Article: Cross-reactivity and inclusivity analysis of CRISPR-based diagnostic assays of coronavirus SARS-CoV-2.
2021 Volume 9, Page(s) e12050
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is the cause of the novel coronavirus disease 2019 (COVID-19) pandemic. Its diagnosis relies on the molecular detection of the viral RNA by polymerase chain ... ...
| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is the cause of the novel coronavirus disease 2019 (COVID-19) pandemic. Its diagnosis relies on the molecular detection of the viral RNA by polymerase chain reaction (PCR) while newer rapid CRISPR-based diagnostic tools are being developed. As molecular diagnostic assays rely on the detection of unique sequences of viral nucleic acid, the target regions must be common to all coronavirus SARS-CoV-2 circulating strains, yet unique to SARS-CoV-2 with no cross-reactivity with the genome of the host and other normal or pathogenic organisms potentially present in the patient samples. This stage 1 protocol proposes |
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| Language | English |
| Publishing date | 2021-10-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2703241-3 |
| ISSN | 2167-8359 |
| ISSN | 2167-8359 |
| DOI | 10.7717/peerj.12050 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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