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  1. Article ; Online: Images in cardiology: fresh thrombus formation in left atrial appendage after temporary suspension of warfarin treatment in a patient with mitral stenosis and atrial fibrillation.

    Lairikyengbam, S K S / Knight, C / Deaner, A

    Heart (British Cardiac Society)

    2008  Volume 94, Issue 12, Page(s) 1593

    MeSH term(s) Anticoagulants/administration & dosage ; Atrial Appendage ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/drug therapy ; Echocardiography, Transesophageal ; Female ; Humans ; Middle Aged ; Mitral Valve Stenosis/diagnostic imaging ; Mitral Valve Stenosis/drug therapy ; Rheumatic Heart Disease/diagnostic imaging ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Warfarin/administration & dosage ; Withholding Treatment
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/hrt.2008.142182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diagnosis as a guide to stroke therapy.

    Lairikyengbam, S K / Jones, P D

    Lancet (London, England)

    1999  Volume 353, Issue 9147, Page(s) 152

    MeSH term(s) Acute Disease ; Anticoagulants/administration & dosage ; Carotid Stenosis/diagnosis ; Carotid Stenosis/drug therapy ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/drug therapy ; Humans ; Prognosis
    Chemical Substances Anticoagulants
    Language English
    Publishing date 1999-01-09
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(05)76192-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interpreting exercise treadmill tests needs scoring system.

    Lairikyengbam, S K S / Davies, A G

    BMJ (Clinical research ed.)

    2001  Volume 325, Issue 7361, Page(s) 443

    MeSH term(s) Coronary Disease/diagnosis ; Electrocardiography ; Exercise Test/methods ; Exercise Tolerance ; Humans ; Predictive Value of Tests ; Severity of Illness Index
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.325.7361.443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Present treatment options for atrial fibrillation.

    Lairikyengbam, S K S / Anderson, M H / Davies, A G

    Postgraduate medical journal

    2001  Volume 79, Issue 928, Page(s) 67–73

    Abstract: Atrial fibrillation is the commonest sustained cardiac arrhythmia. It accounts for >35% of all hospital admissions for cardiac arrhythmias in the United States. The presence of atrial fibrillation increases the mortality of a population by up to twofold. ...

    Abstract Atrial fibrillation is the commonest sustained cardiac arrhythmia. It accounts for >35% of all hospital admissions for cardiac arrhythmias in the United States. The presence of atrial fibrillation increases the mortality of a population by up to twofold. The risk of stroke increases from 1.5% in patients with atrial fibrillation from 50-59 years of age to up to 23.5% for such patients aged 80-89 years. Although the diagnosis of atrial fibrillation is usually straightforward, effective treatment is not. This article will discuss how rhythm control of atrial fibrillation can best be achieved, the controversy over the rhythm versus rate control, the maintenance of sinus rhythm with antiarrhythmic drugs after cardioversion, and prevention of thromboembolism. Finally, the recent advances in various non-pharmacological approaches for the treatment of atrial fibrillation will be highlighted.
    MeSH term(s) Aged ; Algorithms ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/etiology ; Atrial Fibrillation/therapy ; Echocardiography, Transesophageal ; Electric Countershock ; Humans ; Thromboembolism/prevention & control
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pmj.79.928.67
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  5. Article: Implementation of antithrombotic management in atrial fibrillation.

    Lairikyengbam, S K / Davies, A G / Jones, P D

    Postgraduate medical journal

    2001  Volume 77, Issue 909, Page(s) 488

    MeSH term(s) Aged ; Atrial Fibrillation/complications ; Fibrinolytic Agents/therapeutic use ; Humans ; Stroke/prevention & control ; Thromboembolism/prevention & control
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pmj.77.909.488
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  6. Article: Present treatment options for unstable angina and non-Q-wave myocardial infarction.

    Lairikyengbam, S K / Davies, A G / Anderson, M H

    QJM : monthly journal of the Association of Physicians

    2001  Volume 94, Issue 1, Page(s) 5–11

    MeSH term(s) Algorithms ; Angina, Unstable/drug therapy ; Angina, Unstable/surgery ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Coronary Angiography ; Coronary Artery Bypass ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Myocardial Infarction/drug therapy ; Myocardial Infarction/surgery ; Platelet Aggregation Inhibitors/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Anticoagulants ; Heparin, Low-Molecular-Weight ; Platelet Aggregation Inhibitors ; Heparin (9005-49-6) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2001-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 1460-2725 ; 0033-5622
    ISSN (online) 1460-2393
    ISSN 1460-2725 ; 0033-5622
    DOI 10.1093/qjmed/94.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: EcoliWiki: a wiki-based community resource for Escherichia coli.

    McIntosh, Brenley K / Renfro, Daniel P / Knapp, Gwendowlyn S / Lairikyengbam, Chanchala R / Liles, Nathan M / Niu, Lili / Supak, Amanda M / Venkatraman, Anand / Zweifel, Adrienne E / Siegele, Deborah A / Hu, James C

    Nucleic acids research

    2011  Volume 40, Issue Database issue, Page(s) D1270–7

    Abstract: EcoliWiki is the community annotation component of the PortEco (http://porteco.org; formerly EcoliHub) project, an online data resource that integrates information on laboratory strains of Escherichia coli, its phages, plasmids and mobile genetic ... ...

    Abstract EcoliWiki is the community annotation component of the PortEco (http://porteco.org; formerly EcoliHub) project, an online data resource that integrates information on laboratory strains of Escherichia coli, its phages, plasmids and mobile genetic elements. As one of the early adopters of the wiki approach to model organism databases, EcoliWiki was designed to not only facilitate community-driven sharing of biological knowledge about E. coli as a model organism, but also to be interoperable with other data resources. EcoliWiki content currently covers genes from five laboratory E. coli strains, 21 bacteriophage genomes, F plasmid and eight transposons. EcoliWiki integrates the Mediawiki wiki platform with other open-source software tools and in-house software development to extend how wikis can be used for model organism databases. EcoliWiki can be accessed online at http://ecoliwiki.net.
    MeSH term(s) Coliphages/genetics ; Databases, Genetic ; Escherichia coli/genetics ; Genes, Bacterial ; Internet ; Interspersed Repetitive Sequences ; Molecular Sequence Annotation ; Plasmids/genetics ; Software ; Systems Integration
    Language English
    Publishing date 2011-11-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkr880
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  8. Article ; Online: Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.

    Sinha, Neelima / Karche, Navnath P / Verma, Mahip Kalyan / Walunj, Sameer S / Nigade, Prashant B / Jana, Gourhari / Kurhade, Sanjay P / Hajare, Anil K / Tilekar, Ajay R / Jadhav, Ganesh R / Thube, Baban R / Shaikh, Javed S / Balgude, Sudhakar / Singh, Lairikyengbam Bikramjit / Mahimane, Vijaya / Adurkar, Shridhar K / Hatnapure, Girish / Raje, Firoj / Bhosale, Yogesh /
    Bhanage, Dnyaneshwar / Sachchidanand, Sachchidanand / Dixit, Ruchi / Gupta, Rajesh / Bokare, Anand M / Dandekar, Manoj / Bharne, Ashish / Chatterjee, Manavi / Desai, Sagar / Koul, Sarita / Modi, Dipak / Mehta, Maneesh / Patil, Vinod / Singh, Minakshi / Gundu, Jayasagar / Goel, Rajan N / Shah, Chirag / Sharma, Sharad / Bakhle, Dhananjay / Kamboj, Rajender Kumar / Palle, Venkata P

    Journal of medicinal chemistry

    2019  Volume 63, Issue 3, Page(s) 944–960

    Abstract: The discovery of a series of thiophenephenylsulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization of this series led to identification of ... ...

    Abstract The discovery of a series of thiophenephenylsulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization of this series led to identification of compound
    MeSH term(s) Alzheimer Disease/drug therapy ; Animals ; Brain/metabolism ; Clinical Trials as Topic ; Drug Discovery ; Drug Stability ; Humans ; Male ; Molecular Structure ; Nicotinic Agonists/chemical synthesis ; Nicotinic Agonists/pharmacokinetics ; Nicotinic Agonists/pharmacology ; Nootropic Agents/chemical synthesis ; Nootropic Agents/pharmacokinetics ; Nootropic Agents/pharmacology ; Rats, Sprague-Dawley ; Rats, Wistar ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Thiophenes/chemical synthesis ; Thiophenes/pharmacokinetics ; Thiophenes/pharmacology ; alpha7 Nicotinic Acetylcholine Receptor/agonists
    Chemical Substances Nicotinic Agonists ; Nootropic Agents ; Sulfonamides ; Thiophenes ; alpha7 Nicotinic Acetylcholine Receptor
    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type News
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.9b01569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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