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Article ; Online: HIV and Global Cardiovascular Health.

Wagle, Anjali / Goerlich, Erin / Post, Wendy S / Woldu, Bethel / Wu, Katherine C / Hays, Allison G

2022 Volume 24, Issue 9, Page(s) 1149–1157

Abstract: Purpose of review: Because of effective combination antiretroviral therapy, people living with HIV (PLWH) are living longer but developing chronic age-related conditions including cardiovascular disease (CVD), the leading cause of death globally. This ... ...

Abstract	Purpose of review: Because of effective combination antiretroviral therapy, people living with HIV (PLWH) are living longer but developing chronic age-related conditions including cardiovascular disease (CVD), the leading cause of death globally. This review aims to discuss the epidemiology, mechanisms, and clinical considerations of CVD in PLWH from a global perspective. Recent findings: PLWH are at greater risk for CVD at chronologically younger ages than those without HIV. Potential underlying mechanisms for CVD in PLWH include systemic inflammation, comorbidities, immune-mediated, or treatment-related mechanisms. There is also risk factor variation based on geographical location, including non-traditional CVD risk factors. CVD is prevalent in PLWH and increasing on a global scale. Further understanding the unique epidemiology, risk factors, and treatment of CVD in this population will improve the care of PLWH.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular System ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Inflammation ; Risk Factors
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-022-01741-1
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Article ; Online: Multimodality Imaging for Cardiac Evaluation in Patients with COVID-19.

Goerlich, Erin / Minhas, Anum S / Mukherjee, Monica / Sheikh, Farooq H / Gilotra, Nisha A / Sharma, Garima / Michos, Erin D / Hays, Allison G

Current cardiology reports

2021 Volume 23, Issue 5, Page(s) 44

Abstract: Purpose of review: A growing number of cardiovascular manifestations resulting from the novel SARS-CoV-2 coronavirus (COVID-19) have been described since the beginning of this global pandemic. Acute myocardial injury is common in this population and is ... ...

Abstract	Purpose of review: A growing number of cardiovascular manifestations resulting from the novel SARS-CoV-2 coronavirus (COVID-19) have been described since the beginning of this global pandemic. Acute myocardial injury is common in this population and is associated with higher rates of morbidity and mortality. The focus of this review centers on the recent applications of multimodality imaging in the diagnosis and management of COVID-19-related cardiovascular conditions. Recent findings: In addition to standard cardiac imaging techniques such as transthoracic echocardiography, other modalities including computed tomography and cardiac magnetic resonance imaging have emerged as useful adjuncts in select patients with COVID-19 infection, particularly those with suspected ischemic and nonischemic myocardial injury. Data have also emerged suggesting lasting COVID-19 subclinical cardiac effects, which may have long-term prognostic implications. With the spectrum of COVID-19 cardiovascular manifestations observed thus far, it is important for clinicians to recognize the role, strengths, and limitations of multimodality imaging techniques in this patient population.
MeSH term(s)	COVID-19 ; Heart ; Humans ; Multimodal Imaging ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-021-01483-6
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Article: The Role of Multimodality Imaging in HIV-Associated Cardiomyopathy.

Gambahaya, Ellise T / Rana, Rimsha / Bagchi, Shashwatee / Sharma, Garima / Sarkar, Sudipa / Goerlich, Erin / Cupido, Blanche / Mukherjee, Monica / Hays, Allison G

Frontiers in cardiovascular medicine

2022 Volume 8, Page(s) 811593

Abstract: Despite marked advances in therapeutics, HIV infection remains a leading cause of morbidity and mortality worldwide. HIV infection is associated with cardiovascular complications including myocardial dysfunction. The description of HIV-associated ... ...

Abstract	Despite marked advances in therapeutics, HIV infection remains a leading cause of morbidity and mortality worldwide. HIV infection is associated with cardiovascular complications including myocardial dysfunction. The description of HIV-associated cardiomyopathy (HIVAC) has evolved over time from a predominantly dilated cardiomyopathy with systolic dysfunction to one of subclinical diastolic dysfunction. Multimodality cardiovascular imaging plays an integral role in our understanding of the etiology and pathogenesis of HIVAC. Such imaging is also essential in the evaluation of individuals with chronic HIV disease who present with cardiac symptoms, especially of heart failure. In the present review, we will highlight current evidence for the role of multimodality imaging in establishing the diagnosis, etiology and pathophysiology of HIVAC as well as guiding treatment and assessing prognosis.
Language	English
Publishing date	2022-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.811593
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Article: Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.

Minhas, Anum S / Goerlich, Erin / Corretti, Mary C / Arbab-Zadeh, Armin / Kelle, Sebastian / Leucker, Thorsten / Lerman, Amir / Hays, Allison G

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 778762

Abstract: Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong ...

Abstract	Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong prognosticator for cardiovascular events and mortality, and assessment of endothelial function can aid in selecting therapies and testing their response. While the gold standard method of measuring coronary endothelial function remains invasive angiography, several non-invasive imaging techniques have emerged for investigating both coronary and peripheral endothelial function. In this review, we will explore and summarize the current invasive and non-invasive modalities available for endothelial function assessment for clinical and research use, and discuss the strengths, limitations and future applications of each technique.
Language	English
Publishing date	2022-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.778762
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Article: Myocardial Work Efficiency, A Novel Measure of Myocardial Dysfunction, Is Reduced in COVID-19 Patients and Associated With In-Hospital Mortality.

Minhas, Anum S / Gilotra, Nisha A / Goerlich, Erin / Metkus, Thomas / Garibaldi, Brian T / Sharma, Garima / Bavaro, Nicole / Phillip, Susan / Michos, Erin D / Hays, Allison G

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 667721

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.667721
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Article ; Online: Left Atrial Function in Patients with Coronavirus Disease 2019 and Its Association with Incident Atrial Fibrillation/Flutter.

Goerlich, Erin / Minhas, Anum / Gilotra, Nisha / Barth, Andreas S / Mukherjee, Monica / Parziale, Allyson / Wu, Katherine C / Hays, Allison G

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2021 Volume 34, Issue 10, Page(s) 1106–1109

MeSH term(s)	Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Function, Left ; COVID-19 ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2021.05.015
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Unsupervised machine learning demonstrates the prognostic value of TAPSE/PASP ratio among hospitalized patients with COVID-19.

Jani, Vivek / Kapoor, Karan / Meyer, Joseph / Lu, Jim / Goerlich, Erin / Metkus, Thomas S / Madrazo, Jose A / Michos, Erin / Wu, Katherine / Bavaro, Nicole / Kutty, Shelby / Hays, Allison G / Mukherjee, Monica

Echocardiography (Mount Kisco, N.Y.)

2022 Volume 39, Issue 9, Page(s) 1198–1208

Abstract: Background: The ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) is a validated index of right ventricular-pulmonary arterial (RV-PA) coupling with prognostic value. We determined the predictive ... ...

Abstract	Background: The ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) is a validated index of right ventricular-pulmonary arterial (RV-PA) coupling with prognostic value. We determined the predictive value of TAPSE/PASP ratio and adverse clinical outcomes in hospitalized patients with COVID-19. Methods: Two hundred and twenty-nine consecutive hospitalized racially/ethnically diverse adults (≥18 years of age) admitted with COVID-19 between March and June 2020 with clinically indicated transthoracic echocardiograms (TTE) that included adequate tricuspid regurgitation (TR) velocities for calculation of PASP were studied. The exposure of interest was impaired RV-PA coupling as assessed by TAPSE/PASP ratio. The primary outcome was in-hospital mortality. Secondary endpoints comprised of ICU admission, incident acute respiratory distress syndrome (ARDS), and systolic heart failure. Results: One hundred and seventy-six patients had both technically adequate TAPSE measurements and measurable TR velocities for analysis. After adjustment for age, sex, BMI, race/ethnicity, diabetes mellitus, and smoking status, log(TAPSE/PASP) had a significantly inverse association with ICU admission (p = 0.015) and death (p = 0.038). ROC analysis showed the optimal cutoff for TAPSE/PASP for death was 0.51 mm mmHg Conclusion: Impaired RV-PA coupling, assessed noninvasively via the TAPSE/PASP ratio, was predictive of need for ICU level care and in-hospital mortality in hospitalized patients with COVID-19 suggesting utility of TAPSE/PASP in identification of poor clinical outcomes in this population both by traditional statistical and unsupervised machine learning based methods.
MeSH term(s)	Adult ; Humans ; COVID-19 ; Echocardiography, Doppler ; Prognosis ; Prospective Studies ; Unsupervised Machine Learning ; Ventricular Dysfunction, Right ; Ventricular Function, Right
Language	English
Publishing date	2022-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15432
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 359: Show issues

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Article ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients With Coronavirus Disease-19.

Goerlich, Erin / Gilotra, Nisha A / Minhas, Anum S / Bavaro, Nicole / Hays, Allison G / Cingolani, Oscar H

Journal of cardiac failure

2020 Volume 27, Issue 1, Page(s) 100–104

Abstract: Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in ... ...

Abstract	Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in hospitalized patients with COVID-19 and subsequently aimed to identify characteristics of affected patients. We hypothesized that patients with COVID-19 with reduced basal LV strain would demonstrate elevated cardiac biomarkers. Methods and result: Eighty-one consecutive patients with COVID-19 underwent speckle-tracking echocardiography. Those with poor quality speckle-tracking echocardiography (n = 2) or a known LV ejection fraction of <50% (n = 4) were excluded. Patients with an absolute value basal longitudinal strain of <13.9% (2 standard deviations below normal) were designated as cases (n = 39); those with a basal longitudinal strain of ≥13.9% were designated as controls (n = 36). Demographics and clinical variables were compared. Of 75 included patients (mean age 62 ± 14 years, 41% women), 52% had reduced basal strain. Cases had higher body mass index (median 34.1; interquartile range 26.5-37.9 kg/m Conclusions: Reduced basal LV strain is common in patients with COVID-19. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.
MeSH term(s)	Aged ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Echocardiography/methods ; Echocardiography/trends ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2020.09.469
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Article ; Online: Effect of Sex on Coronary Endothelial Dysfunction in People Living With HIV.

Minhas, Anum S / Leucker, Thorsten M / Goerlich, Erin / Soleimani-Fard, Alborz / Schär, Michael / Ziogos, Efthymios / Miller, Eliza / Gerstenblith, Gary / Hays, Allison G

Journal of the American Heart Association

2022 Volume 11, Issue 23, Page(s) e026428

Abstract: Background Impaired coronary endothelial function (CEF) predicts cardiovascular events and occurs in people living with HIV (PLWH). Women compared with men living with HIV have worse cardiovascular outcomes, but prior CEF studies included few women. The ... ...

Abstract	Background Impaired coronary endothelial function (CEF) predicts cardiovascular events and occurs in people living with HIV (PLWH). Women compared with men living with HIV have worse cardiovascular outcomes, but prior CEF studies included few women. The authors aimed to compare CEF in women with HIV versus without HIV, investigate sex differences in CEF and PCSK9 (proprotein convertase subtilisin/kexin type 9) (a proinflammatory biomarker), and evaluate whether increased serum levels of PCSK9 are associated with CEF in PLWH. Methods and Results Magnetic resonance imaging was performed to measure CEF (as percent change in coronary cross-sectional area and coronary blood flow during isometric handgrip exercise, an endothelial-dependent stressor) and serum PCSK9 levels were measured in 106 PLWH and 76 people without HIV. CEF was significantly reduced in women with versus without HIV (cross-sectional area change -0.5%±9.7 versus 9.5%±3.2, respectively). After adjustment for age, body mass index, and menopausal status, women with HIV still had reduced CEF (percentage of cross-sectional area: ß -8.3 [-13 to -3.6],
MeSH term(s)	Female ; Humans ; Proprotein Convertase 9 ; Hand Strength ; HIV Infections/complications ; HIV Infections/drug therapy
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.026428
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Article ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients with COVID-19

Goerlich, Erin / Gilotra, Nisha A. / Minhas, Anum S. / Bavaro, Nicole / Hays, Allison G. / Cingolani, Oscar H.

Journal of Cardiac Failure ; ISSN 1071-9164

2020

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.cardfail.2020.09.469
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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