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Article ; Online: Dietary fructose intake in obese children and adolescents: relation to procollagen type III N-terminal peptide (P3NP) and non-alcoholic fatty liver disease.

Hamza, Rasha Tarif / Ahmed, Alaa Youssef / Rezk, Doaa Gamal / Hamed, Amira Ibrahim

Journal of pediatric endocrinology & metabolism : JPEM

2016 Volume 29, Issue 12, Page(s) 1345–1352

Abstract: ... Procollagen type III N-terminal peptide (P3NP) is a marker for steatohepatitis. Thus, we aimed to assess ...

Abstract	Background: Excessive use of fructose has been incriminated as a risk factor for hepatic steatosis. Procollagen type III N-terminal peptide (P3NP) is a marker for steatohepatitis. Thus, we aimed to assess fructose intake in obese children and its relation to nonalcoholic fatty liver disease (NAFLD) and P3NP. Methods: Fifty-five obese children were compared to 30 controls. All were subjected to dietary fructose and anthropometric assessment, fasting blood sugar (FBS), fasting insulin (FI) and homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, uric acid, alanine aminotransferase (ALT), P3NP and abdominal ultrasound. Results: Patients had higher fructose intake which was associated with increased NAFLD grade. There was an increase in P3NP with increased NAFLD grade. P3NP correlated positively with fructose intake (processed sources and total) and caloric intake. Conclusions: High fructose intake is associated with NAFLD and P3NP may serve as a marker of NAFLD in obese children with a proposed cutoff value of 8.5 ng/mL.
MeSH term(s)	Adolescent ; Anthropometry ; Biomarkers/blood ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Diet/adverse effects ; Energy Intake ; Female ; Fructose/administration & dosage ; Fructose/adverse effects ; Humans ; Insulin Resistance ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/etiology ; Obesity/complications ; Peptide Fragments/blood ; Procollagen/blood ; Prognosis ; Risk Factors ; Sweetening Agents/administration & dosage ; Sweetening Agents/adverse effects
Chemical Substances	Biomarkers ; Peptide Fragments ; Procollagen ; Sweetening Agents ; procollagen Type III-N-terminal peptide ; Fructose (30237-26-4)
Language	English
Publishing date	2016-12-01
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2016-0015
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Article ; Online: Associated Water Dynamics Might Be a Key Factor Affecting Protein Stability in the Crowded Milieu.

Das, Nilimesh / Tarif, Ejaj / Dutta, Abhijit / Sen, Pratik

The journal of physical chemistry. B

2023 Volume 127, Issue 14, Page(s) 3151–3163

Abstract: Over the past 20 years, the most studied and debated aspect of macromolecular crowding is how it affects protein stability. Traditionally, it is explained by a delicate balance between the stabilizing entropic effect and the stabilizing or destabilizing ... ...

Abstract	Over the past 20 years, the most studied and debated aspect of macromolecular crowding is how it affects protein stability. Traditionally, it is explained by a delicate balance between the stabilizing entropic effect and the stabilizing or destabilizing enthalpic effect. However, this traditional crowding theory cannot explain experimental observations like (i) negative entropic effect and (ii) entropy-enthalpy compensation. Herein, we provide experimental evidence that associated water dynamics plays a crucial role in controlling protein stability in the crowded milieu for the first time. We have correlated the modulation of associated water dynamics with the overall stability and its individual components. We showed that rigid associated water would stabilize the protein through entropy but destabilize it through enthalpy. In contrast, flexible associated water destabilizes the protein through entropy but stabilizes through enthalpy. Consideration of entropic and enthalpic modulation through crowder-induced distortion of associated water successfully explains the negative entropic part and entropy-enthalpy compensation. Furthermore, we argued that the relationship between the associated water structure and protein stability should be better understood by individual entropic and enthalpic components instead of the overall stability. Although a huge effort is necessary to generalize the mechanism, this report provides a unique way of understanding the relationship between protein stability and associated water dynamics, which might be a generic phenomenon and should trigger much research in this area.
MeSH term(s)	Water/chemistry ; Thermodynamics ; Entropy ; Proteins/chemistry ; Protein Stability
Chemical Substances	Water (059QF0KO0R) ; Proteins
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.2c09043
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does Viscosity Decoupling Guarantee Dynamic Heterogeneity? A Clue through an Excitation and Emission Wavelength-Dependent Time-Resolved Fluorescence Anisotropy Study.

Tarif, Ejaj / Das, Nilimesh / Sen, Pratik

The journal of physical chemistry. B

2023 Volume 127, Issue 32, Page(s) 7162–7173

Abstract: Traditionally, deviation from Stokes-Einstein-Debye (SED) relation in terms of viscosity dependence of medium dynamics, i.e., ...

Abstract	Traditionally, deviation from Stokes-Einstein-Debye (SED) relation in terms of viscosity dependence of medium dynamics, i.e.,
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c00334
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Article ; Online: Subpicosecond Solvation Response and Partial Viscosity Decoupling of Solute Diffusion in Ionic Acetamide Deep Eutectic Solvents: Fluorescence Up-Conversion and Fluorescence Correlation Spectroscopic Measurements.

Subba, Navin / Tarif, Ejaj / Sen, Pratik / Biswas, Ranjit

The journal of physical chemistry. B

2020 Volume 124, Issue 10, Page(s) 1995–2005

Abstract: Fluorescence up-conversion (∼250 fs instrumental response) coupled with time correlated single photon counting measurements was performed to explore the complete Stokes shift dynamics of a dipolar solute probe, coumarin 153 (C153), in several ionic ... ...

Abstract	Fluorescence up-conversion (∼250 fs instrumental response) coupled with time correlated single photon counting measurements was performed to explore the complete Stokes shift dynamics of a dipolar solute probe, coumarin 153 (C153), in several ionic acetamide deep eutectic solvents (DESs) that contained lithium nitrate/bromide/perchlorate as electrolyte. Combined measurements near room temperature reflected a total dynamic Stokes shift of approximately 800-1100 cm
Language	English
Publishing date	2020-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.0c00061
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Article ; Online: Assessment of health-care workers' attitudes, knowledge, and skills in the care of critically ill Muslim children in New York.

Ijaz, Nadir / Hassan, Amir / Ghannoum, Sarah / Choudhury, Tarif / Piracha, Natasha

Palliative & supportive care

2023 , Page(s) 1–6

Abstract: Objectives: Pediatric health-care workers often care for families of minority religious backgrounds, but little is known about their perspective in providing culturally and spiritually appropriate care for Muslim patients. We aimed to (1) characterize ... ...

Abstract	Objectives: Pediatric health-care workers often care for families of minority religious backgrounds, but little is known about their perspective in providing culturally and spiritually appropriate care for Muslim patients. We aimed to (1) characterize the attitudes, knowledge, and skills of health-care workers in the care of critically ill Muslim children and (2) evaluate preferences for different educational interventions to improve care of critically ill Muslim children. Methods: We administered a single-center, cross-sectional, 33-question, electronic survey of interdisciplinary health-care workers in a large pediatric intensive care unit in New York City to characterize their attitudes, knowledge, and skills in caring for critically ill Muslim children. Results: Of 413 health-care workers surveyed, there were 109 (26%) respondents. Participants responded correctly to 51.7 ± 22.2% (mean ± SD) and 69.2 ± 20.6% of background knowledge and clinical skills questions, respectively. Only 29.8% of participants perceived adequate institutional resources to provide culturally competent care to Muslim patients and their families. Participants identified end-of-life care (47.5%) and bioethical concerns (45%) as needed areas for additional institutional resources. When asked about support to aid in caring for Muslim patients, 43.4% of participants requested a team of Muslim health-care workers to provide guidance. Participants most often requested video-based training modules (32.5%) and written materials (30%) as potential educational interventions. Significance of results: We identify gaps in health-care worker knowledge and skills in the care of the critically ill Muslim child. We also describe possible areas for intervention to facilitate culturally and spiritually appropriate care delivery to Muslim children and families.
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2454009-2
ISSN	1478-9523 ; 1478-9515
ISSN (online)	1478-9523
ISSN	1478-9515
DOI	10.1017/S1478951523001049
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Zs.A 6697: Show issues

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Article ; Online: Does Microsecond Active-Site Dynamics Primarily control Proteolytic Activity of Bromelain? Clues from Single Molecular Level Study with a Denaturant, a Stabilizer and a Macromolecular Crowder

Das, Nilimesh / Yadav, Sandeep / Negi, Kuldeep Singh / Tarif, Ejaj / Sen, Pratik

BBA advances

2022 Volume 2, Page(s) 100041

Abstract: Proteins are dynamic entity with various molecular motions at different timescale and length scale. Molecular motions are crucial for the optimal function of an enzyme. It seems intuitive that these motions are crucial for optimal enzyme activity. ... ...

Abstract	Proteins are dynamic entity with various molecular motions at different timescale and length scale. Molecular motions are crucial for the optimal function of an enzyme. It seems intuitive that these motions are crucial for optimal enzyme activity. However, it is not easy to directly correlate an enzyme's dynamics and activity due to biosystems' enormous complexity. amongst many factors, structure and dynamics are two prime aspects that combinedly control the activity. Therefore, having a direct correlation between protein dynamics and activity is not straightforward. Herein, we observed and correlated the structural, functional, and dynamical responses of an industrially crucial proteolytic enzyme, bromelain with three versatile classes of chemicals: GnHCl (protein denaturant), sucrose (protein stabilizer), and Ficoll-70 (macromolecular crowder). The only free cysteine (Cys-25 at the active-site) of bromelain has been tagged with a cysteine-specific dye to unveil the structural and dynamical changes through various spectroscopic studies both at bulk and at the single molecular level. Proteolytic activity is carried out using casein as the substrate. GnHCl and sucrose shows remarkable structure-dynamics-activity relationships. Interestingly, with Ficoll-70, structure and activity are not correlated. However, microsecond dynamics and activity are beautifully correlated in this case also. Overall, our result demonstrates that bromelain dynamics in the microsecond timescale around the active-site is probably a key factor in controlling its proteolytic activity.
Language	English
Publishing date	2022-01-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	2667-1603
ISSN (online)	2667-1603
DOI	10.1016/j.bbadva.2022.100041
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Article: Simulation as an Educational Tool in the Pediatric Cardiac Intensive Care Unit.

Choudhury, Tarif A / Flyer, Jonathan N / McBride, Mary E

Current pediatrics reports

2021 Volume 9, Issue 3, Page(s) 52–59

Abstract: Purpose of review: This review highlights the use of simulation as an educational tool in the highly specialized pediatric cardiac intensive care unit (PCICU).: Recent findings: Healthcare simulation is used in high acuity medical environments to ... ...

Abstract	Purpose of review: This review highlights the use of simulation as an educational tool in the highly specialized pediatric cardiac intensive care unit (PCICU). Recent findings: Healthcare simulation is used in high acuity medical environments to test healthcare systems. Healthcare simulation can improve team training, patient safety, and improve medical decision-making. Complex physiologies in the PCICU demand effective teamwork to consistently deliver high-quality patient care. Simulation-based PCICU learning objectives depend on a structured cognitive load framework to account for individual learner abilities, team constructs, and healthcare resources. Summary: PCICU simulation programs are strengthened by utilizing traditional education theory, with careful consideration of complex physiologies, interprofessional personnel, and center-specific resources. Virtual platforms should continue to evolve to provide additional, more convenient venues for individual learners and teams. Healthcare systems should frequently intersect with simulation educators to create relevant learning objectives that will contribute to patient safety, improve team performance, and patient outcomes.
Language	English
Publishing date	2021-05-25
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2167-4841
ISSN	2167-4841
DOI	10.1007/s40124-021-00241-0
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Article: Determinants of Open Defecation Among Rural Women in Ghana: Analysis of Demographic and Health Surveys.

Appiah-Effah, Eugene / Boakye, Kingsley / Salihu, Tarif / Duku, Godwin Armstrong / Fenteng, Justice Ofosu-Darko / Boateng, George / Appiah, Francis / Nyarko, Kwabena Biritwum

Environmental health insights

2024 Volume 18, Page(s) 11786302241226774

Abstract: ... in odds ratio. Descriptively, 42 in every 100 women aged 15 to 49 practiced open defecation (n = 1811, 95% CI ...

Abstract	Open defecation continuously remains a major global sanitation challenge, contributing to an estimated 1.6 million deaths per year. Ghana ranks second in Africa for open defecation and had the fourth-lowest sanitation coverage in 2010. Evidence indicates that about 32% of the rural Ghanaian population still practice open defecation due to lack of access to basic sanitation facilities, drifting the country from achieving universal access to sanitation by 2030. Women, particularly those in rural areas, are disproportionately affected by open defecation, facing heightened health risks, harassment, and a loss of dignity. Even though previous studies on open defecation in Ghana exist, they lack national representation and neglect women in rural residents who are disproportionally affected by the repercussions of open defecation. Examining that rural women will contribute to heightening their own vulnerability to health risks by practising open defecation is essential to bridging the literature gap on open defecation practices among rural women. The study investigated determinants of open defecation among rural women in Ghana using data from the female files of the 2003, 2008 and 2014 Demographic and Health Surveys (DHS). A total of 4,284 rural women with complete information on variables of interest were included in the study. The outcome variable was 'open defecation', whilst 14 key explanatory variables (e.g., age, education, wealth status, among others) were used. Two logistic regression models were built, and the outputs were reported in odds ratio. Descriptively, 42 in every 100 women aged 15 to 49 practiced open defecation (n = 1811, 95% CI = 49-52). Open defecation (OD) significantly correlated with educational attainment, wealth status, religion, access to mass media, partner's education, and zone of residence. The likelihood of practicing open defecation reduced among those with formal education [aOR = 0.69, CI = 0.56-0.85], those whose partners had formal education [aOR = 0.64, CI = 0.52-0.80], women in the rich wealth quintile [aOR = 0.12, CI = 0.07-0.20], the traditionalist [aOR = 0.33, CI = 0.19-0.57], and those who had access to mass media [aOR = 0.70, CI = 0.57-0.85]. Residents in the Savannah zone had higher odds of openly defecating [aOR = 21.06, CI = 15.97-27.77]. The prevalence of open defecation is disproportionately pro-poor, which indicates that impoverished rural women are more likely to perform it. Public health initiatives should aim to close the rich-poor divide in OD practice among rural women.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452946-1
ISSN	1178-6302
ISSN	1178-6302
DOI	10.1177/11786302241226774
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Article ; Online: Dynamics at the non-ionic micelle/water interface: Impact of linkage substitution.

Tarif, Ejaj / Mukherjee, Kallol / Kumbhakar, Kajal / Barman, Anjan / Biswas, Ranjit

The Journal of chemical physics

2019 Volume 151, Issue 15, Page(s) 154902

Abstract: ... resolved fluorescence and dielectric relaxation (DR) measurements. We have utilized n-octyl-β-D ... glucopyranoside (OG) and n-octyl-β-D-thioglucopyranoside (OTG) as nonionic surfactants where the oxygen atom ...

Abstract	The impact of atom substitution on the glycoside linkage bridging the head and the tail parts in a nonionic surfactant molecule on aqueous dynamics of the resultant micellar solutions has been explored, employing time-resolved fluorescence and dielectric relaxation (DR) measurements. We have utilized n-octyl-β-D-glucopyranoside (OG) and n-octyl-β-D-thioglucopyranoside (OTG) as nonionic surfactants where the oxygen atom in the glucopyranoside unit is substituted by a sulfur atom. The substitution impact is immediately reflected in the dynamic light scattering measurements of aqueous solutions where the estimated size of the OTG micelles is found to be approximately four times larger than the OG micelles. Steady state spectral features obtained by using a fluorescent probe solute, coumarin 153 (C153), in these micellar solutions are quite similar and indicate locations of the solute at the micelle/water interface for both the surfactants. Interestingly, significant differences in the rotational and solvation dynamics of C153 in these two micellar solutions have been registered. The corresponding DR measurements do not indicate any signature of relaxation typical of bound water. The absence of bound water is further supported by the differential scanning calorimetric measurements. However, the typical slow solvation time scale for aqueous micellar solutions has been observed for these surfactants. Fluctuations in the solute-interface interaction energy due to the solute motion has been argued to be the origin for this slow solvation component as DR measurements do not indicate the presence of qualitatively similar relaxation time scale in the medium.
Language	English
Publishing date	2019-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5121334
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Article: Does Microsecond Active-Site Dynamics Primarily control Proteolytic Activity of Bromelain? Clues from Single Molecular Level Study with a Denaturant, a Stabilizer and a Macromolecular Crowder

Das, Nilimesh / Yadav, Sandeep / Negi, Kuldeep Singh / Tarif, Ejaj / Sen, Pratik

BBA advances. 2022, v. 2

2022

Abstract	Proteins are dynamic entity with various molecular motions at different timescale and length scale. Molecular motions are crucial for the optimal function of an enzyme. It seems intuitive that these motions are crucial for optimal enzyme activity. However, it is not easy to directly correlate an enzyme's dynamics and activity due to biosystems' enormous complexity. amongst many factors, structure and dynamics are two prime aspects that combinedly control the activity. Therefore, having a direct correlation between protein dynamics and activity is not straightforward. Herein, we observed and correlated the structural, functional, and dynamical responses of an industrially crucial proteolytic enzyme, bromelain with three versatile classes of chemicals: GnHCl (protein denaturant), sucrose (protein stabilizer), and Ficoll-70 (macromolecular crowder). The only free cysteine (Cys-25 at the active-site) of bromelain has been tagged with a cysteine-specific dye to unveil the structural and dynamical changes through various spectroscopic studies both at bulk and at the single molecular level. Proteolytic activity is carried out using casein as the substrate. GnHCl and sucrose shows remarkable structure-dynamics-activity relationships. Interestingly, with Ficoll-70, structure and activity are not correlated. However, microsecond dynamics and activity are beautifully correlated in this case also. Overall, our result demonstrates that bromelain dynamics in the microsecond timescale around the active-site is probably a key factor in controlling its proteolytic activity.
Keywords	active sites ; bromelains ; casein ; cysteine ; dyes ; enzyme activity ; proteolysis ; spectroscopy ; stabilizers ; sucrose
Language	English
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2667-1603
DOI	10.1016/j.bbadva.2022.100041
Database	NAL-Catalogue (AGRICOLA)

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