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Article: Re: Whiplash and concussion: similar acute changes in middle-latency SEPs. Zumsteg D, Wennberg R, Gütling E, Hess K. Can J Neurol Sci. 2006;33:379-86.

Zumsteg, Dominik / Wennberg, Richard

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2007 Volume 34, Issue 4, Page(s) 496

MeSH term(s)	Brain Concussion/complications ; Brain Concussion/physiopathology ; Brain Injury, Chronic/etiology ; Brain Injury, Chronic/physiopathology ; Evoked Potentials, Somatosensory ; Humans ; Whiplash Injuries/complications ; Whiplash Injuries/physiopathology
Language	English
Publishing date	2007-11
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
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Article ; Online: Comparison of nocturnal and diurnal metabolomes of rose flowers and leaves.

Zumsteg, Julie / Bossard, Elodie / Gourguillon, Lorène / Villette, Claire / Heintz, Dimitri

Metabolomics : Official journal of the Metabolomic Society

2023 Volume 20, Issue 1, Page(s) 4

Abstract: Introduction: Roses are one of the most essential ornamental flowers and are commonly used in perfumery, cosmetics, and food. They are rich in bioactive compounds, which are of interest for therapeutic effects.: Objectives: The objective of this ... ...

Abstract	Introduction: Roses are one of the most essential ornamental flowers and are commonly used in perfumery, cosmetics, and food. They are rich in bioactive compounds, which are of interest for therapeutic effects. Objectives: The objective of this study was to understand the kinds of changes that occur between the nocturnal and diurnal metabolism of rose and to suggest hypotheses. Methods: Reversed-phase ultrahigh-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry or triple quadrupole mass spectrometry (TQ MS/MS) was used for nontargeted metabolomics and hormonal profiling respectively. For metabolite annotation, accurate mass spectra were compared with those in databases. Results: The hormonal profile of flowers showed an increase in jasmonate at night, while that of leaves indicated an increase in the salicylic acid pathway. Nontargeted analyses of the flower revealed a switch in the plant's defense mechanisms from glycosylated metabolites during the day to acid metabolites at night. In leaves, a significant decrease in flavonoids was observed at night in favor of acid metabolism to maintain a level of protection. Moreover, it might be possible to place back some of the annotated molecules on the shikimate pathway. Conclusion: The influence of day and night on the metabolome of rose flowers and leaves has been clearly demonstrated. The hormonal modulations occurring during the night and at day are consistent with the plant circadian cycle. A proposed management of the sesquiterpenoid and triterpenoid biosynthetic pathway may explain these changes in the flower. In leaves, the metabolic differences may reflect night-time regulation in favor of the salicylic acid pathway.
MeSH term(s)	Metabolomics/methods ; Rosa ; Tandem Mass Spectrometry ; Metabolome ; Flowers/metabolism ; Salicylic Acid/metabolism
Chemical Substances	Salicylic Acid (O414PZ4LPZ)
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2250617-2
ISSN	1573-3890 ; 1573-3882
ISSN (online)	1573-3890
ISSN	1573-3882
DOI	10.1007/s11306-023-02063-1
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Article ; Online: Mass spectrometry imaging for biosolids characterization to assess ecological or health risks before reuse.

Villette, Claire / Maurer, Loïc / Zumsteg, Julie / Mutterer, Jérôme / Wanko, Adrien / Heintz, Dimitri

Nature communications

2023 Volume 14, Issue 1, Page(s) 4244

Abstract: Biosolids are byproducts of wastewater treatment. With the increasing global population, the amounts of wastewater to be treated are expanding, along with the amounts of biosolids generated. The reuse of biosolids is now accepted for diversified ... ...

Abstract	Biosolids are byproducts of wastewater treatment. With the increasing global population, the amounts of wastewater to be treated are expanding, along with the amounts of biosolids generated. The reuse of biosolids is now accepted for diversified applications in fields such as agriculture, engineering, agro-forestry. However, biosolids are known to be potential carriers of compounds that can be toxic to living beings or alter the environment. Therefore, biosolid reuse is subject to regulations, mandatory analyses are performed on heavy metals, persistent organic pollutants or pathogens. Conventional methods for the analysis of heavy metals and persistent organic pollutants are demanding, lengthy, and sometimes unsafe. Here, we propose mass spectrometry imaging as a faster and safer method using small amounts of material to monitor heavy metals and persistent organic pollutants in different types of biosolids, allowing for ecological and health risk assessment before reuse. Our methodology can be extended to other soil-like matrices.
MeSH term(s)	Biosolids ; Persistent Organic Pollutants ; Metals, Heavy/toxicity ; Agriculture ; Soil/chemistry ; Soil Pollutants/analysis ; Sewage
Chemical Substances	Biosolids ; Persistent Organic Pollutants ; Metals, Heavy ; Soil ; Soil Pollutants ; Sewage
Language	English
Publishing date	2023-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40051-0
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Article ; Online: Response of Poplar and Associated Fungal Endophytic Communities to a PAH Contamination Gradient.

Gréau, Lilian / Blaudez, Damien / Heintz, Dimitri / Zumsteg, Julie / Billet, David / Cébron, Aurélie

International journal of molecular sciences

2022 Volume 23, Issue 11

Abstract: Microbial populations associated to poplar are well described in non-contaminated and metal-contaminated environments but more poorly in the context of polycyclic aromatic hydrocarbon (PAH) contamination. This study aimed to understand how a gradient of ... ...

Abstract	Microbial populations associated to poplar are well described in non-contaminated and metal-contaminated environments but more poorly in the context of polycyclic aromatic hydrocarbon (PAH) contamination. This study aimed to understand how a gradient of phenanthrene (PHE) contamination affects poplar growth and the fungal microbiome in both soil and plant endosphere (roots, stems and leaves). Plant growth and fitness parameters indicated that the growth of
MeSH term(s)	Biodegradation, Environmental ; Mycobiome ; Plant Roots/metabolism ; Polycyclic Aromatic Hydrocarbons/metabolism ; Polycyclic Aromatic Hydrocarbons/toxicity ; Populus/metabolism ; Soil ; Soil Microbiology ; Soil Pollutants/metabolism ; Soil Pollutants/toxicity
Chemical Substances	Polycyclic Aromatic Hydrocarbons ; Soil ; Soil Pollutants
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23115909
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Article ; Online: Engineering a tunable bicistronic TetR autoregulation expression system in Gluconobacter oxydans

Monica Bertucci / Ky Ariano / Meg Zumsteg / Paul Schweiger

PeerJ, Vol 10, p e

2022 Volume 13639

Abstract: Acetic acid bacteria are well-known for their ability to incompletely oxidize their carbon sources. Many of the products of these oxidations find industrial uses. Metabolic engineering of acetic acid bacteria would improve production efficiency and yield ...

Abstract	Acetic acid bacteria are well-known for their ability to incompletely oxidize their carbon sources. Many of the products of these oxidations find industrial uses. Metabolic engineering of acetic acid bacteria would improve production efficiency and yield by allowing controllable gene expression. However, the molecular tools necessary for regulating gene expression have only recently started being explored. To this end the ability of the activation-dependent Plux system and two constitutive repression Ptet systems were examined for their ability to modulate gene expression in Gluconobacter oxydans. The activation-dependent Plux system increased gene expression approximately 5-fold regardless of the strength of the constitutive promoter used to express the luxR transcriptional activator. The Ptet system was tunable and had a nearly 20-fold induction when the tetR gene was expressed from the strong constitutive promoters P0169 and P264, but only had a 4-fold induction when a weak constitutive promoter (P452) was used for tetR expression. However, the Ptet system was somewhat leaky when uninduced. To mitigate this background activity, a bicistronic TetR expression system was constructed. Based on molecular modeling, this system is predicted to have low background activity when not induced with anhydrotetracycline. The bicistronic system was inducible up to >3,000-fold and was highly tunable with almost no background expression when uninduced, making this bicistronic system potentially useful for engineering G. oxydans and possibly other acetic acid bacteria. These expression systems add to the newly growing repertoire of suitable regulatable promoter systems in acetic acid bacteria.
Keywords	Promoter ; Induction ; Expression ; Plasmid ; β-D-Glucuronidase UidA ; GFP ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article ; Online: The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts.

Scutenaire, Jérémy / Plassard, Damien / Matelot, Mélody / Villa, Tommaso / Zumsteg, Julie / Libri, Domenico / Séraphin, Bertrand

Nucleic acids research

2022 Volume 51, Issue 2, Page(s) 517–535

Abstract: N6-Methyladenosine (m6A), one of the most abundant internal modification of eukaryotic mRNAs, participates in the post-transcriptional control of gene expression through recruitment of specific m6A readers. In Saccharomyces cerevisiae, the m6A ... ...

Abstract	N6-Methyladenosine (m6A), one of the most abundant internal modification of eukaryotic mRNAs, participates in the post-transcriptional control of gene expression through recruitment of specific m6A readers. In Saccharomyces cerevisiae, the m6A methyltransferase Ime4 is expressed only during meiosis and its deletion impairs this process. To elucidate how m6A control gene expression, we investigated the function of the budding yeast m6A reader Pho92. We show that Pho92 is an early meiotic factor that promotes timely meiotic progression. High-throughput RNA sequencing and mapping of Pho92-binding sites following UV-crosslinking reveal that Pho92 is recruited to specific mRNAs in an m6A-dependent manner during the meiotic prophase, preceding their down-regulation. Strikingly, point mutations altering m6A sites in mRNAs targeted by Pho92 are sufficient to delay their down-regulation and, in one case, to slow down meiotic progression. Altogether, our results indicate that Pho92 facilitate the meiotic progression by accelerating the down-regulation of timely-regulated mRNAs during meiotic recombination.
MeSH term(s)	Homologous Recombination ; Meiosis ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; RNA-Binding Proteins/metabolism ; Methylation
Chemical Substances	Saccharomyces cerevisiae Proteins ; Pho92 protein, S cerevisiae ; RNA-Binding Proteins
Language	English
Publishing date	2022-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac640
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Zs.A 1067: Show issues

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Article: (D-(p-benzoylphenylalanine)13, tyrosine19)-melanin-concentrating hormone, a potent analogue for MCH receptor crosslinking.

Drozdz, R / Hintermann, E / Tanner, H / Zumsteg, U / Eberle, A N

Journal of peptide science : an official publication of the European Peptide Society

1999 Volume 5, Issue 5, Page(s) 234–242

Abstract: A photoreactive analogue of human melanin-concentrating hormone was designed, [D-Bpa13,Tyr19-MCH ... containing the D-enantiomer of photolabile p-benzoylphenylalanine (Bpa) in position 13 and tyrosine ... Radioiodination of [D-Bpa13,Tyr19]-MCH at its Tyr19 residue was carried out enzymatically using solid-phase bound ...

Abstract	A photoreactive analogue of human melanin-concentrating hormone was designed, [D-Bpa13,Tyr19-MCH, containing the D-enantiomer of photolabile p-benzoylphenylalanine (Bpa) in position 13 and tyrosine for radioiodination in position 19. The linear peptide was synthesized by the continuous-flow solid-phase methodology using Fmoc-strategy and PEG-PS resins, purified to homogeneity and cyclized by iodine oxidation. Radioiodination of [D-Bpa13,Tyr19]-MCH at its Tyr19 residue was carried out enzymatically using solid-phase bound glucose oxidase/lactoperoxidase, followed by purification on a reversed-phase mini-column and HPLC. Saturation binding analysis of [125I]-[D-Bpa13,Tyr19]-MCH with G4F-7 mouse melanoma cells gave a K(D) of 2.2+/-0.2 x 10(-10) mol/l and a B(max) of 1047+/-50 receptors/cell. Competition binding analysis showed that MCH and rANF(1-28) displace [125I]-[D-Bpa13,Tyr19]-MCH from the MCH binding sites on G4F-7 cells whereas alpha-MSH has no effect. Receptor crosslinking by UV-irradiation of G4F-7 cells in the presence of [125I]-[D-Bpa13,Tyr19]-MCH followed by SDS-polyacrylamide gel electrophoresis and autoradiography yielded a band of 45-50 kDa. Identical crosslinked bands were also detected in B16-F1 and G4F mouse melanoma cells, in RE and D10 human melanoma cells as well as in COS-7 cells. Weak staining was found in rat PC12 phaeochromocytoma and Chinese hamster ovary cells. No crosslinking was detected in human MP fibroblasts. These data demonstrate that [125I]-[D-Bpa13,Tyr19]-MCH is a versatile photocrosslinking analogue of MCH suitable to identify MCH receptors in different cells and tissues; the MCH receptor in these cells appears to have the size of a G protein-coupled receptor, most likely with a varying degree of glycosylation.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Line ; Humans ; Iodine Radioisotopes/chemistry ; Melanins/chemical synthesis ; Melanins/chemistry ; Molecular Sequence Data ; Photoaffinity Labels ; Radioligand Assay ; Receptors, Pituitary Hormone/chemistry ; Sequence Homology, Amino Acid ; Tumor Cells, Cultured
Chemical Substances	(4-benzoylphenylalanyl(13),tyrosyl(19))-melanin ; Iodine Radioisotopes ; Melanins ; Photoaffinity Labels ; Receptors, Pituitary Hormone ; melanin-concentrating hormone receptor
Language	English
Publishing date	1999-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/(SICI)1099-1387(199905)5:5<234::AID-PSC202>3.0.CO;2-J
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Zs.A 6200: Show issues

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Article ; Online: Electromagnetic evidence that benign epileptiform transients of sleep are traveling, rotating hippocampal spikes.

Wennberg, Richard / Tarazi, Apameh / Zumsteg, Dominik / Garcia Dominguez, Luis

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2020 Volume 131, Issue 12, Page(s) 2915–2925

Abstract: Objective: Benign epileptiform transients of sleep (BETS) have a unique voltage topography and a posteriorly propagating, inferiorly rotating diphasic EEG pattern. The source generators of BETS have not been definitively identified. We aimed to clarify ... ...

Abstract	Objective: Benign epileptiform transients of sleep (BETS) have a unique voltage topography and a posteriorly propagating, inferiorly rotating diphasic EEG pattern. The source generators of BETS have not been definitively identified. We aimed to clarify the cerebral localization of BETS using MEG and electromagnetic source imaging (EMSI). Methods: We analyzed BETS recorded with simultaneous MEG and EEG in four patients with epilepsy. Magnetic source imaging (MSI) and EMSI using equivalent current, single moving and rotating dipole inverse models was performed on averaged BETS potentials. MEG beamforming was performed in one case with abundant BETS. Results: MSI and EMSI revealed hippocampal dipole source maxima in all cases, with current flow direction rotating from inferomedial to superomedial or superolateral between the first and second BETS peaks. Moving dipole analyses revealed spatiotemporal propagation along the anterior-posterior hippocampal axis and concomitant electromagnetic field rotation. Beamformer source reconstruction revealed an identical hippocampal localization. Conclusions: Converging evidence from different electromagnetic inverse modeling methods indicates that BETS are traveling, rotating hippocampal spikes, whose diphasic waveform is due to back and forth propagation along the anterior-posterior axis of the hippocampus. Significance: The hippocampal localization and longitudinal, rotating propagation pattern of BETS raises the possibility of a sleep-related functional role for these hippocampal spikes.
MeSH term(s)	Action Potentials/physiology ; Adult ; Electroencephalography/methods ; Epilepsy/diagnostic imaging ; Epilepsy/physiopathology ; Female ; Hippocampus/diagnostic imaging ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Magnetoencephalography/methods ; Male ; Middle Aged ; Sleep/physiology
Language	English
Publishing date	2020-08-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2020.07.023
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Article ; Online: Large scale micropollutants and lipids screening in the sludge layers and the ecosystem of a vertical flow constructed wetland.

Maurer, Loïc / Villette, Claire / Zumsteg, Julie / Wanko, Adrien / Heintz, Dimitri

The Science of the total environment

2020 Volume 746, Page(s) 141196

Abstract: Wastewater is one of the major sources of micropollutant release into the environment. In order to reduce the impact of wastewater, wastewater treatment plants (WWTP) have been set up, in the instance of vertical flow constructed wetlands (VFCWs). ... ...

Abstract	Wastewater is one of the major sources of micropollutant release into the environment. In order to reduce the impact of wastewater, wastewater treatment plants (WWTP) have been set up, in the instance of vertical flow constructed wetlands (VFCWs). Besides, micropollutants could represent a vast diversity of compounds and compound's choice could bias studies focused on their fate. To overcome this bias, non-targeted screening approaches can be performed. Therefore, the diffusion of micropollutants from raw wastewater in the VFCW compartments (wastewater, plants and sludge) as well as their fate have been investigated using this non-target approach with liquid chromatography (LC) coupled to high resolution mass spectrometry (HRMS) and gas chromatography (GC) coupled to mass spectrometry. To help the operators in their sludge management, this study will be focused on the following question: Is there a specific distribution of micropollutants according to sludge layers? To eliminate the background contamination found both inside the CW and in the surrounding environment, a control coring was performed in bank. A specific distribution could be observed in the top (191 compounds) and bottom layers (38 compounds). However, a distribution over the whole depth for xenobiotics was observed. Micropollutants classes and the main microbial productivity were preferably found in the top layer. The micropollutants fate could however not be restricted to the sludge compartment. Therefore, the specific micropollutants distribution was analyzed in the outputs of the system in their interactions with wastewater (effluent, sludge, and reed rhizomes) to understand their fate. In our study, the results highlighted a consistent part of compounds found in at least two or three of these compartments, with a similar trend in each compartment. These results underline the interactions between the compartments and the global issues of micropollutants distribution as well as its wide spreading in the whole CW ecosystem.
Language	English
Publishing date	2020-07-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.141196
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Article ; Online: Outcomes with brachytherapy based dose escalation for gleason 8 versus 9-10 prostate cancer: An NCDB analysis.

David, John / Luu, Michael / Lu, Diana / Zumsteg, Zachary S / Sandler, Howard / Kamrava, Mitchell

Urologic oncology

2021 Volume 39, Issue 12, Page(s) 829.e19–829.e26

Abstract: Introduction: The addition of brachytherapy (BT) in high risk prostate cancer is supported by Level 1 evidence. Whether all high risk patients benefit from BT to the same extent is unknown. The National Cancer Database (NCDB) was used to investigate ... ...

Abstract	Introduction: The addition of brachytherapy (BT) in high risk prostate cancer is supported by Level 1 evidence. Whether all high risk patients benefit from BT to the same extent is unknown. The National Cancer Database (NCDB) was used to investigate overall survival (OS) differences between GS 8 and 9-10 treated with external beam radiation (EBRT) only or BT +/- EBRT. Materials and methods: We included localized prostate adenocarcinoma definitively treated with radiation between 2004-2014. Patients were stratified into various radiation treatment groups: EBRT 7560 - 8640 cGy, EBRT 5940 - 7540 cGy, and BT +/- EBRT. All EBRT only and BT +/- EBRT patients received ADT. A multivariable Cox proportional hazard model was used to assess OS. Propensity score matching was used to account for differences between groups. Median survival was determined based on Kaplan-Meier survival curves. Results: 30,698 patients were included. On multivariable analysis among GS 8 patients, BT was associated with improved OS compared to 7560 - 8640 cGy (HR-0.80 (95% CI 0.70-0.92, P = 0.002). In Gleason 9-10 BT did not result in improved OS compared to 7560 - 8640 cGy (HR- 0.91 (95% CI 0.79 - 1.05, P = 0.212). Results remained significant with propensity score matching and removing patients with medical comorbidities. Conclusion: BT was associated with improved OS when compared to 7560 - 8640 cGy in GS 8, but not in Gleason 9-10 disease. This hypothesis generating study suggests there may be variable benefit with BT in high risk prostate cancer patients on OS. Future prospective studies are needed to investigate whether the benefit of BT is similar across all high risk prostate cancer patients.
MeSH term(s)	Aged ; Brachytherapy/methods ; Humans ; Male ; Neoplasm Grading ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy ; Treatment Outcome
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2021.04.014
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