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Article ; Online: IsoPSA Performance Characteristics are Unaffected by 5-Alpha Reductase Inhibitors or Alpha-Blockers: Results From the IsoPSA Validation Study.

Scovell, Jason M / Stovsky, Mark / Partin, Alan / Lotan, Yair / Baniel, Jack / Dineen, Martin / Hafron, Jason / Manickam, Kannan / Pliskin, Marc / Wagner, Matthew / Kestranek, Aimee / Klein, Eric A

Urology

2023 Volume 175, Page(s) 132–136

Abstract: Objective: To. determine the impact of 5-α reductase inhibitors or α-blockers on IsoPSA performance for the detection of actionable prostate cancer.: Materials and methods: This is a secondary analysis of data from an institutional review board ... ...

Abstract	Objective: To. determine the impact of 5-α reductase inhibitors or α-blockers on IsoPSA performance for the detection of actionable prostate cancer. Materials and methods: This is a secondary analysis of data from an institutional review board approved, prospective, multicenter(8-sites) study evaluating IsoPSA in men ≥ 50 years of age with a total PSA ≥ 4 ng/mL with planned prostate biopsy who met previously described inclusion and exclusion criteria. Analytic groups included (i)all subjects, (ii-iii)+/- 5-ARI use, (iv-v)+/- α-blocker use. The performance characteristics of IsoPSA in these groups were assessed by ROC curve, sensitivity, and specificity (SP) analysis. Results: A total of 1385 men were recruited with 888 men included in final analysis. Actionable prostate cancer, defined as GG2+, was identified in a total of 316 patients with 40 and 217 patients reporting 5-ARI and α-blocker use respectively. Sensitivity to detect both prostate cancer and actionable cancer was similar between patient subsets (P >.05). SP was similar between patients regardless of 5-ARI(P >.05). Increased SP was noted in patients on α-blockers(GG1+: No-α-blocker: 0.360 vs α-blocker: 0.529, P <.05; GG2+: No-α-blocker: 0.40 vs α-blocker: 0.61, P <.05). ROC analysis demonstrates that IsoPSA performance is unaffected by 5-ARI or α-blocker use for prostate cancer and actionable cancer (GG2+) detection. Conclusion: The performance of IsoPSA for detecting any prostate cancer and clinically actionable prostate cancer is unaffected by commonly used medications (5-ARI and α-blockers) for symptoms of benign prostatic hyperplasia.
MeSH term(s)	Male ; Humans ; 5-alpha Reductase Inhibitors/therapeutic use ; Prostate-Specific Antigen ; Prospective Studies ; Prostatic Neoplasms/pathology ; Prostatic Hyperplasia/complications ; Adrenergic alpha-Antagonists/therapeutic use
Chemical Substances	5-alpha Reductase Inhibitors ; Prostate-Specific Antigen (EC 3.4.21.77) ; Adrenergic alpha-Antagonists
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2023.01.037
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Utilization and Patient-Reported Outcomes of Direct-to-Consumer Telemedicine During the First 6 Weeks of the COVID-19 Pandemic in the Largest Pediatric Ambulatory Network in New York State.

Katzow, Michelle W / Steinway, Caren / Capossela, Errica / Chen, Jack / Chen, Victoria / Fenster, Talia / Galagedera, Nirupa / Hamill, Megan / Lin, Elaine / Mamauag, Erica / Moriarty, Shannon / Pathania, Shivany / Pliskin, Lyndsey / Ripp, Asher / Ronay, Avy / Santiago, Maria T / Yang, Margaret / Jan, Sophia

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2024

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2023.0483
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Zs.A 4576: Show issues

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Article ; Online: Exploring Subfactors of Adult Cognitive Disengagement Syndrome and Impact on Neuropsychological Performance.

Khalid, Elmma / VanLandingham, Hannah B / Basurto, Karen S / Nili, Amanda N / Gonzalez, Christopher / Guilfoyle, Janna L / Ovsiew, Gabriel P / Durkin, Nicole M / Ulrich, Devin M / Resch, Zachary J / Pliskin, Neil H / Soble, Jason R / Cerny, Brian M

Journal of attention disorders

2024 Volume 28, Issue 6, Page(s) 957–969

Abstract: Objective: This study investigated subfactors of cognitive disengagement syndrome (CDS; previously referred as sluggish cognitive tempo) among adults referred for neuropsychological evaluation of attentiondeficit/hyperactivity disorder (ADHD).: Method! ...

Abstract	Objective: This study investigated subfactors of cognitive disengagement syndrome (CDS; previously referred as sluggish cognitive tempo) among adults referred for neuropsychological evaluation of attentiondeficit/hyperactivity disorder (ADHD). Method: Retrospective analyses of data from 164 outpatient neuropsychological evaluations examined associations between CDS subfactors and self-reported psychological symptoms and cognitive performance. Results: Factor analysis produced two distinct but positively correlated constructs: "Cognitive Complaints'' and "Lethargy." Both correlated positively with symptom reports (rs = 0.26-0.57). Cognitive Complaints correlated negatively with working memory, processing speed, and executive functioning performance (rs = -0.21 to -0.37), whereas Lethargy correlated negatively only with processing speed and executive functioning performance (rs = -0.26 to -0.42). Both predicted depression symptoms, but only Cognitive Complaints predicted inattention symptoms. Both subfactors demonstrated modest to nonsignificant associations with cognitive performance after accounting for estimated premorbid intelligence and inattention. Conclusion: Findings indicate a bidimensional conceptualization of CDS, with differential associations between its constituent subfactors, reported symptoms, and cognitive performance.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Lethargy/complications ; Attention Deficit Disorder with Hyperactivity/psychology ; Executive Function ; Cognition
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547231218945
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Article ; Online: Clinical validation of IsoPSA, a single parameter, structure-focused assay for improved detection of prostate cancer: A prospective, multicenter study.

Klein, Eric A / Partin, Alan / Lotan, Yair / Baniel, Jack / Dineen, Martin / Hafron, Jason / Manickam, Kannan / Pliskin, Marc / Wagner, Matthew / Kestranek, Aimee / Stovsky, Mark

Urologic oncology

2022 Volume 40, Issue 9, Page(s) 408.e9–408.e18

Abstract: Background: IsoPSA is a blood-based test that assesses prostate cancer (CaP) risk by partitioning and detecting cancer-specific structural isoforms of prostate specific antigen (PSA) with an aqueous 2- phase system.: Objective: To validate the ... ...

Abstract	Background: IsoPSA is a blood-based test that assesses prostate cancer (CaP) risk by partitioning and detecting cancer-specific structural isoforms of prostate specific antigen (PSA) with an aqueous 2- phase system. Objective: To validate the diagnostic performance of IsoPSA for High-Grade CaP and Any CaP risk on biopsy in men age ≥ 50 with total PSA ≥ 4 ng/ml. Design, setting, and participants: Prospective, multicenter study of 888 men scheduled for prostate biopsy at 8 academic and community sites between August 2015 and August 2020. Intervention: IsoPSA test. Outcome measurements and statistical analysis: Receiver operating characteristic and likelihood ratio analysis used to validate diagnostic performance for previously established IsoPSA Index cutoffs for High-Grade CaP (Gleason Score ≥ 7) and Any CaP (Gleason Score ≥ 6), compare IsoPSA to total PSA and % free PSA, and evaluate subgroups (total PSA 4-10 ng/ml, total PSA > 10 ng/ml, biopsy naïve, prior negative biopsy). Results and limitations: The disease prevalence was 35.6% (High-Grade CaP) and 58.9% (Any CaP). The area under the receiver operating characteristic curve was 0.783 (High-Grade CaP) and 0.770 (Any CaP). IsoPSA outperformed total PSA and % free PSA on area under the receiver operating characteristic curve, specificity, positive and negative predictive value at similar sensitivity. Using selected IsoPSA Index cutoffs, an estimated 46% (High-Grade CaP) and 42% (Any CaP) of biopsies could be avoided in low-risk patients. IsoPSA displayed statistically informative likelihood ratio-based predictive characteristics. IsoPSA maintained accuracy in clinically relevant subgroups. Conclusions: IsoPSA diagnostic performance and predictive value is validated for High-Grade CaP and Any CaP in men age ≥ 50 with total PSA ≥ 4 ng/ml undergoing diagnostic biopsy. IsoPSA outperforms total and % free PSA in discriminating the risk of prostate cancer on biopsy. Patient summary: IsoPSA has the potential to reduce unnecessary biopsies and improve the risk-benefit ratio for CaP early detection.
MeSH term(s)	Biopsy ; Humans ; Male ; Neoplasm Grading ; Prospective Studies ; Prostate ; Prostate-Specific Antigen ; Prostatic Neoplasms ; ROC Curve
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2022.06.002
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Zs.A 4817: Show issues

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Book ; Online: Neuropsychological and psychological testing during COVID-19 ; (502892020-001)

Pliskin, Neil H. / Puente, Antonio E. / Morgan, Jennifer M. / Gillaspy, Stephen R.

PsycEXTRA Dataset

2020

Keywords	covid19
Publisher	American Psychological Association (APA)
Publishing country	us
Document type	Book ; Online
DOI	10.1037/e502892020-001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pain Influences Neuropsychological Performance Following Electrical Injury: A Cross-Sectional Study.

Dorociak, Katherine E / Soble, Jason R / Rupert, Patricia A / Fink, Joseph W / Lee, Raphael C / Anitescu, Magdalena / Weiss, David / Cooke, Gerald / Resch, Zachary J / Pliskin, Neil H

Journal of the International Neuropsychological Society : JINS

2022 Volume 29, Issue 1, Page(s) 35–45

Abstract: Objective: Electrical injury (EI) is a significant, multifaceted trauma often with multi-domain cognitive sequelae, even when the expected current path does not pass through the brain. Chronic pain (CP) research suggests pain may affect cognition ... ...

Abstract	Objective: Electrical injury (EI) is a significant, multifaceted trauma often with multi-domain cognitive sequelae, even when the expected current path does not pass through the brain. Chronic pain (CP) research suggests pain may affect cognition directly and indirectly by influencing emotional distress which then impacts cognitive functioning. As chronic pain may be critical to understanding EI-related cognitive difficulties, the aims of the current study were: examine the direct and indirect effects of pain on cognition following EI and compare the relationship between pain and cognition in EI and CP populations. Method: This cross-sectional study used data from a clinical sample of 50 patients with EI (84.0% male; Results: Higher pain levels were associated with poorer attention/processing speed and executive functioning performance among patients with EI. Depression was significantly correlated with pain and mediated the relationship between pain and attention/processing speed in patients with EI. When comparing the patients with EI and CP, the relationship between pain and cognition was similar for both clinical groups. Conclusions: Findings indicate that pain impacts mood and cognition in patients with EI, and the influence of pain and its effect on cognition should be considered in the assessment and treatment of patients who have experienced an electrical injury.
MeSH term(s)	Humans ; Male ; Adult ; Female ; Cross-Sectional Studies ; Chronic Pain ; Electric Injuries/psychology ; Cognition ; Executive Function ; Neuropsychological Tests
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1230632-0
ISSN	1469-7661 ; 1355-6177
ISSN (online)	1469-7661
ISSN	1355-6177
DOI	10.1017/S1355617721001478
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Zs.A 4440: Show issues

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Article ; Online: Social Determinants of Health: Associations Between Dichotomous Versus Dimensional Scores, Neuropsychological Test Performance, and Psychiatric Symptoms.

Shields, Allison N / Chang, Fini / DeBoer, Adam B / Ka Yin Tse, Phoebe / Wisinger, Amanda M / Basurto, Karen S / Bing-Canar, Hanaan / Khan, Humza / Lapitan-Moore, Franchezka / Stocks, Jane K / Pliskin, Neil H / Song, Woojin / Soble, Jason R / Resch, Zachary J

Assessment

2023 Volume 31, Issue 2, Page(s) 263–276

Abstract: This study examined the utility of dichotomous versus dimensional scores across two measures of social determinants of health (SDOH) regarding their associations with cognitive performance and psychiatric symptoms in a mixed clinical sample of 215 adults ...

Abstract	This study examined the utility of dichotomous versus dimensional scores across two measures of social determinants of health (SDOH) regarding their associations with cognitive performance and psychiatric symptoms in a mixed clinical sample of 215 adults referred for neuropsychological evaluation (
MeSH term(s)	Adult ; Humans ; Male ; Female ; Social Determinants of Health ; Neuropsychological Tests ; Research Design
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1362144-0
ISSN	1552-3489 ; 1073-1911
ISSN (online)	1552-3489
ISSN	1073-1911
DOI	10.1177/10731911231157629
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Article ; Online: Cognitive Performance and Psychiatric Self-Reports Across Adult Cognitive Disengagement Syndrome and ADHD Diagnostic Groups.

Cerny, Brian M / Reynolds, Tristan P / Chang, Fini / Scimeca, Lauren M / Phillips, Matthew S / Ogram Buckley, Caitlin M / Leib, Sophie I / Resch, Zachary J / Pliskin, Neil H / Soble, Jason R

Journal of attention disorders

2022 Volume 27, Issue 3, Page(s) 258–269

Abstract: Objective: Cognitive disengagement syndrome (CDS) is characterized by inattention, under-arousal, and fatigue and frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD). Although CDS is associated with cognitive complaints, its ... ...

Abstract	Objective: Cognitive disengagement syndrome (CDS) is characterized by inattention, under-arousal, and fatigue and frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD). Although CDS is associated with cognitive complaints, its association with objective cognitive performance is less well understood. Method: This study investigated neuropsychological correlates of CDS symptoms among 169 adults ( Results: There were no differences in cognitive performance, significant differences in self-reported psychiatric symptoms (greater CDS symptomatology, impulsivity among the high CDS groups; greater inattention among the positive ADHD/high CDS groups; greater hyperactivity among the positive ADHD groups), significant intercorrelations within cognitive and self-report measures, nonsignificant correlations between cognitive measures and self-report measures. Conclusion: Findings support prior work demonstrating weak to null associations between ADHD and CDS symptoms and cognitive performance among adults.
MeSH term(s)	Humans ; Adult ; Self Report ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Neuropsychological Tests ; Cognition ; Impulsive Behavior
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547221136216
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Zs.A 5196: Show issues

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Article ; Online: The impact of visual memory impairment on Victoria Symptom Validity Test performance: A known-groups analysis.

Stocks, Jane K / Shields, Allison N / DeBoer, Adam B / Cerny, Brian M / Ogram Buckley, Caitlin M / Ovsiew, Gabriel P / Jennette, Kyle J / Resch, Zachary J / Basurto, Karen S / Song, Woojin / Pliskin, Neil H / Soble, Jason R

Applied neuropsychology. Adult

2022 , Page(s) 1–10

Abstract: Objective: We assessed the effect of visual learning and recall impairment on Victoria Symptom Validity Test (VSVT) accuracy and response latency for Easy, Difficult, and Total Items.: Method: A sample of 163 adult patients administered the VSVT and ... ...

Abstract	Objective: We assessed the effect of visual learning and recall impairment on Victoria Symptom Validity Test (VSVT) accuracy and response latency for Easy, Difficult, and Total Items. Method: A sample of 163 adult patients administered the VSVT and Brief Visuospatial Memory Test-Revised were classified as valid (114/163) or invalid (49/163) groups via independent criterion performance validity tests (PVTs). Classification accuracies for all VSVT indices were examined for the overall sample, and separately for subgroups based on visual memory functioning. Results: In the overall sample, all indices produced acceptable classification accuracy (areas under the curve [AUCs] ≥ 0.79). When stratified by visual learning/recall impairment, accuracy indices yielded acceptable classification for both the unimpaired (AUCs ≥0.79) and impaired subsamples (AUCs ≥0.75). Latency indices had acceptable classification accuracy for the unimpaired subsample (AUCs ≥0.74), but accuracy and sensitivity dropped for the impaired sample (AUCs ≥0.67). Conclusions: VSVT accuracy and response latency yielded acceptable classification accuracies in the overall sample, and this effect was maintained in those with and without visual learning/recall impairment for the accuracy indices. Findings indicate that the VSVT is a psychometrically robust PVT with largely invariant cut-scores, even in the presence of bona fide visual learning/recall impairment.
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2021.2021911
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Article: Fiberoptics: the next level up in teleradiology.

Pliskin, M

Telemedicine today

2000 Volume 8, Issue 2, Page(s) 30, 36

MeSH term(s)	Fiber Optic Technology/standards ; Fiber Optic Technology/trends ; Humans ; Pennsylvania ; Sensitivity and Specificity ; Teleradiology/instrumentation
Language	English
Publishing date	2000-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2020939-3
ISSN	1078-0351
ISSN	1078-0351
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