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Article ; Online: L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model.

Corremans, Raphaëlle / D'Haese, Patrick C / Vervaet, Benjamin A / Verhulst, Anja

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: ... NAD) with oral N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) administration. Diabetes was induced ... of 230 mg/kg NAD. Rats were assigned to different groups receiving L-NAME (100 mg/kg/day) (STZ/NAD/L-NAME ... albumin-to-creatinine ratio, and evolving hypofiltration were detected at the end of the study. Daily L ...

Abstract	One of the most important risk factors for developing chronic kidney disease (CKD) is diabetes. To assess the safety and efficacy of potential drug candidates, reliable animal models that mimic human diseases are crucial. However, a suitable model of diabetic kidney disease (DKD) is currently not available. The aim of this study is to develop a rat model of DKD by combining streptozotocin and nicotinamide (STZ/NAD) with oral N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) administration. Diabetes was induced in male Wistar rats by intravenous injection of 65 mg/kg STZ, 15 min after intraperitoneal injection of 230 mg/kg NAD. Rats were assigned to different groups receiving L-NAME (100 mg/kg/day) (STZ/NAD/L-NAME) or vehicle (STZ/NAD) for a period of 9 or 12 weeks by daily oral gavage. All rats developed hyperglycemia. Hyperfiltration was observed at the start of the study, whereas increased serum creatinine, albumin-to-creatinine ratio, and evolving hypofiltration were detected at the end of the study. Daily L-NAME administration caused a rapid rise in blood pressure. Histopathological evaluation revealed heterogeneous renal injury patterns, which were most severe in the STZ/NAD/L-NAME rats. L-NAME-induced NO-deficiency in STZ/NAD-induced diabetic rats leads to multiple characteristic features of human DKD and may represent a novel rat model of DKD.
MeSH term(s)	Animals ; Blood Glucose/analysis ; Blood Pressure ; Diabetes Mellitus, Experimental/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/pathology ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/toxicity ; Male ; NAD/toxicity ; NG-Nitroarginine Methyl Ester/administration & dosage ; NG-Nitroarginine Methyl Ester/toxicity ; Nitric Oxide/metabolism ; Rats ; Rats, Wistar
Chemical Substances	Blood Glucose ; Enzyme Inhibitors ; NAD (0U46U6E8UK) ; Nitric Oxide (31C4KY9ESH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
Language	English
Publishing date	2021-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222312767
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Article ; Online: N-acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: The role of l-cysteine and hydrogen sulphide.

Bourne, Lucie E / Patel, Jessal J / Davies, Bethan K / Neven, Ellen / Verhulst, Anja / D'Haese, Patrick C / Wheeler-Jones, Caroline P D / Orriss, Isabel R

Journal of cellular physiology

2021 Volume 237, Issue 1, Page(s) 1070–1086

Abstract: Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone formation; however, emerging evidence suggests several key differences between these processes. ...

Abstract	Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone formation; however, emerging evidence suggests several key differences between these processes. N-acetylcysteine (NAC) displays antioxidant properties and can generate hydrogen sulphide (H
MeSH term(s)	Acetylcysteine/pharmacology ; Arteries/metabolism ; Glutathione/metabolism ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Osteoblasts/metabolism ; Osteogenesis
Chemical Substances	Glutathione (GAN16C9B8O) ; Acetylcysteine (WYQ7N0BPYC) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2021-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30605
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Article ; Online: L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model

Raphaëlle Corremans / Patrick C. D’Haese / Benjamin A. Vervaet / Anja Verhulst

International Journal of Molecular Sciences, Vol 22, Iss 12767, p

2021 Volume 12767

Abstract	One of the most important risk factors for developing chronic kidney disease (CKD) is diabetes. To assess the safety and efficacy of potential drug candidates, reliable animal models that mimic human diseases are crucial. However, a suitable model of diabetic kidney disease (DKD) is currently not available. The aim of this study is to develop a rat model of DKD by combining streptozotocin and nicotinamide (STZ/NAD) with oral N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) administration. Diabetes was induced in male Wistar rats by intravenous injection of 65 mg/kg STZ, 15 min after intraperitoneal injection of 230 mg/kg NAD. Rats were assigned to different groups receiving L-NAME (100 mg/kg/day) (STZ/NAD/L-NAME) or vehicle (STZ/NAD) for a period of 9 or 12 weeks by daily oral gavage. All rats developed hyperglycemia. Hyperfiltration was observed at the start of the study, whereas increased serum creatinine, albumin-to-creatinine ratio, and evolving hypofiltration were detected at the end of the study. Daily L-NAME administration caused a rapid rise in blood pressure. Histopathological evaluation revealed heterogeneous renal injury patterns, which were most severe in the STZ/NAD/L-NAME rats. L-NAME-induced NO-deficiency in STZ/NAD-induced diabetic rats leads to multiple characteristic features of human DKD and may represent a novel rat model of DKD.
Keywords	diabetic kidney disease ; preclinical model ; hyperfiltration ; albuminuria ; creatinine ; glomerular filtration rate ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Changes in the bacterial community structure in soil under conventional and conservation practices throughout a complete maize (Zea mays L.) crop cycle

Romero-Salas, Edson A / Navarro-Noya, Yendi E / Luna-Guido, Marco / Verhulst, Nele / Crossa, José / Govaerts, Bram / Dendooven, Luc

Applied soil ecology. 2021 Jan., v. 157

2021

Abstract: ... characteristics and the bacterial community structure were monitored in soil with maize (Zea mays L.) and wheat ... Triticum aestivum L.) rotation, zero tillage and crop residue kept (ZTRK) or removed (ZTRR), and ...

Abstract	Agricultural practices and changes in soil conditions, such as water content, inorganic N content, temperature, pH and organic material availability, affect the bacterial community structure. Soil characteristics and the bacterial community structure were monitored in soil with maize (Zea mays L.) and wheat (Triticum aestivum L.) rotation, zero tillage and crop residue kept (ZTRK) or removed (ZTRR), and conventional tillage with monoculture maize (CTMR) or maize-wheat rotation and crop residue removed (CTRR) or kept in the field and ploughed in (CTRK). The soil organic C was significantly affected by tillage practices and decreased ZTRK > CTRK > CTRR = ZTRR > CTMR, while water content and NO₃⁻ concentration showed large fluctuations over the crop cycle, but were not affected significantly by agricultural practices. The bacterial community structure showed large changes over the crop cycle determined by varying soil characteristics, most importantly water content and NO₃⁻ concentration and six bacterial genera, i.e. Achromobacter, Bacillus, Halomonas, Kaistobacter, Pseudomonas and Serratia, while changes due to agricultural practices were much smaller. It was found that the bacterial community structure was affected significantly by time, tillage (zero tillage versus conventional tillage), crop residue management (kept versus removed) and crop rotation (CTMR versus CTRR treatment).
Keywords	Achromobacter ; Halomonas ; Pseudomonas ; Serratia ; Triticum aestivum ; Zea mays ; bacterial communities ; community structure ; conventional tillage ; corn ; crop residue management ; crop residues ; crop rotation ; nitrogen content ; no-tillage ; pH ; soil ecology ; soil organic carbon ; temperature ; water content ; wheat
Language	English
Dates of publication	2021-01
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1196758-4
ISSN	0929-1393
ISSN	0929-1393
DOI	10.1016/j.apsoil.2020.103733
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Article ; Online: The Bacterial Community Structure and Dynamics of Carbon and Nitrogen when Maize (Zea mays L.) and Its Neutral Detergent Fibre Were Added to Soil from Zimbabwe with Contrasting Management Practices.

De la Cruz-Barrón, Magali / Cruz-Mendoza, Alejandra / Navarro-Noya, Yendi E / Ruiz-Valdiviezo, Victor M / Ortíz-Gutiérrez, Daniel / Ramírez-Villanueva, Daniel A / Luna-Guido, Marco / Thierfelder, Cristian / Wall, Patrick C / Verhulst, Nele / Govaerts, Bram / Dendooven, Luc

Microbial ecology

2016 Volume 73, Issue 1, Page(s) 135–152

Abstract: Water infiltration, soil carbon content, aggregate stability and yields increased in conservation agriculture practices compared to conventionally ploughed control treatments at the Henderson research station near Mazowe (Zimbabwe). How these changes in ... ...

Abstract	Water infiltration, soil carbon content, aggregate stability and yields increased in conservation agriculture practices compared to conventionally ploughed control treatments at the Henderson research station near Mazowe (Zimbabwe). How these changes in soil characteristics affect the bacterial community structure and the bacteria involved in the degradation of applied organic material remains unanswered. Soil was sampled from three agricultural systems at Henderson, i.e. (1) conventional mouldboard ploughing with continuous maize (conventional tillage), (2) direct seeding with a Fitarelli jab planter and continuous maize (direct seeding with continuous maize) and (3) direct seeding with a Fitarelli jab planter with rotation of maize sunn hemp (direct seeding with crop rotation). Soil was amended with young maize plants or their neutral detergent fibre (NDF) and incubated aerobically for 56 days, while C and N mineralization and the bacterial community structure were monitored. Bacillus (Bacillales), Micrococcaceae (Actinomycetales) and phylotypes belonging to the Pseudomonadales were first degraders of the applied maize plants. At day 3, Streptomyces (Actinomycetales), Chitinophagaceae ([Saprospirales]) and Dyella (Xanthomonadales) participated in the degradation of the applied maize and at day 7 Oxalobacteraceae (Burkholderiales). Phylotypes belonging to Halomonas (Oceanospirillales) were the first degraders of NDF and were replaced by Phenylobacterium (Caulobacterales) and phylotypes belonging to Pseudomonadales at day 3. Afterwards, similar bacterial groups were favoured by application of NDF as they were by the application of maize plants, but there were also clear differences. Phylotypes belonging to the Micrococcaceae and Bacillus did not participate in the degradation of NDF or its metabolic products, while phylotypes belonging to the Acidobacteriaceae participated in the degradation of NDF but not in that of maize plants. It was found that agricultural practices had a limited effect on the bacterial community structure, but application of organic material altered it substantially.
MeSH term(s)	Bacteria/metabolism ; Carbon/metabolism ; Fertilizers/analysis ; Microbiota ; Nitrogen/metabolism ; Soil/chemistry ; Soil Microbiology ; Zea mays/metabolism ; Zea mays/microbiology ; Zimbabwe
Chemical Substances	Fertilizers ; Soil ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
Language	English
Publishing date	2016-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-016-0807-8
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Article: Thermal preference of Culicoides biting midges in laboratory and semi-field settings.

Hochstrasser, Alec L / Mathis, Alexander / Verhulst, Niels O

Journal of thermal biology

2024 Volume 119, Page(s) 103783

Abstract: Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are hematophagous insects, and some species can transmit a plethora of pathogens, e.g., bluetongue virus and African horse sickness virus, that mainly affect animals. The transmission of ... ...

Abstract	Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are hematophagous insects, and some species can transmit a plethora of pathogens, e.g., bluetongue virus and African horse sickness virus, that mainly affect animals. The transmission of vector-borne pathogens is strongly temperature dependent, and recent studies pointed to the importance of including microclimatic data when modelling disease spread. However, little is known about the preferred temperature of biting midges. The present study addressed the thermal selection of field-caught Culicoides with two experiments. In a laboratory setup, sugar-fed or blood-fed midges were video tracked for 15 min while moving inside a 60 × 30 × 4 cm setup with a 15-25 °C temperature gradient. Culicoides spent over double the time in the coldest zone of the setup compared to the warmest one. This cold selection was significantly stronger for sugar-fed individuals. Calculated preferred temperatures were 18.3 °C and 18.9 °C for sugar-fed and blood-fed Culicoides, respectively. The effect of temperature on walking speed was significant but weak, indicating that their skewed distribution results from preference and not cold trapping. A second experiment consisted of a two-way-choice-setup, performed in a 90 × 45 × 45 cm net cage, placed outdoors in a sheltered environment. Two UV LED CDC traps were placed inside the setup, and a mean temperature difference of 2.2 °C was created between the two traps. Hundred-fifty Culicoides were released per experiment. Recapture rates were negatively correlated with ambient temperature and were on average three times higher in the cooled trap. The higher prevalence of biting midges in cooler environments influences fitness and ability to transmit pathogens and should be considered in models that predict Culicoides disease transmission.
MeSH term(s)	Humans ; Animals ; Ceratopogonidae ; Insect Vectors ; African Horse Sickness Virus ; Environment ; Sugars
Chemical Substances	Sugars
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2024.103783
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Article ; Online: A retrospective chart analysis with 5-year follow-up of early care for geriatric hip fracture patients: why we should continue talking about hip fractures.

Sermon, An / Verhulst, Evelyne / Aerden, Laurens / Hoekstra, Harm

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2024

Abstract: Background: Timing of surgery remains a topic of debate for hip fracture treatment in the geriatric patient population. The quality indicator "early surgery" was implemented in 2014 at the Department of Trauma Surgery of the University Hospitals Leuven ... ...

Abstract	Background: Timing of surgery remains a topic of debate for hip fracture treatment in the geriatric patient population. The quality indicator "early surgery" was implemented in 2014 at the Department of Trauma Surgery of the University Hospitals Leuven to enhance timely operative treatment. In this follow-up study, we aim to evaluate the performance of this quality indicator, the clinical outcomes, and room for improvement. Methods: The charts of 1190 patients surgically treated for an acute hip fracture were reviewed between June 2017 and May 2022 at the University Hospitals Leuven. Primary endpoints were adherence to early surgery, defined as surgery within the next calendar day, and the evaluation of the reasons for deviating from this protocol. Secondary endpoints were length of stay (LOS); intensive care unit (ICU) admission and length of ICU stay; mortality after 30 days, 60 days, 90 days, and 6 months; and 90-day readmission rate. Pearson's Chi-square test and Mann-Whitney U test were used for data analysis. Results: One thousand eighty-four (91.1%) patients received early surgery versus 106 (8.9%) patients who received delayed surgery. The main reasons for surgical delay were the use of anticoagulants (33%), a general health condition not allowing safe surgery and/or existing comorbidities requiring workup prior to surgery (26.4%), and logistical reasons (17.9%). Patient delay and transfer from other hospitals were responsible for respectively 8.5% and 6.6% of delayed surgery. Early surgery resulted in a significantly shorter LOS and ICU stay (12 [8-25] vs. 18 [10-36] and 3 [2-6] vs. 7 [3-13] days, early vs. delayed surgery, respectively). No significant reduction was observed in ICU admission, mortality, and readmission rate. Conclusion: We have been able to maintain the early surgery hip fracture protocol in approximately 90% of the patients. Comorbidities and anticoagulant use were responsible for delayed surgery in the majority of the patients. Correct implementation of the existing protocol on anticoagulant use could lead to a one-third decrease in the number of delayed surgeries. Subsequently, since the LOS and ICU stay in the delayed surgery group were significantly longer, a further increase of early surgery will lower the current economic burden.
Language	English
Publishing date	2024-04-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-024-02514-x
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Article: The Bacterial Community Structure and Dynamics of Carbon and Nitrogen when Maize (Zea mays L.) and Its Neutral Detergent Fibre Were Added to Soil from Zimbabwe with Contrasting Management Practices

De la Cruz-Barrón, Magali / Cruz-Mendoza, Alejandra / Navarro–Noya, Yendi E / Ruiz-Valdiviezo, Victor M / Ortíz-Gutiérrez, Daniel / Ramírez-Villanueva, Daniel A / Luna-Guido, Marco / Thierfelder, Cristian / Wall, Patrick C / Verhulst, Nele / Govaerts, Bram / Dendooven, Luc

Microbial ecology. 2017 Jan., v. 73, no. 1

2017

Abstract	Water infiltration, soil carbon content, aggregate stability and yields increased in conservation agriculture practices compared to conventionally ploughed control treatments at the Henderson research station near Mazowe (Zimbabwe). How these changes in soil characteristics affect the bacterial community structure and the bacteria involved in the degradation of applied organic material remains unanswered. Soil was sampled from three agricultural systems at Henderson, i.e. (1) conventional mouldboard ploughing with continuous maize (conventional tillage), (2) direct seeding with a Fitarelli jab planter and continuous maize (direct seeding with continuous maize) and (3) direct seeding with a Fitarelli jab planter with rotation of maize sunn hemp (direct seeding with crop rotation). Soil was amended with young maize plants or their neutral detergent fibre (NDF) and incubated aerobically for 56 days, while C and N mineralization and the bacterial community structure were monitored. Bacillus (Bacillales), Micrococcaceae (Actinomycetales) and phylotypes belonging to the Pseudomonadales were first degraders of the applied maize plants. At day 3, Streptomyces (Actinomycetales), Chitinophagaceae ([Saprospirales]) and Dyella (Xanthomonadales) participated in the degradation of the applied maize and at day 7 Oxalobacteraceae (Burkholderiales). Phylotypes belonging to Halomonas (Oceanospirillales) were the first degraders of NDF and were replaced by Phenylobacterium (Caulobacterales) and phylotypes belonging to Pseudomonadales at day 3. Afterwards, similar bacterial groups were favoured by application of NDF as they were by the application of maize plants, but there were also clear differences. Phylotypes belonging to the Micrococcaceae and Bacillus did not participate in the degradation of NDF or its metabolic products, while phylotypes belonging to the Acidobacteriaceae participated in the degradation of NDF but not in that of maize plants. It was found that agricultural practices had a limited effect on the bacterial community structure, but application of organic material altered it substantially.
Keywords	Acidobacteriaceae ; Bacillales ; Chitinophagaceae ; Crotalaria juncea ; Halomonas ; Micrococcaceae ; Oxalobacteraceae ; Phenylobacterium ; Pseudomonadales ; Streptomyces ; Xanthomonadales ; Zea mays ; aggregate stability ; bacteria ; bacterial communities ; carbon ; community structure ; conventional tillage ; corn ; crop rotation ; direct seeding ; mineralization ; neutral detergent fiber ; nitrogen ; phylotype ; plowing ; Zimbabwe
Language	English
Dates of publication	2017-01
Size	p. 135-152.
Publishing place	Springer US
Document type	Article
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-016-0807-8
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Article: Street Experiments and COVID-19: Challenges, Responses and Systemic Change.

Verhulst, Lennert / Casier, Corneel / Witlox, Frank

Tijdschrift voor economische en sociale geografie = Journal of economic and social geography = Revue de geographie economique et humaine = Zeitschrift fur okonomische und soziale Geographie = Revista de geografia economica y social

2022 Volume 114, Issue 1, Page(s) 43–57

Abstract: Cities have introduced street experiments, among others, in order to cope with the urgent health challenges caused by the COVID-19 pandemic. They are primarily intended to allow people to move safely in urban spaces according to physical distancing ... ...

Abstract	Cities have introduced street experiments, among others, in order to cope with the urgent health challenges caused by the COVID-19 pandemic. They are primarily intended to allow people to move safely in urban spaces according to physical distancing requirements. It has been suggested that street experiments have the potential to not only respond to pressing needs, but to also trigger systemic change in mobility. This paper explores urban case studies and demonstrates how pandemic-induced street experiments provide a solution to specific challenges to mobility and public space. There are, however, issues concerning equity and citizen participation. Finally, we find that pandemic-induced street experiments have a higher acceptance among the public and authorities, a more permanent character and a greater embeddedness in long-term planning agendas. The paper concludes that the pandemic stimulated the introduction of street experiments and fostered their potential to enable systemic change in urban mobility.
Language	English
Publishing date	2022-12-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1482901-0
ISSN	1467-9663 ; 0040-747X
ISSN (online)	1467-9663
ISSN	0040-747X
DOI	10.1111/tesg.12542
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Article: Aminoglycoside-induced sensorineural hearing loss in pediatric cystic fibrosis patients: A retrospective cohort study.

Jouret, N / Van der Poel, N / Verhulst, S / Lammers, Mjw / Van Rompaey, V / Jacquemin, L / Van Hoorenbeeck, K

Heliyon

2024 Volume 10, Issue 3, Page(s) e25190

Abstract: Background: Pulmonary infections by gram-negative organisms are important in cystic fibrosis (CF). Aminoglycosides (AG) are often part of the treatment regimen. However, they are a well-known cause of ototoxicity. Even minimal hearing impairment in ... ...

Abstract	Background: Pulmonary infections by gram-negative organisms are important in cystic fibrosis (CF). Aminoglycosides (AG) are often part of the treatment regimen. However, they are a well-known cause of ototoxicity. Even minimal hearing impairment in children could have a future impact on functional well-being.We aimed to investigate the progression of sensorineural hearing loss (SNHL) over several years in pediatric CF patients, and to identify risk factors, such as the use of AG, including both intravenous (IV) and inhaled AG. Methods: Retrospective analyses of patient records from children and adolescents followed up at the CF clinic of the Antwerp University Hospital, Belgium, were performed. We collected data on age, sex, pure-tone audiometry, and the use of AG. Descriptive and binary logistic regression analyses, and if indicated generalized estimating equations (GEE) analyses were performed. Results: Forty pediatric patients were enrolled in the study taking part from 2013 to 2020. Pure-tone audiometry revealed an important rate of SNHL over several years, with a prevalence of 29 % for high-frequency SNHL (i.e. 8 kHz). Increasing age was identified as a significant risk factor for the development of SNHL at 8 kHz if 5 or more IV AG courses (p = 0.01) were reported or when IV AG were combined with inhaled AG (p = 0.002). Conclusions: Age combined with the use of IV AG (≥5 courses or in combination with inhaled AG) are predictive for developing high-frequency SNHL (i.e. 8 kHz). We suggest routine annual hearing screening (incl. high-frequency thresholds) in CF patients, starting from childhood.
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25190
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