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  1. Article ; Online: Antibiotic Resistance, Susceptibility Testing and Stewardship in

    Ng, Ho-Yu / Leung, Wai K / Cheung, Ka-Shing

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Despite the declining trend ... ...

    Abstract Despite the declining trend of
    MeSH term(s) Humans ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Clarithromycin/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antibiotics Associated with Lower Survival in Hepatocellular Cancer Patients Receiving Immune Checkpoint Inhibitors Independent of Tumor Status.

    Cheung, Ka Shing / Ka, Lam Lok / Leung, Wai K

    Liver cancer

    2022  Volume 12, Issue 1, Page(s) 91–92

    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2666925-0
    ISSN 1664-5553 ; 2235-1795
    ISSN (online) 1664-5553
    ISSN 2235-1795
    DOI 10.1159/000528824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply.

    Cheung, Ka Shing / Leung, Wai K

    Gastroenterology

    2020  Volume 160, Issue 3, Page(s) 973–974

    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.09.019
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Association between Gut Microbiota and SARS-CoV-2 Infection and Vaccine Immunogenicity.

    Ng, Ho Yu / Leung, Wai K / Cheung, Ka Shing

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Gut microbiota is increasingly recognized to play a pivotal role in various human physiological functions and diseases. Amidst the COVID-19 pandemic, research has suggested that dysbiosis of the gut microbiota is also involved in the development and ... ...

    Abstract Gut microbiota is increasingly recognized to play a pivotal role in various human physiological functions and diseases. Amidst the COVID-19 pandemic, research has suggested that dysbiosis of the gut microbiota is also involved in the development and severity of COVID-19 symptoms by regulating SARS-CoV-2 entry and modulating inflammation. Previous studies have also suggested that gut microbiota and their metabolites could have immunomodulatory effects on vaccine immunogenicity, including influenza vaccines and oral rotavirus vaccines. In light of these observations, it is possible that gut microbiota plays a role in influencing the immune responses to COVID-19 vaccinations via similar mechanisms including effects of lipopolysaccharides, flagellin, peptidoglycan, and short-chain fatty acids. In this review, we give an overview of the current understanding on the role of the gut microbiota in COVID-19 manifestations and vaccine immunogenicity. We then discuss the limitations of currently published studies on the associations between gut microbiota and COVID-19 vaccine outcomes. Future research directions shall be focused on the development of microbiota-based interventions on improving immune response to SARS-CoV-2 infection and vaccinations.
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020452
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  5. Article ; Online: THRB

    Cheng, Jenny Yeuk Ki / Subramaniam, Shreenidhi Ranganatha / Leung, Hoi Shan / Wong, Sammy Wai Chun / Kwok, Jeffrey Sung Shing / Lam, Wai Kei Jacky

    JCEM case reports

    2024  Volume 2, Issue 5, Page(s) luae075

    Abstract: A 4-day-old infant was admitted for neonatal jaundice. He had persistent tachycardia and tachypnea. Initial workup showed a serum free T4 of 75.6 pmol/L (5.87 ng/dL) (reference range: 11.5-28.3 pmol/L; 0.89-2.20 ng/dL) and a nonsuppressed TSH 3.76 mIU/L ( ...

    Abstract A 4-day-old infant was admitted for neonatal jaundice. He had persistent tachycardia and tachypnea. Initial workup showed a serum free T4 of 75.6 pmol/L (5.87 ng/dL) (reference range: 11.5-28.3 pmol/L; 0.89-2.20 ng/dL) and a nonsuppressed TSH 3.76 mIU/L (reference range: 0.72-11.0 mIU/L). A TRH stimulation test showed an exaggerated TSH response with a peak of 92.1 mIU/L at 30 minutes after TRH injection, which suggested the diagnosis of resistance to thyroid hormone β syndrome. Sanger sequencing showed a questionable pathogenic variant in the
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luae075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Letter: non-steroidal anti-inflammatory drugs reduce the risk of post-colonoscopy colorectal cancer-authors' reply.

    Cheung, Ka Shing / Leung, Wai K

    Alimentary pharmacology & therapeutics

    2020  Volume 53, Issue 2, Page(s) 355–356

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Aspirin ; Colonoscopy ; Colorectal Neoplasms ; Humans ; Pharmaceutical Preparations
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Pharmaceutical Preparations ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-12-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac.

    Ng, Ho-Yu / Liao, Yunshi / Zhang, Ruiqi / Chan, Kwok-Hung / To, Wai-Pan / Hui, Chun-Him / Seto, Wai-Kay / Leung, Wai K / Hung, Ivan F N / Lam, Tommy T Y / Cheung, Ka-Shing

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: CoronaVac immunogenicity decreases with time, and we aimed to investigate whether gut microbiota associate with longer-term immunogenicity of CoronaVac. This was a prospective cohort study recruiting two-dose CoronaVac recipients from three centres in ... ...

    Abstract CoronaVac immunogenicity decreases with time, and we aimed to investigate whether gut microbiota associate with longer-term immunogenicity of CoronaVac. This was a prospective cohort study recruiting two-dose CoronaVac recipients from three centres in Hong Kong. We collected blood samples at baseline and day 180 after the first dose and used chemiluminescence immunoassay to test for neutralizing antibodies (NAbs) against the receptor-binding domain (RBD) of wild-type SARS-CoV-2 virus. We performed shotgun metagenomic sequencing performed on baseline stool samples. The primary outcome was the NAb seroconversion rate (seropositivity defined as NAb ≥ 15AU/mL) at day 180. Linear discriminant analysis [LDA] effect size analysis was used to identify putative bacterial species and metabolic pathways. A univariate logistic regression model was used to derive the odds ratio (OR) of seropositivity with bacterial species. Of 119 CoronaVac recipients (median age: 53.4 years [IQR: 47.8-61.3]; male: 39 [32.8%]), only 8 (6.7%) remained seropositive at 6 months after vaccination.
    MeSH term(s) Humans ; Male ; Middle Aged ; Gastrointestinal Microbiome ; Prospective Studies ; Adenosine ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Inactivated
    Chemical Substances sinovac COVID-19 vaccine ; Adenosine (K72T3FS567) ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052583
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  8. Article ; Online: Machine learning models in the prediction of 1-year mortality in patients with advanced hepatocellular cancer on immunotherapy: a proof-of-concept study.

    Lui, Thomas Ka Luen / Cheung, Ka Shing / Leung, Wai Keung

    Hepatology international

    2022  Volume 16, Issue 4, Page(s) 879–891

    Abstract: Introduction: Immunotherapy is a new promising treatment for patients with advanced hepatocellular carcinoma (HCC), but is costly and potentially associated with considerable side effects. This study aimed to evaluate the role of machine learning (ML) ... ...

    Abstract Introduction: Immunotherapy is a new promising treatment for patients with advanced hepatocellular carcinoma (HCC), but is costly and potentially associated with considerable side effects. This study aimed to evaluate the role of machine learning (ML) models in predicting the 1-year cancer-related mortality in advanced HCC patients treated with immunotherapy.
    Method: 395 HCC patients who had received immunotherapy (including nivolumab, pembrolizumab or ipilimumab) between 2014 and 2019 in Hong Kong were included. The whole data sets were randomly divided into training (n = 316) and internal validation (n = 79) set. The data set, including 47 clinical variables, was used to construct six different ML models in predicting the risk of 1-year mortality. The performances of ML models were measured by the area under receiver operating characteristic curve (AUC) and their performances were compared with C-Reactive protein and Alpha Fetoprotein in ImmunoTherapY score (CRAFITY) and albumin-bilirubin (ALBI) score. The ML models were further validated with an external cohort between 2020 and 2021.
    Results: The 1-year cancer-related mortality was 51.1%. Of the six ML models, the random forest (RF) has the highest AUC of 0.92 (95% CI 0.87-0.98), which was better than logistic regression (0.82, p = 0.01) as well as the CRAFITY (0.68, p < 0.01) and ALBI score (0.84, p = 0.04). RF had the lowest false positive (2.0%) and false negative rate (5.2%), and performed better than CRAFITY score in the external validation cohort (0.91 vs 0.66, p < 0.01). High baseline AFP, bilirubin and alkaline phosphatase were three common risk factors identified by all ML models.
    Conclusion: ML models could predict 1-year cancer-related mortality in HCC patients treated with immunotherapy, which may help to select patients who would benefit from this treatment.
    MeSH term(s) Bilirubin ; Carcinoma, Hepatocellular/pathology ; Humans ; Immunotherapy ; Liver Neoplasms/pathology ; Machine Learning ; Retrospective Studies
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-022-10370-3
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  9. Article ; Online: Chemopreventive Effect of Metformin on Gastric Cancer Development.

    Cheung, Ka Shing / Chung, Kit Lam / Leung, Wai K

    Gut and liver

    2021  Volume 16, Issue 2, Page(s) 147–156

    Abstract: ... ...

    Abstract Although
    MeSH term(s) Anticarcinogenic Agents/therapeutic use ; Diabetes Mellitus ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Metformin/pharmacology ; Metformin/therapeutic use ; Prospective Studies ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/etiology ; Stomach Neoplasms/prevention & control ; Tumor Microenvironment
    Chemical Substances Anticarcinogenic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2021-06-22
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2399010-7
    ISSN 2005-1212 ; 1976-2283
    ISSN (online) 2005-1212
    ISSN 1976-2283
    DOI 10.5009/gnl210132
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6610: Show issues Location:
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  10. Article: Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence.

    Cheung, Ka Shing / Leung, Wai K

    Therapeutic advances in gastroenterology

    2019  Volume 12, Page(s) 1756284819834511

    Abstract: Gastric cancer remains one of the leading cancers in the world with a high mortality, particularly in East Asia. ...

    Abstract Gastric cancer remains one of the leading cancers in the world with a high mortality, particularly in East Asia.
    Language English
    Publishing date 2019-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/1756284819834511
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