Disparities ; Health Surveys ; Health Systems Plans/organization & administration ; Health Systems Plans/standards ; Humans ; Indians, North American/psychology ; Indians, North American/statistics & numerical data ; Male ; Middle Aged ; Needs Assessment/statistics & numerical data ; Oklahoma/epidemiology ; Oklahoma/ethnology ; Program Development/methods ; United States/epidemiology ; United States/ethnology ; United States Indian Health Service/legislation & jurisprudence ; United States Substance Abuse and Mental Health Services Administration ; Urban Population/statistics & numerical data
    Language English
    Publishing date 2010-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079045-4
    ISSN 1533-7731 ; 0893-5394
    ISSN (online) 1533-7731
    ISSN 0893-5394
    DOI 10.5820/aian.1701.2010.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study.

    Hellman, Urban / Lejon, Kristina / Do, Lan / Geijer, Mats / Baraliakos, Xenofon / Witte, Torsten / Forsblad-d'Elia, Helena

    Modern rheumatology

    2024  

    Abstract: Objectives There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers, at different time-points in radiographic (r)-axSpA ...

    Abstract Objectives There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers, at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker pattern in r-axSpA patients concerning disease phenotypes and disease activity. Methods Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity. Conclusion Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.
    Language English
    Publishing date 2024-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/roae039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Metabolomics analysis for diagnosis and biomarker discovery of transthyretin amyloidosis.

    Olsson, Malin / Hellman, Urban / Wixner, Jonas / Anan, Intissar

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    2021  Volume 28, Issue 4, Page(s) 234–242

    Abstract: Untargeted metabolomics is a well-established technique and a powerful tool to find potential plasma biomarkers for early diagnosing hereditary transthyretin amyloidosis. Hereditary transthyretin amyloidosis (ATTRv) is a disabling and fatal disease with ... ...

    Abstract Untargeted metabolomics is a well-established technique and a powerful tool to find potential plasma biomarkers for early diagnosing hereditary transthyretin amyloidosis. Hereditary transthyretin amyloidosis (ATTRv) is a disabling and fatal disease with different clinical features such as polyneuropathy, cardiomyopathy, different gastrointestinal symptoms and renal failure. Plasma specimens collected from 27 patients with ATTRv (ATTRV30M), 26 asymptomatic
    MeSH term(s) Amyloid Neuropathies, Familial/diagnosis ; Biomarkers ; Humans ; Metabolomics ; Polyneuropathies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1205246-2
    ISSN 1744-2818 ; 1350-6129
    ISSN (online) 1744-2818
    ISSN 1350-6129
    DOI 10.1080/13506129.2021.1958775
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Increased carotid intima-media thickness in patients with radiographic axial spondyloarthritis compared to controls and associations with markers of inflammation.

    Law, Lucy / Lindqvist, Per / Liv, Per / Hellman, Urban / Lejon, Kristina / Geijer, Mats / Söderberg, Stefan / Forsblad-d'Elia, Helena

    Clinical rheumatology

    2024  Volume 43, Issue 5, Page(s) 1559–1570

    Abstract: Objective: There is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid ... ...

    Abstract Objective: There is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid intima media thickness (cIMT), between patients and controls, and (ii) investigate associations between cIMT, clinical disease activity and inflammation-related laboratory markers in patients with r-axSpA.
    Method: In total, 155 patients diagnosed with r-axSpA using the modified New York criteria and 400 controls were included. Bilateral carotid ultrasound, laboratory testing, and questionaries were acquired. Disease-specific assessments were carried out for patients. Linear regression analysis was used to assess associations.
    Results: Linear regression analyses showed that patients with r-axSpA had increased mean cIMT compared to controls (mean ± SD, 0.8 ± 0.1 mm vs 0.7± 0.1 mm, respectively, unstandardized β (95% CI) -0.076 (-0.10, -0.052), P < 0.001) adjusted for smoking status and age. Linear regression analyses for patients with r-axSpA showed that only males presented significant associations between cIMT and inflammation-related laboratory markers, white blood cell (WBC) count (mean ± SD, 6.8 ± 1.6 10
    Conclusion: Patients with r-axSpA had significantly increased cIMT compared to controls. In male patients, higher WBC and monocyte count were associated with an increase in cIMT suggesting the role of inflammation in the development of atherosclerosis. Key Points •Carotid intima-media thickness was increased in patients with radiographic axial spondyloarthritis compared to controls. •White blood cell and monocyte counts were associated with carotid intima-media thickness in male patients with radiographic axial spondyloarthritis.
    MeSH term(s) Humans ; Male ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Inflammation ; Biomarkers ; Axial Spondyloarthritis ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-024-06913-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Hyaluronan, a beneficial glycosaminoglycan that may affect the phenotype of cardiac hypertrophy — a hypothesis

    Urban Hellman

    International Cardiovascular Forum Journal, Vol 1, Iss 5, Pp 226-

    2014  Volume 229

    Abstract: Myocardial hypertrophy contribute to ventricular diastolic dysfunction and can lead to heart failure, arrhythmia and even sudden death. It have been shown that during development of hypertrophy the concentration of the glycosaminoglycan hyaluronan ... ...

    Abstract Myocardial hypertrophy contribute to ventricular diastolic dysfunction and can lead to heart failure, arrhythmia and even sudden death. It have been shown that during development of hypertrophy the concentration of the glycosaminoglycan hyaluronan increases. The increased concentration correlates to the increased gene expression of fetal and extracellular matrix genes that is associated with cardiac remodeling. Moreover it has been shown that high molecular weight hyaluronan depolarize the membrane potential of cells. The increase of hyaluronan in cardiac hypertrophy could hypothetically affect the resting membrane potential in cardiomyocytes and thus affect the conduction through the heart. Hypothesis. The role of hyaluronan as a molecule adapting the extracellular matrix when the heart is growing could potentially develop to be harmful to cardiomyocyte resting membrane potential and hence contribute to the risk of arrhythmia.
    Keywords Hyaluronan ; cardiac ; hypertrophy ; fetal gene program ; Medicine ; R ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Barcaray International
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top