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  1. Article ; Online: A Route to Two-Dimensional Room-Temperature Organometallic Multiferroics: The Marriage of d-p Spin Coupling and Structural Inversion Symmetry Breaking.

    Feng, Qingqing / Li, Xiangyang / Li, Xingxing

    Nano letters

    2024  Volume 24, Issue 11, Page(s) 3462–3469

    Abstract: Two-dimensional (2D) room-temperature multiferroic materials are highly desirable but still very limited. Herein, we propose a potential strategy to obtain such materials in 2D metal-organic frameworks (MOFs) by utilizing the d-p direct spin coupling in ... ...

    Abstract Two-dimensional (2D) room-temperature multiferroic materials are highly desirable but still very limited. Herein, we propose a potential strategy to obtain such materials in 2D metal-organic frameworks (MOFs) by utilizing the d-p direct spin coupling in conjunction with center-symmetry-breaking six-membered heterocyclic rings. Based on this strategy, a screening of 128 2D MOFs results in the identification of three multiferroics, that is, Cr(1,2-oxazine)
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00210
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  2. Article: Innovations in WO

    Li, Xingxing / Fu, Li / Karimi-Maleh, Hassan / Chen, Fei / Zhao, Shichao

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27740

    Abstract: This review critically examines the progress and challenges in the field of nanostructured tungsten oxide ( ... ...

    Abstract This review critically examines the progress and challenges in the field of nanostructured tungsten oxide (WO
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27740
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  3. Article: High frequency strong current tACS：a new dawn of non-drug therapy for patients with major depressive disorder.

    Hu, Linling / Li, Xingxing / Zhou, Dongsheng / Wu, Shaochang

    General psychiatry

    2023  Volume 36, Issue 6, Page(s) e101261

    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2941976-1
    ISSN 2517-729X ; 2517-729X ; 2096-5923
    ISSN (online) 2517-729X
    ISSN 2517-729X ; 2096-5923
    DOI 10.1136/gpsych-2023-101261
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  4. Article ; Online: Research progress of Ustekinumab in the treatment of inflammatory bowel disease.

    Zhang, Weilin / Zhong, Guoqiang / Ren, Xingxing / Li, Mingsong

    Frontiers in immunology

    2024  Volume 15, Page(s) 1322054

    Abstract: Inflammatory bowel disease (IBD) is a chronic, recurrent gastrointestinal disorder with elusive etiology. Interleukin-12 (IL-12) and IL-23 have emerged as key proinflammatory mediators/cytokines in IBD pathogenesis. Ustekinumab (UST), targeting IL-12 and ...

    Abstract Inflammatory bowel disease (IBD) is a chronic, recurrent gastrointestinal disorder with elusive etiology. Interleukin-12 (IL-12) and IL-23 have emerged as key proinflammatory mediators/cytokines in IBD pathogenesis. Ustekinumab (UST), targeting IL-12 and IL-23, has demonstrated promising efficacy and safety in the treatment of IBD. Recently, UST has become increasingly favored as a potential first-line treatment option. This review delineates UST's mechanism of action, its clinical applications in IBD, including the response rates, strategies for dose optimization for case of partial or lost response, and potential adverse events. This review aims to offer a comprehensive understanding of UST's role as a therapeutic option in IBD management.
    MeSH term(s) Humans ; Ustekinumab/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Interleukin-12 ; Cytokines/therapeutic use ; Interleukin-23
    Chemical Substances Ustekinumab (FU77B4U5Z0) ; Interleukin-12 (187348-17-0) ; Cytokines ; Interleukin-23
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1322054
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  5. Article ; Online: Development of fatty acid metabolism-related models in lung adenocarcinomaA Review.

    Ye, Wei / Li, Xingxing

    Medicine

    2023  Volume 102, Issue 1, Page(s) e32542

    Abstract: Backgroud: Lung adenocarcinoma (LUAD) is 1 of the common malignancy with a poor prognosis.: Materials and methods: Based on bioinformatics, the fatty acid metabolism model of LUAD was developed. We downloaded LUAD transcriptome data from the cancer ... ...

    Abstract Backgroud: Lung adenocarcinoma (LUAD) is 1 of the common malignancy with a poor prognosis.
    Materials and methods: Based on bioinformatics, the fatty acid metabolism model of LUAD was developed. We downloaded LUAD transcriptome data from the cancer genome atlas and gene expression omnibus databases. We used bioinformatics methods to construct a fatty acid metabolism-related predictive risk model to predict the prognosis of LUAD. We further explored the relationship between prognostic models and survival and immunity.
    Results: We identified 17 prognosis-related fatty acid-associated genes and constructed prognostic models. In the the cancer genome atlas cohort, the prognosis was worse in the high-risk score group compared to the low-risk score group. The ROC curve confirmed its accuracy. Subsequently, we used the gene expression omnibus database to confirm the above findings. There were differences in immune infiltrating cell abundance and immune function between the high-risk score group and low-risk score group. The immune dysfunction and exclusion (TIDE) based algorithm showed that the low-risk score group was more suitable for the immune treatment.
    Conclusion: Fatty acid metabolic patterns can deepen the understanding of the immune microenvironment of LUAD and be used to guide the formulation of immunotherapy protocols.
    MeSH term(s) Humans ; Adenocarcinoma of Lung/genetics ; Fatty Acids ; Lipid Metabolism ; Lung ; Lung Neoplasms/genetics ; Prognosis ; Tumor Microenvironment
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032542
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Spatial and temporal distribution characteristics of pCO

    Li, Kai / Cao, Xingxing / Zhou, Shiyu / Li, Linwei

    Environmental science and pollution research international

    2023  Volume 30, Issue 18, Page(s) 53920–53937

    Abstract: Surface rivers play an essential role in carbon cycle processes in karst regions. However, the ... ...

    Abstract Surface rivers play an essential role in carbon cycle processes in karst regions. However, the CO
    MeSH term(s) Humans ; Carbon Dioxide/analysis ; Urbanization ; Rivers ; Carbonates ; Carbon Cycle ; China ; Environmental Monitoring
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbonates
    Language English
    Publishing date 2023-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-26144-9
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  7. Article: Multiple Early Biomarkers to Predict Cognitive Decline in Dementia-Free Older Adults.

    Li, Juan / Jiang, Zhiying / Duan, Shengjie / Zhu, Xingxing

    Journal of geriatric psychiatry and neurology

    2024  , Page(s) 8919887241232650

    Abstract: Introduction: Baseline olfactory impairment, poor performance on cognitive test, and medial temporal lobe atrophy are considered biomarkers for predicting future cognitive decline in dementia-free older adults. However, the combined effect of these ... ...

    Abstract Introduction: Baseline olfactory impairment, poor performance on cognitive test, and medial temporal lobe atrophy are considered biomarkers for predicting future cognitive decline in dementia-free older adults. However, the combined effect of these predictors has not been fully investigated.
    Methods: A group of 110 participants without dementia were continuously recruited into this study, and underwent olfactory, cognitive tests and MRI scanning at baseline and 5-year follow-up. Olfactory function was assessed using the University of Pennsylvania Smell Identification Test (UPSIT). Participants were divided into the cognitive decliners and non-decliners.
    Results: Among 87 participants who completed the 5-year follow-up, cognitive decline was present in 32 cases and 55 remained stable. Compared with non-decliners, cognitive decliners presented lower scores on both the UPSIT and the Montreal Cognitive Assessment (MoCA), and smaller hippocampal volume at baseline (all
    Conclusions: The combination of olfactory test, cognitive test with structural MRI may enhance the predictive ability for future cognitive decline for dementia-free older adults.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035760-9
    ISSN 0891-9887
    ISSN 0891-9887
    DOI 10.1177/08919887241232650
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Construction of Multi-Mode Photoelectrochemical Immunoassays for Accurate Detection of Cancer Markers: Assisted with MOF-Confined Plasmonic Nanozyme.

    Meng, Xingxing / Wang, Jing / Diao, Leilei / Li, Chuanping

    Analytical chemistry

    2024  Volume 96, Issue 3, Page(s) 1336–1344

    Abstract: In clinical diagnostics, sensitive and accurate biomarker monitoring is greatly challenged by the limitations of false positive/negative errors in single-modal photoelectrochemical analysis. Herein, we propose a multimode immunoassay by integrating ... ...

    Abstract In clinical diagnostics, sensitive and accurate biomarker monitoring is greatly challenged by the limitations of false positive/negative errors in single-modal photoelectrochemical analysis. Herein, we propose a multimode immunoassay by integrating photoelectrochemical, colorimetric, and photothermal imaging analysis into one electrode. The immunosensors could simultaneously achieve three detection modes at one electrode, which provided a new pathway for the accurate detection of the target prostate-specific antigen (PSA) and circumvented false-positive or negative errors during the detection process. To this end, an integrated multifunctional chip (TiO
    MeSH term(s) Humans ; Male ; Prostate-Specific Antigen/analysis ; Biosensing Techniques/methods ; Immunoassay/methods ; Metal-Organic Frameworks ; Neoplasms ; Electrochemical Techniques/methods ; Limit of Detection
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Metal-Organic Frameworks
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04952
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Two New 1D Supramolecular Compounds Based on PbI

    Zhang, Xingxing / Li, Jian / Niu, Yunyin

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Two new inorganic-organic hybrid crystals based on ... ...

    Abstract Two new inorganic-organic hybrid crystals based on PbI
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28072934
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    Zs.MO 81: Show issues

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  10. Article ; Online: Self-Heating Multistage Microneedle Patch for Topical Therapy of Skin Cancer.

    Shao, Jundong / Li, Xingxing / Li, Yashi / Lin, Jing / Huang, Peng

    Advanced materials (Deerfield Beach, Fla.)

    2024  Volume 36, Issue 15, Page(s) e2308217

    Abstract: Topical therapy is a favored route for treating skin cancers, but remain many challenges, such as low delivery efficiency, limited tumor tissue penetration, and unsatisfactory blood circulation. Here, a self-heating microneedle (MN) patch with multilevel ...

    Abstract Topical therapy is a favored route for treating skin cancers, but remain many challenges, such as low delivery efficiency, limited tumor tissue penetration, and unsatisfactory blood circulation. Here, a self-heating microneedle (MN) patch with multilevel structures, including a dissolvable base for rapid drug release, a degradable tip for sustained drug release, and a self-heating substrate is described. The thermally enhanced drug release performance is validated through both in vitro and in vivo experiments. High tumor therapeutic efficacy can be achieved due to the rapid release of 5-fluorouracil, while the sustained release of thymoquinone endows the MN patch with long-term tumor inhibition ability. It is further demonstrated the feasibility of such an MN patch for in vivo topical therapy of cutaneous squamous cell carcinoma with high efficacy, low side effects, and long-term inhibition of recurrence. This self-heating MN patch holds great promise for potential clinical applications, especially for the treatment of skin cancers.
    MeSH term(s) Humans ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Carcinoma, Squamous Cell ; Heating ; Drug Delivery Systems ; Pharmaceutical Preparations ; Skin/pathology
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202308217
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